SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase by Xiaobin Wang, Shulin Li, Zichen Li, Zhuona Lin, Zhifeng Wang

“…Despite significant advances in diagnosis and treatment, the compromised therapeutic effect of chemotherapeutic agents, such as Oxaliplatin (OXA), remains a major clinical challenge. …”
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Comparative CT with stress manoeuvres for diagnosing distal isolated tibiofibular syndesmotic injury in acute ankle sprain: a protocol for an accuracy- test prospective study by João Carlos Rodrigues, Mario Lenza, Laercio Alberto Rosemberg, Durval do Carmo Santos Barros, Mario Ferretti, Alexandre Leme Godoy Santos, Marcelo Pires Prado, José Felipe Marion Alloza, Renato Amaral Masagão, Adham do Amaral e Castro, Marco Kawamura Demange

“…The secondary objective is to investigate the participants’ disability outcomes by applying the Foot and Ankle Ability Measure questionnaire.Methods and analyses This study of a diagnostic accuracy test will consecutively select individuals older than 18 years with a clinical diagnosis of a suspected acute syndesmotic injury. …”
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Association between vitamin D deficiency and major depression in patients with chronic kidney disease: a cohort study by I-Wen Chen, I-Wen Chen, Wei-Ting Wang, Yi-Chen Lai, Yi-Chen Lai, Ying-Jen Chang, Yao-Tsung Lin, Kuo-Chuan Hung, Kuo-Chuan Hung

“…Patients were categorized into VDD (≤20 ng/mL) and control (≥30 ng/mL) groups based on measurements within 3 months of CKD diagnosis. The primary outcome was the incidence of major depression within 1 year of follow-up.ResultsAmong 17,955 matched pairs, VDD was associated with increased depression risk at 1 year (hazard ratio [HR]: 1.929; 95% confidence interval [CI]: 1.52–2.448; p < 0.0001). …”
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Three-dimensional evaluation of tongue position and volume in adult patients with different skeletal malocclusions by CHIOU Wei-Cho, MEN Xinrui, ZHANG Kaiwen, JIANG Xiaoge, CHEN Song

“…Objective To analyze the relationship between tongue volume, tongue position, dental and skeletal parameters in adult patients with different skeletal malocclusions, providing references for the etiology, diagnosis, and treatment of skeletal malocclusions. …”
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Diagnostic Accuracy of EndoFaster® and Narrow-Band Imaging Endoscopy in Patients with Impaired Gastric Acid Secretion: A Real-Time Prospective Study by M. Cazzato, G. Esposito, G. Galli, E. Pilozzi, E. Lahner, V. D. Corleto, A. Zullo, E. Di Giulio, B. Annibale

“…EndoFaster® showed an accuracy for corpus atrophic gastritis diagnosis, compared to histopathological evaluation as gold standard, of 87.1% and a sensitivity, specificity, PPV, and NPV of 78.8%, 93.1%, 89.1%, and 85.9%, respectively. pH showed a positive correlation with the severity score of atrophy (r=0.67, 95% CI: 0.73-0.81, and p<0.0001). …”
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Cohort profile: the ChicagO Multiethnic Prevention and Surveillance Study (COMPASS) by Habibul Ahsan, Farzana Jasmine, Muhammad G Kibriya, Briseis Aschebrook-Kilfoy, Liz Stepniak, Rajan Gopalakrishnan, Andrew Craver, Paul Zakin, Saira Tasmin, Karen E Kim, Kathleen H Goss, Marcy List, Michelle LeBeau

“…Moreover, 38% self-reported having had a diagnosis of hypertension, while 66.4% were measured as hypertensive at enrolment.Future plans We plan to expand recruitment up to 100 000 participants from the Chicago metropolitan area in the next decade using a hybrid community and clinic-based recruitment framework that incorporates data collection through mobile medical units. …”
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Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog by Ting Ye, Jingyuan Li, Zhiwei Sun, Yongli Liu, Liangsheng Kong, Shixia Zhou, Junlin Tang, Jianyu Wang, H. Rosie Xing

“…Abstract Lung cancer has the highest mortality rate due to late diagnosis and high incidence of metastasis. Cancer stem cells (CSCs) are a subgroup of cancer cells with self‐renewal capability similar to that of normal stem cells (NSCs). …”
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Subjective and objective stress during body exposure: a comparison of adolescents with anorexia nervosa versus high body dissatisfaction by Valeska Stonawski, Louisa Kuper, Nicolas Rohleder, Gunther H. Moll, Hannah Fischer, Anne-Christine Plank, Tanja Legenbauer, Oliver Kratz, Stefanie Horndasch

“…BD seems to be a transdiagnostic phenomenon with BE as a successful intervention independent of psychiatric diagnosis. Current findings should be validated in larger samples, and the hypothesis of a transdiagnostic BD should be investigated in future research.…”
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Nationwide observational study of incidence, management and outcome of spontaneous coronary artery dissection: a report from the Swedish Coronary Angiography and Angioplasty regist... by Per Tornvall, Eva Swahn, Dimitrios Venetsanos, Troels Yndigegn, Sofia Sederholm Lawesson, Lena Jonasson, Nina Johnston, Henrik Wilander, Christos Pagonis, Christian Dworeck, Thomas Kellerth

“…The index angiographies of patients with registered SCAD were re-evaluated at each centre to confirm the diagnosis. Patients with non-SCAD myocardial infarction (MI) (n=32 601) were used for comparison.Outcome measures Outcomes included all-cause mortality, reinfarction or acute coronary reangiography.Results This study found 147 SCAD patients, rendering an incidence of 0.74 per 100 000 per year and a prevalence of 0.43% of all MIs. …”
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Do Nonsuicidal Severely Depressed Individuals with Diabetes Profit from Internet-Based Guided Self-Help? Secondary Analyses of a Pragmatic Randomized Trial by Sandra Schlicker, Kiona K. Weisel, Claudia Buntrock, Matthias Berking, Stephanie Nobis, Dirk Lehr, Harald Baumeister, Frank J. Snoek, Heleen Riper, David D. Ebert

“…Major depressive disorder diagnosis at the baseline (pprf6=0.01), higher levels of depression (Beck Depression Inventory II; pprpo=0.00; pprf6=0.00), and lower HbA1c (pprpo=0.04) predicted changes in depressive symptoms. …”
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Role of nurses in prevention and nursing of diabetic foot disease (回顾护士在糖尿病足预防和护理中的作用) by GAN Lu (甘露), XIE Wei (谢薇), LIU Qing (刘青), JIANG Yonghong (江永红), YUAN Zheng (袁铮), XIAO Mengyun (肖孟云), MO Mei (莫梅), YUAN Dan (袁丹), CHEN Hongyi (陈红伊), JIANG Qingxia (江青霞), XU Tengfei (徐腾飞), LIU Qiulin (李秋林)

“…Nurses are the primary providers of prevention and early diagnosis of diabetes and its complications. This paper summarized the role of clinical nurse specialist in prevention of diabetic foot disease, diabetic foot care and prevention of diabetic foot wounds. …”
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Epidemiology of endometriosis in Kazakhstan: a national population-based cohort analysis (2014–2019) using data from the national electronic healthcare system by Gulzhanat Aimagambetova, Yesbolat Sakko, Talshyn Ukybassova, Milan Terzic, Milan Terzic, Aizada Marat, Nazira Kamzayeva, Arnur Gusmanov, Gulnur Zhakhina, Sauran Yerdessov, Kamilla Mussina, Dmitriy Syssoyev, Abduzhappar Gaipov, Abduzhappar Gaipov

“…Clinical specialist and health authorities in Kazakhstan must work to ensure the endometriosis proper diagnosis end registration to improve the disease management and outcomes.…”
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A Pilot Randomized Crossover Trial of Wet Suction and Conventional Techniques of Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Upper Gastrointestinal Subepithelial Lesion... by Mika Takasumi, Takuto Hikichi, Minami Hashimoto, Jun Nakamura, Tsunetaka Kato, Hitomi Kikuchi, Yuichi Waragai, Ko Watanabe, Tadayuki Takagi, Rei Suzuki, Mitsuru Sugimoto, Manabu Hayashi, Yuki Sato, Hiroki Irie, Ryoichiro Kobashi, Yoshinori Okubo, Masao Kobayakawa, Hiromasa Ohira

“…Logistic regression analysis showed that higher cellularity may be related to the final diagnosis of gastrointestinal stromal tumors in the dry technique and the SEL location in the upper stomach in the wet technique. …”
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Application of Infrared Thermography and Artificial Intelligence in Healthcare: A Systematic Review of Over a Decade (2013&#x2013;2024) by Jahmunah Vicnesh, Massimo Salvi, Yuki Hagiwara, Hah Yan Yee, Hasan Mir, Prabal Datta Barua, Subrata Chakraborty, Filippo Molinari, U. Rajendra Acharya

“…The reviewed studies demonstrated how various AI techniques, including deep learning and classical machine learning, can be used to develop automated diagnosis systems using IRT images. The efficacy of these AI systems differed depending on the medical field; for example, they could identify dry eye disease with 90&#x2013;100% accuracy, classify diabetic foot ulcers with 85&#x2013;95% accuracy, and detect breast cancer with 80&#x2013;100% accuracy. …”
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GenVFNet: Generating Visual Field From Optical Coherence Tomography Angiography by Conditional Generative Adversarial Networks by Anita Manassakorn, Supatana Auethavekiat, Vera Sa-Ing, Sunee Chansangpetch, Kitiya Ratanawongphaibul, Nopphawan Uramphorn, Visanee Tantisevi

“…To conform with the five severity levels in clinical diagnosis, we quantized the generated VF (GenRawVF) from GenVFNet into five levels and named the quantized image GenVF. …”
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Characteristics of beta parapapillary atrophy in primary angle-closure suspect by Qing Zhang, Ye Zhang, Xiaohua Pan, Hui Feng, Shuning Li, Zhi Li, Meijuan Zhang, Caixia Li, Fei Xiang, Qianqian Ji

“…A larger β-PPA area was associated with older age (p=0.014), greater vertical cup-to-disc ratio (p=0.028), larger disc area (p&lt;0.001) and PACS diagnosis (p=0.035).Conclusion 48.80% of participants with PACS had β-PPA, which is slightly larger than NPACS. …”
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Direct-Acting Oral Anticoagulants in the Management of Cerebral Venous Sinus Thrombosis—Where Do We Stand? by Nikhil Vojjala, Supriya Peshin, Lakshmi Prasanna Vaishnavi Kattamuri, Rabia Iqbal, Adit Dharia, Jayalekshmi Jayakumar, Rafi Iftekhar, Shagun Singh, Mamtha Balla, Claudia S. Villa Celi, Ramya Ramachandran, Rishab Prabhu, Sumeet K. Yadav, Geetha Krishnamoorthy, Vijendra Singh, Karan Seegobin

“…A high index of suspicion is needed because timely diagnosis can significantly alter the natural course of the disease, reduce acute complications, and improve long-term outcomes. …”
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Mutation in the COL2A1 gene is associated with acetabular dysplasia by Miaomiao Xin, Xin Guan, Xin Guan, Jiangfei Yang, Yi Li, Zhentao Man, Hongsheng Sun, Min Fu

“…Bioinformatics analysis was performed to assess the pathogenicity of the identified variant, and 3D protein modeling was conducted to predict its impact on protein structure.ResultsThe proband presented with pain in bilateral hips, and based on clinical symptoms, laboratory findings and imaging studies, the final diagnosis was considered to be acetabular dysplasia with overlapping secondary synovial chondromatosis. …”
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Evaluation of low cryptococcal antigen titer as determined by the lateral flow assay in serum and cerebrospinal fluid among HIV-negative patients: a retrospective diagnostic accura... by Xuan Wang, Jia-Hui Cheng, Ling-Hong Zhou, Jun-Hao Zhu, Rui-Ying Wang, Hua-Zhen Zhao, Ying-Kui Jiang, Li-Ping Huang, Ching-Wan Yip, Chun-Xing Que, Min Zhu, Li-Ping Zhu

“…In conclusion, the results of this study imply that low CrAg LFA titer, either in serum or CSF, is crucial for early diagnosis of cryptococcosis in HIV-negative patients, and lumbar puncture is recommended to be performed routinely for CSF testing when a positive low serum titer is reported. …”
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Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration by Salvador Cervin Serrano, Dalia González Villareal, Maribel Aguilar-Medina, Jose Guillermo Romero-Navarro, Jose Geovanni Romero Quintana, Eliakym Arámbula Meraz, Ignacio Osuna Ramírez, Veronica Picos-Cárdenas, Julio Granados, Iris Estrada-García, Guzman Sánchez-Schmitz, Rosalío Ramos-Payán

“…Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. …”
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