Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease by Zhihao Qi, Quan Li, Shuhua Yang, Chun Fu, Burong Hu

“…<b>Methods:</b> Summary statistics from expression quantitative trait loci (eQTL), DNA methylation QTL (mQTL), and protein QTL (pQTL) on European descent were included. …”
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Decoding the Methylation Patterns of ABC Transporters in Colorectal Cancer by Nurul Nabilah Norhisan, Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Nur Alyaa Afifah Md Shahri, Francis Yew Fu Tieng, Imilia Ismail, Muhammad-Redha Abdullah-Zawawi, Learn-Han Lee, Nurul Syakima Ab Mutalib

“…The molecular mechanisms that drive CRC, particularly the DNA methylation patterns in ATP-binding cassette (ABC) genes, have attracted considerable attention because of their potential roles in CRC drug resistance, initiation, and progression. …”
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Supplementation with serine-enriched non-essential amino acids from minimum essential medium promotes blastocyst development of in vitro-fertilized bovine embryos by Nobuhiko ITAMI, Yuji HIRAO

“…Non-essential amino acids (NEAAs) are widely used for the culture of bovine embryos fertilized in vitro; however, the necessity and optimal concentration of individual NEAA must be verified to produce four-criteria-compliant blastocysts. DNA methylation is a critical event for blastocyst formation in bovines, and serine is a common NEAA that serves as a methyl donor and participates in DNA methylation. …”
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Epigenetic Markers of Renal Function in African Americans by Samantha M. Bomotti, Jennifer A. Smith, Alicia L. Zagel, Jacquelyn Y. Taylor, Stephen T. Turner, Sharon L. R. Kardia

“…Chronic kidney disease (CKD) is an increasing concern in the United States due to its rapidly rising prevalence, particularly among African Americans. Epigenetic DNA methylation markers are becoming important biomarkers of chronic diseases such as CKD. …”
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Role of Epigenetics in Modulating Phenotypic Plasticity against Abiotic Stresses in Plants by Fayaz Ahmad Dar, Naveed Ul Mushtaq, Seerat Saleem, Reiaz Ul Rehman, Tanvir Ul Hassan Dar, Khalid Rehman Hakeem

“…The variation in DNA methylation in different organisms exhibits variable phenotypic responses. …”
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Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts by Xuehong Zhang, Paiyun Li, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang, Dajun Deng, Jing Ni

“…P16 inactivation by DNA methylation often occurs automatically during immortalization of normal cells by TERT. …”
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Hypermethylation in Calca Promoter Inhibited ASC Osteogenic Differentiation in Rats with Type 2 Diabetic Mellitus by Lei Wang, Feng Ding, Shaojie Shi, Xingxing Wang, Sijia Zhang, Yingliang Song

“…This phenomenon may be related to changes in osteogenesis-related gene expression caused by DNA methylation. In this study, we established T2DM models to extract adipose-derived stem cells (ASCs) for different gene identifications through DNA methylation sequencing. …”
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Neighborhood environment associations with cognitive function and structural brain measures in older African Americans by Dima L. Chaar, Le Tu, Kari Moore, Jiacong Du, Lauren A Opsasnick, Scott M Ratliff, Thomas H Mosley, Sharon L. R. Kardia, Wei Zhao, Xiang Zhou, Ana V Diez Roux, Fazlay S Faruque, Kenneth R Butler, Jennifer A Smith

“…We did not find evidence that DNA methylation mediates the observed associations between neighborhood characteristics and cognitive function. …”
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An appropriate DNA input for bisulfite conversion reveals LINE-1 and Alu hypermethylation in tissues and circulating cell-free DNA from cancers. by Trang Thi Quynh Tran, Tung The Pham, Than Thi Nguyen, Trang Hien Do, Phuong Thi Thu Luu, Uyen Quynh Nguyen, Linh Dieu Vuong, Quang Ngoc Nguyen, Son Van Ho, Hang Viet Dao, Tong Van Hoang, Lan Thi Thuong Vo

“…With more than 90% of their sequences being methylated in normal cells, these elements undeniably contribute to the global DNA methylation level and constitute a major part of circulating-cell-free DNA (cfDNA). …”
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Hypermethylation at 45S rDNA promoter in cancers. by Trang Thi Quynh Tran, Trang Hien Do, Tung The Pham, Phương Thi Thu Luu, Oanh Minh Pham, Uyen Quynh Nguyen, Linh Dieu Vuong, Quang Ngoc Nguyen, Tuan Van Mai, Son Van Ho, Than Thi Nguyen, Lan Thi Thuong Vo

“…Our results are in line with the hypothesis that an increase in rDNA methylation is a natural pathway protecting rDNA repeats that are extremely sensitive to DNA damage in cancer cells.…”
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Effects of endocrine disrupting chemicals, blood metabolome, and epigenetics on breast cancer risk: A multi-dimensional mendelian randomization study by Ningning Song, Xinquan Xi, Kuan Yang, Chongzhe Pei, Lingzhou Zhao

“…The study also examines the 1400 blood metabolome as potential mediators and explores EDCs-associated DNA methylation changes as potential factors, with a focus on European populations. …”
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Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells by Adele Murrell

“…Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. …”
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Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence by Valentina Gonzalez-Jaramillo, Eliana Portilla-Fernandez, Marija Glisic, Trudy Voortman, Mohsen Ghanbari, Wichor Bramer, Rajiv Chowdhury, Tamar Nijsten, Abbas Dehghan, Oscar H. Franco, Jana Nano

“…Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood. …”
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Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review by Michele Lanza, Giuditta Benincasa, Dario Costa, Claudio Napoli

“…Although changes in aberrant DNA methylation play a major role in the pathogenesis of most ocular diseases, histone modifications are seldom investigated. …”
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Endoplasmic reticulum stress-related CLIP4 plays a procarcinogenic role in hepatocellular carcinoma: an integrated analysis by Anqi Wang, Sitong Yan, Weijia Jiang, Xiang Chen, Yuhan Huang, Xiangyu Zu, Xiao Du, Lulu Fan, Jiatao Liu, Guoping Sun

“…Furthermore, the DNA methylation pattern of CLIP4 was found to have significant prognostic value. …”
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Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L. by D. V. Petrova, N. V. Permyakova, I. R. Grin, D. O. Zharkov

“…Correct maintenance of the DNA methylation status is based on the balance of methylation, passive demethylation, and active demethylation. …”
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Insights into <i>Solea senegalensis</i> Reproduction Through Gonadal Tissue Methylation Analysis and Transcriptomic Integration by Daniel Ramírez, Marco Anaya-Romero, María Esther Rodríguez, Alberto Arias-Pérez, Robert Mukiibi, Helena D’Cotta, Diego Robledo, Laureana Rebordinos

“…Fish exhibit diverse mechanisms of sex differentiation and determination, shaped by both external and internal influences, often regulated by distinct DNA methylation patterns responding to environmental changes. …”
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Role of Cold atmospheric plasma in cancer management by Shrikant B. Mali

“…CAP triggers responses in tumor cells, causing epigenetic changes in DNA methylation levels and histone modification, and altering the expression and activity of non-coding RNAs, affecting cell regulatory functions. …”
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A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response by Minghan Li, Chang Su, Qianru Wang, Yuetong Chen, Di Jiang, Weijia Wang, Shunjin Chen, Xiangping Li, Ming Fu, Juan Lu

“…Significant changes in CNA and DNA methylation were associated with high ZNF32 expression. …”
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Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model by Alaa AM. Osman, Dávid Laczkó, Máté Vágvölgyi, Adrienn Seres-Bokor, Anita Sztojkov-Ivanov, Kata Kira Kemény, Attila Hunyadi, Eszter Ducza

“…The administration of CAL and 20E in obese rats significantly increased the percent of total DNA methylation.This is the first in vivo study on this natural ecdysteroid, which may offer new alternatives for treating metabolic diseases. …”
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