Molecular testing for cytologically suspicious and malignant (Bethesda V and VI) thyroid nodules to optimize the extent of surgical intervention: a retrospective chart review by Jessica Hier, Galit Avior, Marc Pusztaszeri, Joshua R. Krasner, Noura Alyouha, Veronique-Isabelle Forest, Michael P. Hier, Alex Mlynarek, Keith Richardson, Nader Sadeghi, Michael Tamilia, Richard J. Payne

“…However, to date, the role of molecular testing in cytologically suspicious or positive for malignancy (Bethesda V and VI) thyroid nodules has been controversial. The aim of this study was to determine whether patients who had molecular testing in Bethesda V and VI thyroid nodules had the optimal extent of surgery performed more often than patients who did not have molecular testing performed. …”
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Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review by Yingna Gao, Xiaoqiong Shi, Jianqiao He, Hui Yao, Guoning Yu, Lin Zhao, Yi Ma, Yi Ma, Hongliang Zheng, Minhui Zhu, Caiyun Zhang

“…However, whether dmNPC can be treated with immunochemotherapy alone (without LRRT) remains controversial.Case presentationWe report two cases of dmNPC, both in middle-aged men who mainly presented with epistaxis and systemic pain. …”
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Advantages of different dietary supplements for elite combat sports athletes: a systematic review and Bayesian network meta-analysis by Hua Luo, Tengku Fadilah Tengku Kamalden, Xiaolin Zhu, Changqing Xiang, Nurul Amelina Nasharuddin

“…Abstract With an increasing number of studies delving into the impact of dietary supplements on combat sports performance, researchers are actively seeking a more efficient dietary supplement for use in these sports. Nonetheless, controversies persist. Hence, we undertook a systematic review and Bayesian network meta-analysis to discern the most effective dietary supplements in combat sports by synthesizing the available evidence. …”
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Diagnosis of tuberculosis in buffaloes in Argentina: intradermoreaction, compatible lesions and bacteriological culture by Emilia Irina Martínez, Fabiana Cipolini Galarza, Nolly María Monzón, Ana Gabriela Espasandin, José Luis Konrad, Elvira Falzoni, Soledad Barandiaran, Jimena Marfil, Marcela Martínez Vivot, Diana Elina Martínez

“…The use of this control tool is controversial in buffaloes. The aim of this study is to generate information about buffalo tuberculosis in Corrientes,Argentina, through evaluation of field diagnostic test performance, detection of tuberculosis compatible lesions in previously tuberculinized animals and, confirmation by bacteriological culture. …”
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Pengaruh Pemberian Aspartam terhadap Kadar Glukosa Darah Tikus Diabetes Melitus Diinduksi Aloksan by Ega Purnamasari R.D, Eti Yerizel, Efrida .

“…<br />Kata kunci: aspartam, kadar glukosa darah, diabetes melitus, aloksan</p><p>Abstract</p><p>Aspartame is a low-calorie sugar substitute that is often consumed by people with diabetes, but the safety of aspartame is still controversial. The high intensity of aspartame sweetness could be expected to lower blood glucose levels. …”
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Clinical Study of Sentinel Lymph Node Detection to Evaluate Pelvic Lymph Node Metastasis to Determine the Prognosis of Patients with Early Cervical Cancer by Peipei Li, Shuai Feng, Guodong Zhou, Lu Zhang, Xiugui Sheng, Dapeng Li

“…However, the SLN metastasis detection via SLN biopsy in early-stage cervical cancer remains controversial. The current study is aimed at investigating the feasibility and accuracy of combined tracer method for localization of SLN in initial stages of cervical cancer and to evaluate the clinical value of SLN biopsy in replacing pelvic lymph node resection. …”
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A visual walkthrough of robotic partial mesorectal excision using the Versius surgical system by Amro Mureb

“…Interventions: The required distal margin in partial mesorectal excision (PME) is controversial. Several publications have shown that partial excision of the mesorectum, also called tumour-specific mesorectal excision (TSME), with the division of mesorectum 5 cm below the tumour could be a reasonable approach although total mesorectal excision (TME) is still considered the gold standard for all rectal cancer in many studies. …”
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Age dependent deficits in speech recognition in quiet and noise are reflected in MGB activity and cochlear onset coding by Konrad Dapper, Stephan M. Wolpert, Jakob Schirmer, Stefan Fink, Etienne Gaudrain, Deniz Başkent, Wibke Singer, Sarah Verhulst, Christoph Braun, Ernst Dalhoff, Lukas Rüttiger, Matthias H.J. Munk, Marlies Knipper

“…However, it remains controversial whether central slowing is primarily linked to brain processes as atrophy, or is also associated with the slowing of temporal neural processing from the periphery. …”
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The effectiveness of convalescent plasma administered on the first day of admission for COVID-19 patients: an open-label randomized controlled trial by Saeed Mohammadi, Mandana Pouladzadeh, Hamidreza Kouhpayeh, Shamsi Okati, Mehdi Safdarian, Peyman Eshghi, Parastoo Moradi Choghakabodi, Shahabeddin Mashaei, Sharareh Sanei Sistani, Yalda Khani, Soheila Nasizadeh, Ahmad Reza Shamshiri, Amir Teimourpour, Haijuan Wang

“…Background:. Given the controversial reports on the effect of convalescent plasma (CP) on coronavirus disease 2019 (COVID-19) patients, this study aimed to clarify the efficacy of early CP administration, improve the understanding of its impact on clinical outcomes, guide future research, address safety concerns, and inform public health policies. …”
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Peritoneal chemotherapy delivery systems for ovarian cancer treatment: systematic review of animal models by Marcelo Simonsen, Marcelo Simonsen, Rossana Verónica Mendoza López, Simone Maistro, Lucas Takeshi Ikeoka, Glaucia Fernanda de Lima Pereira, Ademar Benévolo Lugão, José Carlos Sadalla, Maria Lúcia Hirata Katayama, Maria Aparecida Azevedo Koike Folgueira

“…IntroductionIntraperitoneal chemotherapy for ovarian cancer treatment has controversial benefits as most methodologies are associated with significant morbidity. …”
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A topographically controlled tipping point for complete Greenland ice sheet melt by M. Petrini, M. Petrini, M. D. W. Scherrenberg, L. Muntjewerf, L. Muntjewerf, M. Vizcaino, R. Sellevold, G. R. Leguy, W. H. Lipscomb, H. Goelzer

“…Previous work on the magnitude and nature of a threshold for GrIS complete melt remains controversial. Here, we explore a potential SMB threshold for complete melt of the GrIS; the impact and interplay of surface melt and glacial isostatic adjustment (GIA) in determining this threshold; and whether the GrIS exhibits characteristics commonly associated with tipping points, such as sensitivity to external forcing. …”
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Identification of the optimal candidates to benefit from surgery and chemotherapy among elderly female breast cancer patients with bone metastases by Yuchen Hu, Junfeng Tang, Xiaofeng Liu, Yusheng Sun, Baojun Gong, Qing Gao

“…The use of surgery and chemotherapy in this population is controversial. This study seeks to create a tool for forecasting overall survival (OS) in older breast cancer patients with bone metastases and to determine the optimal candidates for surgery and chemotherapy. …”
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Pre-treatment nutrition-related indicators and the prognosis of patients with newly diagnosed epithelial ovarian cancer: an ambispective cohort study by Shirui Wang, Jingyu Zhu, Ningjuan Wu, Nannan Wang, Xiaohe Dang, Minyi Zhao, Juan Zhao, Ding Ma, Xiaofeng Yang

“…BackgroundFew studies have explored the link between nutritional status and prognosis in patients with epithelial ovarian cancer (EOC), and existing findings are controversial. Thus, this study aimed to explore the effects of pre-treatment nutrition-related indicators on the prognosis of patients with newly diagnosed EOC.MethodsIn this ambispective cohort study, 1,020 patients with EOC diagnosed by pathology examination were enrolled and followed-up until December 31, 2023. …”
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Land use planning strategies for food versus non-food estate sustainable farming by D. Juhandi, D.H. Darwanto, M. Masyhuri, J.H. Mulyo, N.A. Sasongko, H.L. Susilawati, A. Meilin, T. Martini

“…BACKGROUND AND OBJECTIVES: Food estate initiative is an Indonesian government program designed to achieve food security though the cultivation of strategic commodities on large-scale agricultural land. Despite being controversial due to the scale of land use and budgetary requirements, the viability of the program has been questioned by critics pointing to the failure of a similar initiative in the past. …”
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AI-based tumor-infiltrating lymphocyte scoring system for assessing HCC prognosis in patients undergoing liver resection by Zhiyang Chen, Tingting Xie, Shuting Chen, Zhenhui Li, Su Yao, Xuanjun Lu, Wenfeng He, Chao Tang, Dacheng Yang, Shaohua Li, Feng Shi, Huan Lin, Zipei Li, Anant Madabhushi, Xiangtian Zhao, Zaiyi Liu, Cheng Lu

“…However, their prognostic value in hepatocellular carcinoma (HCC) remains controversial, with different evidence. Given the heterogeneous outcomes in patients with HCC undergoing liver resection, this study aims to develop an AI-based system to quantify CD8+ TILs and assess their prognostic value for patients with HCC. …”
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Clinical analysis of microscopic modified ostium obstruction surgery for symptomatic sacral Tarlov cysts by HUANG Qin‐guo, WU Yan‐yu, LI Hong, ZHOU Qiang, PENG Lin, LU Yun‐tao

“…However, these techniques are associated with a high risk of cysts recurrence and cerebrospinal fluid (CSF) leakage, resulting in the surgical strategy of TCs remains controversial. We hypothesize that incomplete closure of the ostium between the cysts and the subarachnoid space is the probable cause of surgical failure. …”
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HIF-1α and VEGF Immunophenotypes as Potential Biomarkers in the Prognosis and Evaluation of Treatment Efficacy of Atherosclerosis: A Systematic Review of the Literature by Dimitra P. Vageli, Panagiotis G. Doukas, Dimitrios Georgiou, Michailangelos P. Prokopiou, Nefeli E. Ladaki, Androniki Papadopoulou, Sotirios G. Doukas, Konstantina Zacharouli, Konstantinos P. Makaritsis, Maria Ioannou

“…Exploring pathogenetic mechanisms and therapeutic options, we included several studies using variable methods to evaluate HIF-1α/VEGF immunophenotypes with controversial and innovative results. Data limitations may include the use of different survival methods. …”
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La datation des aqueducs lyonnais : un état des lieux by Aldo Borlenghi, Catherine Coquidé

“…The dating of the Gier aqueduct, the longest of the Lyon aqueducts and the only one to supply the highest part of Colline de Fourvière, has long been a very controversial subject.Several scientific contributions have addressed the question, either dating it to the reign of Augustus or to between the reigns of Claudius and Hadrian. …”
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Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials by Tunmise M. Akhigbe, Tunmise M. Akhigbe, Fabrael B. Fidelis, Fabrael B. Fidelis, Adebayo O. Adekunle, Adebayo O. Adekunle, Victory J. Ashonibare, Victory J. Ashonibare, Bolaji A. Akorede, Bolaji A. Akorede, Mansur S. Shuaibu, Mansur S. Shuaibu, Suliat A. Hassan, Cecilia A. Adegbola, Cecilia A. Adegbola, Precious J. Ashonibare, Precious J. Ashonibare, Opeyemi M. Oladapo, Opeyemi M. Oladapo, Adetomiwa E. Adeogun, Adetomiwa E. Adeogun, Adetomiwa E. Adeogun, Seun G. Bamidele, Seun G. Bamidele, Precious A. Oyedokun, Precious A. Oyedokun, Mungala Mukolokota, Mungala Mukolokota, Omotolani S. Kukoyi, Omotolani S. Kukoyi, Ayoola A. Oladipo, Ayoola A. Oladipo, Olayinka E. Adelowo, Olayinka E. Adelowo, Marvelous D. Akangbe, Marvelous D. Akangbe, Jennifer R. Hughes, Albert M. Ricken, Martine Culty, Maria C. W. Avellar, Roland E. Akhigbe, Roland E. Akhigbe

“…However, the benefits of infertility treatments with antioxidants such as coenzyme Q10 (CoQ10) remains controversial.ObjectivesThe aim of the present study was to assess the effects of CoQ10 supplementation on semen quality, i.e., semen volume, total sperm number, sperm concentration, total sperm motility, percentage of progressive sperm motility and sperm morphology. …”
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Regard rapproché, regard éloigné dans la critique d’art, de Diderot à Huysmans by Michel Delon

“…From Balzac’s Chef-d’œuvre d’un inconnu to Baudelaire’s Salons, from the Goncourt brothers to Huysmans, short- and long-sightedness, line and colour, the detail and the whole maintain the dynamic of the aesthetic effect and stoke the controversies of art criticism. Diderot the materialist and Huysmans the spiritualist meet to celebrate the miracle of art, which brings forth beauty from mere material pigments. …”
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