Cyclophosphamide Pharmacogenomic Variation in Cancer Treatment and Its Effect on Bioactivation and Pharmacokinetics by Ibrahim El-Serafi, Sinclair Steele

“…These results were controversial primarily because of the involvement of several interacting enzymes in the Cy metabolic pathway, which can also be affected by several clinical factors as well as other drug interactions. …”
Get full text

Abortion Laws in Indonesia and Islam: A Clash of Morality, Religion, and Rights by Salsabila Triandani, Windiahsari Windiahsari, Ali Masyhar, Aprila Niravita

“… Abortion remains one of the most controversial legal and ethical issues, balancing between reproductive rights, religious doctrines, and state regulations. …”
Get full text

Social robots in adult psychiatry: a summary of utilisation and impact by Maja Kling, Alfred Haeussl, Nina Dalkner, Frederike T. Fellendorf, Melanie Lenger, Alexander Finner, Julia Ilic, Irina S. Smolak, Lena Stojec, Ina Zwigl, Eva Z. Reininghaus

“…Nevertheless, the application of social robotics in psychiatry remains restricted and controversial. This scoping review aims to provide an overview of the literature on social robots in adult psychiatry concerning their use, effects, and acceptability. …”
Get full text

Relationship of asprosin and diabetes: a meta-analysis by Xiandong Zeng, Xin Sun, Wei He, Jing Xie, Caihong Xin

“…Although some studies have shown that asprosin levels are higher in patients with diabetes than in healthy individuals, the association between asprosin levels and diabetes remains controversial. Aim This meta-analysis aimed to assess asprosin levels in patients with diabetes and in healthy individuals. …”
Get full text

Efficacy of probiotic supplements in the treatment of sarcopenia: A systematic review and meta-analysis. by Yi Wang, Ping Lei

“…Although some studies have confirmed the efficacy of probiotics in the treatment of sarcopenia, the intervention of sarcopenia is a comprehensive consideration of many factors, and the efficacy of probiotics is still controversial. Therefore, this study systematically evaluated the efficacy of probiotics in the intervention of sarcopenia via high-quality meta-analysis, providing a basis for the clinical diagnosis and treatment of sarcopenia. …”
Get full text

Application of Mendelian randomization analysis to explore causal associations of aspirin use with bone mineral density and risk of fracture by Qi-Pei Liu

“…Abstract Objective Previous observational studies on the association between aspirin use, bone mineral density (BMD), and fracture risk have yielded controversial results. This study explored the causal relationship between aspirin use, BMD, and fracture risk using Mendelian randomization (MR). …”
Get full text

Sex, Gore and Provocation: the Influence of Exploitation in John Waters’s Early Films by Elise Pereira Nunes

“…A self-taught filmmaker working with very low budgets, fascinated with Hollywood’s glamor as well as exploitation and underground cinema, John Waters has appropriated techniques and modes of production, distribution and promotion specific to exploitation from the beginning of his career in the late 1960s. The illicit, controversial topics addressed in his early movies, traditionally brought up by exploitation in order to attract audiences whose voyeuristic desires would not be fulfilled by Hollywood’s promotion of moral standards, have predictably put him at the margins of mainstream movie culture. …”
Get full text

The Korean Peninsula as a Hotbed of Cold War 2.0 by R. R. Kalinin

“…The second section shows that, despite its contested and controversial nature, the ‘Cold War 2.0’ concept provides useful insights on how concrete steps of global and regional actors aimed at enhancing their military capabilities are threatening to turn the Korean Peninsula into the arena of a new bipolar confrontation. …”
Get full text

Surgical Results of Anteromedial Plate Osteosynthesis for Diaphyseal Humerus Fracture by Ujjawal Pradhan, S. G. Thejaswi, H. Papa Naik, Sunil Baliga, Nobin Kumar Sharma, Avik Chakravorty

“…Background: Humeral shaft fracture management has always been controversial. There are proponents for both conservative and operative management with intramedullary nailing as well as plate osteosynthesis. …”
Get full text

Starożytne źródła antropocentryzmu by Anita Ganowicz-Bączyk

“…Probably he is also the most controversial one in environmental ethics. The anthropocentric attitude is sometimes meant to be the main cause of the ecological crisis. …”
Get full text

THE PHENOMENON OF CRYPTOCURRENCY FROM DIVERSE PERSPECTIVES by Živilė Nemickienė

“…Given all the failures, the phenomenon, though treated controversially by politicians and financial authorities all around the world, slowly moves towards standardization. …”
Get full text

Post-operative gigantic lumbar pseudomeningocele: A case report by Dionysia Fermeli, Vasileios Panagiotopoulos, Dimitrios Papadakos, Andreas Theofanopoulos, Petros Zampakis, Constantine Constantoyannis

“…Although treatment options are controversial, they should be recognized soon enough in order to avoid central nervous infections, neurological deficits and further comorbidities.…”
Get full text

Public perspectives on COVID-19 triage protocols for access to critical care in extreme pandemic context. by Marie-Eve Bouthillier, Yanick Farmer, Claudia Calderon Ramirez, James Downar, Andrea Frolic, Joseph Dahine, Lucie Opatrny, Diane Poirier, Gina Bravo, Audrey L'Espérance, Antoine Payot, Peter Tanuseputro, Louis-Martin Rousseau, Vincent Dumez, Annie Descôteaux, Clara Dallaire, Karell Laporte, Nathalie Orr Gaucher

“…They have given rise to numerous ethical issues and controversies. Among them is the fear that people will be denied access to ICU on the basis of judgments about their quality of life, social value, frailty or age. …”
Get full text

To be continued? Book review of ‘Nuclear arms control in Russian-American strategic relations (2010 — early 2020s)’ by O.M. Aleksandriya and A.G. Savel’ev by V. I. Mizin

“…The reviewer considers the content of the book’s three chapters and the authors’ key findings regarding such controversial issues, as the ongoing impasse in the strategic dialogue and the possible role of both third countries and new types of weapons in the negotiations on nuclear arms control, whenever they resume. …”
Get full text

Bupropion Mediated Effects on Depression, Attention Deficit Hyperactivity Disorder, and Smoking Cessation by Austin Clark, Brendan Tate, Bretton Urban, Ryan Schroeder, Sonja Gennuso, Shahab Ahmadzadeh, David McGregor, Brook Girma, Sahar Shekoohi, Alan D. Kaye

“…The same is true in the case of bipolar disorder in which there is still limited and controversial data available on bupropion's safety and efficacy. …”
Get full text

Investigating the Relationship Between Orthodontic Treatment and Temporomandibular Joint Disorders in Adolescents by Mohammad Khursheed Alam, Mohammad Younis Hajeer, Renad Atallah Alruwaili, Almas Ali Alfaleh, Ola Bassam Alhashash

“…However, its potential association with the development of temporomandibular joint disorders (TMDs) remains controversial. Materials and Methods: A prospective cohort study was conducted involving 200 adolescents aged 12–18 years undergoing orthodontic treatment. …”
Get full text

Spatial patterns of excess mortality in the first year of the COVID19 pandemic in Germany by Thomas Wieland

“…The question of whether there was excess mortality associated with COVID-19 in Germany in the first year of the pandemic is controversial, as there are different ways of calculating this. …”
Get full text

Spirit și destin sub „teroarea istoriei” by Andrei Milca

“…The brilliant scholar and the most important encyclopedic Romanian spirit of 20-th century, Mircea Eliade is disputed, even in 2007, the year of his centenary. The controversies are the same in the present with those of the past, which stopped Eliade for obtaining the Nobel Prize: for ,,sympathy“ of the young writer, in ’30’s years, for „the Devil“ — the Iron Guard of Corneliu Zelea Codreanu and Nae Ionescu, the teacher and the mentor of Eliade. …”
Get full text

Glucosamine Inhibits the Proliferation of Hepatocellular Carcinoma Cells by Eliciting Apoptosis, Autophagy, and the Anti-Warburg Effect by Misako Samizu, Kaoruko Iida

“…Although glucosamine (GlcN) exhibits antitumor effects, its mechanism of action remains controversial. Additionally, its impact on hepatocellular carcinoma (HCC) is not well understood. …”
Get full text

Appropriate Timing and Type of Physical Training in Patients with COVID-19 for Muscle Health and Quality of Life: A Systematic Review by I. Gusti Putu Suka Aryana, Siti Setiati, Ivana Beatrice Paulus, Dian Daniella

“…Studies regarding effect of physical training on patients with COVID-19 are controversial. This systematic review aims to investigate physical training on muscle health and QOL in patients with COVID-19. …”
Get full text