Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

“…TI-076 exhibits long-term stability and its major constituents are well absorbed orally in mice and rats. …”
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Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways by Mohamed El-Sherbiny, Hany A. Elkattawy, Shimaa Hadhoud, Ahmed N. Nasr, Ateya M. Ibrahim, Ateya M. Ibrahim, Omar Z. Ameer, Noorhan Alsaleebi, Joud Asfari, Madaniah O. Zakari, Moaz A. Mojaddidi, Ehab K. Ali, Hailah M. Almohaimeed, Ahmed Abdeen, Sahar K. Ali, Mamdouh Eldesoqui, Mamdouh Eldesoqui

“…IntroductionLipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a powerful inducer of systemic inflammation and has been extensively utilized in experimental models to simulate inflammatory responses and septic disorders. …”
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Screening potential antileukemia ingredients from sweet potato: integration of metabolomics analysis, network pharmacology, and experimental validation by Lianling Xu, Lianling Xu, Kaixuan Zeng, Kaixuan Zeng, Zuoyue Duan, Zuoyue Duan, Jing Liu, Yan Zeng, Miao Zhang, You Yang, Qulian Guo, Yanling Jin, Wenjun Liu, Ling Guo

“…However, the active ingredients associated with acute myeloid leukemia (AML) treatment and their underlying mechanisms have not been reported to date.ObjectiveThis study aims to identify novel drugs against AML from sweet potato by integrating metabolomics analysis, network pharmacology, and experimental validation.MethodsFirstly, ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was employed to analyze the major constituents in sweet potato. Then, nine active ingredients were selected for validation of their anti-leukemia effects. …”
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A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol by Lei Zhang, Yuqing Tian, Lingling Zhang, Huanyu Zhang, Jinghua Yang, Yi Wang, Na Lu, Wei Guo, Liang Wang

“…Syringaresinol, a phytochemical constituent belonging to lignan, is formed from two sinapyl alcohol units linked via a β-β linkage, which can be found in a wide variety of cereals and medicinal plants. …”
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Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation by Md. Abul Barkat, Afreen Fatima, Bushra Riaz, Mohd. Zaheen Hassan, Tanveer Ahamad, Abdulkareem A. Alanezi, Harshita Barkat, Afaf F. Almuqati, Yahya I. Asiri, Sahabjada Siddiqui

“…The glide module of Maestro software was used to investigate the molecular-docking interaction of the constituents against main protease (Mpro) and papain-like protease (PLpro) of SARS-CoV-2. …”
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Molecular Mechanism of Germinated Foxtail Millet Bioactive Peptides in Attenuating Copper-induced Oxidative Damage in Caenorhabditis elegans by Huiqi ZHANG, Xiao CHEN, Xueling JIN, Jingjing LI, Juanli YUAN, Jinyan GAO, Hongbing CHEN, Yong WU

“…At the genetic level, GRBPs mainly regulated the structural constituent of cuticle and the expression of genes related to cytochrome enzyme P450 in C. elegans. …”
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Saponin content in medicinal plants in response to application of organic and inorganic fertilizers: a meta-analysis by Junyan Lv, Junyan Lv, Shouzan Liu, Shouzan Liu, Chunli Hu, Lan Ding, Hongzhen Wang, Hongzhen Wang, Xin Li, Feng Yang, Feng Yang, Qiong Shen, Qiong Shen, Hongbin Zhang, Hongbin Zhang, Guobiao Ma, Guobiao Ma, Shaobo Zhang, Yan Bai, Yan Bai

“…The application of fertilizers is a key agronomic practice in the artificial cultivation of medicinal plants, aiming to boost yields and enhance the levels of their bioactive constituents. However, systematic investigations on the influence of various fertilizers on the concentration of active compounds in saponin-containing medicinal plants remain insufficient. …”
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A hyperspectral and multi-angular synthetic dataset for algorithm development in waters of varying trophic levels and optical complexity by J. Pitarch, V. E. Brando, V. E. Brando

“…<p>This data paper outlines the development and the structure of a new synthetic dataset within an extended optical domain, encompassing inherent and apparent optical properties (IOPs and AOPs) alongside associated optically active constituents (OACs). Bio-optical modeling benefited from knowledge and data accumulated over the past 3 decades, enabling the imposition of rigorous quality standards and the definition of novel bio-optical relationships that are significant contributions on their own. …”
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Numerical study of the plasticity effect on the behavior of short steel columns filled with concrete loaded axially by Yousria Boulmaali-Hacene Chaouche, Nadia Kouider, Kamel Djeghaba, Bachir Kebaili

“…Indeed, it has been demonstrated that the use of normal or high strength concrete, confined in a steel tube of circular shape can considerably improve its ductility as well as its load capacity, owing to the combination of the qualities of the two constituent materials; these tubes have an effortless execution, indeed, the concrete used in the CFST does not require formwork nor reinforcement, a durability of the two materials as well as a good behavior to fire, which was the effect desired at the origin of their elaboration. …”
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Comparison of Physicochemical Properties, Fatty Acid Composition and Mineral Contents in Common Carp (Cyprinus carpio L.) Fillet and the Native Traditional Product Carp Ham by Skałecki Piotr, Florek Mariusz, Pyć Anna, Kaliniak Agnieszka, Staszowska Agnieszka

“…The study indicated that the traditional manufacturing method retains the most part of the nutritional constituents present in the carp fillets.…”
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Investigation of the Mechanism of Complement System in Diabetic Nephropathy via Bioinformatics Analysis by Bojun Xu, Lei Wang, Huakui Zhan, Liangbin Zhao, Yuehan Wang, Meng Shen, Keyang Xu, Li Li, Xu Luo, Shasha Zhou, Anqi Tang, Gang Liu, Lu Song, Yan Li

“…There were 64 DEGs, and 32 hub genes were identified, enriched pathways of hub genes involved in several functions and expression pathways, such as complement binding, extracellular matrix structural constituent, complement cascade related pathways, and ECM proteoglycans. …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…While CKDu is likely multifactorial, occupational exposure to silica nanoparticles (SiNPs), a major constituent within sugarcane ash, has gained increased attention as a potential contributor. …”
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Urinary Calculi: A Microbiological and Biochemical Analysis at a Tertiary Care Hospital in Eastern Nepal by Pratima Shah, Ratna Baral, C. S. Agrawal, Madhab Lamsal, Dharanidhar Baral, Basudha Khanal

“…Calcium oxalate (84.1%) was common biochemical constituent found in stone formers followed by calcium oxalate + phosphate (8%). …”
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The Modular and Integrated Data Assimilation System at Environment and Climate Change Canada (MIDAS v3.9.1) by M. Buehner, J.-F. Caron, E. Lapalme, A. Caya, P. Du, Y. Rochon, S. Skachko, M. Bani Shahabadi, S. Heilliette, M. Deshaies-Jacques, W. Chang, M. Sitwell

“…The software is designed to be sufficiently general to enable other DA applications, including atmospheric constituents (e.g. ozone), sea ice, and sea surface temperature. …”
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Cerebellar lipid dysregulation in SCA3: A comparative study in patients and mice by Alexandra F. Putka, Varshasnata Mohanty, Stephanie M. Cologna, Hayley S. McLoughlin

“…However, the major constituent of white matter – lipids – remains understudied in SCA3.In this study, we conducted the first unbiased investigation of brain lipids in SCA3, focusing on the disease-vulnerable cerebellum of SCA3 postmortem patients and mouse models. …”
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Identification and Quality Evaluation of Raw and Processed Asarum Species Using Microscopy, DNA Barcoding, and Gas Chromatography-Mass Spectrometry by Guangzhe Yao, Wenjuan Ma, Xuhua Huang, Qi Jia, Jiayuan Shen, Yanxu Chang, Huizi Ouyang, Jun He

“…Safrole, methyleugenol, and 2,6,6-trimethylcyclohepta-2,4-dien-1-one were identified as significant constituents, the presence of which can be used to differentiate between raw and processed Asarum samples. …”
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Minimum-Run Resolution IV Design for Optimized Bio Removal of Fe²⁺ Using <i>Enteromorpha intestinalis</i> Aqueous Extract and Its Extract-Coated Silver Nanoparticles by Doaa G. El-Hosari, Fatma A. Mokhtar, Hussein A. Khalaf, Ahmed R. N. Ibrahim, Rehab M. Mohamed, Mofida E. M. Makhlof

“…A variety of active constituents, including organic acids, lipids, alcohols, and terpenes, were identified through the use of GC-MS, with the findings supported by FTIR spectra. …”
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Chemical Profile and Alcoholic Fermentation Analysis of the Ethiopian Wild Edible Fruit <i>Physalis peruviana</i> L. by Tesfom Zeru Zereahannes, Tarekegn Berhanu Esho, Alayu Woldtensay Teklie, Henock Woldemichael Woldemariam, Neela Satheesh, Aselefech Sorsa Wotango

“…The shade-dried sample exhibited a better composition with regard to most of the characterized constituents than the other dried samples. From all of the results obtained, the shade-dried sample showed higher antioxidant activity, and, among the investigated minerals, its K content was found to be the highest (313.66 ± 0.05 g/100 g). …”
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Phytochemical Screening and Cytotoxic Properties of Ethanolic Extract of Young and Mature Khat Leaves by Rashad Alsanosy, Hassan A. Alhazmi, Shahnaz Sultana, Ashraf N. Abdalla, Yassin Ibrahim, Mohammed Al Bratty, David Banji, Ibrahim Khardali, Asaad Khalid

“…Though many of the constituents of khat leaves have been identified, the complete phytochemical profile of young and mature leaves was not performed or compared; also, no evidence is available to affirm the cytotoxicity of young or mature leaves. …”
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A Rule-Based Parser in Comparison with Statistical Neuronal Approaches in Terms of Grammar Competence by Simon M. Strübbe, Alexander T. D. Grünwald, Irina Sidorenko, Renée Lampe

“…The purpose of the present study is to compare the performance of our rule-base parser with two state-of-the-art statistical parsers, one based on dependencies between words (SpaCy parser) and the other based on linguistic constituents (Stanford parser). Although large language models (LLMs), which are the technical basis of the software ChatGPT, were not designed specifically for grammatical parsing, because of their popularity, users, especially language learners, often ask them grammatical questions as well. …”
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