Integrated Bioinformatics Identifies FREM1 as a Diagnostic Gene Signature for Heart Failure by Chenyang Jiang, Weidong Jiang

“…Enrichment analysis shows that most of them are related to hypertrophy, matrix structural constituent, protein binding, inflammatory immune pathway, cardiovascular disease, and inflammatory disease. …”
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Scenario-aware access control model by Dibin SHAN, Xuehui DU, Wenjuan WANG, Na WANG, Aodi LIU

“…Dynamic access control model is the theoretical basis for constructing a dynamic access control system for big data.However, most existing access control models can only fulfill dynamic access control in a single scenario and are unable to adapt to access control in multiple types of dynamic scenarios.These scenarios include changes in the contextual environment of big data, changes in entity relationships, and changes in the state of objects.To address these issues, an analysis was conducted based on the research of existing access control models and the dynamic factors of big data.Subsequently, scenario-aware access control (SAAC) model was proposed, which was based on dynamic factor conversion and scenario unified modeling.All types of dynamic factors were converted into basic elements such as attributes and relationships.Then, scene information was incorporated to model the various types of constituent elements in a unified manner.A big data dynamic access control model was constructed based on scene information to support multi-type dynamic factors and extended dynamic factors.The working framework of the SAAC model was designed, and the SAAC rule learning algorithm and SAAC rule execution algorithm were proposed corresponding to the workflow of the framework.This enabled the automatic learning of access control rules and dynamic access control decision-making.The security of the proposed model was analyzed and verified by introducing the non-transitive non-interference theory.To validate the effectiveness of the access control policy mining method of the proposed model, experimental comparisons were conducted between the SAAC model and baseline models such as ABAC-L, PBAC-X, DTRM, and FB-CAAC using four datasets.The experimental results demonstrate that the SAAC model and its strategy mining method outperforms the baseline models in terms of metrics such as area under the curve AUC, monotonicity, and steepness of the ROC curve.This verification confirms that the proposed model can support multiple types of dynamic factors and dynamic factor extensions, and that the combined effect of the access control rules obtained from its mining algorithm is relatively high.…”
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Management of business processes of the organization in the context of digital transformation by A. V. Zheregelya

“…The article is devoted to the analysis of the modern organizations’ digital transformation trend and its constituent factors. The organizational changes of Russian companies that use a digital tool for intermittent organizational and economic processes in order to increase the effectiveness of their activities and management efficiency are considered in most detail. …”
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The liminal space between hope and grief: The phenomenon of uncertainty as experienced by people living with relapsing-remitting multiple sclerosis. by Eva C van Reenen, Inge A M van Nistelrooij, Leo H Visser, Janet W K de Beukelaar, Stephan T F M Frequin, Alistair R Niemeijer

“…The following four constituents further illuminate the meaning of the phenomenon: Having to constantly (re)define unfamiliar and intangible bodily changes on one's own; Unsteady navigating amidst a destabilization of the imagined life; Relating to others as a source of, mirror or buffer for uncertainty; Going through overwhelming fears and worries while clinging to one's own logic.…”
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Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor Microenvironment by Li Y, Yang Q, Li D, Li W, Men W

“…Yilin Li,1,* Qiwei Yang,1,* Danni Li,2 Wenya Li,1 Wanfu Men1 1Department of Thoracic Surgery, the First Hospital of China Medical University, Shenyang, 110002, People’s Republic of China; 2Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wanfu Men; Wenya Li, Email 472581624@163.com; saint5288@hotmail.comAbstract: In recent years, with an increasingly profound comprehension of the tumor microenvironment, it has been discovered that the constituent cells within the immune microenvironment, such as macrophages, CD4+T cells, and CD8+T cells, interact with tumor cells in manners conducive to tumorigenesis and progression. …”
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L’entrepreneuriat dans le tourisme sportif comme stratégie de reconversion des sportifs professionnels by Abderrahim RHARIB, Younes EL HASSANI

“…Les résultats laissent penser que l’entrepreneuriat dans le tourisme sportif constitue une stratégie de reconversion appropriée pour les athlètes dans la mesure où il permet de mettre à profit leur capital sportif et social, celui-ci se révèle être un avantage compétitif par rapport aux autres entreprises présentes sur le marché.…”
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De Ford aux Jeux Olympiques by Egidio Dansero, Matteo Puttilli

“…L’hypothèse ici proposée est que la station est au centre d’un réseau dense de relations territoriales multi-scalaires (avec la métropole, les villes de montagne voisines, les grands flux internationaux), qui constituent à la fois un instrument pour lire et analyser la territorialité de la station et une ressource indispensable dans la redéfinition de ses modèles de développement.…”
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Computer Simulation on Analgesic Functional Chemome Characteristics of <italic>Radix Saposhnikoviae</italic> by Chunsong ZHENG, Xiaojie XU, Hongzhi YE, Jinxia YE, Guangwen WU, Xianxiang LIU

“…Objective:To investigate analgesic functional chemome characteristics of <italic>Radix Saposhnikoviae</italic> (RS), and provide information on molecular basis for clinical application of RS in Bi syndrome therapy.Methods:The chemical components of RS were retrieved from <italic>the Handbook of the Constituents in Chinese Herb Original Plants</italic> and other literatures, and the molecular dataset of RS was constructed for computer simulation. …”
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Exploration of the intermolecular interactions in polyethylene glycol 400 + alkyl methacrylate mixtures at ambient temperatures by means of thermophysical and spectroscopic methods by Anil Kumar Nain, Nidhi, Neha Chaudhary

“…The partial molar and excess partial molar properties (volume and compressibility) of the constituent molecules in the mixture at all mole fractions, and at infinite dilution were computed. …”
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Protective Effect of Hydroalcoholic Extract of Stachys pilifera on Oxidant-Antioxidant Status in Renal Ischemia/Reperfusion Injuries in Male Rats by Zahra Moslemi, Izadpanah Gheitasi, Amir Hossein Doustimotlagh

“…Reactive oxygen species are considered the major constituents involved in the biochemical and pathophysiological changes that were shown during kidney I/R. …”
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A Phage‐Based Approach to Identify Antivirulence Inhibitors of Bacterial Type IV Pili by Tori M. Shimozono, Nancy J. Vogelaar, Megan T. O'Hara, Zhaomin Yang

“…While the T4PM presents a promising antivirulence target, the systematic identification of inhibitors for its multiple protein constituents remains a considerable challenge. Here we report a novel high‐throughput screening (HTS) approach for discovering T4P inhibitors. …”
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Le tourisme émetteur chinois entre contrôle étatique et émancipation des individus : le cas des voyages de noce en France by Marine L’Hostis, Maxime Dejean

“…La Chine constitue le premier foyer émetteur du tourisme international aussi bien en termes de recettes que du nombre d’individus, et ce, depuis 2013. …”
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Surface and Catalytic Properties of the CuO/AlO System Treated with Different Proportions of ZnO by Gamil A. El-Shobaky, Nabil H. Amin, Sahar A. El-Molla

“…It was found that ZnO treatment of CuO/Al 2 O 3 did not modify the activation energy of the catalyzed reaction but rather changed the concentration of catalytically active constituents without changing their energetic nature.…”
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Evaluation of Antioxidant, Antimicrobial, and Cytotoxic Activities and Correlation with Phytoconstituents in Some Medicinal Plants of Nepal by Keshav Ranabhat, Kamal Prasad Regmi, Sarwesh Parajuli, Ranjita Thapa, Arjun Prasad Timilsina, Saurav Katuwal, Shantel Fleming, Akkal Dev Mishra, Khaga Raj Sharma, Bishnu P. Regmi

“…This study aims to analyze the phytochemical constituents from the extracts of ten such plants and evaluate their antimicrobial, cytotoxicity, and antioxidant properties. …”
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La géologie en feuilleton by Jiwoon Jung

“…Outre cette origine inattendue, De l’enseignement de la géologie est un texte problématique dans sa constitution aussi : bien que ce feuilleton apparaisse dans le roman comme un pamphlet de l’anti-catastrophisme des années 1830, il est constitué en effet non seulement des ouvrages des actualistes / uniformitaristes, mais aussi de ceux des catastrophistes dont les parutions traversent tout le xixe siècle. …”
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Characterization of Essential Oils and Fatty Acids Composition of Stored <i>Ginger</i> (<i>Zingiber officinale</i> Roscoe) by C.C. Oforma, G.A. Udourioh, C.M. Ojinnaka

“…The specific dominant constituents were zingiberene (28.57%), Arcurcumene (14.22%) and Geranyl Acetate (13.28%). …”
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Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications by Eleftheria Papachristoforou, Vaia Lambadiari, Eirini Maratou, Konstantinos Makrilakis

“…Excess reactive oxygen species (ROS) production is very harmful to cell constituents, especially proteins, lipids, and DNA, thus causing damage to the cell. …”
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Effects of atractylodin and β-Eudesmol on P-glycoprotein and Caco-2 cells permeability by Artitaya Thiengsusuk, Wiriyaporn Sumsakul, Kesara Na–Bangchang

“…Background: Atractylodin and β-eudesmol are the major constituents of Atractylodes lancea (Thunb.) D.C. (AL) which have been demonstrated potential activities against cholangiocarcinoma in a series of in vitro and in vivo studies. …”
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1+(no)1=3, and more by Carmen García

“…Nonetheless, systemic ethics consists of attending to multiple possibilities beyond binary choices, advocating for relational location of responsibility, coherently with an epistemology that conceives the minimal unit of observation as including not only the constituent parts of a system, but also how these interrelate and their contexts of occurrence. …”
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Streptomyces sp. strain MUSC 5 from mangrove forest in Malaysia: Identification, antioxidant potential and chemical profiling of its methanolic extract by Hefa Mangzira Kemung, Loh Teng-Hern Tan, Kok-Gan Chan, Hooi-Leng Ser, Jodi Woan-Fei Law, Bey Hing Goh

“… The present study explored the antioxidant potential of a Streptomyces sp. strain MUSC 5 from the mangrove forest soil in the Pahang State, Peninsular of Malaysia and determined the presence of biologically active chemical constituents contained in the methanolic extract. The 16S rRNA genomic DNA extraction, phylogenetic analysis and phenotyping methods were used to confirm identity of strain. …”
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