Depression Paradox in Cardiovascular Outcomes of Adult Patients with Obstructive Sleep Apnea: Insights from 2 Million Nationwide Hospitalizations by Rupak Desai, Sashwath Srikanth, Shaylika Chauhan, Zainab Gandhi, Warda Shahnawaz, Aleen Rahman, Bisharah Rizvi, Akhil Jain

“…OBJECTIVE: Depression is a frequent comorbidity in obstructive sleep apnea (OSA) patients. …”
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Association of dietary intake of live microbes with bowel health and depression in US adults: a cross-sectional study of NHANES 2005–2010 by Jikang Shi, Qian Zhao, Zhuoshuai Liang, Heran Cui, Yawen Liu, Yi Cheng, Ming Zhang

“…Gastrointestinal disorders are the common comorbidity of depression and 24.3% of patients with depression have disordered bowel habits. …”
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Relationship Between Obstructive Sleep Apnea and Enuresis in Children: Current Perspectives and Beyond by Wang Z, Zhang P, Shi R, Yang S, Liu K, Zhou Z, Li Q

“…The benefits of positive airway pressure (PAP) therapy in children with NE remain to be further studied.Conclusion: NE and OSA comorbidity seriously affect the physical and mental health of children. …”
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Prospective registry of heart failure with preserved ejection fraction in México: EDIFICE-Mx by Diego Araiza-Garaygordobil, Oscar-Ulises Preciado-Gutierrez, Jorge Daniel Sierra-Lara Martinez, Hector Gonzalez-Pacheco, Rodrigo Gopar-Nieto, Ximena Latapi-Ruiz Esparza, Sarai Hernandez-Pastrana, Braiana-Angeles Diaz-Herrera, Amada Alvarez-Sangabriel, Antonio Jordan-Rios, Alexandra Arias-Mendoza

“…Conclusions: We observed a substantial comorbidity burden impacting quality of life, as indicated by KCCQ scores. …”
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Impact of re-operation on progression-free survival in patients with recurrent GBM: Experience in a tertiary referral center. by Houssein Darwish, Tasnim Diab, Sarah Kawtharani, Mounir Barake, Bader Ali, Nagham Ramadan, Hiba Fadlallah, Jeannot Kekedjian, Marwan Najjar, Hazem I Assi

“…However, a notable association was observed with Charlson comorbidity index (CCI) ≤3, indicating higher reoperation rates (p = 0.022). …”
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Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs by Jocelyn Mott, Arnon Gal, Antonio Maria Tardo, Alisa Berg, Riley Claude, Alexis Hoelmer, Mei Lun Mui, Avin Arjoonsingh, Chen Gilor

“…Seventy‐nine percent (26/33) of the dogs had comorbidities with 42% (11/26) having more than 1 comorbidity. …”
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Chronic kidney disease in patients with psoriatic arthritis: a cohort study by Dafna D Gladman, Vinod Chandran, Richard J Cook, Fadi Kharouf, Shangyi Gao, Shahad Al-Matar

“…Its development is associated with related comorbidities, joint damage and NSAID use. Methotrexate seems to be protective.…”
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The criteria for choice of myocardial revascularization method in patients with stable coronary artery disease in routine clinical practice by O.A. Yepanchintseva, O.J. Zharinov, K.O. Mikhaliev, A.V. Khokhlov, B.M. Todurov

“…In patients with similar coronary artery lesions, the potential criteria for MR method include such characteristics, as severity of symptoms, comorbidity and prior CAD treatment.…”
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Clinical Features and Risk Factors for Outcome in Hemodialysis Patients with COVID-19 after Complete Liberalization of Epidemic Control in China by Shuang Zhang, Shu-Xin Liu, Zhi-Hong Wang, Ping Xiao, Hong Liu, Yan Lu, Cui Dong, Lian-Lian You

“…Over half (60%) of the study participants were male, and the majority had hypertension as a comorbidity. Multivariable analysis revealed that age, pre-dialysis diastolic pressure, fever, white blood cell (WBC) count, potassium, β2-microglobulin level, and calcium were independent risk factors for disease severity, while platelets, urea nitrogen, serum chlorine and creatinine were identified as independent protective factors. …”
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The influence of neurovegetative and psychological characteristics of infertile patients with long-term COVID-19 on the effectiveness of assisted reproductive technologies by O.G. Boichuk, I.S. Golovchak, T.V. Kolomiichenko

“…These patients have a higher level of stressogenic load: comorbidity with chronic somatic pathology (58.8%), conflict situations in the family (31.3%), dissatisfaction with their sexual relationships (58.7%), a significantly higher level of fear of COVID -19 (29.73±1.31 points). …”
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Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis by Christian Gluud, Marija Barbateskovic, Sara Russo Krauss, Janus C Jakobsen, Sesilje Bondo Petersen, Sarah Louise Klingenberg, Snezana Djurisic, Mette Kenfelt, De Zhao Kong

“…Objectives To assess the benefits and harms of aluminium adjuvants versus placebo or no intervention in randomised clinical trials in relation to human vaccine development.Design Systematic review with meta-analysis and trial sequential analysis assessing the certainty of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).Data sources We searched CENTRAL, MEDLINE, Embase, LILACS, BIOSIS, Science Citation Index Expanded and Conference Proceedings Citation Index-Science until 29 June 2021, and Chinese databases until September 2021.Eligibility criteria Randomised clinical trials irrespective of type, status and language of publication, with trial participants of any sex, age, ethnicity, diagnosis, comorbidity and country of residence.Data extraction and synthesis Two independent reviewers extracted data and assessed risk of bias with Cochrane’s RoB tool 1. …”
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The evolving landscape of COVID-19: factors associated with in-hospital COVID-19 related mortality during the 2023–2024 phase of JN.1 subvariant dominance by Drieda Zaçe, Albiana Çekrezi, Christopher Jones, Ludovica Ferrari, Giuseppe De Simone, Elisabetta Teti, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati, Anna Maria Geretti

“…Results Among 122 individuals (median age 76 years, 58.2% males, median comorbidity index 5), 114/122 (93.4%) had received ≥ 1 SARS-CoV-2 vaccination, with a median of 23 months elapsed since the last dose. …”
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CHARGE-AF in a national routine primary care electronic health records database in the Netherlands: validation for 5-year risk of atrial fibrillation and implications for patient s... by Ralf E Harskamp, Wim A M Lucassen, Henk C P M van Weert, Jelle C L Himmelreich, Claire Aussems, Mark M J Nielen

“…Complete CHARGE-AF cases were older and had higher AF incidence and cardiovascular comorbidity rate than incomplete cases. There were 5264 (4.7%) new AF cases during 5-year follow-up among complete cases. …”
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Low-Dose Ketamine Infusion for Perioperative Pain Management in Patients Undergoing Laparoscopic Gastric Bypass: A Prospective Randomized Controlled Trial by Mitchell T. Seman, Shawn H. Malan, Matthew R. Buras, Richard J. Butterfield, Kristi L. Harold, James A. Madura, David M. Rosenfeld, Andrew W. Gorlin

“…Obesity is a common comorbidity seen in the perioperative setting and is associated with many diseases including cardiovascular disease and obstructive sleep apnea. …”
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Technological monitoring of motor parameters to assess multidimensional frailty of older people in the PRO-HOME project by Emanuele Seminerio, Wanda Morganti, Marina Barbagelata, Sanket Rajeev Sabharwal, Simone Ghisio, Camilla Prete, Barbara Senesi, Simone Dini, Romina Custureri, Simonetta Galliani, Simona Morelli, Gianluca Puleo, Carlo Berutti-Bergotto, Antonio Camurri, Alberto Pilotto, PRO-HOME Project Investigators Group

“…Patients underwent a standard Comprehensive Geriatric Assessment (CGA) to compute the Multidimensional Prognostic Index (MPI), including basic and instrumental activities of daily living (ADL, IADL), cognition (Short Portable Mental Status Questionnaire, SPMSQ) and nutrition, risk of pressure sores (Exton-Smith Scale, ESS), comorbidity, number of drugs and cohabitation status. …”
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Reference values for the 1-minute sit-to-stand test to assess functional capacity and short-term mortality in people with idiopathic pulmonary fibrosis and fibrotic connective tiss... by Meng-Yun Tsai, Kuo-Tung Huang, Chiann-Yi Hsu, Yi-Hsuan Yu, Pin-Kuei Fu

“…Assessments included the 1MSTS, 6MWT, pulmonary function test (PFT), GAP score, mMRC scale, and Charlson Comorbidity Index (CCI). The association between 1MSTS repetitions and other variables was calculated using Spearman’s rho. …”
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Preliminary findings of a randomized controlled trial investigating the efficacy of transcranial magnetic stimulation in treatment-resistant depression: a post-hoc analysis on the... by Julian Maciaszek, Joanna Rymaszewska, Tomasz Wieczorek, Patryk Piotrowski, Dorota Szcześniak, Jan A. Beszłej, Monika Małecka, Bogna Bogudzińska, Adrianna Senczyszyn, Damian Siwicki, Marta Biercewicz, Krzysztof Kowalski, Anna Zimny, Przemysław Podgórski, Karolina Fila-Pawłowska

“…The main aim of our study was to compare the efficacy of active TMS and sham–placebo protocols in combined therapy of treatment-resistant depression with evaluation of possible personality disorders comorbidity.MethodsThe study was conducted between December 2019 and December 2022, as a randomized, double-blind, active comparator-controlled and sham-controlled parallel trial. …”
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Patterns of Amphotericin B Use and Factors Related to Mortality in a Low-Middle Income Country: An Observational and Longitudinal Study by Luis Fernando Valladales-Restrepo, Lian Manuela Soto-Romero, Luis Fernando Navarrete-Santa, Rodrigo Montoya-García, Jaime Andrés Ríos-Montoya, Alejandra Sabogal-Ortiz, Jorge Enrique Machado-Alba

“…In-hospital mortality was common, and factors such as increased comorbidities, higher qSOFA scores, coinfection with <i>Mycobacterium tuberculosis</i> and invasive procedures like mechanical ventilation were linked to increased mortality.…”
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Impact of Benign Prostatic Hyperplasia on Postoperative Complications and Periprosthetic Joint Infections After Total Joint Arthroplasty: A Systematic Review and Meta-Analysis by Sina Esmaeili, MD, Hannaneh Razaghi, MD, Mahda Malekshahi, MD, Mohammad Soleimani, MD, Seyyed Hossein Shafiei, MD, Mohammadreza Golbakhsh, MD

“…While the relationship between various comorbidities and these complications has been well-documented, this study aims to specifically investigate the impact of benign prostatic hyperplasia (BPH) on postoperative outcomes. …”
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Evaluating the effectiveness of the Smart About Meds (SAM) mobile application among patients discharged from hospital: protocol of a randomised controlled trial by Susan J Bartlett, Robyn Tamblyn, David L Buckeridge, Bettina Habib, Emily McDonald, Daniala L Weir, Elizaveta Frolova, Rolan Alattar, Jessica Rogozinsky, Caroline Beauchamp, Rosalba Pupo

“…Multivariable logistic regression will estimate differences between treatment groups in the proportion of patients experiencing the primary outcome and will assess modification of intervention effects by hospital, unit, age, sex and comorbidity burden. With a sample size of 3250, the study will have 80% power to detect a 5% absolute reduction in the primary outcome. …”
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