Impact of COVID-19 on rheumatic diseases in india: Determinants of mortality and adverse outcome: A retrospective, cross-sectional cohort study by Avinash Jain, Vineeta Shobha, S Chandrashekara, Padmanabha Shenoy, Sapan C Pandya, Prakash Chotalia, Sharath Kumar, Sourabh Malviya, Yogesh Preet Singh, Abhishek Patil, Vikas Gupta, Puja Srivastava, Vijaya Prasanna Parimi, Chanakya Kodishala, Ramya Janardana, Benzeeta Pinto, Sudhir Bhandari, Govind Rankawat, Praveen Pratap Jadhav, Damodaram Potugari, Vishnu Sharma, Alpana Parmar, Sunitha Kayidhi, Paul T Antony, Ashish Badika, Amit Sharma

“…Complete recovery was seen in 95.5% of patients and 4.47% (n = 20) expired due to COVID. The presence of comorbidity, dyspnea, and a higher neutrophil count was statistically significantly associated with death (P < 0.05). …”
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Leveraging machine learning and rule extraction for enhanced transparency in emergency department length of stay prediction by Waqar A. Sulaiman, Charithea Stylianides, Andria Nikolaou, Andria Nikolaou, Zinonas Antoniou, Ioannis Constantinou, Lakis Palazis, Anna Vavlitou, Theodoros Kyprianou, Theodoros Kyprianou, Efthyvoulos Kyriacou, Antonis Kakas, Antonis Kakas, Marios S. Pattichis, Andreas S. Panayides, Constantinos S. Pattichis, Constantinos S. Pattichis

“…To enhance interpretability, a novel rule extraction method for GB model was implemented using relevant important predictors, such as triage acuity, comorbidity scores, and arrival methods. By combining predictive analytics with interpretable rule-based methods, this research provides actionable insights for optimizing patient flow and resource allocation. …”
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Co-design of the neurodevelopment assessment scale by Tsz Ying Wong, Syeda Ishra Azim, Christa Lam-Cassettari, Ping-I. Lin, Ping-I. Lin, Antonio Mendoza Diaz, Antonio Mendoza Diaz, Antonio Mendoza Diaz, Alicia Montgomery, Anne Masi, Kylie-Ann Mallitt, Kylie-Ann Mallitt, Andrew Whitehouse, Mark R. Dadds, Valsamma Eapen

“…IntroductionNeurodevelopmental disorders (NDDs) have high comorbidity rates and shared etiology. Nevertheless, NDD assessment is diagnosis-driven and focuses on symptom profiles of individual disorders, which hinders diagnosis and treatment. …”
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Evaluation of a transdiagnostic mental health intervention in German primary care: study protocol for a parallel-group, two-arm, cluster randomised controlled pilot study by Christopher Ebert, Marie Vogel, Jochen Gensichen, Hanna Reif, Lena Grögor, Lukas Junker, Thomas Ehring, Alkomiet Hasan, Stefan Leucht, Kirsten Lochbühler, for the POKAL-Group

“…However, factors such as time constraints, limited experience in managing mental health conditions and high rates of comorbidity may hinder adequate treatment. To improve psychological care, adopting a transdiagnostic approach shows potential. …”
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Racial differences in takotsubo cardiomyopathy outcomes in a large nationwide sample by Raja Zaghlol, Amit K. Dey, Sameer Desale, Ana Barac

“…After the adjustment for differences in age, gender, comorbidities (using the enhanced Charlson comorbidity index), hospital location/teaching status, and socio‐economic factors, all differences were significantly attenuated or eliminated. …”
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Comparison of the regional and general anesthesia as a risk factor of perioperative arrhythmia: a two-group observational study by N.M. Semenko, Iu.L. Kuchyn, K.Yu. Bielka, M.S. Frank

“…Regional anesthesia has less hemodynamic effects and is the method of choice in patients with cardiovascular comorbidity. However, given the risk of cardiotoxicity due to the resorptive effect of the local anesthetic, in older patients and with existing risk factors, it is crucial to account for the arrhythmogenic effects of local anesthetics and adjust the dosage accordingly.…”
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IMAGINE Network’s Mind And Gut Interactions Cohort (MAGIC) Study: a protocol for a prospective observational multicentre cohort study in inflammatory bowel disease and irritable bo... by Russell J de Souza, Sandra Zelinsky, Levinus A Dieleman, Charles N Bernstein, Laura Targownik, Paul Moayyedi, Deborah A Marshall, John Lavis, Michael Surette, Jennifer Cunningham, Glenda MacQueen, Stephen Vanner, Premysl Bercik, Karen L Madsen, John D Rioux, Elena Verdú, Anthony Otley, Aida Fernandes

“…Introduction Gut microbiome and diet may be important in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and comorbid psychiatric conditions, but the mechanisms are unclear. …”
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Mental and behavioral health problems among displaced Myanmar adults exhibiting suboptimal adherence to chronic disease medication treatment in Thailand by Judith K Bass, Amanda Nguyen, Kittipong Sornlorm, Ye Htut Oo, Jarntrah Sappayabanphot, Catherine Lee, Wongsa Laohasiriwong

“…The factors associated with more severe mental health problems were identified as having debt along with poor financial situation, having comorbid hypertension and diabetes, and having the worse scoring on the sleep problems scale. …”
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Preoperative Alcohol Use Disorder Associated with Increased Complications, Readmission, and Cost Following Ankle Arthrodesis by Weston E. McDonald BS, Joshua L. Morningstar BS, Sarah Jenkins MD, Christopher E. Gross MD, Daniel J. Scott MBA, MD

“…Preoperative demographics, comorbidities, postoperative outcomes, cost of admission, and total length of stay (LOS) were analyzed between cohorts. …”
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Understanding preoperative health-related quality of life in rotator cuff tear patients: role of patients’ characteristics by Daniela Brune, Thomas Stojanov, Andreas Marc Müller, David Weibel, Sabina Hunziker, Stephanie Erdbrink, ARCR_Pred Study Group, Laurent Audigé

“…., moderate: β, -12.70; 95% CI [-16.18 to -9.21]), presence of at least one comorbidity (β, -3.71; 95% CI [-5.91 to -1.52]), and pain (β, -1.81; 95% CI [-2.36 to -1.26]). …”
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Age-stratified outcomes of bioprosthetic and mechanical aortic valve replacements in an Australian cohort of 13 377 patients by Sallie-Anne Pearson, Louisa R Jorm, Leonard N Girardi, Oluwadamisola Temilade Sotade, Michael Falster

“…Objectives To quantify age-stratified outcomes of bioprosthetic valve (BV) and mechanical valve (MV) surgical aortic valve replacement (AVR) in Australian patients.Design Retrospective cohort study using population-based linked hospital morbidity and mortality data.Setting Public and private hospitals.Participants Patients aged 18 years and over undergoing AVR from 2001 to 2013, stratified by age (18–64 years; 65+ years).Main outcome measures Age-standardized index AVR rates; rates and multivariable-adjusted (age, sex, Charlson Comorbidity Index) incidence rate ratios (IRRs) for reoperation, incident cardiovascular events (hospitalization or death for acute myocardial infarction (AMI), stroke, major hemorrhage or thromboembolism) and mortality (cardiovascular and all-cause).Results Our cohort comprised 13 377 patients, of whom 3464 (26%) were aged 18–64 years. …”
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Factors influencing fatigue among patients undergoing hemodialysis: a multi-center cross-sectional study by Bushra Alshammari, Sameer A. Alkubati, Awatif Alrasheeday, Eddieson Pasay-An, J. Silvia Edison, Norah Madkhali, Ahmed K. Al-Sadi, Maha Salem Altamimi, Sahar Obeid Alshammari, Areej A. Alshammari, Farhan Alshammari

“…Multiple linear regression demonstrated that employment status (student), comorbidity condition (one chronic disease), dialysis duration, satisfaction with dialysis time, and dialysis time were found to affect the fatigue scores (R2 = 0.302, p ˂ 0.001). …”
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Course of DISease In patients reported to the Swedish CPAP Oxygen and VEntilator RegistrY (DISCOVERY) with population-based controls by Josefin Sundh, Magnus Ekström, Andreas Palm, Krister Ågren, Ludger Grote, Mirjam Ljunggren, Bengt Midgren, J Theorell-Haglöw

“…The rationale behind the set up the retrospective nationwide DISCOVERY cohort was to study several questions including disease course and risk factors for incident disease, impaired quality of life, hospitalisation risk and mortality in patients with chronic respiratory failure with long-term oxygen therapy (LTOT), long-term mechanical ventilation (LTMV) and obstructive sleep apnoea (OSA) on treatment with continuous positive airway pressure (CPAP).Participants and settings Data from the national quality registry for respiratory insufficiency and sleep apnoea (Swedevox) and a population-based control group from Statistics Sweden were merged with governmental registries, the Swedish Cancer Registry, the Swedish Cause of Death Registry, the Swedish Drug registry, the Swedish National Patient Registry and the Swedish Dental Health Registry and with national quality registries for diabetes, rheumatic diseases (Swedish Rheumatology Quality Registry), stroke (RiksStroke), heart failure (RiksSvikt), acute heart infarction care (SwedeHeart) and intensive care (SIR) and with socioeconomic data from Statistics Sweden (SCB).Findings to date The cohort comprises 25 804 unique patients with LTOT since 1987 (54.1% females, age 73.3±9.8 years, body mass index (BMI) 26.6±6.5 kg/m2), 8111 with LTMV since 1996 (48.6% women, age 60.6±16.9 years, BMI 32.9±10.8 kg/m2), 65 809 with OSA on CPAP since 2010 (29.5% women, age 57.2±12.5 years, BMI 31.9±6.2 kg/m2) and 145 224 persons in a population-based control group from same time span up to March 2018 (51.7% women, age 49.9±20.4 year, BMI 24.9±4.0 years).Future plans In patients with chronic respiratory failure and sleep apnoea important questions regarding comorbidity burden, hospitalisation rate, mortality and treatment outcomes are still unexplored to a large extent. …”
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Cost analysis of dermal allograft patch utilization in rotator cuff repair by Adrik Z. Da Silva, BS, Joshua Mizels, MD, Christopher E. Clinker, BS, Minkyoung Yoo, PhD, Richard Nelson, PhD, Christopher Joyce, MD, Robert Z. Tashjian, MD, Peter N. Chalmers, MD

“…Via chart review, we collected demographics, medical comorbidities, tear characteristics, and intraoperative repair characteristics. …”
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Impact of Surgeon Specialty on Ankle Arthrodesis Readmission, Complication, and Infection Rates: A Medicare Analysis by Devon Nixon MD, Hyunkyu Ko PhD, Brook Martin PhD

“…Infection risk most notably persisted in analyses controlling for comorbidities. Infection following AA can lead to devastating outcomes for patients. …”
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Application of Damage Control tactics in the treatment of patients with generalized peritonitis and septic shock by A. Е. Demko, S. A. Shlyapnikov, I. M. Batyrshin, A. V. Оsipov, J. S. Оstroumova, D. S. Sklizkov, D. V. Fomin

“…Both groups are representative in terms of demographics, comorbidity, severity of peritonitis and organ dysfunction.RESULTS. …”
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PHENOTYPE OF VIBRATION DISEASE IN COMBINATION WITH ARTERIAL HYPERTENSION: NEW TARGETS FOR NUTRITIONAL-METABOLIC DISORDERS by Alyona Mikhailovna Gorbunova, Oksana Nikolaevna Gerasimenko

“…Introduction. Comorbidity in the modern world is a predictor of a more severe course of most diseases and has a significant impact on the characteristics, course and outcomes of the disease in the structure of occupational pathology. …”
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Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes by Mehdi Maanaoui, Florence Debillon, Rémi Lenain, Frédérique Defrance, Marie-Christine Vantyghem, Marine Van Triempont, François Provôt, Mikael Chetboun, Julie Kerr-Conte, Aghiles Hamroun, Marie Frimat, Violeta Raverdy, François Pattou, Marc Hazzan, François Glowacki

“…Abstract Type 2 diabetes (T2D) is a common comorbidity in kidney transplant recipients, representing a significant proportion of the candidate pool. …”
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Nested multilevel modelling study of smoking and smokeless tobacco consumption among middle aged and elderly Indian adults: distribution, determinants and socioeconomic disparities by Pritam Halder, Ankita Chattopadhyay, Shivani Rathor, Sayan Saha

“…Females, OBC (other backward castes), urban residence had lower odds in all the categories, while being widow/ separated/ divorced, belonging to Muslim community, having clerical and skilled occupation, poor self-rated health, comorbidity and multimorbidity had higher odds. With decrease in the wealth index, educational status and frequency of physical activity the odds of tobacco consumption increased. …”
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Comparing the effectiveness and cost-effectiveness of sulfonylureas and newer diabetes drugs as second-line therapy for patients with type 2 diabetes by Angelo Avogaro, Giovanni Corrao, Giacomo Pellegrini, Francesco Saverio Mennini, Riccardo Candido, Matteo Franchi, Giuliano Buzzetti, Arturo Cavaliere, Agostino Consoli, Irene Marzona, Stefano Palcic

“…For each cohort member who started SU, one patient who began other second-line treatments was randomly selected and matched for sex, age, Multisource Comorbidity Score, and previous duration of metformin treatment. …”
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