NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression by Shuangyan Li, Lishan Yan, Chaoying Li, Lijuan Lou, Fengjiao Cui, Xiao Yang, Fuchu He, Ying Jiang

“…Abstract Niemann-Pick disease type C protein 1 (NPC1), classically associated with cholesterol transport and viral entry, has an emerging role in cancer biology. …”
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Experimental Testing of Nonredundant Near-Field to Far-Field Transformations with Spherical Scanning Using Flexible Modellings for Nonvolumetric Antennas by Francesco D'Agostino, Flaminio Ferrara, Claudio Gennarelli, Rocco Guerriero, Massimo Migliozzi

“…The NF data needed to perform the classical spherical NF-FF transformation are then accurately and efficiently retrieved from the acquired nonredundant ones via optimal sampling interpolation formulas. …”
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Identifying Primary Spontaneous Pneumothorax from Administrative Databases: A Validation Study by Eric Frechette, Keegan Guidolin, Ayman Seyam, Yun-Hee Choi, Sarah Jones, J. Andrew McClure, Jennifer Winick-Ng, Blayne Welk, Richard A. Malthaner

“…The proposed algorithm is adequate to identify cases of PSP from administrative databases in the age group classically associated with the disease. This makes possible its utilization in large population-based studies.…”
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A meta-analysis of the effect of protein synthesis inhibitors on rodent fear conditioning by Carneiro, Clarissa F. D., Amorim, Felippe E., Amaral, Olavo B.

“…In this work, we studied protein synthesis inhibition, a classic intervention used to disrupt fear learning, reconsolidation, and extinction in rodents, to explore how meta-analyses can identify potential moderators of its effect. …”
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Correlation-based feature selection of single cell transcriptomics data from multiple sources by Nenad S. Mitić, Saša N. Malkov, Mirjana M. Maljković Ružičić, Aleksandar N. Veljković, Ivan Lj. Čukić, Xin Lin, Minjie Lyu, Vladimir Brusić

“…Bioinformatics data is high-dimensional, making it practically impossible to apply the majority of “classical” algorithms for classification and clustering. …”
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Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups by Ali Yaseen, Jaleel Samanje, Qahtan Adnan Rasheed, Rafah Sabah Barrak, Afraa Brahim

“…All these samples were subjected to classical microbiological testing, which included culturing directly on mannitol salt agar and antibiotic susceptibility test (A.S.T). …”
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A Fractal Analysis of the Size Effect in Quasi-Brittle Materials: Experimental Tests and Peridynamic Simulations by Leandro Ferreira Friedrich, Luis Eduardo Kosteski, Édiblu Silva Cezar, Angélica Bordin Colpo, Caroline Bremm, Giuseppe Lacidogna, Ignacio Iturrioz

“…More precisely, the error of the sum of the fractal exponents, computed with respect to the theoretical one, is equal to −1.20% and −2.10% for the experimental and numerical results, respectively. Moreover, the classical dimensional analysis has been employed to demonstrate that the scale effect can be naturally described by the PD model parameters, allowing to extend the results for scales beyond those analyzed experimentally.…”
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B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies by Xiaojie Wang, Jianqiang Hao, Daniel L. Metzger, Ziliang Ao, Mark Meloche, C. Bruce Verchere, Lieping Chen, Dawei Ou, Alice Mui, Garth L. Warnock

“…More importantly, B7-H4 plays an indispensable role in alloimmunity in the absence of the classic CD28/CTLA-4 : B7 pathway, suggesting a synergistic/additive effect with other agents such as CTLA-4 on inhibition of unwanted immune responses.…”
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Enhancing Rooftop Photovoltaic Segmentation Using Spatial Feature Reconstruction and Multi-Scale Feature Aggregation by Yu Xiao, Long Lin, Jun Ma, Maoqiang Bi

“…To address these challenges, this paper proposes a novel model based on the Res2Net architecture, an enhanced version of the classic ResNet optimized for multi-scale feature extraction. …”
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Assessment of IL-6 Pathway Inhibition in Gastrointestinal Behçet’s Disease from Immunological and Clinical Perspectives by Makoto Naganuma, Mitsuhiro Takeno, Aykut Ferhat Çelik, Robert Moots, Philippe Pinton, Tadakazu Hisamatsu

“…This review provides an overview of GIBD, including the diagnosis and immunopathogenesis as it is currently understood, and evaluates the emerging role of the inhibition of IL-6 (classic and trans-signaling) as an alternative treatment option for patients with GIBD. …”
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A Two-Stage Robust Optimization Method Based on the Expected Scenario for Islanded Microgrid Energy Management by Qing Duan, Wanxing Sheng, Haoqing Wang, Caihong Zhao, Chunyan Ma

“…One of the main challenges in microgrid system energy management is dealing with uncertainties such as the power output from renewable energy sources. The classic two-stage robust optimization (C-TSRO) method was proposed to cope with these uncertainties. …”
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A Comparative Study on Phenotypic versus ITS-Based Molecular Identification of Dermatophytes Isolated in Dakar, Senegal by Khadim Diongue, Ludivine Bréchard, Mamadou Alpha Diallo, Mame Cheikh Seck, Mouhamadou Ndiaye, Aida Sadikh Badiane, Stéphane Ranque, Daouda Ndiaye

“…Classically, dermatophytes are identified by phenotypic methods even if these methods, sometimes, remain difficult or uncertain. …”
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Experimental study and physical modeling of ceiling temperature distribution of fires in a large open-plan compartment with unilateral asymmetric openings by Xiaoyu Shan, Yuanzhou Li, Yong Jiang, Yong Hu

“…The results showed that an increase in the dimensions of the asymmetric openings positively impacted the combustion rate of the fire source and the flame inclination; the latter increased in the direction away from the opening. The previous classical models based on open confined spaces underestimated the maximum ceiling temperature, whereas the model relying on the virtual origins performed well. …”
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Crack path in liquid metal embrittlement: experiments with steels and modeling by T. Auger, S. Hémery, M. Bourcier, C. Berdin, M. Martin, I. Robertson

“…Using state of the art characterization tools (Focused Ion Beam and Transmission Electron Microscopy) a clear understanding of crack path is emerging for these systems where a classical fractographic analysis fails to provide useful information. …”
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Livelihood Vulnerability Index of Resettled Peasants Displaced by Land Acquisition of An Airport by Embun Sari, Joyo Winoto, Endriatmo Soetarto, Zaenal Asikin, Sri Fajar Ayu, Meutia Nauly

“…Law Number 2 of 2012 concerning Land Acquisition for Development in the Public Interest addresses the classic problem of infrastructure project development: land acquisition. …”
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Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context by Paulette Bioulac-Sage, Christine Sempoux, Laurent Possenti, Nora Frulio, Hervé Laumonier, Christophe Laurent, Laurence Chiche, Jean Frédéric Blanc, Jean Saric, Hervé Trillaud, Brigitte Le Bail, Charles Balabaud

“…In Europe and North America, hepatocellular adenomas (HCA) occur, classically, in middle-aged woman taking oral contraceptives. …”
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Dietary Supplementation of Astragalus Polysaccharides Enhanced Immune Components and Growth Factors EGF and IGF-1 in Sow Colostrum by Lunbo Tan, Ting Wei, Anwen Yuan, Jun He, Jinhui Liu, Daojun Xu, Qing Yang

“…Samples were measured using porcine immunoglobulin (Ig) G, IgM, classical swine fever virus antibody (CSFV Ab), epidermal growth factor (EGF), and insulin-like growth factor- (IGF-) 1 ELISA Quantitation Kits. …”
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Ultrasound imaging of the perithyroid fascial space: a comparative analysis with anatomical correlations by Ying Wei, Zhen-long Zhao, Yun Niu, Li-li Peng, Yan Li, Ming-an Yu

“…Isolating fluid was injected into classic anatomical spaces: anterior cervical (58.5%), pretracheal (71.8%, including Berry’s ligament in 196 cases), retropharyngeal (43.7%), and carotid (1.2%). …”
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Current Advances in Pharmacotherapy and Technology for Diabetic Retinopathy: A Systematic Review by Lei Lu, Ying Jiang, Ravindran Jaganathan, Yanli Hao

“…Diabetic retinopathy (DR) is classically defined by its vascular lesions and damage in the neurons of the retina. …”
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Amortissement des phonons dans un superfluide 2D : insuffisance de la règle d’or de Fermi à basse température by Castin, Yvan, Serafin, Alan, Sinatra, Alice

“…We confirm this prediction with classical phonon-field simulations and a non-perturbative theory in H3, where the fourth order is regularized by hand, giving a complex energy to the virtual phonons of the four-phonon collisional processes. …”
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