A face-off between Smaug and Caspar modulates primordial germ cell count and identity in Drosophila embryos by Girish Deshpande, Subhradip Das, Adheena Elsa Roy, Girish S Ratnaparkhi

“…In Drosophila melanogaster, PGC formation and specification depends on two independent factors, the maternally deposited specialized cytoplasm (or germ plasm) enriched in germline determinants, and the mechanisms that execute the even partitioning of these determinants between the daughter cells. Prior work has shown that Oskar protein is necessary and sufficient to assemble the functional germ plasm, whereas centrosomes associated with the nuclei that invade the germ plasm are responsible for its equitable distribution. …”
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Pancreatic organogenesis mapped through space and time by Marissa A. Scavuzzo, Wojciech J. Szlachcic, Matthew C. Hill, Natalia M. Ziojla, Jessica Teaw, Jeffrey C. Carlson, Jonathan Tiessen, Jolanta Chmielowiec, James F. Martin, Malgorzata Borowiak

“…We found that four transcriptionally unique subtypes of mesenchyme in the developing pancreas spatially coordinate throughout development, with each subtype at fixed locations in space and time in relation to other cells, including beta cells, vasculature, and epithelial cells. Our work provides insight into the mechanisms of pancreatic development by showing that cells are organized in a space and time manner.…”
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A Numerical Approach to Analysis of an Environment-Friendly Sn-Based Perovskite Solar Cell with SnO2 Buffer Layer Using SCAPS-1D by Sunirmal Kumar Biswas, Md. Shamsujjoha Sumon, Kushal Sarker, Mst. Farzana Orthe, Md. Mostak Ahmed

“…The main aim of this study is to develop an environment-friendly and highly efficient structure that can be used as an alternative to other toxic lead-based perovskite solar cells. This work performed a numerical analysis for the proposed (Al/ZnO/SnO2/CH3NH3SnI3/Ni) device structure. …”
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Biodegradable triboelectric nanogenerator as a implantable power source for embedded medicine devices by Gang Jian, Shangtao Zhu, Xiao Yuan, Shengqiao Fu, Ning Yang, Chao Yan, Xu Wang, Ching-Ping Wong

“…After stopping the electric field, the release of DOX normalized, facilitating the precise killing of cancer cells. Our work demonstrates the broad potential of BI-TENGs in the field of cancer treatment.…”
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Correlating NAD(P)H lifetime shifts to tamoxifen resistance in breast cancer cells: A metabolic screening study with time-resolved flow cytometry by Samantha Valentino, Karla Ortega-Sandoval, Kevin D. Houston, Jessica P. Houston

“…Results show that tamoxifen-resistant breast cancer cells have increased utilization of glycolysis for energy production compared to tamoxifen-sensitive breast cancer cells. This work is impacting because it establishes an early step toward developing a reliable screening technology in which large cell censuses can be differentiated for drug sensitivity in a label-free fashion.…”
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Boosting high-performance in Zr-rich side protonic solid oxide electrolysis cells by optimizing functional interlayer by Chunmei Tang, Ning Wang, Sho Kitano, Hiroki Habazaki, Yoshitaka Aoki, Siyu Ye

“…As a result, the P-SOEC yields high current density of 0.83 A cm−2 at 600 °C in 1.3 V among all the reported Zr-rich side cells. This work not only offers an efficient functional interlayer for P-SOECs but also holds the potential to achieve P-SOECs with high performances and long-term stability.…”
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Inhibition of cancer cells using target-specific 2A3 antibody-conjugated gold nanoclusters by Jui-Chi Kuo, Tsung-Rong Kuo, Fajar Rinawati, Erna Susilowati, Sucipto, Dyah Ika Krisnawati

“…Conclusion: Combination with the results of cell viability assay and fluorescence imaging, the surface ligand of 2A3 antibody on 2A3-AuNCs exhibited promising inhibition of CEACAM6 overexpressed cancer cells. Our work provides a potential application of AuNCs in cancer therapy. …”
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Toward measurements of absolute membrane potential in Bacillus subtilis using fluorescence lifetime by Debjit Roy, Xavier Michalet, Evan W. Miller, Kiran Bharadwaj, Shimon Weiss

“…We observed a population-level MP heterogeneity of ∼6-10 mV indicating a considerable degree of diversity of physiological and metabolic states among individual cells. Our work paves the way for deeper insights into bacterial electrophysiology and bioelectricity research.…”
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Human Fetal Liver: An In Vitro Model of Erythropoiesis by Guillaume Pourcher, Christelle Mazurier, Yé Yong King, Marie-Catherine Giarratana, Ladan Kobari, Daniela Boehm, Luc Douay, Hélène Lapillonne

“…In this in vitro model, maturation that is enucleation reaches a lower level compared to adult sources as observed for embryonic or iP, but, interestingly, they (i) displayed a dramatic in vitro expansion (100-fold more when compared to CB CD34+) and (ii) 100% cloning efficiency in hematopoietic progenitor assays after 3 days of erythroid induction, as compared to 10–15% cloning efficiency for adult CD34+ cells. This work supports the idea that FL remains a model of study and is not a candidate for ex vivo RBCS production for blood transfusion as a direct source of stem cells but could be helpful to understand and enhance proliferation abilities for primitive cells such as ES cells or iPS.…”
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DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma by Jianyu Yang, Yongsheng Jiang, Ruizhe He, Wei Liu, Minwei Yang, Lingye Tao, Xueliang Fu, Yang Shen, Jiao Li, Dejun Liu, Yanmiao Huo, Junfeng Zhang, Rong Hua, Zhigang Zhang, Yongwei Sun

“…We then confirmed these results and demonstrated that a higher expression of DKK2 imparts the recruitment of CD8+ T cells. Our work suggested that DKK2 imparts tumor immune evasion and is associated with poor prognosis in pancreatic ductal adenocarcinoma.…”
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Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation by S. Landman, V. L. de Oliveira, M. Peppelman, E. Fasse, E. van Rijssen, S. C. Bauland, P. van Erp, I. Joosten, H. J. P. M. Koenen

“…Taken together, we demonstrate that inhibition of skin inflammation by Treg infusion, next to a reduction of infiltrating effector T cells, is mediated by restoring both the local and systemic balance between cytokine-producing effector T cells and immunoregulatory T cells. This work furthers our understanding of Treg-based immunotherapy.…”
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Les conseils consultatifs régionaux : vers une nouvelle gouvernance pour les pêches de l’union européenne ? by Sarah Lelong

“…As a consequence, the regional advisory councils (RACs) were created as communication cells between the different bodies engaged into the decision-making process and information exchange. Since these cells are working at a regional level, they enable the participation of professional to the Communitarian decision process in the field of fisheries and then facilitate the acceptation of rules as well as environmental objectives. …”
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Forecasting Photovoltaic Module Remaining Life-Time Using Accelerated Aging Testing and Modelling on Aged Modules by Julien Dupuis, Christine Abdel Nour

“… This work investigates the possibility of predicting the remaining lifetime of a power plant by making accelerated aging testing on monocrystalline silicon cells modules working on a photovoltaic plant for eleven years in France and compares the results with the same testing done on modules from the same batch eleven years ago when they were new. …”
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On Harvesting Energy from Tree Trunks for Environmental Monitoring by Cleonilson P. Souza, Fabrício B. S. Carvalho, Filype A. N. Silva, Hening A. Andrade, Nathália de V. Silva, Orlando Baiocchi, Ivan Müller

“…Additionally, it is also shown that it is possible to harvest thermal energy during the day and during the night while photovoltaic cell only works under sunlight.…”
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γδ T Cells’ Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models by Xavier Charmetant, Xavier Charmetant, Xavier Charmetant, Guillaume Rigault, Chien-Chia Chen, Hannah Kaminski, Hannah Kaminski, Jonathan Visentin, Jonathan Visentin, Benjamin Taton, Gabriel Marseres, Virginie Mathias, Alice Koenig, Alice Koenig, Alice Koenig, Thomas Barba, Thomas Barba, Thomas Barba, Pierre Merville, Pierre Merville, Stéphanie Graff-Dubois, Emmanuel Morelon, Emmanuel Morelon, Emmanuel Morelon, Julie Déchanet-Merville, Valérie Dubois, Jean-Paul Duong van Huyen, Lionel Couzi, Lionel Couzi, Olivier Thaunat, Olivier Thaunat, Olivier Thaunat

“…The generation of donor-specific antibodies (DSA) requires that alloreactive B cells receive help from follicular helper T (TFH) cells. Recent works have suggested that γδ T cells could contribute to T cell-dependent humoral responses, leading us to investigate their role in DSA generation. …”
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Time‐restricted versus standard‐duration immunosuppression after allogeneic hematopoietic stem cell transplantation: Results of the prospective randomized HOVON‐96 trial by Annoek E. C. Broers, Ellen Meijer, Bronno van der Holt, Cornelis N. de Jong, Erfan Nur, Geerte L. van Sluis, Goda Choi, Michel van Gelder, Johan A. Maertens, Jürgen Kuball, Dries Deeren, Heleen A. Visser‐Wisselaar, Lamberdina A. H. M. Meulendijks, Jan J. Cornelissen, the HOVON Stem Cell Transplantation Working Group

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