First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies by Peter Ellmark, Jeffrey Yachnin, Ana Carneiro, Lena Schultz, Amanda Hahn, Sumeet Ambarkhane, Karin Enell Smith, Gustav J. Ullenhag

“…ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.Methods In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to patients with advanced, unresectable solid tumors having received multiple standard-of-care treatments. …”
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Clinicopathological Analysis of 14 Cases of Primary Pulmonary Lymphoepithelial Carcinoma by Yixuan FANG, Anzhe WANG, Lumin SHEN, Xiao YUAN, Yu KONG

“…It is currently classified as a distinct subtype within squamous cell carcinomas. This study aims to explore the clinicopathological characteristics of PPLEC and its subtypes, with the objective of enhancing understanding and improving diagnostic accuracy for this disease. …”
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Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing by Anitha S, Nandini Robin Nadar, Srividya Shivakumar, Sharma S C, Siddharth P, Surekha Varalakshmi V, Rajesh Lenka, Rajadurai S

“…Skin injuries may be due to acute or chronic trauma, infections, and operations and can cause severe dysfunction or death. Hence, early clinical intervention becomes crucial in managing the problem. …”
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A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization by Xiancheng Xia, Yang Li, Rongkang Huang, Yuanbin Wang, Wenxuan Xiong, Hui Zhou, Min Li, Xidong Lin, Youchen Tang, Bo Zhang

“…More importantly, upon entry into tumor cells, ICN catalyze the generation of reactive oxygen species via the Fenton‐like reaction while simultaneously consuming intracellular glutathione, thereby inducing tumor cell death via chemodynamic therapy. …”
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Oakland score to identify low-risk patients with lower gastrointestinal bleeding performs well among emergency department patients by Daniel D. DiLena, Sean C. Bouvet, Madeline J. Somers, Maqdooda A. Merchant, Theodore R. Levin, Adina S. Rauchwerger, Dana R. Sax

“…The Oakland Score composite outcome includes re-bleeding, defined as additional blood transfusion requirements and/or a further decrease in hematocrit (Hct) >/= 20% after 24 h in clinical stability; red blood cell transfusion; therapeutic intervention to control bleeding, including surgery, mesenteric embolization, or endoscopic hemostasis; in-hospital death, all cause; and re-admission with further LGIB within 28 days. …”
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Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer by Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, María Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

“…Cancer affects 9 million people every year constituting one of the main causes of death. However, current treatments are frequently associated with adverse effects and can exhibit limitations in therapeutic efficacy. …”
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Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence‐Associated Pathologies by Yujiao He, Yanchen Liu, Mingyue Zheng, Yuxiu Zou, Mujie Huang, Linsheng Wang, Ge Gao, Zhongjun Zhou, Guoxiang Jin

“…A blocking peptide, TAT‐PEP, specifically abrogating ATAD3A phosphorylation, results in elevated cell death by preventing doxorubicin‐induced senescence, thus leading to enhanced tumor sensitivity to chemotherapy. …”
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Validation of hyperthermia as an enhancer of chemotherapeutic efficacy: insights from a bladder cancer organoid model by Ying Xu, Guoliang Sun, Tiantian Yang, Huaibiao Li, Poyi Hu, Wanru Luo, Tingke Zhang, Haoran Liu, Guoyi Chen, Zhangqun Ye, Yuqing Wu, Jie Yu, Wanyi Chen, Kai Zhao, Chunyan Liu, Huiping Zhang

“…Treatment with gemcitabine or pirarubicin under hyperthermic conditions caused pronounced structural damage to the organoids and increased cell death compared to that in the normothermically treated group. …”
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TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients... by Heather L. McArthur, Sara M. Tolaney, Rebecca Dent, Peter Schmid, Jamil Asselah, Qiang Liu, Jane Lowe Meisel, Naoki Niikura, Yeon Hee Park, Gustavo Werutsky, Giampaolo Bianchini, Jay C. Andersen, Robert Kozarski, Nana Rokutanda, Barbara Pistilli, Sibylle Loibl

“…Datopotamab deruxtecan (Dato-DXd), a TROP2-directed antibody-drug conjugate consisting of a humanized IgG1 monoclonal antibody attached via a plasma-stable cleavable linker to a topoisomerase-I inhibitor payload, has shown efficacy alone or in combination with durvalumab, a selective, high-affinity anti-programmed cell death ligand 1 antibody, in early-phase clinical studies. …”
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Analysis of MLKL, RIP1 and RIP3 Immunostaining Markers in Human Liver Tissue from Fatal Yellow Fever Cases: Insights into Necroptosis by Vanessa do Socorro Cabral Miranda, Luiz Fabio Magno Falcão, Hellen Thais Fuzii, Marcos Luiz Gaia Carvalho, Jeferson da Costa Lopes, Arnaldo Jorge Martins Filho, Ana Cecilia Ribeiro Cruz, Raimunda do Socorro da Silva Azevedo, Jorge Rodrigues de Sousa, Mayumi Duarte Wakimoto, Pedro Fernando da Costa Vasconcelos, Juarez Antônio Simões Quaresma

“…Necroptosis is a regulated form of cell death implicated in several pathological conditions, including viral infections. …”
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Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis by S. Casaro, J. G. Prim, T. D. Gonzalez, F. Cunha, A. C. M. Silva, H. Yu, R. S. Bisinotto, R. C. Chebel, J. E. P. Santos, C. D. Nelson, S. J. Jeon, R. C. Bicalho, J. P. Driver, Klibs N. Galvão

“…Immune activation and systemic inflammation were characterized by increased proportion of circulating polymorphonuclear cells (PMN) prepartum, B-cell activation at parturition, interleukin-8 prepartum and at parturition, and interleukin-1β at parturition. …”
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Risk factors and machine learning prediction models for intrahepatic cholestasis of pregnancy by Yingchun Ren, Xiaoying Shan, Gengchao Ding, Ling Ai, Weiying Zhu, Ying Ding, Fuzhou Yu, Yun Chen, Beijiao Wu

“…Abstract Background Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that occurs in the second and third trimesters of pregnancy and is associated with a significant risk of fetal complications, including premature birth and fetal death. In clinical practice, the diagnosis of ICP is predominantly based on the presence of pruritus in pregnant women and elevated serum total bile acid. …”
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Wheat Leaf Rust Effector Pt48115 Localized in the Chloroplasts and Suppressed Wheat Immunity by Lulu Song, Liping Cui, Hao Li, Na Zhang, Wenxiang Yang

“…The amino acid sequence polymorphism analysis of Pt48115 in seven different leaf rust races showed that it was highly conserved. Pt48115 inhibited cell death induced by Bcl-2-associated X protein (BAX) from mice or infestans 1 (INF1) from <i>Phytophthora infestans</i> in <i>Nicotiana benthamiana</i> and by DC3000 in wheat, and its 145–175 amino acids of the C-terminal are critical for its function. …”
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Identification of fatty acid anabolism patterns to predict prognosis and immunotherapy response in gastric cancer by Weijie Sun, Yanhong Xia, Feifan Jin, Jinghao Cao, Gaoping Wu, Keyi Li, Yanhua Yu, Yunyi Wu, Gaoqi Ye, Ke Xu, Dengpan Liu, Weidong Jin

“…Abstract Gastric cancer (GC), one of the most common and heterogeneous malignancies, is the second leading cause of cancer death worldwide and is closely related to dietary habits. …”
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Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway by Yan Li, Hong Wang, Xiaoyang Li, Yuan He, Huiquan Liu, Dong Han, Ting Mei, Yixuan Li, Zilong Xu, Xiaoying Wei, Jianguo Wang, Peijie Zhou, Yuwen Wang, Ziye Li, Junhao Ning, Anlin Wang, Jingjing Cheng, Dong Qian

“…Furthermore, disruption of tumor-intrinsic Pgam5 significantly facilitated CD8+ T cells activation and improved anti-programmed cell death protein-1 therapeutic efficacy with macrophages depletion compromising synergistic antitumor immune response.Conclusion Our results shed light on the effect of tumor mitochondria dynamics on TAMs in tumor microenvironment. …”
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Prognostic Value of Procalcitonin for Morbidity and Mortality in Patients after Cardiac Surgery by Ahmad Amouzeshi, Farshid Abedi, Mahmoud Zardast, Yaser Rezaeian Bilondi, Zahra Amouzeshi

“…The postoperative serum PCT level is significantly correlated with sternum wound infection (p=0.001), packed cells (PC) transfusion (p=0.003), and death (p=0.003). …”
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Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trialResearch in context by Abha A. Gupta, Anna Tinker, Derek Jonker, Rahma Jamal, Hal Hirte, Eric W. Winquist, Quincy Chu, Christian Kollmannsberger, Ralph Wong, Thierry Alcindor, Torsten O. Nielsen, Ming Tsao, Tricia R. Cottrell, Diane Provencher, John Hilton, Monika K. Krzyżanowska, Christine Elser, Sebastien Hotte, Joana Sederias, Siwei Zhang, Wei Tu, Janet Dancey

“…Summary: Background: Dual inhibition of cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmed death ligand 1 (PD-L1) has been shown to be an effective treatment strategy in many cancers. …”
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Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…Endothelial cells are the major component of BBB, on which the increased expression of CD40 could mediate BBB dysfunction in diabetics. …”
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Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids by Shelley Barnhart, Masami Shimizu-Albergine, Eyal Kedar, Vishal Kothari, Baohai Shao, Melissa Krueger, Cheng-Chieh Hsu, Jingjing Tang, Jenny E. Kanter, Farah Kramer, Danijel Djukovic, Vadim Pascua, Yueh-Ming Loo, Lucrezia Colonna, Sadie J. Van den Bogaerde, Jie An, Michael Gale, Jr., Karen Reue, Edward A. Fisher, Sina A. Gharib, Keith B. Elkon, Karin E. Bornfeldt

“…We propose that ACSL1 induction is a mechanism used by IFN-I to increase phosphatidic acid saturation while protecting the cells from saturated fatty acid-induced cell death.…”
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ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer by Pingping Su, Xiaodan Mao, Jincheng Ma, Lixiang Huang, Lirui Yu, Shuting Tang, Mingzhi Zhuang, Zhonglei Lu, Kelvin Stefan Osafo, Yuan Ren, Xinrui Wang, Xite Lin, Leyi Huang, Xiaoli Huang, Elena Ioana Braicu, Jalid Sehouli, Pengming Sun

“…CUT & Tag sequencing and The Cancer Genome Atlas database analysis showed that ERRα participated in glycolysis and programmed cell death, which resulted in EC progression. Conclusions ERRα inhibits pyroptosis in an NLRP3-dependent manner and induces glycolytic metabolism, resulting in cisplatin resistance in EC cells.…”
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