Therapeutic Potential of <i>Lappula patula</i> Extracts on Germline Development and DNA Damage Responses in <i>C. elegans</i> by Qinghao Meng, Anna Hu, Weiyu Xiao, Robert P. Borris, Hyun-Min Kim

“…Apoptosis was quantified by monitoring cell death during the pachytene stage. LC-MS was used to identify bioactive compounds within the extracts. …”
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Endophytic fungi related to the ash dieback causal agent encode signatures of pathogenicity on European ash by Maryam Rafiqi, Chatchai Kosawang, Jessica A. Peers, Lukas Jelonek, Hélène Yvanne, Mark McMullan, Lene R. Nielsen

“…Amongst shared secreted proteins are cell death-inducing effector candidates, such as necrosis, and ethylene-inducing peptide 1-like proteins, Nep1-like proteins, that are upregulated during in planta growth of all Hymenoscyphus species. …”
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Manganese Inhalation as a Parkinson Disease Model by José Luis Ordoñez-Librado, Verónica Anaya-Martínez, Ana Luisa Gutierrez-Valdez, Laura Colín-Barenque, Enrique Montiel-Flores, Maria Rosa Avila-Costa

“…The present study examines the effects of divalent and trivalent Manganese (Mn2+/Mn3+) mixture inhalation on mice to obtain a novel animal model of Parkinson disease (PD) inducing bilateral and progressive dopaminergic cell death, correlate those alterations with motor disturbances, and determine whether L-DOPA treatment improves the behavior, to ensure that the alterations are of dopaminergic origin. …”
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Identification of Ferroptosis-Associated Long Noncoding RNA Prognostic Model and Tumor Immune Microenvironment in Thyroid Cancer by Yongjian Lin, Fu Gan, Xiaoyu He, Huachu Deng, Yong Li

“…Ferroptosis is a form of cell death distinct from apoptosis, which involves antitumor drug-related research. …”
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The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis by Gordon P. Flake, Alicia B. Moore, Norris Flagler, Benita Wicker, Natasha Clayton, Grace E. Kissling, Stanley J. Robboy, Darlene Dixon

“…The consequence of this process of slow ischemia with nutritional and oxygen deprivation is a progressive myocyte atrophy (or inanition), culminating in cell death, a process that we refer to as inanosis. …”
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lnc-MRGPRF-6:1 Promotes ox-LDL-Induced Macrophage Ferroptosis via Suppressing GPX4 by Zhihuan You, Xiaotian Ye, Meihua Jiang, Ning Gu, Caihong Liang

“…Ferroptosis, a newly discovered mode of cell death, emerges as a new target for atherosclerosis (AS). …”
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Deregulated JNK signaling enhances apoptosis during hyperthermia by Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Noriko Hosoya, Kiyoshi Miyagawa

“…The kinase activity of MAPK members was assessed through in vitro kinase assays. Cell death was assessed in the absence or presence of siRNAs targeting MAPK-related members.Results Hyperthermia decreased the levels of MAP3Ks, such as ASK1 and MLK3 which are JNK kinase kinase members, but not those of the downstream MAP2K/SEK1 and MAPK/JNK. …”
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Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer by Yuanyuan Wang, Chenxi Hu, Tianpeng Du, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang

“…The TME were tended to an environment beneficial for killing tumors by enhancing chemotactic factor release, increasing CD8+ T cell infiltration and activation, and decreasing the amount of regulatory T cells. …”
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Immune-mediated mechanisms in acute osteofascial compartment syndrome: insights from multi-omics analysis by Qinzhen Lu, He Ling, Yonghui Lao, Junjie Liu, Wei Su, Zhao Huang

“…Results Our research findings indicate that AOCS is an immune-mediated inflammatory disease, primarily involving immune cells, especially neutrophils. In addition, genes associated with ferroptosis, a form of regulated cell death, are found to be upregulated in the rat model, with non-coding RNAs playing a role in regulatory interactions. …”
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Non-invasive electron paramagnetic resonance imaging detects tumor redox imbalance induced by ferroptosis by Kazuhiro Kato, Hironobu Yasui, Hideo Sato-Akaba, Miho C. Emoto, Hirotada G. Fujii, Maciej M. Kmiec, Periannan Kuppusamy, Masaki Nagane, Tadashi Yamashita, Osamu Inanami

“…Targeting ferroptosis, cell death caused by the iron-dependent accumulation of lipid peroxides, and disruption of the redox balance are promising strategies in cancer therapy owing to the physiological characteristics of cancer cells. …”
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Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella by Dinh-Huy Nguyen, Sung-Hwan You, Hien Thi-Thu Ngo, Khuynh Van Nguyen, Khang Vuong Tran, Tan-Huy Chu, So-young Kim, Sang-Jun Ha, Yeongjin Hong, Jung-Joon Min

“…Localized secretion of ClyA from SAM-FC induces immunogenic cancer cell death and promotes release of tumor-specific antigens and damage-associated molecular patterns, which establish long-term antitumor memory. …”
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Pre-injection of exosomes can significantly suppress ovarian cancer growth by activating the immune system in mice by Yuanyuan Wang, Changyi Zhang, Huimin Zeng, Liangliang Wang, Zanhong Wang, Zhiqiang Han

“…Abstract As a type of “cold tumor” with limited immune cell infiltration, ovarian cancer has historically shown limited efficacy in immunotherapy. …”
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Glycosylated lysosomal membrane protein promotes tissue repair after spinal cord injury by reducing iron deposition and ferroptosis in microglia by Fangru Ouyang, Meige Zheng, Jianjian Li, Jinxin Huang, Jianan Ye, Jingwen Wang, Yuanzhe Zhao, Fangli Shan, Ziyu Li, Shuishen Yu, Fei Yao, Dasheng Tian, Li Cheng, Juehua Jing

“…Abstract Excessive iron deposition can lead to ferroptosis, a form of iron-dependent cell death detrimental to neuronal survival. Microglia have been identified as having a high capacity for iron deposition, yet it remains unclear whether microglia undergo ferroptosis while phagocytosing excessive amounts of iron after spinal cord injury (SCI). …”
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L-Arginine Supplementation in Type II Diabetic Rats Preserves Renal Function and Improves Insulin Sensitivity by Altering the Nitric Oxide Pathway by Taylor Claybaugh, Sarah Decker, Kelly McCall, Yuriy Slyvka, Jerrod Steimle, Aaron Wood, Megan Schaefer, Jean Thuma, Sharon Inman

“…This would impede the formation of reactive oxygen species which contributes to cell damage and death. LA supplementation preserved GFR in the treated diabetic rats compared to untreated diabetic rats. …”
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Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Additionally, copper can bind aberrantly to several neuronal proteins, including alpha-synuclein, tau, superoxide dismutase 1, and huntingtin, thereby inducing neurotoxicity and ultimately cell death. This study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases, with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease pathogenesis. …”
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Hypericin mediated photodynamic therapy induces ferroptosis via inhibiting the AKT/mTORC1/GPX4 axis in cholangiocarcinoma by Wei An, Kai Zhang, Guangbing Li, Shunzhen Zheng, Yukun Cao, Jun Liu

“…Ferroptosis is a novel regulated cell death(RCD), which is controlled by glutathione peroxidase4(GPX4) with the characteristics of iron dependent and excessive intracellular accumulation of lipid peroxides. …”
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Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus) by Jiale Shi, Congji Yang, Yuanyuan Qin, Qingqing Liu, Shengqi Hua, Defeng Wu, Wei Dong

“…Our findings may serve as a foundation for elucidating the mechanism underlying the molecular metabolism of programmed cell death and should be useful for marker-assisted selection breeding in watermelon.…”
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Macrophage-inherited exosome excise tumor immunosuppression to expedite immune-activated ferroptosis by Yan Liu, Junjie Liu, Qin Wang, Kun Zhang, Chunyan Zhu, Duo Wang, Guanhua Qiu, Xiaoqi Zhu, Chao Fang

“…M1 macrophage-derived exosomes can inherit more functions and genetic substances than nanovesicles since nanovesicles inevitably suffer from substance and function loss caused by extrusion-arised structural damage.Results Inspired by it, spontaneous homing to tumor and M2-like macrophage polarization into M1-like ones are attained, which not only significantly magnify oxidative stress but also mitigate ITM including M2-like macrophage polarization and regulatory T cell decrease, and regulate death pathways.Conclusions All these actions accomplish a synergistic antitumor enhancement against tumor progression, thus paving a general route to mitigate ITM, activate immune responses, and magnify ferroptosis.…”
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Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy by Xiaopeng Li, Yang Zhong, Pengyuan Qi, Daoming Zhu, Chenglong Sun, Nan Wei, Yang Zhang, Zhanggui Wang

“…This nanodrug combines dual GSH depletion, starvation therapy, and RT to promote immunogenic cell death and stimulate the systemic immune response. …”
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Salivary microbiota dysbiosis and elevated polyamine levels contribute to the severity of periodontal disease by Md Haroon Rashid, Sandhya Pavan Kumar, Resma Rajan, Anitha Mamillapalli

“…Elevated oxidative stress observed in gingivitis and periodontitis could have resulted in cell death. Conclusion The current study shows the role of salivary microbiota and polyamines in gingivitis and different periodontitis stages. …”
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