Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus by Lucie Caillon, Anais R. F. Hoffmann, Alexandra Botz, Lucie Khemtemourian

“…We will also discuss recent findings on the mechanism of hIAPP-membrane damage and on hIAPP-induced cell death. Finally, the development of successful antiamyloidogenic agents that prevent hIAPP fibril formation will be examined.…”
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Cognitive disorders: Potential astrocyte-based mechanism by Shiyu Li, Yeru Chen, Gang Chen

“…Neurodegenerative diseases are a common type of organic disease related to the pathology of neuronal death and disruption of glial cell balance, ultimately accompanied with cognitive impairment. …”
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Mucormycosis Leading to Cerebral Edema and Cerebellar Tonsillar Herniation after Allogeneic Bone Marrow Transplant: A Case Report by Chetan Jeurkar, Lauren Margetich, Ziver Sahin

“…Mucormycosis following hematopoietic stem cell transplant (HSCT) carries a very high mortality rate. …”
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Phytochemicals Mediated Remediation of Neurotoxicity Induced by Heavy Metals by Vivek Kumar Gupta, Shweta Singh, Anju Agrawal, Nikhat Jamal Siddiqi, Bechan Sharma

“…Heavy metals induced neurotoxicity and impairment in signalling cascade leading to cell death (apoptosis) has been indicated by several workers. …”
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Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases by Leilei Chen, Qingqing Shen, Yingjuan Liu, Yunqi Zhang, Liping Sun, Xizhen Ma, Ning Song, Junxia Xie

“…However, an imbalance in metal ions, whether excessive or insufficient, is detrimental and can contribute to neuronal death through oxidative stress, ferroptosis, cuproptosis, cell senescence, or neuroinflammation. …”
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Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? by Claus Desler, Thomas Lau Hansen, Jane Bruun Frederiksen, Maiken Lise Marcker, Keshav K. Singh, Lene Juel Rasmussen

“…If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. …”
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Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction by Yasuo Miura, Yusuke Matsui, Hitomi Kaneko, Mitsumasa Watanabe, Mitsuru Tsudo

“…Iron chelation therapy (ICT) has been applied for the patients with iron overload-associated liver dysfunction since it is one of the causes of death in patients with intractable hematological diseases requiring multiple red blood cell transfusions. …”
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Identifying key genes in cancer networks using persistent homology by Rodrigo Henrique Ramos, Yago Augusto Bardelotte, Cynthia de Oliveira Lage Ferreira, Adenilso Simao

“…We integrate mutation data from six cancer types and three biological functions: DNA Repair, Chromatin Organization, and Programmed Cell Death. We systematically evaluated the impact of gene removal on topological voids ( $$\beta _2$$ structures) within the Cancer Consensus Networks. …”
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The spatiotemporal and paradoxical roles of NRF2 in renal toxicity and kidney diseases by Yiying Bian, Jize Dong, Zhengsheng Zhou, Hua Zhou, Yuanyuan Xu, Qiang Zhang, Chengjie Chen, Jingbo Pi

“…These changes are directly or indirectly connected to altered antioxidant defense, damage repair, inflammatory response, regulated cell death and fibrogenesis, culminating ultimately in either protective or deleterious outcomes. …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…However, the underlying mechanism of Met-dependent antitumor immunity remains to be elucidated.Methods MitoTEMPO, a scavenger of mitochondrial superoxide, abolished the antitumor effect of Met, but not antiprogrammed cell death (PD-1) antibody (Ab) treatment. Consequently, we studied the mechanism of the Met-induced antitumor effect. …”
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HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAFV600E-mutant microsatellite stable colorectal cancer by Xin Li, Peng Yang, Jin Gu, Nan Chen, Dengbo Ji, Jinhong Xia, Jinying Jia, Zhuang Sun, Mengyuan Shi, Hanyang Wang, Zhaoya Gao

“…Finally, we established a CT26 BRAFV637E mouse cell line and validated the efficacy of combining these inhibitors and programmed death 1 (PD-1) blockades in immunocompetent mice.Results Drug screening identified histone deacetylase (HDAC) inhibitor and mitogen-activated protein kinase kinase (MEK) inhibitor as significantly effective against BRAFV600E MSS CRC. …”
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S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism by Min Yang, Weiwei Cui, Xiaoting Lv, Gaozhong Xiong, Caiyu Sun, Haocheng Xuan, Wei Ma, Xiuling Cui, Yeping Cheng, Lihui Han, Bo Chu

“…Abstract Ferroptosis is a newly identified programmed cell death induced by iron-driven lipid peroxidation and implicated as a potential approach for tumor treatment. …”
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Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury by Suhui Yu, Jianming Xie, Yukai Xiang, Shengjie Dai, Dinglai Yu, Hongwei Sun, Bicheng Chen, Mengtao Zhou

“…In vitro, we found that AT-Lipoxin A4 markedly suppressed protein expression in TNF-α signals in human pulmonary microvascular endothelial cell, such as tumor necrosis factor receptor-associated factor 2 (TRAF2), TNF-R1-associated death domain (TRADD), receptor-interacting protein (RIP), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. …”
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Metagenomic analysis of DNA viruses from posttransplant lymphoproliferative disorders by Vikas R. Dharnidharka, Marianna B. Ruzinova, Chun‐Cheng Chen, Priyanka Parameswaran, Harry O'Gorman, Charles W. Goss, Hongjie Gu, Gregory A. Storch, Kristine Wylie

“…In univariable analysis, death within 5 years of PTLD diagnosis was associated with anellovirus (P = 0.037) and gammapapillomavirus (P = 0.036) detection by MSS, higher tissue qPCR levels of the predominant human anellovirus species torque teno virus (TTV; P = 0.016), T cell type PTLD, liver, brain or bone marrow location. …”
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Incidence and predictors of mortality among HIV positive children on anti-retroviral therapy in the selected health facilities of West Wollega Zone, Western Ethiopia: Retrospective... by Gelane Gurmu, Emiru Merdassa, Gemechu Tiruneh, Keneni Efrem, Firezer Belay, Lalisa Mekonnen, Jira Wakoya Feyisa, Matiyos Lema, Adisu Tafari Shama, Markos Desalegn

“…Anemia, WHO clinical stage, CD4 cell count, and delayed developmental milestones were independent predictors of mortality. …”
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Blast‐Overpressure Induced Modulation of PARP‐SIRT‐NRF2 Axis in Stress Signaling of Astrocytes and Microglia by Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Ramkumar Thiayagarajan, Supriya Mahajan, Krishnamoorthy Gunasekaran

“…Animal studies indicate the over‐activation of PARP1 as a significant downstream event underlying the neurological sequelae of several traumatic and neurodegenerative disorders, irrespective of the mode of cell death. PARP over‐activation forms ADP polymers on several nuclear proteins, known as trans‐PARylation, by consuming nicotinamide adenine dinucleotide (NAD+) and ATP. …”
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Correlation of diabetes and adverse outcomes in hospitalized COVID-19 patients admitted to a tertiary hospital in China during a small-scale COVID-19 outbreak by Yu Li, Guanni Li, Jiahong Li, Zirui Luo, Yaxuan Lin, Ning Lan, Xiaodan Zhang

“…By multivariate logistic regression analysis, the death of COVID-19 patients with diabetes is positively correlated with age and CRP (p < 0.05), and has a trend towards significance with fasting blood glucose (p < 0.1). …”
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Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver Nanoparticles by Mojgan Taebi, Mahnaz Amiri, Niloofar Rashidi, Mahsa Sistani, Sanaz Hadizadeh, Razieh Razavi, Ali Reza Farzinnejad, Meysam Ahmadi Zeidabadi, Somayeh Karami Mohajeri

“…Furthermore, the AgNPs exhibited potent antibacterial effects, leading to cell death through increasing the membrane permeability and disrupting bacterial wall integrity. …”
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Phenylbutyric Acid Modulates Apoptosis and ER Stress‐Related Gene Expression in Glycogen Storage Disease Type Ib In Vitro Model by Marina Parezanovic, Nina Stevanovic, Marina Andjelkovic, Milena Ugrin, Sonja Pavlovic, Maja Stojiljkovic, Anita Skakic

“…Results Treatment with the most effective dose of 1 mM 4‐PBA reduced the expression of UPR markers and executioner caspases, while increased BCL2/BAX ratio in G6PT‐deficient cells. Our results proved the concept that 4‐PBA could alleviate markers of ER stress detected in the GSD Ib in vitro model system and prevent cell death. …”
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Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition by Shuangqian Yan, Panpan Xue, Ying Sun, Tingjie Bai, Sijie Shao, Xuemei Zeng

“…Transcriptomic analysis validates Cu‐HPB/C's impact on cholesterol homeostasis and reveals cell death mechanisms including oxidative stress, ferroptosis, cuproptosis, and apoptosis. …”
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