Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands by Bárbara Marques, Diogo M. Engrácia, João Franco Machado, Jaime A. S. Coelho, Filipa Mendes, Tânia S. Morais

“…Conclusions: Both compounds exhibited moderate to high cytotoxic activity, with complex 1 showing a greater propensity to induce cell death, particularly in the A431 and MDA-MB 231 cell lines.…”
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Intra-mesenteric steroids for steroid-refractory graft-versus-host disease in pediatric patients: A safe option by Ana M. Aristizábal, Lina P. Montaña, Jaiber Gutiérrez, Diego Medina, Alexis A. Franco, Eliana Manzi, Ángela Devia Zapata, Walter Mosquera

“…Graft-versus-host disease is a serious complication after hematopoietic stem cell transplantation and is a major cause of death post-transplantation. …”
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Characteristics and prognostic factors of chronic kidney disease patients with Pneumocystis jirovecii pneumonia by Liu Xiao-hua, Wu Jing-jing, Zeng Ming, Ge Yi-fei, Zhang Bo, Wu Bu-yun, Mao Hui-juan

“…The cluster of differentiation 4 receptors （CD4） cell count averaged at 292.3 cells/μL， and 60.0% of the patients had CD4 cell count<200 cells/μL. …”
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Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option? by Daniele Fanale, Giuseppe Bronte, Francesco Passiglia, Valentina Calò, Marta Castiglia, Florinda Di Piazza, Nadia Barraco, Antonina Cangemi, Maria Teresa Catarella, Lavinia Insalaco, Angela Listì, Rossella Maragliano, Daniela Massihnia, Alessandro Perez, Francesca Toia, Giuseppe Cicero, Viviana Bazan

“…Alteration of tubulin-microtubule equilibrium determines the disruption of the mitotic spindle, halting the cell cycle at the metaphase-anaphase transition and, eventually, resulting in cell death. …”
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Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts by Yanqiu Huang, Yi Zhou, Yadan Xu, Xiaoyu Wang, Ziyi Zhou, Kang Wu, Qiqi Meng, Liao Wang, Yang Yang, Hong Gao, Juan Ji, Xu Jiang, Yang Yang, Lipeng Hao, Hui Wang

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Ultrastructural and Molecular Changes in the Developing Small Intestine of the Toad Bufo regularis by S. A. Sakr, G. M. Badawy, H. T. El-Borm

“…In conclusion, the recorded remodeling of the small intestine represents a model for clarifying the mechanism whereby cell death and proliferation are controlled.…”
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Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis by Yinzi Xin, Wei Wang, Enyu Mao, Hefeng Yang, Song Li

“…It was involved in the progress of a programmed cell death called pyroptosis, which was caspase-1 dependent and ultimately triggered inflammatory mediator interleukin IL-1β release. …”
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Gastrointestinal Stromal Tumours: Etiology, Pathology and Clinical Management by Martin E Blackstein, Pierre Dubé, Jonathan A Fletcher, Oliver R Keller, Margaret Knowling, Richard Létourneau, Donald Morris, Robert Riddell, Stewart Rorke, Carol J Swallow, Canadian Advisory Committee on GIST

“…Investigation of the regulation of cell growth, differentiation and death by signalling pathways has led to a greater understanding of how alterations in these pathways play a critical role in the development of some cancers, and has opened new opportunities for their treatment. …”
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Modeling synergy and individual effects of X-ray induced photodynamic therapy components by Farideh. S. Hossein, Nadia Naghavi, Ameneh Sazgarnia, Atefeh Vejdani Noghreiyan

“…Simultaneously, the effects of RT in the presence of TiO2 nanoscintillators evaluated experimentally on HT-29 cell line. Simulation results predicted necrosis and apoptosis death of cancerous cells and estimated the minimum XPDT efficiency under specific conditions. …”
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Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects by Lei Wei, Sijie Ou, Youshi Meng, Lanfeng Sun, Lin Zhang, Yuling Lu, Yuan Wu

“…Previous studies suggest that glycyrrhizin may regulate key processes involved in epilepsy pathogenesis, such as neuroinflammation and cell death, but its effects on pyroptosis have not been reported.MethodsThis study employed bioinformatics techniques to identify potential molecular targets for glycyrrhizin in epilepsy treatment and then validated using a kainic acid-induced status epilepticus mouse model.ResultsGlycyrrhizin treatment significantly prolonged seizure latency, reduced seizure duration, and alleviated neuronal damage in the status epilepticus mouse model. …”
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Neurobiology of Vascular Dementia by Ana-Maria Enciu, Stefan N. Constantinescu, Laurenţiu M. Popescu, Dafin F. Mureşanu, Bogdan O. Popescu

“…However, in a very large majority of cases, these alterations occur in an already aged brain, characterized by a milieu of cellular and molecular events common for different neurodegenerative diseases. The cell signaling defects and molecular dyshomeostasis might lead to neuronal malfunction prior to the death of neurons and the alteration of neuronal networks. …”
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Disseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia by Yonal Ipek, Dogru Hulya, Aktan Melih

“…All-trans retinoic acid (ATRA) is a subgroup of the retinoid family, which induces complete remission (CR) in APL by causing differentiation and apoptosis in immature malignant promyelocytes rather than inducing cell death by cytotoxicity (Warrell et al. (1993), Liu et al. (2000), and Cassinat et al. (2001)). …”
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Biological characterization and clinical significance of cuproptosis-related genes in lung adenocarcinoma by Meilin Li, Yu Tan, Zhixin Li, Lingfeng Min

“…Cuproptosis is a novel cell death mechanism. The aim of this study was to examine the biological characteristics and clinical significance of genes associated with cuproptosis in lung adenocarcinoma (LUAD), and to understand the molecular mechanisms underlying the occurrence and progression of LUAD. …”
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Functionalized Selenium Nanoparticles Enhance Anticancer Efficacy of Doxorubicin for Hepatocellular Carcinoma Therapy by Min Guo, Ying Tang, Liang Hua, Wanling Li, Guifang Gong, Yali Zhu, Bing Zhu, Yu Xia

“…The cell viability, scratch migration, and invasion chamber assays indicated that HA-Se@DOX showed stronger ability to suppress HepG2 cells growth and migration/invasion compared to Se@DOX or DOX alone. …”
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Dysplasia in Inflammatory Bowel Diseases: Definition and Clinical Impact by Karel Geboes, Paul Rutgeerts

“…They can identify changes in DNA content and molecular changes resulting from defects of genes controlling cell proliferation and death or tissue structure. …”
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miRNAs and Melanoma: How Are They Connected? by Adriana Taveira da Cruz, Miriam Galvonas Jasiulionis

“…Therefore these molecules are considered essential in the processing of many biological responses, such as cell proliferation, apoptosis, and stress responsiveness. …”
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Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain by Geeta Ramesh, Andrew G. MacLean, Mario T. Philipp

“…The latter may mediate neuronal and glial cell injury and death through production of proinflammatory factors such as cytokines and chemokines. …”
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Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization by Nikos G. Gavalas, Alexandra Karadimou, Meletios A. Dimopoulos, Aristotelis Bamias

“…Ovarian cancer is one of the leading causes of cancer-related death among women. Resistance to the disease occurs in more than 70% of the cases even after treated with chemotherapy agents such as paclitaxel- and platinum-based agents. …”
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The Role of the Immune System in Huntington’s Disease by Gisa Ellrichmann, Christiane Reick, Carsten Saft, Ralf A. Linker

“…As part of the adaptive immune system, dendritic cells (DCs) prime T-cell responses secreting inflammatory mediators. …”
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Treatment of Acute Graft-versus-Host Disease in Liver Transplant Recipients by Edward Kim, Alina Adeel, Adel Bozorgzadeh, Shinya Amano, Curtis T. Barry, Jennifer S. Daly, Deepika Devuni, Zendee Elaba, Laura Houk, Paulo N. Martins, Babak Movahedi, Muthalagu Ramanathan, Nicole M. Theodoropoulos

“…Acute graft-versus-host disease (aGvHD) is a rare complication of liver transplantation associated with high morbidity and mortality. Death typically occurs due to complications related to severe infection, shock, and multiorgan failure. …”
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