Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration by Ping-Wu Zhang, Zi-He Wan, Weifeng Li, Abhishek Vats, Kunal Mehta, Laura Fan, Lingli Zhou, Sean Li, Gloria Li, Casey J. Keuthan, Cynthia Berlinicke, Cheng Qian, Noriko Esumi, Elia J Duh, Donald J. Zack

“…Retinal structure and function were evaluated by spectral-domain optical coherence tomography (SD-OCT) and electroretinography (ERG). Cell death genes were analyzed at 24 and 72 h after LD using the Mouse Pan-Cell Death Pathway PCR Array (88 genes). …”
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The Natural History of Uterine Leiomyomas: Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation by Gordon P. Flake, Alicia B. Moore, Deloris Sutton, Grace E. Kissling, John Horton, Benita Wicker, David Walmer, Stanley J. Robboy, Darlene Dixon

“…The end stage of this process is an involuted tumor with a predominance of collagen, little to no proliferative activity, myocyte atrophy, and myocyte cell death. Since many of the dying cells exhibit light microscopic and ultrastructural features that appear distinct from either necrosis or apoptosis, we refer to this process as inanosis, because it appears that nutritional deprivation, or inanition, is the underlying cause of cell death. …”
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Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis by Flora Magno de Jesus Oliveira, Cassiano Felippe Gonçalves-de-Albuquerque, Isabel Matos Medeiros de Moraes, Patrícia Alves Reis, Vinicius Novaes Rocha, Patrícia Torres Bozza, Adriana Ribeiro Silva, Hugo Caire de Castro Faria Neto

“…Sepsis is characterized by a life-threatening organ dysfunction caused by an unbalanced host response to microbe infection that can lead to death. Besides being currently the leading cause of death in intensive care units worldwide, sepsis can also induce long-term consequences among survivors, such as cognitive impairment. …”
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Potato Physiological Disorders - Brown Center and Hollow Heart by Chad M. Hutchinson

“…Brown center is characterized by a region of cell death in the pith of the tuber which results in brown tissue. …”
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Correlation between Ferroptosis-Related Gene Signature and Immune Landscape, Prognosis in Breast Cancer by Jiahao Zhu, Qingqing Chen, Ke Gu, You Meng, Shengjun Ji, Yutian Zhao, Bo Yang

“…Breast cancer (BC) is the most commonly diagnosed cancer and second leading cause of cancer-related death in women worldwide. Ferroptosis, an iron-dependent newly discovered mode of cell death, can be induced by lenaltinib and plays an important role in the biological behaviors of BC. …”
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Pathogenic role of lipids in non-alcoholic fatty liver disease by Yu. O. Shulpekova

“…The subsequent biochemical changes cause disorders of cellular respiration, disorder of mitochondrial integrity, increase probability of hepatocyte death. Excessive accumulation of free fatty acids acts as direct impulse for development of endoplasmic reticulum stress, and resulting events inside a cell are named «lipotoxic stress» or «lipoapoptosis». …”
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Identification and validation of five ferroptosis-related molecular signatures in keloids based on multiple transcriptome data analysis by Zhen Sun, Yonghong Qin, Xuanfen Zhang

“…Ferroptosis, a form of regulated cell death, plays a crucial role in the development of fibrosis; however, its role in the mechanisms of keloid formation remains poorly understood.MethodsThis study aimed to identify key genes associated with ferroptosis in keloid formation. …”
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Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection. by Jacques Augenstreich, Anna T Phan, Charles N S Allen, Anushka Poddar, Hanzhang Chen, Lalitha Srinivasan, Volker Briken

“…Interferon-gamma pre-treatment did not affect LC3 recruitment frequency or autophagosome acidification but increased the susceptibility of the macrophage to Mtb-induced cell death. LC3 recruitment and lysotracker staining were mutually exclusive events, alternating on some MCVs multiple times thus demonstrating a reversible aspect of the autophagy response. …”
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Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…Many GPCRs modulate ERS and UPR signaling via ERS sensors, IRE1α, PERK, and ATF6, to support cancer cell survival and inhibit cell death. By regulating downstream signaling pathways such as NF-κB, MAPK/ERK, PI3K/AKT, TGF-β, and Wnt/β-catenin, GPCRs also upregulate mesenchymal transcription factors including Snail, ZEB, and Twist superfamilies which regulate cell polarity, cytoskeleton remodeling, migration, and invasion. …”
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The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028 by Cheng Liang, Jianfu Jiang, Jinkai Li, Xiao Lin, Wenjun Huang, Keng Po Lai, Jian Chen

“…The results of gene ontology highlighted the involvement of CA028’s targets in the cell proliferation, cell apoptosis, and migration ability of melanoma cells. …”
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TGF-β1 inhibitor enhances the therapeutic effect of microwave ablation on hepatocellular carcinoma by Shufang Xiang, Juan Li, Mei Zhang

“…TUNEL assays were used to detect cell death ratio. Histopathological changes were examined by hematoxylin and eosin staining. …”
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Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53. by Kenneth Y Wertheim, Robert Chisholm, Paul Richmond, Dawn Walker

“…The continuous automaton represents the tumour microenvironment as a grid-like structure, where each voxel is associated with continuous variables such as the oxygen level therein. Each discrete cell agent is defined by several attributes, including its cell cycle position, mutations, gene expression pattern, and more with behaviours such as cell cycling and cell death being stochastically dependent on these attributes. …”
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Tannic acid elicits differential gene regulation in prostate cancer apoptosis by Kandir Sinan, Karakurt Sevtap, Gökçek-Saraç Çiğdem, Karakurt Serdar

“…Cell proliferation, cytotoxicity, and effects of tannic acid on the cell death mechanism were evaluated. mRNA expression levels of 84 genes were explored in cells following tannic acid treatment. …”
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Physicochemical properties, structure, growth-promoting and antioxidant activities of Glycyrrhiza leaf polysaccharides modified by fermentation by Juan Du, Yuan Wang, Xia Li, Zhalaga, Na Liu, Wenwen Wang, Jingwei Qi, Xiaoli Fan, Xiaoping An

“…FGLP exhibited superior protective effects against lipid peroxidation and cell death induced by AAPH. Graphical Abstract…”
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Tennis Rehabilitation Training-Assisted Paclitaxel Nanoparticles in Treatment of Lung Tumor by Di Hu, YiMin Yang

“…Its mechanism of action is to prevent tumor rupture by stabilizing tumor proteins, while preventing cell division, leading to cell death, thereby inhibiting the spread of lung tumors. …”
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Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block by Alisha Khan, Sana Riaz, Robert Carhart

“…Pembrolizumab is a monoclonal antibody directed towards programmed cell death protein 1 (PD-1) and is an antineoplastic drug which has a growing variety of oncologic uses. …”
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Diversity in the Regulation of Autophagy and Mitophagy: Lessons from Parkinson's Disease by Charleen T. Chu

“…Complete clearance of mitochondria can be observed during normal maturation of certain mammalian cell types, and during certain forms of neuronal cell death. …”
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Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications by Yating Cong, Na Li, Zixin Zhang, Yan Shang, Hailong Zhao

“…Abstract Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms and signaling pathways. …”
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Neoadjuvant anti-PD-1-based immunotherapy: evolving a new standard of care by Drew M Pardoll, Suzanne L Topalian

“…Neoadjuvant (presurgical) anti-programmed cell death protein-1 (PD-1)-based immunotherapy as a new approach to cancer treatment has been developing on an accelerated trajectory since the seminal clinical trial results from studies in lung cancer and melanoma were published in 2018. …”
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LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro. by Robin Jansen, Marc Pawlitzki, Michael Gliem, Sven G Meuth, Stefanie Schreiber, Michael-W Görtler, Jens Neumann

“…Our present study reveals the relevance of a β2 integrin, lymphocyte function-associated antigen-1 (LFA-1), as a potential key player in protecting neuronal cell death after oxygen-glucose deprivation in organotypic hippocampal cell cultures. …”
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