PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…This time span is designated as «death window».It was found that injections of exogenous DNA result in sustained increase in bone marrow cell (BMC) apoptosis, which occurs throughout the time of DNA administration (18–30 hours). …”
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Ascorbic acid-containing compound efficacy in ischemic brain damage by Rita M. Termulaeva, Konstantin Y. Belanov, Natalya D. Bunyatyan, Aleksander S. Pirozhkov, Dmitrii E. Timoshkin, Ekaterina V. Blinova, Olga V. Vasilkina, Kirill D. Blinov, Elena V. Semeleva, Aleksander A. Dmitriev, Dmitrii S. Blinov

“…Conclusion: 3-EA dose-dependently suppresses the death of cerebral cortex cells under the excitotoxic effects of glutamate and ischemia/reoxygenation. …”
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Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons by Calum Harvey, Alicja Nowak, Sai Zhang, Tobias Moll, Annika K Weimer, Aina Mogas Barcons, Cleide Dos Santos Souza, Laura Ferraiuolo, Kevin Kenna, Noah Zaitlen, Christa Caggiano, Pamela J Shaw, Michael P Snyder, Jonathan Mill, Eilis Hannon, Johnathan Cooper-Knock

“…Our work is relevant for all diseases featuring death of rare cell-types.…”
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Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developin... by Akihiko Kawahara, Tetsuro Sasada, Koichi Azuma, Hidenobu Ishii, Norikazu Matsuo, Takaaki Tokito, Tomoaki Hoshino, Yohei Miyagi, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Kenta Murotani

“…Peripheral blood samples were collected from 53 patients with NSCLC before treatment with PD-1 (Programmed cell death-1) inhibitors. The plasma concentrations of 21 PFAAs, 14 metabolites, and neopterin were measured by liquid chromatography–mass spectrometry. …”
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Phagocytosis by macrophages decreases the radiance of bioluminescent Staphylococcus aureus by Elles C. Boonstra, Liliana Agresti, Henny C. van der Mei, Paul C. Jutte, Jelmer Sjollema

“…S. aureus was released extracellularly as a result of macrophage cell death. Following this release, the bacteria increased their bioluminescence again. …”
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Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer by Eeshrita Jog, Ashwin Kumar Jainarayanan, Alessandro La Ferlita, Arnab Chakraborty, Afiya Dalwai, Showket Yahya, Anusha Shivashankar, Bhagya Shree Choudhary, Aakash Chandramouli, Mufaddal Kazi, Darshan Jain, Nileema Khapare, Akshaya B, Bushra K. Khan, Poonam Gera, Prachi Patil, Rahul Thorat, Nandini Verma, Lalit Sehgal, Avanish Saklani, Siddhesh S. Kamat, Sorab N. Dalal, Nazia Chaudhary

“…Blocking the conversion of free fatty acids into LDs by treatment with statins or inhibiting lipin1 expression disrupts lipid homeostasis, leading to lipotoxicity and ferroptotic cell death in both DTPs and patient-derived organoids (PDOs) in vitro. …”
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Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL-17/MIP-1β, IL-12/VEGF, and IL-10/IP-10 Axis by Nadja Pinto Garcia, Alexander Leonardo S. Júnior, Geyse Adriana S. Soares, Thainá Cristina C. Costa, Alicia Patrine C. dos Santos, Allyson Guimarães Costa, Andréa Monteiro Tarragô, Rejane Nina Martins, Flávia do Carmo Leão Pontes, Emerson Garcia de Almeida, Erich Vinícius de Paula, Olindo Assis Martins-Filho, Adriana Malheiro

“…We performed measurements of the frequency of innate and adaptive immunity cells, cytokines, chemokines, and growth factors and immunophenotyping of Toll-like receptor and adhesion molecule expression in the blood of SCA patients and healthy donors to evaluate the different profiles of these biomarkers, the relationship among them, and their correlation to laboratory records and death risk. …”
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Analysis of risk factors for radiation-induced oral mucositis for nasopharyngeal carcinoma and prognostic value of EGF and STREM-1 by Puyu Jiang, Po Xue, Jiani Wu

“…Background: This study analyzed the risk factors of radiation-induced oral mucositis (RIOM) for nasopharyngeal carcinoma (NPC) and the correlation between epidermal growth factor (EGF), soluble myeloid cell expression trigger receptor-1 (sTREM-1), and disease severity. …”
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Extracellular matrix re-normalization to improve cold tumor penetration by oncolytic viruses by Geofrey F. Soko, Geofrey F. Soko, Benson K. Kosgei, Stephene S. Meena, Stephene S. Meena, Ying Jing Ng, Huihui Liang, Bing Zhang, Qingjun Liu, Tielong Xu, Xinju Hou, Xinju Hou, Ray P. S. Han

“…The use of oncolytic viruses (OVs) to induce immunogenic cell death (ICD) in tumor cells is a well-established strategy for initiating the cancer immunity cycle (CIC). …”
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Clinical implications of proximal tubular multicilia in glomerular diseases by Bohye Kim, Boram Weon, Evonne Kim, Sohee Park, Wencheng Jin, Nayeon Shin, Yun Kyu Oh, Chun Soo Lim, Jung Pyo Lee, Obin Kwon, Jeonghwan Lee

“…Introduction: Multiciliated cells (MCCs) have been identified in the proximal tubules of patients with kidney disease; however, their clinical significance is unknown. …”
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Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cells Combined with Normothermic Machine Perfusion Repairs Bile Duct Injury in a Rat Model of DCD Liver Transplantation via A... by Xuan Tian, Huan Cao, Longlong Wu, Weiping Zheng, Mengshu Yuan, Xiang Li, Hongli Song, Zhongyang Shen

“…Livers from donors after circulatory death (DCD) are inevitably exposed to a longer warm ischemic period, which might increase the incidence of postoperative bile duct complications. …”
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EIF4A3-induced circ_0022382 promotes breast cancer cell progression through the let-7a-5p/PI3K/AKT/mTOR signaling pathway and SLC7A11 axis by Wei Liu, Wei Liu, Jun Zhang, Jiawen Zhang, Yu Ye, Jianqin Zhu, Qiwen Yu, Tao Li, Tao Li, Xiaochun Sun, Huabiao Chen, Huabiao Chen

“…Circular RNAs (circRNAs) have been found to be specifically expressed in cancers and regulate the growth and death of tumor cells. The role of circRNAs in breast cancer remain unknown. …”
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Recent trends in studying of alcohol-induced liver disease by I. I. Komkova, M. S. Zharkova, M. V. Mayevskaya

“…In the studies it was demonstrated, that there is significant difference in death rate of liver cirrhosis between European countries. …”
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(5E,7E)-4,5,6 Trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate from Euclea crispa (L.) Inhibits Ovarian Cancer Cell Growth by Controlling Apoptotic and Me... by Chella Perumal Palanisamy, Bo Cui, Hongxia Zhang, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan

“…The protein that is responsible for the death of cells (Bcl-2 and Bcl-xL) was reduced (p<0.05), while the protein expression of p53 and caspase-9 was increased (p<0.05) in compound 2-treated HO-8910 cells. …”
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Apoptosis in the liver of male <em>db/db</em> mice during the development of obesity and type 2 diabetes by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, M. A. Cherepanova, D. V. Vasendin, E. L. Zavjalov

“…The mechanisms of programmed cell death are actively involved in maintaining cellular homeostasis along development of NAFLD. …”
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Evaluation of Anti-Cancer, Pro-Apoptotic, and Anti-Metastatic Effects of Synthetic Analogue Compound 2-Imino-7-Methoxy-4-(4-fluorophenyl)-2H-1,3-Thiazino [3,2-a] Benzimidazole on P... by Mpho Ndou, Marthe C. D. Fotsing, Michael H. K. Kengne, Edwin M. Mmutlane, Derek T. Ndinteh, Mthokozisi B.C. Simelane, Lesetja Motadi, Mpho Choene

“…Caspase 3/7 activity was upregulated in PaCa-2 and downregulated in A375, suggesting caspase-dependent and caspase-independent cell death, respectively. p53 and Bax were upregulated on both cell lines which suggests that the compound might have induced apoptosis and autophagy. …”
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Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways by Lisha Ye, Katarina Stoklund Dittlau, Adria Sicart, Rekin'’s Janky, Philip Van Damme, Ludo Van Den Bosch

“…We used human induced pluripotent stem cell (hiPSC)-derived motor neurons from sALS patients to investigate early disease mechanisms. …”
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Transcriptional activity of repair, apoptosis and cell cycle genes (TP53, MDM2, ATM, BAX, BCL-2, CDKN1A, OGG1, XPC, PADI4, MAPK8, NF-KB1, STAT3, GATA3) in chronically exposed perso... by V. S. Nikiforov, E. A. Blinova, A. I. Kotikova, A. V. Akleyev

“…These data are consistent with current views on the activation of programmed cell death.…”
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Analysis of different therapeutic schemes combining cyclophosphamide and doublestranded DNA preparation for eradication of Krebs-2 primary ascites in mice by E. A. Potter, E. V. Dolgova, A. M. Minkevich, V. P. Nikolin, N. A. Popova, Ya. R. Efremov, S. I. Baiborodin, V. A. Rogachev, A. S. Proskurina, A. V. Kozel, O. S. Taranov, V. V. Omigov, E. I. Vereschagin, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…The timing of injections is chosen so that they target the cells that were insensitive to the previous treatments as they were in the G2/M phase. 3-4 rounds of injections are needed to eliminate the subpopulation of tumor-initiating cancer stem cells. …”
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Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism by Markus Brüll, Selina Multrus, Michael Schäfer, Ivana Celardo, Christiaan Karreman, Marcel Leist

“…Cell Death and Disease…”
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