Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes by Gina Manda, Alexandru-Ionel Checherita, Maria Victoria Comanescu, Mihail Eugen Hinescu

“…Molecular switches deciding on the renal cells fate in diabetic nephropathy are presented, such as hypertrophy versus death choices in mesangial cells and podocytes. …”
Get full text

Early Neural Cell Death Is an Extensive, Dynamic Process in the Embryonic Chick and Mouse Retina by Teresa Chavarría, Jimena Baleriola, Raquel Mayordomo, Flora de Pablo, Enrique J. de la Rosa

“…Orchestrated proliferation, differentiation, and cell death contribute to the generation of the complex cytoarchitecture of the central nervous system, including that of the neuroretina. …”
Get full text

Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia by Rong Lin, Rong Lin, XiaoYing Weng, XiaoYing Weng, Liang Lin, Liang Lin, XuYang Hu, XuYang Hu, ZhiYan Liu, ZhiYan Liu, Jing Zheng, Jing Zheng, FenFang Shen, FenFang Shen, Rui Li, Rui Li

Subjects: Get full text

Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy by Cong Xu, Shaodi Wen, Xiaoyue Du, Xinhua Zou, Elaine Lai-Han Leung, Guoren Zhou, Qibiao Wu, Bo Shen

Subjects: “…Regulated cell death (RCD)…”
Get full text

Editorial: Novel treatments for cardiovascular diseases by targeting inflammation, oxidative stress, and cell death by Dong Fan, Li Wang, Abhijit Chakraborty, Cheng-Lin Zhang, Feng Hua Yang

Subjects: Get full text

Circadian Rhythms and Breast Cancer: The Role of Per2 in Doxorubicin-Induced Cell Death by Megan I. Mitchell, Anna-Mart Engelbrecht

“…Due to the severe dose limiting side effects associated with current chemotherapeutic strategies, including the use of doxorubicin, a need for more effective adjuvant therapies to increase cancer cell susceptibility has arisen. This study was therefore aimed at characterizing the role of Per2 in normal breast epithelia (MCF-12A) and in ER− breast cancer cells (MDA-MB-231) and also at determining the role of Per2 in doxorubicin-induced cell death. …”
Get full text

Inflammasomes, Autophagy, and Cell Death: The Trinity of Innate Host Defense against Intracellular Bacteria by Teresa Krakauer

“…Inflammasome activation is an innate host defense mechanism initiated upon sensing pathogens or danger in the cytosol. Both autophagy and cell death are cell autonomous processes important in development, as well as in host defense against intracellular bacteria. …”
Get full text

Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells by Sukannika Tubtimsri, Tiraniti Chuenbarn, Suwisit Manmuan

“…Results Quercetin treatment reduced the vitality of KON cells and had minimal effect on MRC cells. Following quercetin treatment, the characterization of apoptosis and cell death in KON cells was observed. …”
Get full text

DNA Replication Arrest and P53-Dependent and P53-Independent Cell Death Pathways in Xeroderma Pigmentosum Variant Cells by James E. Cleaver, Eileen Crowley, Mohammed Kashani-Sabet, Charles L. Limoli

Get full text

Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism by Felix Pfister, Lucas R. Carnell, Lisa Löffler, Philipp Boosz, Niels Schaft, Jan Dörrie, René Stein, Malte Lenz, Erdmann Spiecker, Christian M. Huber, Sami Haddadin, Carola Berking, Christoph Alexiou, Christina Janko

“…Importantly, SPIONs suppressed cytokine release in the loaded CAR‐T cells, shifting the cell death phenotype in the tumor cells from pyroptosis to apoptosis. …”
Get full text

Beyond immortality: Epstein–Barr virus and the intricate dance of programmed cell death in cancer development by Arezoo Esmaeili, Prankur Awasthi, Samira Tabaee

Subjects: Get full text

Mitochondrial Complex I Inhibitors and Forced Oxidative Phosphorylation Synergize in Inducing Cancer Cell Death by Roberta Palorini, Tiziana Simonetto, Claudia Cirulli, Ferdinando Chiaradonna

“…In this study, we show that glucose deprivation and mitochondrial Complex I inhibitors synergize in inducing cancer cell death. In particular, our results reveal that low doses of Complex I inhibitors, ineffective on immortalized cells and in high glucose growth, become specifically cytotoxic on cancer cells deprived of glucose. …”
Get full text

HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms by Shruti Ghai, Rejina Shrestha, Kuo-Hui Su

Get full text

OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress by Alessandra Donato, Fiona K. Ritchie, Lachlan Lu, Mehershad Wadia, Ramon Martinez-Marmol, Eva Kaulich, Kornraviya Sankorrakul, Hang Lu, Sean Coakley, Elizabeth J. Coulson, Massimo A. Hilliard

“…However, our knowledge of the genetic elements that can be manipulated to protect neurons from oxidative stress-induced cell death is still very limited. Here, using Caenorhabditis elegans as a model system, combined with the optogenetic tool KillerRed to spatially and temporally control ROS generation, we identify a previously uncharacterized gene, oxidative stress protective 1 (osp-1), that protects C. elegans neurons from oxidative damage. …”
Get full text

Microfluidic Cultures of Basal Forebrain Cholinergic Neurons for Assessing Retrograde Cell Death by Live Imaging by Srestha Dasgupta, Mansi Pandya, Wilma Friedman

“…This study further establishes a novel method of tracing and imaging live BFCNs exposed to stimuli in their distal axons with the aim of assessing retrograde cell death. The in vitro compartmental culture system of BFCNs that allows live imaging may be applied to investigate various effects of axon- or soma-specific stimuli that affect BFCN health, maintenance, and death, to model events that occur in the context of brain injury and neurodegenerative disorders.…”
Get full text

Lack of GAGA protein in Trl mutants causes massive cell death in Drosophila spermatogenesis and oogenesis by N. V. Dorogova, A. E. Zubkova, E. V. Fedorova, E. U. Bolobolova, E. M. Baricheva

“…The results obtained showed that the lack of GAF protein causes massive germ cell death in both females and males of Drosophila, but this death manifests itself in different ways, depending on the sex. …”
Get full text

Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients by Joanna Bartosińska, Ewelina Zakrzewska, Dorota Raczkiewicz, Joanna Purkot, Anna Michalak-Stoma, Małgorzata Kowal, Dorota Krasowska, Grażyna Chodorowska, Krzysztof Giannopoulos

“…Psoriasis is a chronic inflammatory disease mediated by T cell immunity. Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. …”
Get full text

Para-Phenylenediamine Induces Apoptotic Death of Melanoma Cells and Reduces Melanoma Tumour Growth in Mice by Debajit Bhowmick, Kaushik Bhar, Sanjaya K. Mallick, Subhadip Das, Nabanita Chatterjee, Tuhin Subhra Sarkar, Rajarshi Chakrabarti, Krishna Das Saha, Anirban Siddhanta

“…Very little is known about whether p-PD has any effect on the melanin producing cells. We have demonstrated p-PD mediated apoptotic death of both human and mouse melanoma cells in vitro. …”
Get full text

A new paradigm for cancer immunotherapy: targeting immunogenic cell death-related noncoding RNA by Guojuan Sun, Ling He

Subjects: Get full text

Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy by Yuqing Wang, Yiting Xu, Yong Qu, Yifang Jin, Juanmei Cao, Jinshan Zhan, Zhuoxia Li, Chuxing Chai, Changzheng Huang, Min Li

“…Photodynamic therapy (PDT) is a relatively safe treatment modality that not only induces multiple modes of tumor cell death but also mediates the secondary immunological responses against tumor resistance and metastasis. …”
Get full text