Anti-proliferative and photodynamic activities of Senna didymobotrya (Fresen.) leaf alkaloid-rich extracts against breast cancer cells by Kolawole A. Olofinsan, Heidi Abrahamse, Blassan P. George

“…Abstract Background Amongst all neoplastic diseases, breast cancer represents a major cause of death among the female population in developed and developing countries. …”
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Differential Proteomic Analysis Predicts Appropriate Applications for the Secretome of Adipose-Derived Mesenchymal Stem/Stromal Cells and Dermal Fibroblasts by Stefania Niada, Chiara Giannasi, Alice Gualerzi, Giuseppe Banfi, Anna Teresa Brini

“…The adult stem cell secretome is currently under investigation as an alternative to cell-based therapy in regenerative medicine, thanks to the remarkable translational opportunity and the advantages in terms of handling and safety. …”
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Polystyrene Nanoplastics Elicit Multiple Responses in Immune Cells of the <i>Eisenia fetida</i> (<i>Savigny</i>, 1826) by Huijian Shi, Yaoyue Wang, Xiangxiang Li, Xiaoyang Wang, Yuntao Qi, Shaoyang Hu, Rutao Liu

“…The difficulty of the NP in causing cell death by disrupting the plasma membrane was demonstrated by the results of the lactate dehydrogenase release assays in relation to cell necrosis. …”
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Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma by Daniel Pölöske, Helena Sorger, Anna Schönbichler, Elvin D. deAraujo, Heidi A. Neubauer, Anna Orlova, Sanna H. Timonen, Diaaeldin I. Abdallah, Aleksandr Ianevski, Heikki Kuusanmäki, Marta Surbek, Elisabeth Heyes, Thomas Eder, Christina Wagner, Tobias Suske, Martin L. Metzelder, Michael Bergmann, Maik Dahlhoff, Florian Grebien, Roman Fleck, Christine Pirker, Walter Berger, Emir Hadzijusufovic, Wolfgang R. Sperr, Lukas Kenner, Peter Valent, Tero Aittokallio, Marco Herling, Satu Mustjoki, Patrick T. Gunning, Richard Moriggl

“…They induced cell death and growth arrest in both AML/NKCL cell lines and primary AML patient blasts. …”
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Systemic Administration of Mesenchymal Stem Cells Increases Neuron Survival after Global Cerebral Ischemia In Vivo (2VO) by Luisa Perasso, Carla Emilia Cogo, Debora Giunti, Carlo Gandolfo, Piero Ruggeri, Antonio Uccelli, Maurizio Balestrino

“…We tested the hypothesis that intravenous infusion of bone marrowderived stromal cells (mesenchimal stem cells, MSC) reduce brain damage after transient global ischemia. …”
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Recent trends and therapeutic potential of phytoceutical‐based nanoparticle delivery systems in mitigating non‐small cell lung cancer by Adam Haysom‐McDowell, Keshav Raj Paudel, Stewart Yeung, Sofia Kokkinis, Tammam El Sherkawi, Dinesh Kumar Chellappan, Jon Adams, Kamal Dua, Gabriele De Rubis

“…Lung cancer is the leading cause of cancer death globally, with non‐small cell lung cancer accounting for the majority (85%) of cases. …”
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Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway by Ya-Ni Wang, Ling-Ling Zhang, Xiao-Yun Fan, Sha-Sha Wu, Sheng-Quan Zhang

“…The results could have some indications in revealing the apoptotic damage of the airway epithelial cells. Besides, inhibition of cationic protein-induced apoptotic death in airway epithelial cells could be considered as a potential target of anti-injury or antiremodeling in asthmatics.…”
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Early detection of myocarditis caused by immune checkpoint inhibitor therapy with nivolumab and ipilimumab for advanced recurrent renal cell carcinoma by Maki Todo, Yodo Gatate, Shintaro Nakano, Go Kaneko, Masayuki Hagiwara, Takayuki Takahashi, Yuta Umezawa, Genji Ueda, Shiho Ishikawa, Yoshinori Makino, Masafumi Oyama, Suguru Shirotake

“…Abstract Combination therapy with nivolumab and ipilimumab for advanced renal cell carcinoma (RCC) may cause immune-related myocarditis; however, its incidence in this cancer type and regimen remains unknown. …”
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PARP‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing MDA‐MB‐231 Breast Cancer Cells by Magalie Hervieu, Arnaud J. Legrand, Emilie Floquet, Thierry Idziorek, Corentin Spriet, Didier Monté, Vincent Villeret, Marc Aumercier, Souhaila Choul‐li

“…In a previous study, we revealed that poly(ADP‐ribose) polymerase‐1 (PARP‐1) inhibition by PJ‐34 results in Ets‐1 level increase in cells, which is related with cell death of Ets‐1‐expressing cancer cells. …”
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NCOA4 linked to endothelial cell ferritinophagy and ferroptosis:a key regulator aggravate aortic endothelial inflammation and atherosclerosis by Li Zhu, Zijian Liu, Jiahui Liu, Zhenglong Li, Youli Bao, Xin Sun, Wenchen Zhao, An Zhou, Hongfei Wu

“…Ferroptosis is a novel mode of cell death induced by decreased antioxidant capacity of the organism and accumulation of reactive oxygen species. …”
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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

“…Here, we report the efficacy and safety of this combination regimen in treatment-naive advanced or metastatic non-small-cell lung cancer (NSCLC) patients with a programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) of 1% or greater (PD-L1-positive) and patients with previously treated small-cell lung cancer (SCLC). …”
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Insights into the Mode of Action of Novel Morpholinated Curcumin Derivatives Exhibiting Potent Antitumor Activity in Bladder Cancer Cells In Vitro by Paulina Kobylka, Pawel Bakun, Joanna Kuzminska, Tomasz Goslinski, Marek Murias, Malgorzata Kucinska

“…An ELISA-based protein panel was used to find the potential molecular targets, while flow cytometric, colorimetric, fluorescent, and luminescent assays were used to investigate the cell death mechanism. It was shown that compound <b>2a</b> exerted a more potent cytotoxic effect under hypoxic conditions, while compound <b>2a-B</b> demonstrated a comparable effect in normoxic and hypoxic conditions. …”
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The Effect of A2E on the Uptake and Release of Calcium in the Lysosomes and Mitochondria of Human RPE Cells Exposed to Blue Light by Mao-Mei Luo, Lin Chen, Shu Wang, Chun Zeng, De-Zhi Li, YeGe Bi, Long-Qian Liu, Shan-Jun Cai

“…We aimed to explore the effect of N-retinylidene-N-retinylethanolamine (A2E) on the uptake and release of calcium in lysosomes and mitochondria by establishing a model of human retinal pigment epithelial (RPE) cell injury induced by exposure to blue light. Primary human RPE cells were cultured from passages 4 to 6 and exposed to blue light at an intensity of 2000 ± 500 lux for 6 hours. …”
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Single-cell RNA sequencing and immune microenvironment analysis reveal PLOD2-driven malignant transformation in cervical cancer by Zhiheng Lin, Fengxin Wang, Renwu Yin, Shengnan Li, Yuquan Bai, Baofang Zhang, Chenlin Sui, Hengjie Cao, Dune Su, Lianwei Xu, Honghong Wang

“…Cervical cancer remains the primary cause of cancer-related death despite major improvements in screening and treatment approaches, especially in low- and middle-income nations. …”
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PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation by Yin-Li Zhang, Zhanhong Hu, Huifang Jiang, Jiamin Jin, Yan Zhou, Mengru Lai, Peipei Ren, Siya Liu, Ying-Yi Zhang, Yan Rong, Wei Zheng, Shen Zhang, Xiaomei Tong, Songying Zhang

“…Employing both wild-type and mutated PATL2V401F/R402W variants, we characterized the protein interactome of PATL2, identifying disruptions of PATL2V401F/R402W variants predominantly affecting cell cycle-related proteins, including CDC23, APC1 and MAD2L1. …”
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Dynamic Changes in Parameters of Complete Blood Count Predict Disease Severity and Prognosis in Patients with COVID-19; A Prospective Study by Toktam Alirezaei, Mahdi Baratnia, Rama Bozorgmehr, Yasamansadat Keshmiri, Faezeh Ebrahimpour, Maryam Arefnia, Mohammadali Ghodsirad

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Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway by Chen Feng, Wei Mao, Chenyang Yuan, Pin Dong, Yuying Liu

“…Cell Death and Disease…”
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Effects of Tp53 Gene Mutations on the Survival of Non-Small Cell Lung Cancer (NSCLC); A Short Review by Zhang C, Yang C, Shi Q

“…Chi Zhang,1,2,&ast; Chao Yang,3,&ast; Qingming Shi1,2 1Department of Oncology, Anhui Chest Hospital, Hefei, 230022, People’s Republic of China; 2Anhui Medical University Clinical College of Chest, Hefei, 230022, People’s Republic of China; 3Department of Urology, Anhui Provincial Children’s Hospital, Hefei, 230022, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qingming Shi, Email shqm0324@163.com, shqm0324@hotmail.comAbstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. …”
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Could serum Raftlin and GPER-1levels be new biomarkers for early detection of non-small cell lung cancer? by Aykut Eliçora, Berrak Güven, Hüseyin Engin, Gokcen Tugba Çevik, Hüseyin Fatih Sezer

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Cardiac regeneration: 20 years of development and update in zebrafish and mouse by Lekun Gui, Lijun Jin, Huangjun Liu

“…Cardiovascular diseases are one of the leading causes of death globally. The primary pathological mechanism in myocardial infarction and heart failure is irreversible cardiomyocyte loss. …”
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