Therapeutic potential of brentuximab vedotin in breast cancer and lymphoma via targeted apoptosis and gene regulation by Abeer Ezzat, Mohga Shafiek, Shimaa Shawki, Shaimaa Abdel-Ghany, Mahmoud Nazih, Hussein Sabit

“…Apoptosis detection confirmed Brentuximab-induced cell death, with significant increases in late apoptosis in cancer lines, especially by 72 h. …”
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RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5. by Julie J Loiselle, Justin G Roy, Leslie C Sutherland

“…Lung cancers are the leading cause of cancer-related deaths worldwide, with small cell lung cancer (SCLC) being the most aggressive type. …”
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On the mathematical modelling of tumor-induced angiogenesis by Luis L. Bonilla, Vincenzo Capasso, Mariano Alvaro, Manuel Carretero, Filippo Terragni

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Prognostic significance of lymph node ratio in esophageal squamous cell carcinoma: insights from the South Asian population by Sajida Qureshi, Waqas Ahmad Abbasi, Hira Abdul Jalil, Saba Mughal, Muhammad Saeed Quraishy

“…This study aims to assess the prognostic significance of LNR in esophageal squamous cell carcinoma (ESCC) patients undergoing concurrent neoadjuvant therapy followed by minimally invasive esophagectomy (MIE).MethodsThis retrospective study analyzed the clinical data of ESCC patients who underwent concurrent neoadjuvant therapy followed by MIE at Dr. …”
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Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis by Wei B, Wang S, Li S, Gu Q, Yue Q, Tang Z, Zhang J, Liu W

“…Cuproptosis is a newly recognized copper-induced cell death mechanism. Our study explored the novel role of cuproptosis-related genes (CRGs) in AS, focusing on immune cell infiltration and molecular clustering.Methods: By analyzing the peripheral blood gene expression datasets obtained from GSE73754, GSE25101, and GSE11886, we identified the expression patterns of cellular factors and immune infiltration cell related to cuproptosis. …”
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Arsenic inducible islet β-cell dysfunction and ferroptosis through m6A-YTHDF2-dependent CHAC1 enhancement by Tianming Qiu, Jingyuan Zhang, Jinwei Song, Chenbing Wu, Xiaofeng Yao, Ningning Wang, Guang Yang, Jie Bai, Li Lv, Xiance Sun

“…Ferroptosis, a regulated cell death pathway dependent on GPX4, has been implicated in arsenic-induced β-cell dysfunction. …”
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Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach by Xiongfa Ji, Xin Qian, Guowen Luo, Wenjie Yang, Wenhan Huang, Zehua Lei, Jiaqi Zhou, Guoqing Zhong, Jielong Zhou, Nan Liu, Limin Ma, Mei Li, Xiangmei Liu, Shuilin Wu, Yu Zhang

“…These nanoparticles induce tumor cell death selectively through hyperthermia and microwave dynamic effects upon targeted microwave irradiation. …”
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Pharmacological targeting of caspase-8/c-FLIPL heterodimer enhances complex II assembly and elimination of pancreatic cancer cells by Corinna König, Nikita V. Ivanisenko, Vladimir A. Ivanisenko, Dagmar Kulms, Inna N. Lavrik

“…Here, we show that FLIPinB enhances the cell death in pancreatic cancer cells induced by combinatorial treatment with DL, gemcitabine and Mcl-1 inhibitor S63845. …”
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Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2/M arrest and cellular senescence during hypoxic kidney injury by Kurt T. K. Giuliani, Purba Nag, Benjamin C. Adams, Xiangju Wang, Seokchan Hong, Anca Grivei, Rebecca L. Johnston, Nicola Waddell, Kenneth K. C. Ho, Yilin Tian, Muhammad Ali Khan, Chang Seong Kim, Monica S. Y. Ng, Glenda Gobe, Jacobus P. J. Ungerer, Josephine M. Forbes, Helen G. Healy, Andrew J. Kassianos

“…Cell Death and Disease…”
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Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma by Haihua Wang, Songqing Fan, Yuting Zhan, Yue Xu, Yao Du, Jiadi Luo, Hongjing Zang, Shuping Peng, Weiyuan Wang

“…Cell Death and Disease…”
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Comparative Evaluation of Tear Film and Corneal Surface in Chronic Smokers and Non Smokers: A Cross-sectional Study by Ruchi Dabas, Meena Kumari, Manisha Rathi, Monika Dahiya, Rajni Yadav, Sumit Sachdeva

“…Introduction: Tobacco smoking is the primary avoidable cause of mortality, resulting in the deaths of seven million people worldwide annually. …”
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Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk by Fahad M. Aldakheel, Hadeel Alnajran, Shatha A. Alduraywish, Ayesha Mateen, Mohammed S. Alqahtani, Rabbani Syed

“…Abstract Prostate cancer (PCa) remains a significant global health challenge, with approximately 1.6 million new cases and 366,000 deaths annually. Despite high survival rates for localized prostate cancer, recurrence poses a substantial risk due to inherent biological factors and residual disease. …”
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Lidocaine could promote the cuproptosis through up-regulating the long noncoding RNA DNMBP-AS1 in Hep-2 cells by Wei Liu, Yi Yu, Yi He, Meihong Lv

“…Abstract Background Lidocaine is a traditional local anesthetic, which has been reported to trigger apoptosis through the mitochondrial pathway, independent of death receptor signaling. Cuproptosis is a copper triggered mitochondrial cell death mode. …”
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Exploring Amanita muscaria (L.) Lam.: Cytotoxic, proapoptotic and antiferroptotic effect of acetone extract on JAR choriocarcinoma cell line by Milojević Sara D., Nikodijević Danijela D., Milutinović Milena G., Kosanić Marijana M., Petrović Nevena N., Jovanović-Krivokuća Milica G., Nacka-Aleksić Mirjana M.

“…The pharmaceutical industry has long focused on nature-derived biologically active compounds to address challenges in cancer treatment, particularly overcoming cancer cell resistance to programmed cell death, including apoptosis and ferroptosis. …”
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PD-L1 Expression and CD8+ T Cell Infiltration Predict a Favorable Prognosis in Advanced Gastric Cancer by Yangyang Wang, Chunchao Zhu, Wei Song, Jun Li, Gang Zhao, Hui Cao

“…Advanced gastric cancer (AGC) has high morbidity and mortality in East Asia, and it is urgent to explore new treatments to improve patient prognosis. Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have exhibited remarkable activity in clinical trials and were approved by the FDA for clinical therapy in several types of tumors. …”
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Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect by Chunying Cui, Yuji Wang, Yaonan Wang, Ming Zhao, Shiqi Peng

“…Alsterpaullone, a small molecule cyclin-dependent kinase (CDK) inhibitor, regulates the cell cycle progression. Beyond death-inducing properties, we identified the effect of alsterpaullone on cycle procedure and apoptosis of HeLa cell. …”
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Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7) by P. Suganya Devi, M. Saravana Kumar, S. Mohan Das

“…Breast cancer is a leading cause of death in women worldwide both in the developed and developing countries. …”
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The efficacy of neoadjuvant immunotherapy and lymphocyte subset predictors in locally advanced esophageal squamous cell carcinoma: A retrospective study by Ruotong Wang, Shaodi Wen, Xiaoyue Du, Jingwei Xia, Bowen Hu, Yihan Zhang, Guoren Zhou, Feng Jiang, Xiaomin Lu, Miaolin Zhu, Xinyu Xu, Bo Shen

“…Abstract Background Despite the recognized therapeutic potential of programmed cell death protein 1/programmed death‐ligand 1 (PD‐1/PD‐L1) inhibitors in advanced esophageal squamous cell carcinoma (ESCC), their role in neoadjuvant therapy and reliable efficacy biomarkers remain elusive. …”
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Evaluation of Vaso-occlusive Crises in United States Sickle Cell Disease Patients: A Retrospective Claims-based Study by Nirmish Shah, Menaka Bhor, Lin Xie, Steve Arcona, Rashid Halloway, Jincy Paulose, Huseyin Yuce

“…Sickle cell disease (SCD) is a life-threatening vascular disease that burdens affected persons physically. …”
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Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors. by Shirley D Wenker, María Isabel Farias, Victoria Gradaschi, Corina Garcia, Juan Beauquis, María Celeste Leal, Carina Ferrari, Xianmin Zeng, Fernando J Pitossi

“…In vitro, conditioned media from activated BV2 microglial cells increased cell death, decreased Tyrosine hydroxylase-positive cells and induced morphological alterations on human neural stem cells-derived dopaminergic precursors at two differentiation stages: 19 days and 28 days. …”
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