Prosaposin – A plausible biomarker in head and neck squamous cell carcinoma by Avradeep Datta, Rajandeep Kaur, Anshika Chauhan, Geeta Singh Boora, Himanshu Garg, Debajyoti Chatterjee, Jaimanti Bakshi, Sushmita Ghoshal, Arnab Pal

“…However, cell death remained unchanged with the downregulation of PSAP. …”
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Mechanisms of Cytotoxicity of Chemical Agents to Giant Cell Tumors: An In Vitro Study by Achmad Fauzi Kamal, Akbar Rizki Beni Asdi, Ahmad Jabir Rahyussalim, Rio Wikanjaya, Resda Akhra Syahrani, Tri Kurniawati, Septelia Inawati Wanandi

“…Flow cytometry using Annexin V showed cell death due to necrosis, with the highest concentration amounting to 0.3%. …”
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Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix by Liju Zong, Qianqian Zhang, Yuncan Zhou, Yujia Kong, Shuangni Yu, Jie Chen, Youzhong Zhang, Yang Xiang

“…The purpose of this study was to investigate the expression levels of the immune checkpoint proteins, programmed cell death-ligand 1 (PD-L1), B7-H3, B7-H4, and V-domain Ig suppressor of T cell activation (VISTA), as well as the significance thereof, in clear cell carcinoma (CCC) of the cervix (a rare histological subtype of cervical cancer). …”
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ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition by Si-qi Zhao, Min-jie Chen, Fei Chen, Zhao-feng Gao, Xiao-ping Li, Ling-yu Hu, Hai-ying Cheng, Jin-yan Xuan, Jian-guo Fei, Zheng-wei Song

“…In vitro assays demonstrated that ENTPD8 inhibits HCC cell proliferation, invasion, and migration. Mechanistically, ENTPD8 regulates programmed death-ligand 1 (PD-L1) expression through miR-214-5p modulation. …”
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Relationship between iron deficiency and severity of tuberculosis: Influence on T cell subsets by Zheyue Wang, Zhenpeng Guo, Qiang Zhang, Chenchen Yang, Xinling Shi, Qin Wen, Yuan Xue, Zhixin Zhang, Jianming Wang

“…Summary: Tuberculosis (TB) remains a leading cause of death globally, with nearly half of TB patients experiencing iron deficiency. …”
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Immunosuppression and Outcomes in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck by Doriana Iancu, Ana Fulga, Doina Vesa, Iuliu Fulga, Dana Tutunaru, Andrei Zenovia, Alin Ionut Piraianu, Elena Stamate, Corina Sterian, Florentin Dimofte, Mihail Alexandru Badea, Alin Laurentiu Tatu

“…Although most cSCCs can be treated surgically, some recur and metastasize, resulting in death. The role of immune status is not yet determined in the prognosis of these patients. …”
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Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway by Sun Kening, Chen Ping, Zhang Liang, Lu Zhidong, Jin Qunhua

“…In conclusion, deguelin treatment, when applied in vitro, induced apoptotic cell death and resulted in mitotic cessation at the G2/M phase through modulation of cell cycle regulatory mRNAs in multiple myeloma cells.…”
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Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade... by Lucie Heinzerling, Michael Fluck, Caroline Robert, Celeste Lebbe, Erika Richtig, Sven D Koch, Ulrike Gnad-Vogt, Tobias Seibel, Thomas Eigentler, Juan Martin-Liberal, Sebastian Ochsenreither, Peter Mohr, Patrick Terheyden, Carsten Weishaupt, Michael Erdmann, Lukas Koch, Ainara Soria, Igor Samoylenko, Jürgen Krauß, Peter Brossart, Franz Georg Bauernfeind, Marina Gonzalez, Peter Wengenmayer, Ioannis Thomas, Artem Poltoratskiy, Marina Sekacheva, Beate Schmitt-Bormann, Gianluca Quintini, Martin Falk, Paula Codó, Arjun Oberoi, Jana Hess, Yulia Semiletova, Casilda Llacer Perez, Oliver Schönborn-Kellenberger

“…We investigated intratumoral (IT) administration of CV8102 in patients with anti-programmed cell death protein-1 (PD-1) therapy-naïve or anti-PD-1 therapy-refractory cutaneous melanoma (cMEL) and in patients with advanced cutaneous squamous cell carcinoma, head and neck squamous cell carcinoma and adenoid cystic carcinoma.Methods This open-label, cohort-based, phase I dose escalation study aimed to establish the maximum tolerated dose (MTD), recommended dose (RD), safety and preliminary efficacy of CV8102 as monotherapy or in combination with a PD-1 inhibitor. …”
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Myotubularin-Related Phosphatase 3 Promotes Growth of Colorectal Cancer Cells by Bo’an Zheng, Xiaojun Yu, Rui Chai

“…Knockdown of MTMR3 resulted in a significant reduction in cell proliferation in both HCT116 and SW1116 cells. …”
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Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics by Xinying Zhang, Jiajie Xie, Zixin Yang, Carisa Kwok Wai Yu, Yaohua Hu, Jing Qin

“…By integrating multiple bioinformatics analyses, we explored the biological differences underlying tumour cell heterogeneity at the single-cell level and identified tumour cell subcluster-specific biomarkers and potential therapeutic drugs for each subcluster. …”
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Refractory myasthenia gravis treated with autologous hematopoietic stem cell transplantation by Benjamin Beland, Jan Storek, Liam Quartermain, Christopher Hahn, C. Elizabeth Pringle, Pierre R. Bourque, Michael Kennah, Natasha Kekre, Christopher Bredeson, David Allan, Kareem Jamani, Christopher White, Harold Atkins

“…The grafts were depleted of immune cells by selecting CD34+ cells. HSCT conditioning consisted of high‐dose cytoreductive therapy and anti‐thymocyte globulin. …”
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Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease by Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu

“…The ALB+KRT7+ epithelial cells were demonstrated to have stem cell properties and malignant transformation potentials. …”
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The impact of PD-L1 polymorphisms on the efficacy of immune checkpoint inhibitors depends on the tumor proportion score: a retrospective study by Keiichiro Suminaga, Takashi Nomizo, Hironori Yoshida, Hiroaki Ozasa

“…Abstract Purpose This study aims to clarify the relationship between rs2282055, a single-nucleotide polymorphism (SNP) in programmed death-ligand 1 (PD-L1), and TPS. Polcaro et al. (2024) showed that rs822336, a SNP in PD-L1, predicts the effect of immune checkpoint inhibitors (ICIs). …”
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Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6 by Johannes Woelk, Florian Hornsteiner, Stephanie Aschauer-Wallner, Patrizia Stoitzner, Gottfried Baier, Natascha Hermann-Kleiter

“…Cell Death and Disease…”
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Dasatinib enhances curcumin-induced cytotoxicity, apoptosis and protective autophagy in human schwannoma cells HEI-193: The role of Akt/mTOR/p70S6K signalling pathway by Pang Pengfei, Zhang Shirong

“…Cellular toxicity, cell proliferation, and cell death were determined by LDH, MTT, and trypan blue dye assays, respectively. …”
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A division-dependent compartmental model for computing cell numbers in CFSE-based lymphocyte proliferation assays by H. Thomas Banks, W. Clayton Thompson, Cristina Peligero, Sandra Giest, Jordi Argilaguet, Andreas Meyerhans

“…Some key features of a mathematical description of an immune response are an estimate of the number of responding cells and the manner in which those cells divide, differentiate, and die. …”
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Trying to Kill a Killer; Impressive Killing of Patient Derived Glioblastoma Cultures Using NK-92 Natural Killer Cells Reveals Both Sensitive and Highly Resistant Glioblastoma Cells by Jane Yu, Hyeon Joo Kim, Jordyn Reinecke, James Hucklesby, Tennille Read, Akshata Anchan, Catherine E. Angel, Euan Scott Graham

“…ECIS has been powerful in revealing that at higher ET ratios, the glioblastoma cells are acutely sensitive to the NK-92 cells, and the observed glioblastoma cell death is supported by the high-content imaging data. …”
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PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD) by Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Laura Scalambra, Maria Sofia Semprini, Olga Maria Pittino, Chiara Cappello, Irene Siracusa, Ilaria Candida Chillico, Martina Di Noia, Cristian Turato, Silvia De Siervi, Francesco Lescai, Teresa Ciavattini, Giulia Lopatriello, Luca Bertoli, Hugo De Jonge, Luisa Iamele, Annalisa Altimari, Elisa Gruppioni, Andrea Ardizzoni, Marzia Rossato, Francesco Gelsomino, Pier-Luigi Lollini, Arianna Palladini

“…Abstract Background Non-Small Cell Lung Cancer (NSCLC) is the leading cause of cancer death worldwide. …”
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Non–Small-Cell Lung Cancer. Unusual Small Bowel Metastasis with Invagination by Miguel Ángel Serra Valdés, Briggette Fernández González, Mariana Medell Gago

“…Malignant tumors, in Cuba, are the second leading cause of death after heart disease. Lung cancer is the leading cause of death worldwide in malignant tumors, predominantly in men. …”
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Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects by Sang Eon Park, Hyeong Seop Kim, Soo Jin Kwon, Min-Jeong Kim, Suk-joo Choi, Soo-young Oh, Gyu Ha Ryu, Hong Bae Jeon, Duk L. Na, Jong Wook Chang

“…We focused on the role of primed MSCs (human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) exposed to an AD cell line via a coculture system) in reducing the levels of Aβ and inhibiting cell death. …”
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