Advanced Applications of Fuel Cells during the COVID-19 Pandemic by Shammya Afroze, Md Sumon Reza, Quentin Cheok, Shafi Noor Islam, Abdalla M. Abdalla, Juntakan Taweekun, Abul K. Azad, Nima Khalilpoor, Alibek Issakhov

“…These makeshift hospitals need an uninterrupted power supply to continuously maintain all the electrical facilities. Fuel cells, especially solid oxide fuel cells, play an essential role in meeting the additional energy needs of humankind during this critical moment. …”
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Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

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Extracellular cold-inducible RNA-binding protein in CNS injury: molecular insights and therapeutic approaches by Dmitriy Lapin, Archna Sharma, Ping Wang

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Secretion of One Adipokine Nampt/Visfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells by Yi-Ching Lin, Hui-Chung Wu, Chen-Chung Liao, Yi-Chih Chou, Shwu-Fen Pan, Chi-Ming Chiu

“…We found that the transition of Nampt/visfatin from intracellular into extracellular form was induced by H2O2 treatment in 293T cells and confirmed that this phenomenon was not due to cell death but through the secretion of Nampt/visfatin. …”
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Inhibition of the anti-apoptotic protein BCL2 in EML4-ALK cell models as a second proposed therapeutic target for non-small cell lung cancer. by Richard Junior Zapata Dongo, Diletta Fontana, Luca Mologni, Juan Enrique Faya Castillo, Stefany Fiorella Infante Varillas

“…On the other hand, overexpression of BCL2, a protein involved in cell death regulation, has been observed in NSCLC and is considered a potential therapeutic target. …”
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PSMA2 promotes chemo- and radioresistance of oral squamous cell carcinoma by modulating mitophagy pathway by Chun-I Wang, Cheng-Yi Chen, Ting-Wen Chen, Chun-Chia Cheng, Shu-Wen Hong, Tsung-You Tsai, Kai-Ping Chang

“…Cell Death Discovery…”
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Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

“…We have applied RNA sequencing, flow cytometry, ELISA, cellular/molecular immunological technology, and mouse models of solid cancers.Results Our study provided evidence that S1PR3 high expression is positively associated with resistance to programmed cell death protein-1 (PD-1)-based immunotherapy and increased T-cell exhaustion. …”
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Expression of LGI1 Impairs Proliferation and Survival of HeLa Cells by Nadia Gabellini, Valentina Masola

“…HeLa cell clones stably expressing LGI1 exhibited a significant impairment of proliferation and a consistent increase of cell death when compared with control cells lacking expression of LGI1. …”
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Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis by Despina Giakomidi, Despina Giakomidi, Ayoola Ishola, Meritxell Nus, Meritxell Nus

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Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial CellsSummary by Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Wael El-Rifai, Zhibin Chen, Jianwen Que, Timothy C. Wang, Olivier G. Boutaud, Karoline Briegel, Sergey I. Dikalov, Monica T. Garcia-Buitrago, Alexander I. Zaika

“…Dysregulation of proteostasis induces ferroptotic cell death and is mediated by modification of cellular proteins with reactive isoLGs that can be prevented by isoLG scavengers. …”
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Prognostic Value of Endothelial Progenitor Cells in Acute Myocardial Infarction Patients by Gongjie Ye, Xiaodan Chen, Yinchao Zhou, Jianqing Zhou, Yongfei Song, Xiaoyong Yang, Lei Yang

“…The counts of EPCs were found to be significantly higher in the survival group compared to the death group (P<0.05). In the univariate analysis, it was observed that the 28-days mortality rate was associated with the several factors, including the APACHEⅡscore (P=0.00), vasoactive inotropic score (P=0.03), GAP (P=0.00), HCY (P=0.00), creatinine (P=0.00), C-reactive protein (P=0.00), HbAlc (P=0.00), CI (P=0.01), quartiles of CD34+/CD133+ cells (P=0.00), and quartiles of CD34+/CD133+/KDR+ cells (P=0.00). …”
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Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity by Seyed Jalal Hosseinimehr, Seyed Amir Hossein Hosseini

“…Findings of this study show that resveratrol enhanced the cell death induced by 131I on thyroid cancer cell. …”
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The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment by Manuel Varas-Godoy, Gregory Rice, Sebastián E. Illanes

“…These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. …”
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The deregulated physiology in oral squamous cell carcinoma- a brief review by Keerthika Saravanan, Madhu Narayan, Krishnan Rajkumar

“…In cancer biology, hallmarks of cancer represent the normal physiology gone astray such as sustaining proliferative signaling, evading growth suppressors, avoiding immune destruction, activating invasion and metastasis, tumor promoting inflammation, enabling replicative immortality, inducing angiogenesis and resisting cell death that thus serve as blueprints for understanding core cancer characteristics. …”
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Contribution of long-lived plasma cells to antibody-mediated allograft rejection by Eunkyeong Jang, Jeehee Youn

“…However, accumulating evidence indicates that LLPCs, unlike conventional short-lived plasma cells, can respond to extrinsic signals from their survival niches and can resist cell death associated with intracellular stress through cell-intrinsic mechanisms. …”
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Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells by Yu Zhang, Dilaware Khan, Julia Delling, Edda Tobiasch

“…Human mesenchymal stem cells (hMSCs) are considered a promising cell source for regenerative medicine, because they have the potential to differentiate into a variety of lineages among which the mesoderm-derived lineages such adipo- or osteogenesis are investigated best. …”
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Adenocarcinoma with Neuroendocrine Differentiation of the Colon Accompanying Osteoclast-Like Giant Cells by Mitsuhiro Tachibana, Tadahiro Isono, Yutaka Tsutsumi

“…CD8/granzyme B-positive tumor-infiltrating lymphocytes and CD163/CD68-positive macrophages, frequently forming OGCs, were observed particularly at the invasion front. The carcinoma cells were labeled focally for synaptophysin and diffusely for the DR locus of the human leukocyte antigen and programmed death-ligand 1 (PD-L1). …”
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Combination Effects of Docetaxel and Doxorubicin in Hormone-Refractory Prostate Cancer Cells by Eleftheria Tsakalozou, Allison M. Eckman, Younsoo Bae

“…Equipotent drug combination treatments (7×7) revealed that the DOC/DOX combination leads to high synergy and effective cell death only in a narrow concentration range in DU145. …”
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Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition by Aimin Yang, Xia Xiao, Mingfeng Zhao, Amanda C. LaRue, Bradley A. Schulte, Gavin Y. Wang

“…Although bone marrow (BM) suppression is one of the primary side effects of anticancer drugs, it is not known if pharmacological inhibition of dual mTORC1/2 affects BM hematopoietic stem and progenitor cells (HSPCs) function and plasticity. Here we report that dual inhibition of mTORC1/2 by AZD or its analogue (KU-63794) depletes mouse BM Lin−Sca-1+c-Kit+ cells in cultures via the induction of apoptotic cell death. …”
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Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells by Hidehito Saito, Keisuke Okita, Noemi Fusaki, Michael S. Sabel, Alfred E. Chang, Fumito Ito

“…Tumor-infiltrating lymphocytes (TILs) that express programmed cell death protein-1 (PD-1) are tumor-reactive T cells, and adoptive cell therapy with autologous TILs has been found to achieve durable complete response in selected patients with metastatic melanoma. …”
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