Antioxidant Effect of Beer Polyphenols and Their Bioavailability in Dental-Derived Stem Cells (D-dSCs) and Human Intestinal Epithelial Lines (Caco-2) Cells by Marina Di Domenico, Antonia Feola, Pasqualina Ambrosio, Federica Pinto, Giovanni Galasso, Armando Zarrelli, Giovanni Di Fabio, Marina Porcelli, Salvatore Scacco, Francesco Inchingolo, Lucio Quagliuolo, Andrea Ballini, Mariarosaria Boccellino

“…In the presence of an intense stressing event, cells activate specific responses to counteract cell death or senescence which is known to act as a key-task in the onset of age-related pathologies and in the loss of tissue homeostasis. …”
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Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya

“…Our research group previously reported the combination of gemcitabine and cytotoxic T lymphocytes to be more effective than single-agent treatment for the elimination of CCA cells. However, gemcitabine treatment of CCA cells upregulates the expression of an immune checkpoint protein (programmed death-ligand 1 [PD-L1]) that consequently inhibits the cytotoxicity of T lymphocytes. …”
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Comparison of autologous hematopoietic cell transplantation, matched sibling donor hematopoietic cell transplantation, and chemotherapy in patients with favorable- and intermediate... by Mingyang Wang, Shulian Chen, Qiuqiu Zhang, Linyu Yuan, Xue Wang, Junshi Zhang, Xiaoyu Zhang, Yigeng Cao, Dongmei Li, Xinxiao Lu, Meijiao Wang, Xiaosi Jiang, Rongli Zhang, Xin Chen, Qiaoling Ma, Jialin Wei, Donglin Yang, Yi He, Aiming Pang, Sizhou Feng, Mingzhe Han, Weihua Zhai, Xingli Zhao, Erlie Jiang

“…IntroductionHematopoietic stem cell transplantation (HSCT) and chemotherapy are considered potentially curative options for post-remission therapy in acute myeloid leukemia (AML). …”
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Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles by Giada Santin, Luigi Scietti, Paola Veneroni, Sergio Barni, Graziella Bernocchi, Maria Grazia Bottone

“…The results obtained show that the cellular organelles are the target of cisPt, so their damage can induce cell death.…”
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An improved model of t cell development in the thymus and its stability analysis by Hongjing Shi, Wanbiao Ma

“…Based on some important experimental dates, in this paper weshall introduce time delays into Mehrs's non-linear differential system modelwhich is used to describe proliferation, differentiation and death of T cells inthe thymus (see, for example, [3], [6], [7] and [9]) and give a revised nonlineardifferential system model with time delays. …”
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Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation

“…Analysis of its mode of action showed that IL-18 induced cell cycle arrest in the S phase; however, it did not trigger apoptotic cell death. …”
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Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation by Athip Nilkaeo, Suthinee Bhuvanath

“…Analysis of its mode of action showed that IL-18 induced cell cycle arrest in the S phase; however, it did not trigger apoptotic cell death. …”
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The theory of oxidative stress as a direct cause of cell aging by Milagros Lisset León Regal, Raúl Cedeño Morales, Rodolfo Javier Rivero Morey, Jeisy Rivero Morey, Diana Laura García Pérez, Leissay Bordón González

“…The loss of functional capacities, aging and death are inherent to all living matter due to metabolism and other factors causing the formation of substances which damage irreversibly cell structure components. …”
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Modeling the interaction of cytotoxic T lymphocytes and influenzavirus infected epithelial cells by Abdessamad Tridane, Yang Kuang

“…Since detailed and definite mechanisms thattrigger CTL production and cell death are still debatable, we utilize two plausiblemathematical models for the CTLs response to influenza infection (i) logisticgrowth and (ii) threshold growth. …”
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A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia by Bhawna Sethi, K. S. Butola, Yogesh Kumar

“…Waldenström's macroglobulinemia is a B-cell neoplasm characterized by infiltration of the bone marrow by a lymphoplasmacytic infiltrate and an IgM monoclonal gammopathy. …”
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Synergistic effect of blocking cancer cell invasionrevealed by computer simulations by Kazuhisa Ichikawa

“…Invasion and metastasis are the main cause of death in cancer patients. The initial step of invasion is the degradation of extracellular matrix (ECM) by primary cancer cells in a tissue. …”
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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…This resulted in apoptosis, pyroptosis, and immunogenic cell death in tumor cells by Clo. Furthermore, Clo-induced GSDME-mediated pyroptosis partly assists in activating T cell immunity via CCL5 and CXCL10. …”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

“…Sequencing data and pathway analysis suggested that dinaciclib is a potent cell death inducer in MB cells. We found that dinaciclib-triggered apoptosis is triggered by CDK9 inhibition and the resultant reduction in RNA pol II phosphorylation, which leads to the downregulation of the oncogenic marker MYC, and the anti-apoptotic protein MCL-1. …”
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Klinefelter syndrome diagnosed at autopsy and small-cell lung carcinoma by Haruyasu Sakuranaka, Ryoma Tanaka, Yuji Yamakawa, Shiho Yamada, Komei Igei, Yasuo Asai

“…He was diagnosed with small-cell lung carcinoma. Chemotherapy was administered, but the disease progressed, eventually leading to death. …”
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Effects of Muse Cell on a Mouse Model With Acute Encephalopathy by Tatsuya Kawaguchi, Tetsuji Mori, Kaori Adachi, Jun Fujii, Yoshihiro Maegaki, Fumiko Obata

“…Conclusion These effects could be a result of the direct and/or indirect upregulation of IL‐10, an anti‐inflammatory cytokine, in the Muse cell–treated brain. Although non‐Muse cells, a residual cell population in the bone marrow after isolating Muse cells, also improved some symptoms, their effects were weaker than those of Muse cells. …”
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The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells by Sabrina Bimonte, Maddalena Leongito, Antonio Barbieri, Vitale del Vecchio, Michela Falco, Aldo Giudice, Raffaele Palaia, Vittorio Albino, Raimondo Di Giacomo, Antonella Petrillo, Vincenza Granata, Francesco Izzo

“…Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide malignancy and the third leading cause of cancer death in patients. Several studies demonstrated that hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, tumor progression, metastasis development, and drug resistance. …”
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Pregnancy Outcomes among Patients with Sickle Cell Disease in Brazzaville by F. O. Galiba Atipo Tsiba, C. Itoua, C. Ehourossika, N. Y. Ngakegni, G. Buambo, N. S. B. Potokoue Mpia, A. Elira Dokekias

“…Introduction. Sickle cell disease (SCD) is one of the most common genetic diseases in the world. …”
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Effect of Hematopoietic Stem Cell Transplantation Regimen on Tacrolimus Pharmacokinetics by Haruno Oku, BS, Saki Yoshida, BS, Takumi Hotta, BS, Hirohito Muroi, BS, Keizo Fukushima, PhD, Kei Irie, PhD, Tatsuya Hirano, BS, Yoshimitsu Shimomura, MD, Takayuki Ishikawa, MD, PhD, Hiroaki Ikesue, PhD, Nobuyuki Muroi, PhD, Tohru Hashida, PhD, Nobuyuki Sugioka, PhD

“…ABSTRACT: Objectives: Treatment with tacrolimus requires strict control of the whole-blood concentration in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). In patients undergoing cord blood transplantation (CBT), there is a negative correlation between volume of distribution of tacrolimus and hemoglobin levels, which reflect the red blood cell (RBC) count. …”
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Advancing risk stratification in kidney transplantation: integrating HLA-derived T-cell epitope and B-cell epitope matching algorithms for enhanced predictive accuracy of HLA compa... by Matthias Niemann, Matthias Niemann, Benedict M. Matern, Benedict M. Matern, Gaurav Gupta, Bekir Tanriover, Fabian Halleck, Klemens Budde, Eric Spierings, Eric Spierings

“…IntroductionThe immune-mediated rejection of transplanted organs is a complex interplay between T cells and B cells, where the recognition of HLA-derived epitopes plays a crucial role. …”
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Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer by Hany E. Marei, Khaled Bedair, Anwarul Hasan, Layla Al-Mansoori, Sara Caratelli, Giuseppe Sconocchia, Alice Gaiba, Carlo Cenciarelli

“…The T cell-based immunotherapy known as chimeric antigen receptor (CAR) T cell treatment, which uses the patient’s immune cells to fight cancer, has demonstrated remarkable efficacy in treating hematologic malignancies; nevertheless, the treatment effects in solid tumors, like breast cancer, have not lived up to expectations. …”
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