Myocardial Restoration: Is It the Cell or the Architecture or Both? by Duc Thang Vu, Theo Kofidis

“…Myocardial infarction is the leading cause of death in developed countries. Cardiac cell therapy has been introduced to clinical trials for more than ten years but its results are still controversial. …”
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A model for asymmetrical cell division by Ali Ashher Zaidi, Bruce Van Brunt, Graeme Charles Wake

“…We present a model that describes the growth, division and death of a cell population structured by size. The model is an extension of that studied by Hall and Wake (1989) and incorporates the asymmetric division of cells. …”
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Feedback regulation in multistage cell lineages by Wing-Cheong Lo, Ching-Shan Chou, Kimberly K. Gokoffski, Frederic Y.-M. Wan, Arthur D. Lander, Anne L. Calof, Qing Nie

“…Here we report on the existence and uniquenessof steady states in this system, as well as local and global stability of these steady states.In particular, we identify parameter conditions for the stability of the system when negativefeedback loops are represented either as Hill functions, or in more general terms.Our results suggest that two factors -- autoregulation of the proliferation oftransit amplifying (TA) progenitor cells, and a low death rate of TD cells -- enhance the stability of this system.…”
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The Role of Glucose, Serum, and Three-Dimensional Cell Culture on the Metabolism of Bone Marrow-Derived Mesenchymal Stem Cells by Byron Deorosan, Eric A. Nauman

“…The results indicate that glucose and extracellular matrix were significant factors in the metabolic response of the cells. However, cells cultured in low density collagen exhibited considerable cell death, likely because of physical contraction of the collagen hydrogel which was not observed in the higher density collagen. …”
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Genomics Analysis of Metabolic Pathways of Human Stem Cell-Derived Microglia-Like Cells and the Integrated Cortical Spheroids by Julie Bejoy, Xuegang Yuan, Liqing Song, Thien Hua, Richard Jeske, Sébastien Sart, Qing-Xiang Amy Sang, Yan Li

“…The expression of genes related to glycolysis and hypoxia signaling was increased in cocultured D-MG spheroids, indicating the metabolic shift to aerobic glycolysis, which is in favor of M1 polarization of microglia-like cells. In addition, the metabolic pathways and the signaling pathways involved in cell proliferation, cell death, PIK3/AKT/mTOR signaling, eukaryotic initiation factor 2 pathway, and Wnt and Notch pathways were analyzed. …”
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SNX30 inhibits lung adenocarcinoma cell proliferation and induces cell ferroptosis through regulating SETDB1 by Xinjie Fan, Qichu Zhu, Chengzhuo Du, Jinlai Chen, Yingming Su

“…Ferroptosis is an iron-dependent regulatory cell death pathway that is crucial for tumor growth. …”
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Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space by Maria Moreno-Villanueva, Maria Moreno-Villanueva, Luis E. Jimenez-Chavez, Luis E. Jimenez-Chavez, Stephanie Krieger, Liang-Hao Ding, Ye Zhang, Adriana Babiak-Vazquez, Mark Berres, Sandra Splinter, Kristen E. Pauken, Brian C. Schaefer, Brian E. Crucian, Honglu Wu

“…The dysregulated genes and pathways were mostly involved in energy and oxygen metabolism, immune responses, cell adhesion/migration and cell death/survival.DiscussionBased on the DEG and the associated pathways and functions, we propose that mitochondria dysfunction was caused by constant modulation of mechano-sensing receptors in microgravity, which triggered a signaling cascade that led to calcium overloading in mitochondria. …”
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T Cells in Gastric Cancer: Friends or Foes by Amedeo Amedei, Chiara Della Bella, Elena Silvestri, Domenico Prisco, Mario M. D'Elios

“…As for any type of cancer, T cells are crucial for recognition and elimination of gastric tumor cells. …”
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Advances in Cell and Immune Therapies for Melanoma by Tanase Timis, Sanda Buruiana, Delia Dima, Madalina Nistor, Ximena Maria Muresan, Diana Cenariu, Adrian-Bogdan Tigu, Ciprian Tomuleasa

“…Emerging approaches, including adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) and oncolytic virotherapy, are showing promise. …”
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Relevance of the GH-VEGFB/VEGFA axis in liver grafts from brain-dead donors with alcohol-associated liver disease by Marc Micó-Carnero, Marc Micó-Carnero, Carlos Rojano-Alfonso, Carlos Rojano-Alfonso, Cristina Maroto-Serrat, Cristina Maroto-Serrat, Juan Carlos Cutrin, Araní Casillas-Ramírez, Araní Casillas-Ramírez, Carmen Peralta

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Translocator Protein (18 kDa) Mapping with [I]-CLINDE in the Quinolinic Acid Rat Model of Excitotoxicity: A Longitudinal Comparison with Microglial Activation, Astrogliosis, and Ne... by Nicolas Arlicot, Claire Tronel, Sylvie Bodard, Lucette Garreau, Brice de la Crompe, Inge Vandevelde, Denis Guilloteau, Daniel Antier, Sylvie Chalon

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Effects of Adipose-tissue Derived Mesenchymal Stem Cells on PBMCs in Co-culture with HeLa Cell Line by Maryam Dorfaki, mahdi ghatrehsamani, fahimeh Lavi Arab, Mona Roozbehani, Majid Khoshmirsafa, Reza Falak, Fatemeh Keshavarz, Fatemeh Faraji

“…Objective: Cervical cancer, the most common reproductive system cancer being women, is the fourth leading cause of cancer-related deaths. The use of mesenchymal stem cells (MSCs) for treating various diseases is being studied, but their use in cervical cancer has not been well explored. …”
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Curcumin Protects Human Umbilical Vein Endothelial Cells against H2O2-Induced Cell Injury by Jipeng Ouyang, Rong Li, Haiqin Shi, Jianping Zhong

“…As a conclusion, curcumin could mitigate H2O2-induced oxidative stress and cell death in HUVECs and may be a potential therapeutic drug for migraine.…”
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Synergism of d-limonene and temozolomide on migratory and apoptotic behaviors of human glioblastoma cell lines by Megha Gautam, Reema Gabrani

“…Furthermore, the influence of this combination on cell cycle progression, cell migration, and cell death was also investigated. …”
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Exploring molecular disparities of H-type vasculature endothelial cells in osteonecrosis of the femoral head through single-cell analysis by Wei Shi, Dong Li, Qian Xu, Kai Zhang, Xinyu Liang, Hui Li, Zhijun Li, Huafeng Zhang

“…This study, based on single-cell RNA sequencing (scRNA-seq), aims to explore the changes in H-type vasculature endothelial cells (H_ECs) in osteonecrosis of the femoral head (ONFH) and hip osteoarthritis (HOA), focusing on the death modes such as ferroptosis, pyroptosis, and parthanatos. …”
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Increasing Donor Endothelial Cell Pool by Culturing Cells from Discarded Pieces of Human Donor Corneas for Regenerative Treatments by Mohit Parekh, Vito Romano, Alessandro Ruzza, Stephen B. Kaye, Diego Ponzin, Sajjad Ahmad, Stefano Ferrari

“…To investigate if the peripheral corneal endothelium that is usually discarded after a corneal transplant could be used for endothelial cell culture. Methods. Donor corneas (n = 19) with a mean age of 72 years, male : female ratio of 15 : 4, and death-to-preservation time of 10 hours were assessed for endothelial cell density (ECD) and number of dead cells before isolation. …”
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Infiltration of CD8+ cytotoxic T-cells and expression of PD-1 and PD-L1 in ovarian clear cell carcinoma by Mengdi Fu, Huimei Zhou, Jiaxin Yang, Dongyan Cao, Zhen Yuan

“…Assessing the expression of programmed cell death ligand 1 (PD-L1), PD-1, and CD8+T cell infiltration in OCCC is crucial, as their correlation with patient survival may provide valuable prognostic insights. …”
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Molecular and immune landscape of tumours in geriatric patients with non-small cell lung cancer, melanoma and renal cell carcinoma by Abdul Rafeh Naqash, April K Salama, Emil Lou, Andrew Elliott, Wafik S El-Deiry, Chul Kim, Stephen V Liu, Anwaar Saeed, Hirva Mamdani, Khalil Choucair, Dipesh Uprety, Phillip Walker, Himisha Beltran, Matthew James Oberley, Azhar Saeed, Lujia Chen

“…This study aimed to explore potential biomarkers of response to ICI in patients ≥80 years.Methods and analysis We analysed tumour samples (n=24 123) from patients ≥80 (versus<80) with non-small cell lung cancer (NSCLC), melanoma (MEL), and renal cell cancer (RCC). …”
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Hair Cell Protection from Ototoxic Drugs by Peng Wu, Xianmin Wu, Chunhong Zhang, Xiaoyun Chen, Yideng Huang, He Li

“…Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. …”
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Effects of IL-6 and TNF-α Cytokines on Cell Proliferation in Androgen Dependent/Independent Prostate Cancer Cell Lines by Serhad Onat, Feray Köçkar, Sümeyye Aydoğan Türkoğlu

“…Prostate cancer, caused by abnormal and uncontrolled growth of the cells that make up the prostate tissue, is second only to related deaths in men. …”
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