Decompensation of β-Cells in Diabetes: When Pancreatic β-Cells Are on ICE(R) by Roberto Salvi, Amar Abderrahmani

“…Inappropriate induction of ICER accounts for pancreatic β-cells dysfunction and ultimately death elicited by chronic hyperglycemia, fatty acids, and oxidized LDL. …”
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The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells by Yun Zhao, Shanel Dhani, Vladimir Gogvadze, Boris Zhivotovsky

“…Cell Death Discovery…”
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Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma by Yue Dai, Hongchen Li, Shiyin Fan, Kai Wang, Ziyi Cui, Xinyu Zhao, Xue Sun, Mingen Lin, Jiaxi Li, Yi Gao, Ziyin Tian, Hui Yang, Bingbing Zha, Lei Lv, Yanping Xu

“…Cell Death and Disease…”
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

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Mesenchymal Stem Cells Carrying Viral Fusogenic Protein p14 to Treat Solid Tumors by Inducing Cell–Cell Fusion and Immune Activation by Yao Wang, Xunlei Pang, Ruirui Li, Jiuzhou Chen, Chen Wen, Huihuang Zhu, Tingyu Long, Jianjie Li, Lijun Zheng, Youcai Deng, Junnian Zheng, Bo Xu

“…MSCs-p14 cocultured with different cancer cells and effienctly induced cancer cell fusion and caused widespread cancer cell death in vitro. …”
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Hydroxychloroquine Potentiates Apoptosis Induced by PPARα Antagonist in 786-O Clear Cell Renal Cell Carcinoma Cells Associated with Inhibiting Autophagy by Ruizhe Mao, Jian Shi, Xuyi Ma, Haiyan Xu

“…In recent years, peroxisome proliferator-activated receptor-α (PPARα) antagonists have been reported as a targeted therapeutic drug capable of inducing apoptosis and cell cycle arrest in the ccRCC cell line. Autophagy, which can be induced by stress in eukaryotic cells, plays a complex role in the proliferation, survival, and death of tumor cells. …”
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Medicarpin suppresses lung cancer cell growth in vitro and in vivo by inducing cell apoptosis by Shen Zongyi, Yin Liqi, Chang Manxia, Wang Haifeng, Hao Mingxuan, Liang Youfeng, Guo Rui, Bi Ying, Wang Jiansong, Yu Changyuan, Li Jinmei, Zhai Qiongli, Cheng Runfen, Zhang Jinku, Sun Jirui, Yang Zhao

“…We found that MED could significantly inhibit proliferation, induce apoptosis, and cell cycle arrest of A549 and H157 cell lines. Basically, MED induced cell apoptosis of LC cells by upregu lating the expression of pro-apoptotic proteins BAX and Bak1, leading to the cleavage of caspase-3 (Casp3). …”
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Real-world ePRO use and clinical outcomes using electronic patient-reported symptom monitoring for patients with advanced non-small-cell lung cancer receiving first-line pembrolizu... by L. Johnetta Blakely, Sabine Oskar, Ian Kudel, Ashley Roush, Zoya Shamsi, Toni Perry, Annette Christianson, Brittni Smith, Thomas Burke

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CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma by Kangkang Yang, Yushuang Wang, Yuli Jian, Bo Wang, Hao Du, Yuqing Xia, Jianlei Bi, Meihua Guo, Zhi Li, Ning Wang

“…PANoptosis, a form of cell death regulated by PANoptosomes, plays a role in numerous cancer types. …”
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Comparative efficacy of programmed death ligand 1 inhibition and chemotherapy in advanced gastric or gastroesophageal junction cancer with combined positive score – a meta-analysis... by Zakari Shaibu, Fumeng Yang, Liu Ting, Lily Dzidula, Amina Elmi Yusuf, Zhi-hong Chen, Wei Zhu

“…Immune checkpoint inhibitors, particularly targeting programmed cell death ligand-1 (PD-L1), have emerged as promising agents to enhance patient outcomes. …”
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Geospatial clustering and correlates of deaths during the Ebola outbreak in Liberia: a Bayesian geoadditive semiparametric analysis of nationally representative cross-sectional sur... by Fiifi Amoako Johnson, Barbara Sakyi

“…The analysis covered 11 928 (women=7854 and men=4074) respondents for whom complete data were available.Outcome measures The outcome variable was the death of a household member or relative during the Ebola outbreak in Liberia, coded 1 if the respondent reported death and 0 otherwise.Methods We applied the Bayesian geoadditive semiparametric regression to examine the extent of geospatial clustering of deaths at the district-level and community-level development and socioeconomic factors associated with the observed clustering.Results Almost a quarter (24.8%) of all respondents reported the death of a household member or relative during the Ebola outbreak. …”
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Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins by Maria Angelica Freitas-Cortez, Fatemeh Masrorpour, Hong Jiang, Iqbal Mahmud, Yue Lu, Ailing Huang, Lisa K. Duong, Qi Wang, Tiffany A. Voss, Claudia S. Kettlun Leyton, Bo Wei, Wai-Kin Chan, Kevin Lin, Jie Zhang, Efrosini Tsouko, Shonik Ganjoo, Hampartsoum B. Barsoumian, Thomas S. Riad, Yun Hu, Carola Leuschner, Nahum Puebla-Osorio, Jing Wang, Jian Hu, Michael A. Davies, Vinay K. Puduvalli, Cyrielle Billon, Thomas P. Burris, Philip L. Lorenzi, Boyi Gan, James W. Welsh

“…One way the immune system fights back is by inducing ferroptosis, a type of cell death, in tumor cells through CD8 + T cells. …”
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Coexistent Non–Small Cell Carcinoma and Small Cell Carcinoma in a Patient Presenting with Hyponatremia by Mitchell D. Ross, Sreeja Biswas Roy, Pradnya D. Patil, Jasmine L. Huang, Nitika Thawani, Ralph Drosten, Tanmay S. Panchabhai

“…Navigational bronchoscopy biopsy of the RUL lesion revealed squamous non–small cell lung cancer (NSCLC). Endobronchial ultrasound-guided transbronchial needle aspiration of the LLL lesion revealed small cell lung cancer (SCLC). …”
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Secondary prevention of preeclampsia by Muhammad Ilham Aldika Akbar, Muhammad Ilham Aldika Akbar, Roudhona Rosaudyn, Khanisyah Erza Gumilar, Khanisyah Erza Gumilar, Renuka Shanmugalingam, Gustaaf Dekker, Gustaaf Dekker

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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…Cell Death Discovery…”
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Myeloma cell-derived CXCL7 facilitates proliferation of tumor cells and occurrence of osteolytic lesions through JAK/STAT3 pathway by Yue Wang, Tianwei Lan, Qiongyan Zhang, Chi Zhou, Peng Liu

“…Cell Death and Disease…”
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Involvement of PPARs in Cell Proliferation and Apoptosis in Human Colon Cancer Specimens and in Normal and Cancer Cell Lines by G. Martinasso, M. Oraldi, A. Trombetta, M. Maggiora, O. Bertetto, R. A. Canuto, G. Muzio

“…PPAR involvement in cell growth was investigated “in vivo” and “in vitro” and was correlated with cell proliferation and apoptotic death. …”
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MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo by Karolin Walter, Kanishka Tiwary, Marija Trajkovic-Arsic, Ana Hidalgo-Sastre, Laura Dierichs, Sven T. Liffers, Jiangning Gu, Johann Gout, Lucas-Alexander Schulte, Jan Münch, Thomas Seufferlein, Bruno Sainz, Jens T. Siveke, Eva Rodriguez-Aznar, Patrick C. Hermann

“…Herein, we use a genetically engineered mouse model of pancreatic cancer and primary pancreatic cancer cells were derived from this model to demonstrate that small-molecule MEK inhibitors functionally abrogate cancer stem cell populations as demonstrated by reduced sphere and organoid formation capacity. …”
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Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis by Xinyan Hao, Yucheng Tang, Wenjie Xu, Ming Wang, Jiayi Liu, Yongjiang Li, Jun He, Yanjin Peng, Pengcheng Sun, Dehua Liao, Xiongbin Hu, Tiantian Tang, Min Zhou, Ruyue Han, Jiemin Wang, João Conde, Daxiong Xiang, Junyong Wu

“…Additionally, BV2 microglial cells were engineered to overexpress programmed death-1 (PD-1), and the membrane is employed for nanocomplex coating, effectively blocking the CDDP-induced upregulation of programmed death ligand 1 (PD-L1). …”
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La “belle” ou la Veuve : résistances, rébellions et tentatives d'évasion des condamnés à mort en France au XXe siècle by Nicolas Picard

“…Prisoners who had been sentenced to death were subjected to a severe prison regime, a guarantee against suicide and escape. …”
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