鼻咽癌中EB病毒潜伏膜蛋白1启动子的突变

“…【目的】 检测EB病毒潜伏膜蛋白1 (LMP1) 远端启动子L1-TR在鼻咽癌(NPC)组织中的突变情况并探讨突变对启动子活性的影响【方法】 用聚合酶链反应(PCR)方法分别扩增出B95.8细胞和新鲜鼻咽癌组织细胞中EB病毒(EBV)的L1-TR片段，并测序比较其核苷酸序列的差异构建含原型和突变型L1-TR启动子的荧光素酶报告质粒并分别转染HaCat细胞B95.8细胞和C666-1细胞，比较两种启动子的活性【结果】 和B95.8原型比较，鼻咽癌组织中的EB病毒L1-TR启动子区域有多处缺失插入和点突变，且启动子活性明显降低(P < 0.05)【结论】 鼻咽癌组织中LMP1启动子 L1-TR的活性与B95.8原型相比明显降低，这在EB病毒的免疫逃避机制中可能有一定的意义…”
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Lui, « pour toujours, a embrassé ma bouche, toute frémissante » : Paolo et Francesca dans la peinture préraphaélite et esthétique by Anne-Florence Gillard-Estrada

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“Son palabrejas que se ponen de moda”: perspectivas docentes sobre la interculturalidad en la enseñanza de lenguas a adultos en contextos de migración by Denise Paola Holguín Vaca

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Antecedentes da voz e do silêncio de trabalhadores do setor público federal by Débora Bruna Alves Almeida, Thales Fabricio da Costa e Silva

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Utopía, mito y ficción. Imaginarios de lo femenino en el periódico literario el Museo Yucateco by Romina España Paredes

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ESTIMAREA PROPRIETĂȚILOR ATRACTIVE A CAPCANELOR FEROMONALE ȘI LUMINOASE PENTRU MONITORIZAREA SEZONIERĂ A SPECIEI INVAZIVE HALYOMORPHA HALYS STAL by USM ADMIN

“…Metoda de monitorizare cu capcane luminoase are atât avantaje: o gamă largă de atragere a insectelor, siguranță față de mediu, abordare integrată, cât și limitări legate de sensibilitatea la factori externi, cum ar fi iluminarea, condițiile meteorologice, caracteristicile fiziologice ale speciilor atrase etc. …”
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Fault Diagnosis Approach for Rotating Machinery Based on Feature Importance Ranking and Selection by Zong Yuan, Taotao Zhou, Jie Liu, Changhe Zhang, Yong Liu

“…Thirdly, the categorical boosting (CatBoost) algorithm is introduced to rank the fault features by a certain strategy, and the optimal feature set is further utilized to identify and diagnose the fault types. …”
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The Linguistic Landscape of Urban Vellore: A Comprehensive Analysis of Language Distribution, Choice, and Implications in the Commercial Space Through Shop Signs by Mishra Sneha

“…The study utilizes the conceptual frameworks of Communication Accommodation Theory (CAT) and Social Representation Theory (SRT) to explore the dynamics of shop signs. …”
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Overexpression of the <i>GmPM35</i> Gene Significantly Enhances Drought Tolerance in Transgenic Arabidopsis and Soybean by Xinyu Wang, Yao Sun, Rui Wang, Xinyang Li, Yongyi Li, Tianyu Wang, Zhaohao Guo, Yan Li, Wenxi Qiu, Shuyan Guan, Qi Zhang, Piwu Wang, Mingze Li, Siyan Liu, Xuhong Fan

“…The activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) were increased by an average of 34.28%, 26.12%, and 30.01%, respectively, in soybean plants overexpressing the <i>GmPM35</i> gene compared with wild-type soybeans. …”
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Colonic Oxidative and Mitochondrial Function in Parkinson’s Disease and Idiopathic REM Sleep Behavior Disorder by C. Morén, Í. González-Casacuberta, J. Navarro-Otano, D. Juárez-Flores, D. Vilas, G. Garrabou, J. C. Milisenda, C. Pont-Sunyer, M. Catalán-García, M. Guitart-Mampel, E. Tobías, F. Cardellach, F. Valldeoriola, A. Iranzo, E. Tolosa

“…Antioxidant enzymes SOD2 (iRBD: 2.30±0.92, PD: 1.48±0.39, and controls: 1.09±0.318) and Gpx1 (iRBD 0.29±0.12, PD: 0.56±0.33, and controls: 0.38±0.16) did not show significant differences between groups. CAT was only detected in 2 controls and 1 iRBD subject. …”
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La expansión de las narrativas transmedia en los videojuegos de las empresas de streaming. Los videojuegos en Netflix: Stranger Things 1984 y Narcos: Cartel Wars Unlimited by Ana Sixchel Galicia Martínez

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El profesorado ante la educación inclusiva: perfiles actitudinales y orientaciones para su formación by Pablo Palomero-Fernández, Katherine Gajardo-Espinoza, Noelia Santamaría-Cárdaba

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Transparencia en la Corona española by Alfredo Ramírez Nárdiz

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Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway by Mengjing Zhao, Min Zhang, Shoudong Ni

“…Rg1 markedly enhances the activities of SOD, GSH, and CAT, while reducing levels of MDA and ROS, indicating an improvement in antioxidant defense capacity. …”
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The Effects of Early-Life Predator Stress on Anxiety- and Depression-Like Behaviors of Adult Rats by Lu-jing Chen, Bing-qing Shen, Dan-dan Liu, Sheng-tian Li

“…Here, we investigated both short-term and long-term changes of anxiety- and depression-like behaviors of Wistar rats after being exposed to chronic feral cat stress in juvenile ages. The 2-week predator stress decreased spontaneous activities immediately following stress but did not increase depression- or anxiety-like behaviors 4 weeks after the stimulation in adulthood. …”
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Defense responses of the green microalgae Chlorella vulgaris to the vanadium pentoxide nanoparticles by Kalehjahi Hanifeh Akbarian, Kosari-Nasab Morteza, Amini Mojtaba, Movafeghi Ali

“…Although, non-enzymatic antioxidant system in C. vulgaris displayed an average action, antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) showed a dose dependent increasing trend. …”
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Entre árabe y latín en los textos medievales by José Martínez Gázquez

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Presentarse como candidato a la dirección de departamento universitario: una decisión compleja by Carmen Álvarez-Álvarez

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Therapeutic effect of natural melanin from edible fungus Auricularia auricula on alcohol-induced liver damage in vitro and in vivo by Ruolin Hou, Xin Liu, Xiaoping Wu, Mingfeng Zheng, Junsheng Fu

“…As a result, AAM reduced the levels of ALT, AST, TG, and MDA, increased the levels of ADH, SOD, and CAT in liver damage mice. The therapeutic effect of AAM may be related to inhibition of CYP2E1 expression and activation of Nrf2 and its downstream antioxidase. …”
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Effects of Low Concentration of Glyphosate-Based Herbicide on Genotoxic, Oxidative, Inflammatory, and Behavioral Meters in Danio rerio (Teleostei and Cyprinidae) by Eduardo Bortolon Ribas, Gustavo Colombo Dal-Pont, Ariana Centa, Marcos Otávio Bueno, Ricardo Cervini, Rosana Claudio Silva Ogoshi, Claudriana Locatelli

“…The results showed that there was a reduction in the activity of the antioxidant enzymes of catalase (CAT) and glutathione-S-transferase (GST) in the liver at all concentrations and at the highest concentration in the brain. …”
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