CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

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Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies by Apolline Lefèvre, Apolline Lefèvre, Zinnia P. Parra-Guillen, Zinnia P. Parra-Guillen, Iñaki F. Trocóniz, Iñaki F. Trocóniz, Iñaki F. Trocóniz, Christophe Boetsch, Nicolas Frances

Subjects: “…cancer immunotherapy (CIT)…”
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Author Correction: Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti‑in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa‑thai Yenchitsomanus, Aussara Panya

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A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types by Zhen Zeng, Tianbei Zhang, Jiajia Zhang, Shuai Li, Sydney Connor, Boyang Zhang, Yimin Zhao, Jordan Wilson, Dipika Singh, Rima Kulikauskas, Candice D. Church, Thomas H. Pulliam, Saumya Jani, Paul Nghiem, Suzanne L. Topalian, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith

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Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya

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Characteristics and clinical significance of immune cells in omental milky spots of patients with gastric cancer by Yasunobu Mano, Yasunobu Mano, Yuka Igarashi, Yuka Igarashi, Keisuke Komori, Keisuke Komori, Itaru Hashimoto, Itaru Hashimoto, Hayato Watanabe, Kosuke Takahashi, Kazuki Kano, Hirohito Fujikawa, Takanobu Yamada, Hidetomo Himuro, Hidetomo Himuro, Taku Kouro, Taku Kouro, Feifei Wei, Feifei Wei, Kayoko Tsuji, Kayoko Tsuji, Shun Horaguchi, Shun Horaguchi, Shun Horaguchi, Mitsuru Komahashi, Mitsuru Komahashi, Mitsuru Komahashi, Takashi Oshima, Tetsuro Sasada, Tetsuro Sasada

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Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach by Punchita Rujirachaivej, Teerapong Siriboonpiputtana, Kornkan Choomee, Kamonlapat Supimon, Thanich Sangsuwannukul, Pucharee Songprakhon, Krissada Natungnuy, Piriya Luangwattananun, Pornpimon Yuti, Mutita Junking, Pa-thai Yenchitsomanus

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Low dose ATG-Fresenius for GVHD prophylaxis: a comparative study with ATG-Thymoglobulin by Itai Falicovich, Boaz Nachmias, Shlomo Elias, Eran Zimran, Adir Shaulov, Polina Stepensky, Batia Avni, Sigal Grisariu

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A bivalent COVID-19 mRNA vaccine elicited broad immune responses and protection against Omicron subvariants infection by Jun Liu, Li Wang, Alexandra Kurtesi, Patrick Budylowski, Kyle G. Potts, Haritha Menon, Yilin Tan, Philip Samaan, Xinan Liu, Yisen Wang, Queenie Hu, Reuben Samson, Freda Qi, Danyel Evseev, Cini John, Kristofor K. Ellestad, Yue Fan, Frans Budiman, Ellaine Riczly Tohan, Suji Udayakumar, Jennifer Yang, Eric G. Marcusson, Anne-Claude Gingras, Douglas J. Mahoney, Mario A. Ostrowski, Natalia Martin-Orozco

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Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury by Zurab Kakabadze, Nickolas Kipshidze, Konstantine Mardaleishvili, Gocha Chutkerashvili, Irakli Chelishvili, Albrecht Harders, George Loladze, Gocha Shatirishvili, Nodar Kipshidze, David Chakhunashvili, Konstantine Chutkerashvili

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Role of the androgen receptor in melanoma aggressiveness by Marzia Di Donato, Costanza Maria Cristiani, Mariaelena Capone, Cinzia Garofalo, Gabriele Madonna, Lucia Carmela Passacatini, Margaret Ottaviano, Paolo Antonio Ascierto, Ferdinando Auricchio, Ennio Carbone, Antimo Migliaccio, Gabriella Castoria

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Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity by Xiaoping Wang, Qiaoxia Wang

“…Except for its diagnosis in liver cancer, AFP has become a target for liver cancer immunotherapy. Although the immunogenicity of AFP is weak and it could induce the immune escapes through inhibiting the function of dendritic cells, natural killer cells, and T lymphocytes, AFP has attracted more attention in liver cancer immunotherapy. …”
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Development of [F]FPy-WL12 as a PD-L1 Specific PET Imaging Peptide by Wojciech G. Lesniak PhD, Ronnie C. Mease PhD, Samit Chatterjee PhD, Dhiraj Kumar PhD, Ala Lisok MA, Bryan Wharram MS, Venkateswara Rao Kalagadda PhD, Leisha A. Emens MD, PhD, Martin G. Pomper MD, PhD, Sridhar Nimmagadda PhD

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WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers by Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

“…These results provided us with the rationale for elicitation of CTL responses targeting the WT1 product for cancer immunotherapy. On the basis of these findings, we performed a phase I clinical trial of a WT1 peptide cancer vaccine for the patients with malignant neoplasms. …”
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Alternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy by Shay Tzaban, Ori Stern, Elad Zisman, Galit Eisenberg, Galit Eisenberg, Shiri Klein, Shiri Klein, Shoshana Frankenburg, Michal Lotem, Michal Lotem, Michal Lotem

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Exploring the current potential of immunotherapeutic-based treatment approaches for the management of oral cancer: An updated review by Abin V. Geevarghese, R. Gopika

“…This article outlines the traditional approaches for the treatment of oral cancer and immunotherapy, and it ends with an overview of future advances in oral cancer immunotherapy. It is expected that immunotherapy that targets the tumor microenvironment will provide an innovative approach for the beneficial treatment of oral cancer.…”
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Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity by Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang

“…Intriguingly, a recent study demonstrates that LTX-315, one of the most promising and extensively studied oncolytic peptides, inhibits PD-L1 expression via ATP11B, thus enhancing the effectiveness of cancer immunotherapy by targeting the PD-1/PD-L1 axis. Therefore, this commentary discusses the broad effects and perspectives of oncolytic peptides on anticancer immunity, further highlighting the potential issues and directions of oncolytic peptides in cancer immunotherapy.…”
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Immunotherapy of Cancer: Reprogramming Tumor-Immune Crosstalk by Kyle K. Payne, Amir A. Toor, Xiang-Yang Wang, Masoud H. Manjili

“…The advancement of cancer immunotherapy faces barriers which limit its efficacy. …”
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Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer by Kuang Youlin, Zhang Li, Weng Xiaodong, Liu Xiuheng, Zhu Hengchen

“…These results suggest that combining activation of 4-1BB and blockade of CTLA-4 may offer a new strategy for prostate cancer immunotherapy.…”
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Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine IFNα and is enhanced by CD47 blockade by Junjie Li, Yuandong Luo, Quanlan Fu, Shuxian Tang, Pingping Zhang, Ian H. Frazer, Xiaosong Liu, Tianfang Wang, Guoying Ni

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