Computing-network intelligence: research progress and prospects by ZHU Hailong, YANG Fan, JIANG Ruyi, JIA Qingmin, ZHOU Xiaomao, XIE Renchao, HUANG Tao

“…To address the need for enhanced intelligence in computing power networks, the background and concept of the computing-network intelligence (CNI) were first introduced briefly. Then, followed by the proposal of a novel basic architecture and operational mechanism for CNI, intelligent resource allocation and service scheduling of multi-dimensional resources were achieved through key technologies such as computing-network perception, intelligent decision-making, computing power routing, automation, and self-optimization. …”
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Does Rabbit Antithymocyte Globulin (Thymoglobuline®) Have a Role in Avoiding Delayed Graft Function in the Modern Era of Kidney Transplantation? by Lluís Guirado

“…A reduced rate of DGF has been reported with rATG (started intraoperatively) and delayed CNI therapy compared to IL-2RA induction with immediate CNI in patients at high immunological risk, but not in lower-risk patients. …”
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来氟米特对于肾移植术后抗排斥反应的前瞻性研究

“…试验组免疫抑制方案采用Lef联合CNI和激素,对照组采用骁悉(MMF)联合CNI和激素.比较两组术后急性排斥发生率.肾功能情况和不良反应发生情况.…”
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Plasma S100β is a predictor for pathology and cognitive decline in Alzheimer’s disease by Geetika Nehra, Bryan J. Maloney, Rebecca R. Smith, Wijitra Chumboatong, Erin L. Abner, Peter T. Nelson, Björn Bauer, Anika M. S. Hartz

“…Results As expected, we detected elevated Aβ and tau pathology in brain tissue sections from AD patients compared to CNI. However, we found no differences in microvascular diameters in cleared AD and CNI brain tissue sections. …”
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Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration by Nan Jiang, Cheng Wu, Xunrong Zhou, Guanghua Zhai, Jian Wu

“…Recent studies have found that cavernous nerve injury (CNI) during prostate cancer surgery and other pelvic surgery results in medically induced CNIED in more than 80% of patients. …”
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Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study by Steffen Hartleif, Michael Schumm, Michaela Döring, Markus Mezger, Peter Lang, Marc H. Dahlke, Joachim Riethmüller, Alfred Königsrainer, Rupert Handgretinger, Silvio Nadalin, Ekkehard Sturm

“…Calcineurin inhibitors (CNI) have significantly improved patient and graft survival in pediatric liver transplantation (pLT). …”
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Evaluation of Elexacafor/Tezacaftor/Ivacaftor therapy after lung transplantation in Cystic Fibrosis: The Dutch National KOALA study by Johanna P. van Gemert, Bart Luijk, Merel E. Hellemons, Klara A. Visser, Carina.M.E. Hansen, Renske van der Meer, C. Tji Gan, Hester van der Vaart, Onno W. Akkerman, Willie N. Steenhuis, Marieke Verkleij, Harry G.M. Heijerman, Erik A.M. Verschuuren

“…Monitoring renal function and CNI trough levels is recommended.…”
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Conversion to Sirolimus Therapy in Kidney Transplant Recipients with New Onset Diabetes Mellitus after Transplantation by Massimiliano Veroux, Tiziano Tallarita, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Carmela Guerrieri, Antonino D'Assoro, Sebastiano Cimino, Pierfrancesco Veroux

“…Among 344 kidney transplant recipients, 29 patients developed a NODAT (6.6%) and continued with a reduced dose of calcineurin inhibitors (CNI) (8 patients, Group A) or were converted to sirolimus (SIR) (21 patients, Group B). …”
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Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…The trial will compare the novel GvHD prophylaxis regimens post-transplant cyclophosphamide (PTCy) in combination with a CNI or sirolimus (PTCy-CNI or PTCy-sirolimus, respectively) to a current standard-of-care GvHD prophylaxis involving the use of Thymoglobulin (a specific brand of ATG containing rabbit polyclonal antibodies). …”
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Consequences of Repetitive Head-Impact Exposure in Sports - literature review by Wiktoria Gajek-Flanczewska, Sebastian Flanczewski, Małgorzata Wirkijowska, Katarzyna Wójtowicz, Jakub Wirkijowski, Agata Walczak, Paulina Woźniak, Ewa Wietrzykowska, Dominika Sobolewska, Katarzyna Michalczyk-Fraszka, Martyna Śliwińska, Anna Podraza

“…This article reviews the biophysical mechanisms of concussions, the risks of CTE and chronic neurocognitive impairment (CNI), and the challenges in diagnosing and managing these conditions. …”
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Everolimus in Heart Transplantation: An Update by Stephan W. Hirt, Christoph Bara, Markus J. Barten, Tobias Deuse, Andreas O. Doesch, Ingo Kaczmarek, Uwe Schulz, Jörg Stypmann, Assad Haneya, Hans B. Lehmkuhl

“…Immediate and adequate reduction of CNI exposure is mandatory from the start of everolimus therapy.…”
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Structural, Elastic, and Electronic Properties of Antiperovskite Chromium-Based Carbides ACCr3 (A = Al and Ga) by D. F. Shao, W. J. Lu, S. Lin, P. Tong, Y. P. Sun

“…The band structures of AlCCr3 and GaCCr3 are very similar to those of the superconducting antiperovskite MgCNi3. The similarity may make AlCCr3 and GaCCr3 behave superconductively, which needs to be further investigated in theoretical and experimental studies.…”
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Neurotrophic Effect of Adipose Tissue-Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium-Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury by Xin Chen, Qiyun Yang, Tao Zheng, Jun Bian, Xiangzhou Sun, Yanan Shi, Xiaoyan Liang, Guoquan Gao, Guihua Liu, Chunhua Deng

“…The aim of this study is to investigate whether adipose tissue-derived stem cells (ADSCs) can ameliorate cavernous nerve injury-induced erectile dysfunction (CNIED) rats and to determine its mechanism. Twenty-eight days after intracavernous injection of 5-ethynyl-2-deoxyuridine- (EdU-) labeled ADSCs, the erectile function of all the rats was evaluated by intracavernosal pressure (ICP). …”
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De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients: A Place for Interaction? by Josefina Alberu, Maria Inés Vargas-Rojas, Luis E. Morales-Buenrostro, Jose C. Crispin, Roxana Rodríguez-Romo, Norma O. Uribe-Uribe, Gabriel Carrasco, Diana Gómez-Martín, Jorge Alcocer-Varela

“…All patients received triple drug immunosuppressive therapy (CNI + MMF or AZA + PDN); 83% received anti-CD25. …”
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Differences in use of telemedicine integrated into traditional primary health care – a comparative observational study by Pär Eriksson, Maria Randjelovic, Hans Thulesius, Tora Hammar, Stefan Lagrosen, Evalill Nilsson

“…In contrast, no statistically significant differences were seen between the two groups regarding SES, measured as Care Need Index (CNI). Regarding HSB, a proxy measure (health record entries) showed more entries for users than non-users.Conclusions Our findings suggest that users are more likely to be women and below the age of 60. …”
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提前口服用药方案与抗CD25诱导方案 在亲体肾移植中的疗效对比

“…【目的】 比较在亲体肾移植中,采用提前口服免疫抑制剂方案或术前抗CD25诱导方案对于受体术后早期安全性和有效性的影响65377;【方法】 60例亲体肾移植受体均采用钙调蛋白阻滞剂(CNI) + 吗替麦考酚酯(MMF) + 激素(Prednisone)三联免疫治疗,按是否应用抗CD25诱导随机将其分为两组,诱导组(Ⅰ组)30例,提前口服免疫抑制剂组(以下简称提前用药组,Ⅱ组)30例,观察比较两组在术后3个月内安全性和有效性的情况,以及两组部分病例移植1年后人/肾存活率和肌酐清除率(Ccr)的情况65377; 【结果】 诱导组2例(6.7%)和提前用药组1例(3.3%)发生急性排斥反应(P = 1.00);两组术后3个月内的血清肌酐(Scr)及肾功能恢复情况,肝功能损害65380;白细胞减少65380;感染等并发症情况以及部分移植一年后患者人/肾存活率和肌酐清除率情况,均无统计学意义(P > 0.05)65377; 【结论】 在亲体肾移植中,提前口服用药方案的使用是安全65380;有效的,可以替代抗CD25诱导方案,其远期效果及适用范围有待于进一步观察65377;…”
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Evaluation of Protocol Biopsy Utility 12 Months after Renal Transplantation: A Multicenter Observational Analysis by Bruno Moulin, Pierre Merville, Karine Renaudin, David Buob, Sophie Ferlicot, Michel Delahousse, Jacques Dantal, Laetitia Albano, Christelle Barbet, Georges Mourad, Laure-Hélène Noel

“…In the SB group, slight nonspecific changes were observed in 51 cases, rejection (acute or chronic) in 6 cases, CNI-related toxicity in 15 cases, recurrence of initial disease in two cases, and interstitial fibrosis/tubular atrophy (IF/TA) in 83 cases (71.6%), of which 35 cases (30.2%) were grade II/III lesions. eGFR <50 mL/min/1.73 m² at month 6 predicted IF/TA grade II or III (OR 3.85, 95% CI 1.64, 9.05, 𝑃<0.002). …”
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COVID-19 Infection Clinical Profile, Management, Outcome, and Antibody Response in Kidney Transplant Recipients: A Single Centre Experience by Sanjiv Jasuja, Gaurav Sagar, Anupam Bahl, Shalini Verma

“…Anti-nucleosides (mycophenolate or azathioprine) were discontinued in 76.1% and calcineurin inhibitors (CNI) in 26.9%. Significant mortality (p<0.001) was observed in patients presenting with SpO2 <94 needing ICU care, ventilation, dialysis/acute kidney injury (AKI), and empirical therapies like convalescent plasma and remdesivir. …”
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