Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron. by G Robert Aguilar, Berta Vidal, Hongzhu Ji, Joke Evenblij, Chien-Po Liao, Hongfei Ji, Giulio Valperga, Christopher Fang-Yen, Oliver Hobert

“…We show (a) that 2 orthologs of the vertebrate bHLHe22/e23 genes, called hlh-17 and hlh-32, function redundantly to specify the identity of a single head interneuron class (AUA), as well as an individual motor neuron (VB2); (b) that the PTF1a ortholog hlh-13 acts as a terminal selector to control terminal differentiation and function of the sole octopaminergic neuron class in C. elegans, RIC; and (c) that the NHLH1/2 ortholog hlh-15 controls terminal differentiation and function of the peptidergic AVK head interneuron class, a known neuropeptidergic signaling hub in the animal. …”
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Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review by Asmaa Ibrahim, Kazeem Yusuff, Ahmed Awaisu, Hazem Elewa

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Early Differentiation of Human CD11c+NK Cells with γδ T Cell Activation Properties Is Promoted by Dialyzable Leukocyte Extracts by Dalia Ramírez-Ramírez, Eduardo Vadillo, Lourdes Andrea Arriaga-Pizano, Héctor Mayani, Sergio Estrada-Parra, Marco Antonio Velasco-Velázquez, Sonia Mayra Pérez-Tapia, Rosana Pelayo

“…Our findings suggest that DLE increases their differentiation toward a conspicuous CD56+CD16+CD11c+ NK-like cell population endowed with properties such as IFNy production, tumor cell cytotoxicity, and the capability of inducing γδ T lymphocyte proliferation. …”
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Development of Virus-Like Particles (VLPs) for Hepatitis C Virus genotype 4: a novel approach for vaccine development in Egypt by Ahmed A. Ali, Rasha A. M. Azouz, Nahla A. Hussein, Reem El-Shenawy, Naiera M. Helmy, Yasmine S. El-Abd, Ashraf A. Tabll

Subjects: “…Hepatitis C Virus (HCV)…”
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Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis by Jiahui Sun, Xuefan Jiang, Ming Zhao, Lina Ma, Hui Pei, Nanyang Liu, Hao Li

“…We conducted this meta-analysis to evaluate the contribution of MTHFR C677T (rs1801133) gene variants to the risk of MCI. …”
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Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model by Rui Dang, Mridul Dalmia, Ziyuan Ma, Mengmeng Jin, Kushal Aluru, Vincent R. Mirabella, Ava V. Papetti, Li Cai, Peng Jiang

“…Notably, the NLGN3 R451C astroglia demonstrate enhanced branching, indicating a more intricate morphology. …”
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Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort by Doron Boltin, Zohar Levi, Tsachi Tsadok Perets, Hemda Schmilovitz-Weiss, Rachel Gingold-Belfer, Ram Dickman, Iris Dotan

“…There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H. pylori) infection. The 13C-urea breath test result (C13-UBT) utilizes H. pylori urease activity and is a highly accurate diagnostic assay. …”
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Were sanctuary wells in Roman Gaul intentionally contaminated using animal carcasses (3rd–4th c. AD)? by Sébastien Lepetz, Alice Bourgois

“…This paper addresses the question of animal remains (isolated bones and complete skeletons) discovered in the fill of Roman sanctuary wells in northern France and their links with the dismantling of places of worship from the 3rd c. onwards. Several recently excavated sites (Vieil-Évreux, Mesnil-Saint-Nicaise and Ménestreau) and some comparative sites are presented. …”
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Gutiérrez Sanín, Francisco. (2017). La destrucción de una República. Bogotá, D. C.: Universidad Externado de Colombia. by Cristian de Jesús Acosta Olaya

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Efecto de UV-C en las características fisicoquímicas y microbiológicas de la uvilla (Physalis Peruviana L.) by Gabriela Maribel Jaramillo-Sánchez, Josselyn Katherine Bueno-Cuenca, Nubia Lisbeth Matute-Castro, Mercedes Campo-Fernández, Verónica Patricia Bravo-Bravo, Andrea Carolina Solano-Solano, Sandra Elizabeth Córdova-Márquez

“…Se aplicaron tratamientos con UV-C durante diferentes tiempos de exposición (7, 10 y 13 minutos) y los frutos se almacenaron tanto a temperatura de refrigeración (5 ± 1 °C) como a temperatura ambiente (24 ± 1 °C). …”
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Allergen degradation of bee pollen by lactic acid bacteria fermentation and its alleviatory effects on allergic reactions in BALB/c mice by Shuting Yin, Qiangqiang Li, Yuxiao Tao, Enning Zhou, Kun Wang, Wanwen Chen, Xiangxin Li, Liming Wu

“…Moreover, FBP showed alleviatory effects in BALB/c mice, which relieved pathological symptoms and lowered production of allergic mediators. …”
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Segmentasi Pelanggan B2B dengan Model LRFM Menggunakan Algoritma Fuzzy C-Means pada Rotte Bakery by Dea Putri Ananda, Siti Monalisa

“…Dalam penelitian ini, kami menggunakan model LRFM (Length, Recency, Frequency, dan Monetary) dengan Algoritma Fuzzy C-Means untuk melakukan segmentasi pelanggan. Metode validasi Davies Bouldien-Index digunakan untuk menentukan jumlah cluster yang optimal. …”
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Successful Treatment of Hepatitis C with Simeprevir, Sofosbuvir, and Ribavirin in an HIV Coinfected Liver Transplant Patient with Advanced Chronic Kidney Disease by Anna Maruyama, Trana Hussaini, Nilufar Partovi, Siegfried R. Erb, Vladimir Marquez Azalgara, Nadia Zalunardo, Neora Pick, Mark Hull, Eric M. Yoshida

“…Although major advances have occurred in treating patients with hepatitis C virus (HCV) with the development of new direct-acting antivirals (DAAs), treatment of liver transplant recipients with HCV, human immunodeficiency virus (HIV) coinfection, and renal disease is challenging due to the lack of efficacy and safety data in this population. …”
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Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3 by Imama Maslahah, Mohammad Saifur Rohman, Nashi Widodo, Agustina Tri Endharti, Didik Utomo

“…SNP of C-5434T was genotyped in 56 hypertensive patients by using RFLP. …”
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Increased Eligibility for Treatment of Chronic Hepatitis C Infection with Shortened Duration of Therapy: Implications for Access to Care and Elimination Strategies in Canada by Sergio M Borgia, Adenike Rowaiye

“…BACKGROUND: All oral, highly effective direct-acting antiviral combinations, such as sofosbuvir-ledipasvir, have recently been licensed in Canada but cost as much as $67,000 for a 12-week course of therapy, representing a major economic barrier to predominately single-payer health care systems such as that found in Ontario. In hepatitis C virus (HCV) genotype 1 noncirrhotic patients with a baseline viral load of <6×106 IU/mL, treatment with sofosbuvir-ledipasvir can be shortened to eight weeks without compromising ≥95% efficacy. …”
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Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients by Dan Chen, Wenwu Sun, Jia Li, Bohua Wei, Wei Liu, Xiaopin Wang, Fan Song, Liangkai Chen, Junhui Yang, Li Yu

“…This study aimed at determining the relationship between baseline cystatin C levels and coronavirus disease 2019 (COVID-19) and investigating the potential prognostic value of serum cystatin C in adult patients with COVID-19. 481 patients with COVID-19 were consecutively included in this study from January 2, 2020, and followed up to April 15, 2020. …”
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An efficient strategy to boost photoelectrochemical water oxidation of g-C3N4 films modified with NiO as cocatalyst by Lingling Bi, Jiahao Zhan, Wenhao Zhang, Zhenzhou Wu, Weichuan Xu, Xiaobo Liang, Lijing Zhang, Bin Yan, Chunyi Xu

Subjects: “…g-C3N4…”
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Safety and efficacy of telaprevir in treatment of a chronic hepatitis C in patients of the Russian population included in early access program study by D. T. Abrurakhmanov, V. G. Morozov, I. G. Nikitin, P. O. Bogomolov, N. I. Geyvandova, Ye. N. Bessonova, I. G. Bakulin, V. A. Isakov, K. V. Zhdanov, M. V. Mayevskaya, Ye. A. Nurmukhametova, E. Z. Burnevich, Ye. V. Chesnokov, V. D. Pasechnikov, A. Hill, I. Lonjon-Domanec, S. N. Kizhlo

“…In 153 patients with severe liver fibrosis caused by hepatitis C virus (genotype 1), on background of triple AVT with telaprevir high level of immediate virologic response and low level of the preterm treatment discontinuation was marked.…”
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Molecular Characterization and Clinical Characteristics of m5C-Based RNA Methylation in Spinal Cord Injury: Validated by qPCR by Liang Cao, Wen Jun Pi, Qiang Zhang, Qing Li

“…We explore the expression patterns and potential roles of m5C-based regulators of RNA modification after SCI. …”
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Crystal structure of methyl ((4-aminobenzyl)sulfonyl)-L-prolinate, C13H18N2O4S by Wang Zhen, Zhao Feng-Lan, Hou Gui-Ge, Meng Qing-Guo

“…C13H18N2O4S, orthorhombic, P212121 (no. 19), a = 6.8619(2) Å, b = 12.0735(4) Å, c = 16.6591(5) Å, V = 1380.16(7) Å3, Z = 4, R gt(F) = 0.0236, wR ref(F 2) = 0.0604, T = 150 K.…”
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