Associations between CAG repeat size, brain and spinal cord volume loss, and motor symptoms in spinocerebellar ataxia type 3: a cohort study by Zhi-Xian Ye, Xuan-Yu Chen, Meng-Cheng Li, Xin-Yuan Chen, Yu-Sen Qiu, Ru-Ying Yuan, Zhi-Li Chen, Min-Ting Lin, Jian-Ping Hu, Ying Fu, Wan-Jin Chen, Ning Wang, Shi-Rui Gan, on behalf of the OSCCAR Investigators

“…SCA3 patients evolved along a stage-independent decline that began in the cerebellum, progressed to spinal cord, brainstem, thalami, and basal ganglia, and extensive subcortex. …”
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Altered functional brain connectivity in Dyt1 knock-in mouse models by R. Z. Adury, B. J. Wilkes, P. Girdhar, Y. Li, D. E. Vaillancourt, D. E. Vaillancourt, D. E. Vaillancourt

“…EMX mice, while showing less extensive network disruptions, exhibited increased functional connectivity between cerebellum and seeds in the striatum and brainstem. These functional connectivity alterations between nodes in the basal ganglia and the cerebellum in both dGAG, EMX models underscore the involvement of cerebellum in dystonia. …”
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N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells by Juan Hong, Yan Chen, Yanping Zhang, Jieying Li, Liujie Ren, Lin Yang, Lusen Shi, Ao Li, Tianyu Zhang, Huawei Li, Peidong Dai

“…The number of ribbon synapse decreased, and this was accompanied by increased auditory brainstem response thresholds and reduced wave I amplitudes. …”
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Influence of High-Frequency Repetitive Transcranial Magnetic Stimulation on Neurobehavioral and Electrophysiology in Patients with Disorders of Consciousness by Jian-Min Chen, Qing-Fa Chen, Zhi-Yong Wang, Yang-Jia Chen, Nan-Nan Zhang, Jian-Wen Xu, Jun Ni

“…The outcome measures of performed pre- and postintervention included the latencies of the N20 and N20-P25 amplitudes of SEP, brainstem auditory-evoked potential (BAEP) grade, JFK Coma Recovery Scale-Revised (CRS-R) score, and Glasgow Coma Scale (GCS) score; any adverse events were recorded at any time during the intervention. …”
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The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs by Huan Lin, Xuanyi Li, Huiying Zhang, Yi Mu, Xi Wang, Naveena Konduru, Renlong Ji, Wen Liu, Wen Liu, Wen Liu, Zhao Fei, Wen Jiang, Wen Jiang, Wen Jiang, Yuehua Qiao, Yuehua Qiao, Yuehua Qiao

“…Auditory function was assessed using Auditory Brainstem Responses (ABR), while changes in sound energy transmission were measured using WAI and Distortion Products Otoacoustic Emissions (DPOAE).ResultsIncreased ABR thresholds in EH models were statistically significant (p < 0.05). …”
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Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma by Kaiqiang Chen, Jihong Chen, Yanming Cheng, Danni Hong, Cairong Hu, Penggang Bai, Jinyong Lin, Yang Yang, Xiuchun Zhang

“…Moreover, the HA plans had better sparing, particularly for the optic chiasm, optic nerves, and parotid glands (P ​< ​0.05), while no statistically significant differences were observed for other critical structures such as the brainstem, spinal cord, and temporal lobes (P ​> ​0.05). …”
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Development and Beta Validation of an mHealth-Based Hearing Screener (SRESHT) for Young Children in Resource-Limited Countries: Pilot Validation Study by Vidya Ramkumar, Deepashree Joshi B, Anil Prabhakar, James W Hall, Ramya Vaidyanath

“…Objective-based otoacoustic emissions and auditory brainstem response have been used in high-income countries for establishing early hearing screening and intervention programs. …”
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Candidate SNP markers of changes in the expression levels of the human <i>SCN9A</i> gene as a hub gene for pain generation, perception, response and anesthesia by P. A. Dotsenko, K. A. Zolotareva, R. A. Ivanov, I. V. Chadaeva, N. L. Podkolodnyy, V. A. Ivanisenko, P. S. Demenkov, S. A. Lashin, M. P. Ponomarenko

“…This conclusion was consistent with literature data on a key role an efficient signal transduction from the peripheral to the central system from the peripheral to the central system for adjusting the human circadian rhythm through detection of a change from the dark of night to the light of day and for identification of the direction of the source of sound by auditory brainstem nuclei, for generating the response to cold stress and for physical coordination. 21 candidate SNP marker of significant SCN9A over- and underexpression. …”
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Involvement of Cholesterol Metabolic Pathways in Recovery from Noise-Induced Hearing Loss by Na Sai, Xi Shi, Yan Zhang, Qing-qing Jiang, Fei Ji, Shuo-long Yuan, Wei Sun, Wei-Wei Guo, Shi-Ming Yang, Wei-Ju Han

“…We used miniature pigs exposed to white noise at 120 dB (A) as a model. Auditory brainstem response (ABR) measurements were made before noise exposure, 1 day and 7 days after noise exposure. …”
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Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic tool by Shigeo Sakuragi, Tomoya Uchida, Naoki Kato, Boxiao Zhao, Toshiki Takahashi, Akito Hattori, Yoshihiro Sakata, Yoshiyuki Soeda, Akihiko Takashima, Hideaki Yoshimura, Gen Matsumoto, Hiroko Bannai

“…Tau aggregation originates in the brainstem and entorhinal cortex and then spreads throughout the brain in Alzheimer’s disease (AD), which is the most prevalent type of tauopathy. …”
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Genetic and audiological determinants of hearing loss in high-risk neonates by Yanan Shi, Naiyao Zhang, Na Du, Tongxi Zheng, Ying Yu, Youjin Li

“…Methods: We conducted initial hearing screenings, including automated auditory brainstem response, distortion product otoacoustic emission, and acoustic immittance on 443 high-risk neonates within 7 days after birth and 42 days (if necessary) after birth. …”
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Identification of genetic mechanisms of non-isolated auditory neuropathy with various phenotypes in Chinese families by Yang Cao, Xiaolong Zhang, Lan Lan, Danyang Li, Jin Li, Linyi Xie, Fen Xiong, Lan Yu, Xiaonan Wu, Hongyang Wang, Qiuju Wang

“…Diagnostic assessments included auditory brainstem response and distortion product otoacoustic emissions, supplemented by other examinations. …”
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Hsp70/Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model by Guoxia Zhu, Yongxiang Wu, Yang Qiu, Keyong Tian, Wenjuan Mi, Xinqin Liu, Yuanyuan Chen, Jinwen Jia, Jiasheng Luo, Lianjun Lu, Jianhua Qiu

“…Moreover, the auditory brainstem responses (ABRs) and electron microscopy revealed that SC could protect against acute acoustic trauma (AAT) based on a significant reduction of hearing impairment and visible reduction in outer hair cell loss as well as ultrastructural changes in OHCs and SGNs. …”
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The multifaceted role of the inferior colliculus in sensory prediction, reward processing, and decision-making by Xinyu Du, Haoxuan Xu, Peirun Song, Yuying Zhai, Hangting Ye, Xuehui Bao, Qianyue Huang, Hisashi Tanigawa, Zhiyi Tu, Pei Chen, Xuan Zhao, Josef P Rauschecker, Xiongjie Yu

“…The inferior colliculus (IC) has traditionally been regarded as an important relay in the auditory pathway, primarily involved in relaying auditory information from the brainstem to the thalamus. However, this study uncovers the multifaceted role of the IC in bridging auditory processing, sensory prediction, and reward prediction. …”
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Age dependent deficits in speech recognition in quiet and noise are reflected in MGB activity and cochlear onset coding by Konrad Dapper, Stephan M. Wolpert, Jakob Schirmer, Stefan Fink, Etienne Gaudrain, Deniz Başkent, Wibke Singer, Sarah Verhulst, Christoph Braun, Ernst Dalhoff, Lukas Rüttiger, Matthias H.J. Munk, Marlies Knipper

“…Based on previous analyses performed in these same subjects, elevated thresholds in extended high-frequency regions were linked to cochlear synaptopathy and auditory brainstem delays. Also, independent of hearing loss, poor speech-performing groups in quiet or with ipsilateral noise during TFS or TENV coding could be linked to lower or better outer hair cell performance and delayed or steeper auditory nerve responses at stimulus onset. …”
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Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma by Thomas Kapapa, Vanida Wernheimer, Andrea Hoffmann, Tamara Merz, Fabia Zink, Eva-Maria Wolfschmitt, Oscar McCook, Josef Vogt, Martin Wepler, David Alexander Christian Messerer, Claire Hartmann, Angelika Scheuerle, René Mathieu, Simon Mayer, Michael Gröger, Nicole Denoix, Enrico Clazia, Peter Radermacher, Stefan Röhrer, Thomas Datzmann

“…Extracerebral, intraparenchymal–extraventricular and intraventricular blood, combined with brainstem and basal ganglia injury, influenced the experiment and its outcome. …”
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Fractionated robotic radiosurgery for unfavorable nonfunctioning pituitary macroadenoma: 5-year outcomes from a single institution protocol by Akrita Bhatnagar, Monica Pernia Marin, Jonathan W. Lischalk, Min Ji Koh, Siviero Agazzi, Simeng Suy, Brent T. Harris, Susmeeta T. Sharma, Edward Aulisi, Amjad Anaizi, Mohamed H. Khattab, Walter C. Jean, Walter C. Jean, Sean P. Collins, Brian T. Collins

“…A tumor was considered unfavorable if the gross tumor volume (GTV) was larger than 5 cc or if it closely approached a critical structure (optic apparatus, brainstem, or pituitary gland). Local control was calculated using the Kaplan–Meier method.ResultsTwenty predominantly female patients (60%), ages 21–77 (median: 53 years), were included in this study. …”
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An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene by Zita Reisz, Rita Pereira, Smitha Nevis, Alan Mackay, Leena Bhaw, Yura Grabovska, Ross Laxton, Valeria Molinari, Anna Burford, Barnaby Clark, Cristina Bleil, Bassel Zebian, Erika Pace, Annette Weiser, Fernando Carceller, Lynley Marshall, Andrew King, Istvan Bodi, Safa Al-Sarraj, Chris Jones, Matthew Clarke

“…We report one such case of a 2-year-old female presenting with neurological symptoms; MRI imaging identified a brainstem lesion which was biopsied. Histology showed diffusely infiltrating pleomorphic astrocytes, multinucleated cells, and conspicuous mitotic activity; the diagnosis was DMG, H3 K27-altered (immunohistochemistry: H3K27me3 loss, H3K27M positivity). …”
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Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[18F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nit... by Skye Hsin-Hsien Yeh, Wen-Sheng Huang, Chuang-Hsin Chiu, Chuan-Lin Chen, Hui-Ting Chen, Dae Yoon Chi, Zhengxing Ge, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Chun-Tse Hung, Geng-Ying Li, Chi-Wei Chang

“…At 3 h postinjection of LPS, in vivo, the [18F]FBAT accumulation ratios at 30 min post intravenous (i.v.) radiotracer injection for the whole brain, cortex, cerebellum, and brainstem were 2.16±0.18, 1.53±0.25, 1.41±0.21, and 1.90±0.12, respectively, compared to those of mice not injected with LPS. …”
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Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

“…Two-month-old C57BL/6 J mice were exposed to white noise at 96 dB SPL for 8 h per day over 7 days to induce TTS. Auditory brainstem response (ABR) was monitored to assess changes in hearing thresholds, tracking the effects of noise exposure until the mice reached 12 months of age. …”
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