Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer’s Disease by A. Ahnaou, C. Walsh, N. V. Manyakov, S. A. Youssef, W. H. Drinkenburg

“…The ability of the K18 seed in the brainstem LC to elicit such robust functional alterations in distant hippocampal structures in the absence of pathology challenges the classic view that tau pathology spread to an area is necessary to elicit functional impairments in that area.…”
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Primary large B-cell lymphoma of the central nervous system misdiagnosed as autoimmune encephalitis: a case report by Aihui Ren, Guanwen Zeng, Riling Chen, Zhixing Cao, Wenyan Zhuo, Yubin Liang, Yubin Liang

“…Initial cerebrospinal fluid (CSF) analysis was unremarkable, while MRI scans (both plain and contrast-enhanced) showed abnormal signals in the left brainstem, thalamus, and basal ganglia regions, with specific enhancement patterns, and arterial spin labeling (ASL) demonstrated hyperperfusion. …”
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Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice by Max Meuser, Susanne Schwitzer, Parisa Faraji, Arne Ernst, Dietmar Basta

“…Methods: Frequency-specific auditory brainstem potential thresholds (ABR) were determined in young adult mice. …”
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Chiari malformation with concurrent papilledema: a patient-level meta-analysis of case reports and case series by Alejandro Pando, Daniel J. Valdivia, Daniel A. Brenner, Mohammed Ali Alvi, Hai Sun, James K. Liu, Ira Goldstein

“…Abstract Background Chiari I malformation, characterized by the displacement of cerebellar tonsils, and Chiari 1.5, involving cerebellar tonsils and brainstem displacement, share symptoms with Idiopathic Intracranial Hypertension, including headache, paresthesia, vision issues, shoulder/arm pain, diplopia, numbness, and motor weakness. …”
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ASSOCIATION BETWEEN SENSORIAL OTOLITHIC DEFICIT AND HEARING LOSS IN CHILDREN by Constantin Guma, Cristian Marius Mârțu, Sebastian Cozma, Raluca Olariu, Luminița Rădulescu, Alexandru Stingheriu, Iustin Iațentiuc, Mădălina Georgescu, Violeta Necula, Oana Bitere-Popa

“…The audiological assessment protocol included tympanometry, otoacoustic emissions, auditory steady-state response, and brainstem-evoked response audiometry. The subjects were divided into two groups as follows: a normal hearing group and a group with varying degrees of hearing loss. …”
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A Cross Sectional Study of Assessment of Hearing in Infants of Gestational Diabetes Mothers by Srikanth Gopinath, Arulmozhi Sakthignanavel, Atul Mukul Bage, Rajan ND, Sasmita Mishra

“…Hearing screening among the infants were done using Otoacoustic emissions and Brainstem evoked response audiometry (OAE and BERA). …”
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Hippocampus-sparing volume-modulated arc therapy in patients with World Health Organization grade II glioma: a feasibility study by Renxian Xie, Renxian Xie, Hongxin Huang, Hongxin Huang, Qingxin Cai, Jiayang Lu, Tong Chen, Tong Chen, Keyan Xie, Jianzhou Chen, Chuangzhen Chen

“…Regarding the protection of OARs, HS VMAT plans were equally capable and even lowered the radiation dosages to the brainstem (35.56 vs. 41.74 Gy, p = 0.017) and spinal cord (1.34 vs. 1.43 Gy, p = 0.006). …”
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Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss by Jiali Liu, Haisen Peng, Yuehui Liu, Chunhua Li, Wen Xie

“…Hearing function and loss of outer hair cells (HCs) in ARHL rats were measured using the auditory brainstem response and cochlear silver nitrate staining, respectively. …”
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Stem Cell Therapy for the Treatment of Amyotrophic Lateral Sclerosis: Comparison of the Efficacy of Mesenchymal Stem Cells, Neural Stem Cells, and Induced Pluripotent Stem Cells by Lauren Frawley, Noam Tomer Taylor, Olivia Sivills, Ella McPhillamy, Timothy Duy To, Yibo Wu, Beek Yoke Chin, Chiew Yen Wong

“…Background/Objectives: <i>Amyotrophic lateral sclerosis</i> (ALS), or Lou Gehrig’s disease, is a debilitating, incurable neurodegenerative disorder characterised by motor neuron death in the spinal cord, brainstem, and motor cortex. With an incidence rate of about 4.42 cases per 100,000 people annually, ALS severely impacts motor function and quality of life, causing progressive muscle atrophy, spasticity, paralysis, and eventually death. …”
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Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients by Amgad Droby, Avital Yoffe-Vasiliev, Daniel Atias, Kyle B. Fraser, Omar S. Mabrouk, Nurit Omer, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Moran Artzi, Dafna Ben Bashat, Roy N. Alcalay, Avi Orr-Urtreger, Julia C. Shirvan, Jesse M. Cedarbaum, Nir Giladi, Anat Mirelman, Avner Thaler

“…PD-SAA+ patients showed lower whole-brain gray matter, putamenal, brainstem, and substantia nigra volumes, reduced FC in the left caudate, and lower fractional anisotropy in the left fronto-occipital fasciculus compared to PD-SAA−. …”
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Tyrosine hydroxylase of the brain and it’s regulation by glucocorticoids by E. V. Sukhareva, T. S. Kalinina, V. V. Bulygina, N. N. Dygalo

“…Moreover, our treatment led to increase in TH mRNA levels in 25- and 70-day-old animals, as well as an increase in enzyme activity in the brainstem and cerebral cortex of adult rats. The long-term changes in TH expression are limited by the perinatal period of development. …”
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Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence by Bu-Sheng Tong, Zi-Yu He, Chen-Ru Ding, Juan-Mei Yang, Jing Wang, Zhao Han, Yi-Bo Huang, Na Gao, Xian-Hao Jia, Fang-Lu Chi, Dong-Dong Ren

“…We evaluated the mechanism of hearing loss in a guinea pig model of bony dehiscence with various sizes and locations along the superior semicircular canal. Auditory brainstem responses (ABRs) and laser Doppler velocimetry were used to measure hearing loss and vibration changes before and after fenestration, as well as after restorative patching. …”
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Safety of transtympanic application of probiotics in a chinchilla animal model by Carol Nhan, Aren Bezdjian, Shyamali Saha, Satya Prakash, Lily H. P. Nguyen, Sam J. Daniel

“…Ten chinchillas each had one ear randomly assigned to receive 109 CFU/mL of Lactobacillus plantarum solution, while the contralateral ear received saline. Auditory brainstem responses were measured bilaterally at 8, 20, 25 kHz before, at 7–10 days after application, and at 28 days after application of probiotic or saline. …”
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Activation of the periaqueductal gray controls respiratory output through a distributed brain network by Mitchell Prostebby, Jashan Saini, Vivian Biancardi, Vivian Biancardi, Vivian Biancardi, Clayton T. Dickson, Clayton T. Dickson, Clayton T. Dickson, Clayton T. Dickson, Silvia Pagliardini, Silvia Pagliardini, Silvia Pagliardini

“…In contrast, stimulating PAG terminals in either preBötC or pFL with long or shorter timescale stimuli could not completely replicate the effects of direct PAG stimulation and also did not produce any respiratory reset.ConclusionsOur results show that the effects of PAG activity on respiration are not mediated solely by PAG inputs to either the preBötC or pFL and more likely involve integration across a larger network of brainstem areas.…”
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Neurophysiological Effects of Chronic Indoor Environmental Toxic Mold Exposure on Children by Ebere C. Anyanwu, Andrew W. Campbell, Aristo Vojdani

“…The children then underwent a series of neurophysiological tests including electroencephalogram (EEG), brainstem evoked potential (BAEP), visual evoked potential (VEP), and somatosensory evoked potential (SSEP). …”
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Conversion from clinically isolated syndrome to multiple sclerosis: what paraclinical tests findings are the most characteristic? by M. Malciūtė, I. Čelpačenko, R. Stankevičiūtė, R. Balnytė

“…The data were obtained from medical records and included findings of paraclinical tests (magnetic resonance imaging (MRI), IgG levels and oligoclonal bands (OCBs) in cerebrospinal fluid (CSF), and brainstem auditory evoked potential (BAEP)) and final diagnosis. …”
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Identifying key signs of motor neurone disease in primary care: a nested case–control study using the QResearch database by Aleksandar Radunović, Carol Coupland, Julia Hippisley-Cox, Christopher J McDermott, Tom A Ranger, Judith Burchardt, Xue W Mei

“…Patients who reported symptoms indicative of damage to the lower brainstem and its connections were diagnosed sooner than those who presented with respiratory or cognitive signs.Conclusion This is the first study that has identified, confirmed and quantified the association of key symptoms and signs with MND diagnosis. …”
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Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling by Kelly G. Jameson, Sabeen A. Kazmi, Takahiro E. Ohara, Celine Son, Kristie B. Yu, Donya Mazdeyasnan, Emma Leshan, Helen E. Vuong, Jorge Paramo, Arlene Lopez-Romero, Long Yang, Felix E. Schweizer, Elaine Y. Hsiao

“…Metabolite-induced and receptor-dependent increases in vagal activity correspond with the activation of brainstem neurons. Results from this study reveal that the gut microbiome regulates select metabolites in the intestinal lumen that differentially activate vagal afferent neurons, thereby enabling the microbial modulation of chemosensory signals for gut-brain communication.…”
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CircRNA-miRNA-mRNA regulatory network in high-altitude hypobaric hypoxia-induced hearing impairment and hearing acclimatization by Danzeng Awang, Kanzi Danzeng, Tianheng Wang, Quzong Deji, Mengting Huang, Hailong Ren, Xinzhu Liu, Binghan Zhao, Lanzi Gongga

“…Hearing acclimatization was determined using the Auditory Brainstem Response (ABR) test. Cochlea tissues were isolated, and high-throughput circRNA analysis and mRNAs-sequencing were performed. …”
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A Novel Nomogram for Predicting the Risk of Pneumonia After Intracerebral Hemorrhage by Sun Y, Zhang L, Huang B, He Q, Hu B

“…In the multivariate analysis, ten variables were included in the model: age (β= 0.023, P< 0.001), hospital days (β=0.392, P< 0.001), baseline mRS score (β=0.484, P< 0.001), baseline GCS score (β=− 0.285, P< 0.001), hs-CRP (β=0.328, P< 0.001), hematoma volume (β=0.376, P< 0.001), brainstem hemorrhage (β=0.956, P=0.002), intraventricular hemorrhage (β=0.629, P=0.001), and β-blocker (β=0.899, P< 0.001) In the training subset, the areas under curve were 0.805 (95% CI, 0.773– 0.833). …”
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