Transport of Alzheimer's associated amyloid-β catalyzed by P-glycoprotein. by James W McCormick, Lauren McCormick, Gang Chen, Pia D Vogel, John G Wise

“…However, previous studies on the ability of P-gp to directly transport the Alzheimer's associated amyloid-β (Aβ) protein have produced contradictory results. …”
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Letter response to Clifford et al. “Navigating late‐stage dementia: A perspective from the Alzheimer's Association” by Stanley Arnold Terman, Karl E. Steinberg, Thaddeus Mason Pope

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Chronic neuropsychiatric sequelae of SARS‐CoV‐2: Protocol and methods from the Alzheimer's Association Global Consortium by Gabriel A. deErausquin, Heather Snyder, Traolach S. Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, Carmela Tartaglia, Charlotte Teunissen, Krister Håkanson, Rufus Akinyemi, Kameshwar Prasad, Giovanni D'Avossa, Gabriela Gonzalez‐Aleman, Akram Hosseini, George D. Vavougios, Perminder Sachdev, John Bankart, Niels Peter Ole Mors, Richard Lipton, Mindy Katz, Peter T. Fox, Mohammad Zia Katshu, M. Sriram Iyengar, Galit Weinstein, Hamid R. Sohrabi, Rachel Jenkins, Dan J. Stein, Jacques Hugon, Venetsanos Mavreas, John Blangero, Carlos Cruchaga, Murali Krishna, Ovais Wadoo, Rodrigo Becerra, Igor Zwir, William T. Longstreth, Golo Kroenenberg, Paul Edison, Elizabeta Mukaetova‐Ladinska, Ekkehart Staufenberg, Mariana Figueredo‐Aguiar, Agustín Yécora, Fabiana Vaca, Hernan P. Zamponi, Vincenzina Lo Re, Abdul Majid, Jonas Sundarakumar, Hector M. Gonzalez, Mirjam I. Geerlings, Ingmar Skoog, Alberto Salmoiraghi, Filippo Martinelli Boneschi, Vibuthi N. Patel, Juan M. Santos, Guillermo Rivera Arroyo, Antonio Caballero Moreno, Pascal Felix, Carla Gallo, Hidenori Arai, Masahito Yamada, Takeshi Iwatsubo, Malveeka Sharma, Nandini Chakraborty, Catterina Ferreccio, Dickens Akena, Carol Brayne, Gladys Maestre, Sarah Williams Blangero, Luis I. Brusco, Prabha Siddarth, Timothy M. Hughes, Alfredo Ramírez Zuñiga, Joseph Kambeitz, Agustin Ruiz Laza, Norrina Allen, Stella Panos, David Merrill, Agustín Ibáñez, Debby Tsuang, Nino Valishvili, Srishti Shrestha, Sophia Wang, Vasantha Padma, Kaarin J. Anstey, Vijayalakshmi Ravindrdanath, Kaj Blennow, Paul Mullins, Emilia Łojek, Anand Pria, Thomas H. Mosley, Penny Gowland, Timothy D. Girard, Richard Bowtell, Farhaan S. Vahidy

“…Discussion The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long‐term neurocognitive sequelae of SARS‐CoV‐2 infection. …”
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Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population by Yuxia Li, Meimei Kang, Can Sheng, Guanqun Chen, Taoran Li, Jun Wang, Yanning Cai, Rong Wang, Ying Han

“…We investigated the relationship between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) levels and apolipoprotein epsilon 4 (ApoE ɛ4) alleles, as well as other factors that cause cognitive decline, in the cognitively normal population. …”
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The role of dyadic cognitive report and subjective cognitive decline in early ADRD clinical research and trials: Current knowledge, gaps, and recommendations by Rachel L. Nosheny, Rebecca Amariglio, Sietske A.M. Sikkes, Carol Van Hulle, Maria Aparecida Camargos Bicalho, N. Maritza Dowling, Sonia Maria Dozzi Brucki, Zahinoor Ismail, Kensaku Kasuga, Elizabeth Kuhn, Katya Numbers, Anna Aaronson, Davide Vito Moretti, Arturo X. Pereiro, Gonzalo Sánchez‐Benavides, Allis F. Sellek Rodríguez, Prabitha Urwyler, Kristina Zawaly, for the Dyadic Patterns of Subjective Report working group within the Subjective Cognitive Decline Professional Interest Area, Alzheimer's Association ISTAART

“…The Subjective Cognitive Decline Professional Interest Area within the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment convened a working group focused on dyadic patterns of subjective report. …”
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Application of the revised criteria for diagnosis and staging of Alzheimer's disease: Drug development and clinical practice by Clifford R. Jack, Ana Graf, Samantha C. Burnham, Erin G Doty, Hans J. Moebius, Philip Montenigro, Eric Siemers, Kaycee M. Sink, Leslie M. Shaw, Charlotte Thim Hansen, Kristin R. Wildsmith, Simin Mahinrad, Maria C. Carrillo, Christopher J. Weber

“…Abstract The newly proposed revised criteria for diagnosis and staging of Alzheimer's disease (AD) by the Alzheimer's Association (AA) Workgroup represent a significant milestone in the field. …”
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Current understanding of AD pathophysiology and impact of amyloid‐beta targeted treatments on biomarkers and clinical endpoints by Ronald C. Petersen, Ana Graf, Maria C. Carrillo, Christopher J. Weber

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Understanding recent advances in non‐amyloid/non‐tau (NANT) biomarkers and therapeutic targets in Alzheimer's disease by Linda J. Van Eldik, Eric R. Siemers, Emily C. Collins, Michael Gold, David Henley, Peter Johannsen, Hans J. Möbius, Melanie Shulman, Jin Zhou, Maria Carrillo, Christopher Weber

“…Highlights The Alzheimer's Association Research Roundtable (AARR) convened leaders from industry, academia, and government to review the current state of non‐beta amyloid and non‐tau (NANT) targets on underlying Alzheimer's disease (AD) pathophysiology. …”
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Alzheimer's disease drug development in an evolving therapeutic landscape by Stacie Weninger, Michael C. Irizarry, Adam S. Fleisher, Teresa León, Paul Maruff, David S. Miller, Sheila Seleri, Maria C. Carrillo, Christopher J. Weber

“…Highlights The Alzheimer's Association Research Roundtable (AARR) convened leaders from industry and academia, as well as patients, clinicians, and government and regulatory agency scientists to discuss the topic, “Alzheimer's Disease Drug Development in an Evolving Therapeutic Landscape.” …”
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Alzheimer's disease: part 2 – the present by Ricardo Nitrini

“…Recently, new diagnostic criteria for AD were presented by the Alzheimer's Association, causing controversy about their use in clinical practice.…”
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Person‐centered assessment of apathy and resistance to care in people living with dementia: Review of existing measures by Benjamin T. Mast, Emilee M. Ertle, Ann Kolanowski, Gail Mountain, Esme Moniz‐Cook, Margareta Halek

“…Abstract Introduction The review described in this paper builds upon the Dementia Care Practice Recommendations (DCPR) published by the Alzheimer's Association in 2018 and addresses behavior change and the need for targeted outcome measures that evolve from person‐centered frameworks and help evaluate interventions. …”
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Living Lab Dementia: process evaluation of an academic-practice partnership in German long term care for people living with dementia - study protocol by Andrea Leinen, Felix Bühler, Sascha Köpke, Mareike Löbberding, Gabriele Meyer, Helga Schneider-Schelte, Stefan Wilm, Anja Bieber, Martin N. Dichter

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Hypothalamic volume is associated with age, sex and cognitive function across lifespan: a comparative analysis of two large population-based cohort studiesResearch in context by Peng Xu, Santiago Estrada, Rika Etteldorf, Dan Liu, Mohammad Shahid, Weiyi Zeng, Deborah Früh, Martin Reuter, Monique M.B. Breteler, N. Ahmad Aziz

“…Funding: Institutional funds, Federal Ministry of Education and Research of Germany, Alzheimer's Association.…”
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The Effectiveness of Motor Imagery in Balance and Functional Status of Older People with Early-Stage Dementia by Anna Christakou, Christina Bouzineki, Marousa Pavlou, George Stranjalis, Vasiliki Sakellari

“…Methods: Overall, 160 participants (43 men, 117 women, MMSE M = 23.20, SD = 0.15) from an Athens Day Care Center of the Alzheimer Association were randomized to (a) the MI and exercise group (experimental group) (n = 55), (b) the only exercise group (1st control group) (n = 52) and (c) the neither MI nor exercise group (2nd control group) (n = 53). …”
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Cerebrospinal Fluid Classical Biomarker Levels in Mixed vs. Pure A⁺T⁺ (A⁺T₁⁺) Alzheimer’s Disease by Ioanna Tsantzali, Athanasia Athanasaki, Fotini Boufidou, Vasilios C. Constantinides, Maria-Ioanna Stefanou, Christos Moschovos, Christina Zompola, Sotirios G. Paraskevas, Anastasios Bonakis, Sotirios Giannopoulos, Georgios Tsivgoulis, Elisabeth Kapaki, George P. Paraskevas

“…<b>Methods</b>: Classical CSF AD biomarkers were determined in a total of 61 patients, classified as both beta amyloid- and tau-positive A⁺T⁺ (or A⁺T₁⁺ according to the recently revised Alzheimer Association criteria for diagnosis and staging of AD). …”
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Effects of Mental Imagery on Quality of Life, Cognitive, and Emotional Status in Older Adults with Early-Stage Alzheimer’s Disease Dementia: A Randomized Controlled Trial by Anna Christakou, Christina Bouzineki, Marousa Pavlou, George Stranjalis, Vasiliki Sakellari

“…The sample from an Athens Day Care Center of the Alzheimer Association was randomized to (a) the MI and exercise group (intervention group, n = 55), (b) the only exercise group (1st control group, n = 52), and (c) the neither MI nor exercise group (2nd control group, n = 53). …”
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Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges by Saeid Safiri, Saeid Safiri, Amir Ghaffari Jolfayi, Asra Fazlollahi, Soroush Morsali, Soroush Morsali, Aila Sarkesh, Amin Daei Sorkhabi, Behnam Golabi, Reza Aletaha, Kimia Motlagh Asghari, Sana Hamidi, Sana Hamidi, Seyed Ehsan Mousavi, Sepehr Jamalkhani, Nahid Karamzad, Nahid Karamzad, Ali Shamekh, Reza Mohammadinasab, Mark J. M. Sullman, Mark J. M. Sullman, Fikrettin Şahin, Ali-Asghar Kolahi

“…The National Institute on Aging and the Alzheimer's Association have updated diagnostic criteria to include biomarker data, enhancing early diagnosis.ConclusionThe management of AD includes pharmacological treatments, such as cholinesterase inhibitors and NMDA receptor antagonists, which provide symptomatic relief but do not slow disease progression. …”
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Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China by Yongxiang Wang, Xiaolei Han, Xianda Zhang, Zhonglin Zhang, Lin Cong, Shi Tang, Tingting Hou, Cuicui Liu, Xiaojuan Han, Qinghua Zhang, Jianli Feng, Ling Yin, Lin Song, Yi Dong, Rui Liu, Yuanjing Li, Tiia Ngandu, Miia Kivipelto, Heather Snyder, Maria Carrillo, Jonas Persson, Laura Fratiglioni, Lenore J Launer, Jianping Jia, Yifeng Du, Chengxuan Qiu

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Identification of late-stage tau accumulation using plasma phospho-tau217Research in context by Marcel S. Woo, Joseph Therriault, Erin M. Jonaitis, Rachael Wilson, Rebecca E. Langhough, Nesrine Rahmouni, Andrea Lessa Benedet, Nicholas J. Ashton, Cécile Tissot, Juan Lantero-Rodriguez, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez Arias, Seyyed Ali Hosseini, Tobey J. Betthauser, Firoza Z. Lussier, Robert Hopewell, Gallen Triana-Baltzer, Hartmuth C. Kolb, Andreas Jeromin, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Jesse Klostranec, Paolo Vilali, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Sterling C. Johnson, Pedro Rosa-Neto

“…Funding: This research is supported by the Weston Brain Institute, Canadian Institutes of Health Research (CIHR) [MOP-11-51-31; RFN 152985, 159815, 162303], Canadian Consortium of Neurodegeneration and Aging (CCNA; MOP-11-51-31 -team 1), the Alzheimer's Association [NIRG-12-92090, NIRP-12-259245], Brain Canada Foundation (CFI Project 34874; 33397), the Fonds de Recherche du Québec—Santé (FRQS; Chercheur Boursier, 2020-VICO-279314). …”
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