Efficacy and safety of edoxaban in patients with chronic thromboembolic pulmonary hypertension: protocol for a multicentre, randomised, warfarin-controlled, parallel group trial -... by Keiichi Fukuda, Satoshi Yasuda, Hiroyuki Tsutsui, Toyoaki Murohara, Kohtaro Abe, Koichiro Tatsumi, Junji Kishimoto, Yu Taniguchi, Yuichi Tamura, Koji Todaka, Shun Minatsuki, Kazuya Hosokawa, Yuko Kobayakawa, Takumi Inami, Nobutaka Ikeda

“…Currently, the use of direct oral anticoagulants (DOACs) in CTEPH has increased with the advent of four DOACs. The safety of DOACs is superior to warfarin, with less intracranial bleeding in patients with non-valvular atrial fibrillation and venous thromboembolism. …”
Get full text

Complex Cloud-Sea Background Simulation for Space-Based Infrared Payload Digital Twin by Wen Sun, Yejin Li, Fenghong Li, Guangsen Liu, Peng Rao

“…The advent of Industry 4.0 has highlighted the requirements for the digitization and intelligent evolution of space-based payloads. …”
Get full text

Miniperc percutaneous nephrolithotomy versus retrograde intrarenal surgery in the treatment of juxta uretero-pelvic junction upper ureteric calculi: A prospective, randomized contr... by T. P. Pradhyumna Koushik, Vivek Meyyappan, Nakul Baban Aher, Hariharasudhan Sekar, Gayathri Thiruvengadam, Sriram Krishnamoorthy

“…Offering PCNL for smaller stones was considered an overkill by many urologists. However, with the advent of miniaturized PCNL and improvisations in RIRS techniques, more and more of such stones are tackled with ease. …”
Get full text

Acute effects of physical exercise on cognitive function and neurotrophins in patients with type 1 diabetes: A systematic review by Emanuele Zanardo, Giulia Quinto, Francesca Battista, Federica Duregon, Marco Vecchiato, Chiara Bergia, Kirk Erickson, Andrea Ermolao, Daniel Neunhaeuserer

Get full text

THE BIOSYNTHESIS REGULATION OF POTATO STEROIDAL GLYCOALKALOIDS by K. A. Ivanova, S. V. Gerasimova, E. K. Khlestkina

“…In the course of potato domestication, plants with a lower SGA level were selected. The advent of approaches for manipulation with the regulation of metabolic pathways provides an opportunity to overcome the undesirable direct relationship between the potato resistance to pests and the toxicity of its tubers. …”
Get full text

The Contemporary Critical Reception of Walter Pater: Retrospective and Proleptical Views by Geoffrey Sadock

“…Since the advent of the Computer Age, there has been a veritable explosion in late Victorian studies in general and in Pater studies in particular. …”
Get full text

Leadership Perceptions, Educational Struggles and Barriers, and Effective Modalities for Teaching Vertigo and the HINTS Exam: A National Survey of Emergency Medicine Residency Prog... by Mary McLean, Justin Stowens, Ryan Barnicle, Negar Mafi, Kaushal Shah

Get full text

Medicinal plants used to treat human ailments in Wadla District, Northern Ethiopia: An ethnobotanical approach by Sara Yosef, Ermias Lulekal, Asfaw Debela, Muhidin Tahir

“…Introduction: The global population started using traditional medicine before the advent of allopathic or modern medicine to manage several diseases. …”
Get full text

Transcriptome analysis of ovarian cancer uncovers association between tumor-related inflammation/immunity and patient outcome by Jingfang Wang, Wenrui Zhu, Xia Li, Yuanyuan Wu, Wenhui Ma, Yangzhou Wang, Weihong Zhao, Fang Wei, Wenhao Wang

“…In recent years, with the advent of PARPi, the treatment of ovarian cancer has entered a new stage of full-process management. …”
Get full text

Stock price prediction with attentive temporal convolution-based generative adversarial network by Ying Liu, Xiaohua Huang, Liwei Xiong, Ruyu Chang, Wenjing Wang, Long Chen

“…Traditional prediction models such as ARIMA and classic linear regression models are often inadequate for capturing the complex dynamics of stock prices. The advent of deep learning has led to substantial improvements in prediction accuracy, with various recurrent neural networks widely employed for representation learning from stock sequences. …”
Get full text

Postoperative Analgesic Effects of Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Pediatric Lower Abdominal Surgeries: A Systematic Review and Meta-Analysis by Aldalati AY, Hussein AM, Ataya R, Alrabadi B, Odat RM, Idrees M, Al-dabagh A, Kamal Z, Aloudat O, Al-qaoud A

“…Abdullah Yousef Aldalati,1 Ayham Mohammad Hussein,2 Raghad Ataya,1 Bassel Alrabadi,1 Ramez M Odat,1 Muhammad Idrees,3 Ahmad Al-dabagh,4 Zaid Kamal,5 Osama Aloudat,6 Ahmad Al-qaoud7 1Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 2Faculty of Medicine, Al-Balqa’ Applied University, Salt, Jordan; 3Lahore General Hospital, Lahore, Punjab, Pakistan; 4Faculty of Medicine, Sana’a University, Sana’a, Yemen; 5Department of General Surgery, Advent Health Medical Group, Tampa FL, USA; 6Department of Pediatrics of Saint Louis University School of Medicine, SSM Health Cardinal Glennon Children’s Hospital, St. …”
Get full text

From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment by Basingab FS, Alshahrani OA, Alansari IH, Almarghalani NA, Alshelali NH, Alsaiary AH, Alharbi N, Zaher KA

“…We initially explored the historical context of breast cancer treatment, highlighting the limitations of conventional therapies, such as surgery, radiation, and chemotherapy. The advent of nanotechnology has introduced a new era characterized by the development of various nanoparticles, including liposomes, dendrimers, and gold nanoparticles, designed to target cancer cells with remarkable precision. …”
Get full text

Enabling regulatory policy globally will promote realization of the potential of animal biotechnology by Eric Hallerman, Justin Bredlau, Luiz Sergio A. Camargo, Maria Lucia Zaidan Dagli, Margaret Karembu, Daniel Kovich, Anne Ndanu Muia, Mariana L. Murrone, Pedro Jesus Rocha-Salavarrieta, Rhodora Romero-Aldemita, Mark Tizard, Mark Walton, Diane Wray-Cahen

“…Only one biotech animal in the world that was developed for food production has reached the market under a GMO or rDNA approval process. The advent of genome editing techniques has revolutionized the scientific approach to introducing changes into DNA sequences and how biotechnology can be used to enhance agricultural breeding. …”
Get full text

Evaluating survival outcomes and treatment recommendations in resectable gastric cancer by Saad Sabbagh, Iktej Singh Jabbal, María Herrán, Mohamed Mohanna, Sindu Iska, Mira Itani, Barbara Dominguez, Kaylee Sarna, Zeina Nahleh, Arun Nagarajan

Get full text

A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

“…Abstract Background The advent of immunotherapy has revolutionized the treatment paradigm for gastric cancer (GC), offering unprecedented clinical benefits. …”
Get full text

Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial by Jeffrey M. Clarke, George R. Simon, Hirva Mamdani, Lin Gu, James E. Herndon, Thomas E. Stinchcombe, Neal Ready, Jeffrey Crawford, Guru Sonpavde, Stephen Balevic, Andrew B. Nixon, Michael Campa, Elizabeth B. Gottlin, Huihua Li, Ruchi Saxena, You Wen He, Scott Antonia, Edward F. Patz

Get full text

Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…For this reason, the growing tendency to build sumptuous dwellings, with an enviable viewpoint overlooking the Sarno plain below, led to buildings being extended above and beyond the defensive walls, even reusing structural parts that were no longer considered necessary.In the same way, many of the cisterns behind them lost their function, being converted into rooms in the house or used as stairways or corridors.The large basins seem to have retained their function until the advent of the aqueduct system, introduced in Pompeii in the Augustan age. …”
Get full text

5G Networks Security Mitigation Model: An ANN-ISM Hybrid Approach by Rafiq Ahmad Khan, Habib Ullah Khan, Hathal Salamah Alwageed, Hussein Al Hashimi, Ismail Keshta

“…The advent of Fifth-Generation (5G) networks has introduced significant security challenges due to increased complexity and diverse use cases. …”
Get full text

On the tracks of an uninvited guest, the Asian tiger mosquito, Aedes albopictus in Cyprus by Riccardo Piccinno, Giulia Fiorenza, Marlen Ines Vasquez, Jeremy Bouyer, Gregoris Notarides, Ludvik Marcus Gomulski, Soteris Meletiou, Mustafa Akiner, Antonios Michaelakis, Federico Forneris, Giovanni Maga, Giuliano Gasperi, Anna Rodolfa Malacrida

“…An ongoing mosquito dispersal within the Limassol district was detected, suggesting the presence of established, hidden adventive populations. These mosquitoes share a high degree of ancestry with those in the Balkans and parts of northern Italy that border the Adriatic Sea. …”
Get full text

ColMA‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells by Giacomo Cortella, Erwin Pavel Lamparelli, Maria Camilla Ciardulli, Joseph Lovecchio, Emanuele Giordano, Nicola Maffulli, Giovanna Della Porta

“…Abstract The advent of bioprinting has enabled the creation of precise three‐dimensional (3D) cell cultures suitable for biomimetic in vitro models. …”
Get full text