Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice by Christian Thome, Jan Maximilian Janssen, Seda Karabulut, Claudio Acuna, Elisa D'Este, Stella J Soyka, Konrad Baum, Michael Bock, Nadja Lehmann, Johannes Roos, Nikolas A Stevens, Masashi Hasegawa, Dan A Ganea, Chloé M Benoit, Jan Gründemann, Lia Y Min, Kalynn M Bird, Christian Schultz, Vann Bennett, Paul M Jenkins, Maren Engelhardt

“…The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation of output generation. …”
Get full text

Finite volume modeling of neural communication: Exploring electrical signaling in biological systems by Muzammal Saleem, Muhammad Saqib, Badar Saad Alshammari, Shahid Hasnain, Amjad Ayesha

“…This article investigates neuronal dynamics in neuroscience, employing mathematical frameworks such as the Hodgkin Huxley model to describe them. Action potentials electrical signals generated by neurons are crucial for communication within the nervous system. …”
Get full text

Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients by Cristina Deflorio, Emanuela Onesti, Clotilde Lauro, Giorgio Tartaglia, Aldo Giovannelli, Cristina Limatola, Maurizio Inghilleri, Francesca Grassi

“…Denervated muscles undergo fibrillations due to spontaneous activation of voltage-gated sodium (Na+) channels generating action potentials. Fibrillations also occur in patients with amyotrophic lateral sclerosis (ALS). …”
Get full text

Finite Element Modelling for Biophysical Models of Nervous System Stimulation: Best Practices for Multiscale Adaptive Meshing by Rodrigo L., Siobhan Mackenzie Hall, Francisco Saavedra R., Pablo Aqueveque N., James J. FitzGerald, Brian Andrews

“…We evaluate the impact of differentiation errors on calculating the Activating Function and predicting action potentials in a Hodgkin-Huxley (H-H) axon model. …”
Get full text

Sodium butyrate restored TRESK current controlling neuronal hyperexcitability in a mouse model of oxaliplatin-induced peripheral neuropathic pain by Idy H.T. Ho, Yidan Zou, Kele Luo, Fenfen Qin, Yanjun Jiang, Qian Li, Tingting Jin, Xinyi Zhang, Huarong Chen, Likai Tan, Lin Zhang, Tony Gin, William K.K. Wu, Matthew T.V. Chan, Changyu Jiang, Xiaodong Liu

“…Current clamp recording of action potentials and persistent outward current of Twik-related-spinal cord K+ (TRESK) channel were recorded in DRG neurons with small diameters extract. …”
Get full text

Iconography of abnormal non-neuronal cells in pediatric focal cortical dysplasia type IIb and tuberous sclerosis complex by Joyce Zhang, Deneen Argueta, Xiaoping Tong, Harry V. Vinters, Gary W. Mathern, Carlos Cepeda

“…A paradigm shift occurred when our group demonstrated that BC/GC in pediatric cases of FCDIIb and TSC are unable to generate action potentials and lack synaptic inputs. Hence, their role in epileptogenesis remained obscure. …”
Get full text

Power spectral analysis of voltage-gated channels in neurons by Christophe Magnani, Lee E. Moore

“…A striking relationship is also shown between fluctuation and quadratic power spectra, suggesting that voltage-dependent random mechanisms can have a significant impact on deterministic nonlinear responses, themselves known to have a crucial role in the generation of action potentials in biological neural networks.…”
Get full text

Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I by Bryan Neumann, Stephen McCarthy, Shane Gonen

“…Abstract Voltage-gated sodium channels (NaVs) selectively permit diffusion of sodium ions across the cell membrane and, in excitable cells, are responsible for propagating action potentials. One of the nine human NaV isoforms, NaV1.8, is a promising target for analgesics, and selective inhibitors are of interest as therapeutics. …”
Get full text

Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus by Natalia Avaliani, Ulrich Pfisterer, Andreas Heuer, Malin Parmar, Merab Kokaia, My Andersson

“…This was accompanied by mature electrophysiological properties and fast high amplitude action potentials at six months after transplantation. …”
Get full text

Mining the Virgin Land of Neurotoxicology: A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels by Zhirui Liu, Jie Tao, Pin Ye, Yonghua Ji

“…Voltage-gated sodium channels (VGSCs) are important membrane protein carrying on the molecular basis for action potentials (AP) in neuronal firings. Even though the structure-function studies were the most pursued spots, the posttranslation modification processes, such as glycosylation, phosphorylation, and alternative splicing associating with channel functions captured less eyesights. …”
Get full text

Spike reliability is cell type specific and shapes excitation and inhibition in the cortex by Simone Russo, Garrett B. Stanley, Farzaneh Najafi

“…Abstract Neurons encode information in the highly variable spiking activity of neuronal populations, so that different repetitions of the same stimulus can generate action potentials that vary significantly in terms of the count and timing. …”
Get full text

Action Video Game Experience Related to Altered Large-Scale White Matter Networks by Diankun Gong, Weiyi Ma, Jinnan Gong, Hui He, Li Dong, Dan Zhang, Jianfu Li, Cheng Luo, Dezhong Yao

“…WM network modulates the distribution of action potentials, coordinating the communication between brain regions and acting as the framework of neural networks. …”
Get full text

Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells. by Xuexing Du, Jennifer Crodelle, Victor James Barranca, Songting Li, Yunzhu Shi, Shangbang Gao, Douglas Zhou

“…Specifically, by conducting voltage clamp and mutant experiments, we identify key ion channels, particularly the L-type voltage-gated calcium channel (EGL-19) and potassium channels (SHK-1, SLO-2), which are crucial for generating action potentials. We develop Hodgkin-Huxley-based models for these channels and integrate them to capture the cells' electrical activity. …”
Get full text

Minimal state models for ionic channels involved in glucagon secretion by Virginia González-Vélez, Amparo Gil, Iván Quesada

“…Then, we simulate dynamic ionic currents following experimental protocols.Our aims are 1) To understand the individual ionic channel functioning and modulation that could affect glucagon secretion, and 2) To simulate ionic currents actually measured in voltage-clamp alpha-cell experiments in mice.Our estimations indicate that alpha cells are highly permeable to sodium and potassium which mainly manage action potentials. We have also found that our estimated N-type calcium channel population and density in alpha cells is in good agreement to those reported for L-type calcium channelsin beta cells. …”
Get full text

Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing by Barbara Imbrosci, Angela Neitz, Thomas Mittmann

“…The somatodendritic compartment receives and integrates synaptic inputs while the axon relays relevant synaptic information in form of action potentials (APs) across long distance. Despite this well accepted notion, recent research has shown that, under certain circumstances, the axon can also generate APs independent of synaptic inputs at axonal sites distal from the soma. …”
Get full text

Design, Development and Control of a Hopping Machine – an Exercise in Biomechatronics by Kuldip Naik, Mehran Mehrandezh, John Barden

“…It can be also used as a biomechatronics test bed to simulate the effect of different timings in firing action potentials in jump-causing leg muscles on achieving a desired jumping height in the animal kingdom.…”
Get full text

Dynamic Support Culture of Murine Skeletal Muscle-Derived Stem Cells Improves Their Cardiogenic Potential In Vitro by Klaus Neef, Philipp Treskes, Guoxing Xu, Florian Drey, Sureshkumar Perumal Srinivasan, Tomo Saric, Erastus Nembo, Judith Semmler, Filomain Nguemo, Christof Stamm, Douglas B. Cowan, Antje-Christin Deppe, Maximilian Scherner, Thorsten Wittwer, Jürgen Hescheler, Thorsten Wahlers, Yeong-Hoon Choi

“…Whole-cell patch-clamp studies revealed similarities to pacemaker action potentials and responsiveness to cardiac specific pharmacological stimuli. …”
Get full text

Reactive Oxygen Species Donors Increase the Responsiveness of Dorsal Horn Neurons and Induce Mechanical Hyperalgesia in Rats by Hee Young Kim, Inhyung Lee, Sang Woo Chun, Hee Kee Kim

“…The t-BOOH increased the frequency and the amplitude of excitatory postsynaptic potentials, depolarized membrane potential in SG neurons, and increased the frequency of action potentials evoked by depolarizing current pulses. …”
Get full text

MicroRNAs in atrial fibrillation – have we discovered the Holy Grail or opened a Pandora’s box? by Alkora Ioana Balan, Alina Scridon

“…Altered expression of different miRNAs has been related to proarrhythmic changes in the duration of action potentials and atrial fibrosis. In clinical studies, miRNA changes have been associated with AF, whereas in experimental studies miRNA manipulation has emerged as a potential therapeutic approach. …”
Get full text

Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) Regulates Basal Cardiac Pacemaker Function: Pros and Cons by Tatiana M. Vinogradova, Edward G. Lakatta

“…This is a critical issue with respect to how cardiac pacemaker cells fire spontaneous action potentials. This review aspires to explain and unite apparently contradictory results of pharmacological studies in the literature that have demonstrated a fundamental role of basal CaMKII activation for basal cardiac pacemaker function, as well as studies in mice with genetic CaMKII inhibition which have been interpreted to indicate that basal spontaneous SANC firing is independent of CaMKII activation. …”
Get full text