SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…Understanding the mechanisms of tumorigenesis and the underlying molecular pathways in TNBC could aid in identifying new therapeutic targets. Methods In this study, we conducted bioinformatics analysis of the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases to examine PTPN11 (encoding SHP2) expression levels and perform survival analysis in TNBC. …”
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Interpretable machine learning and radiomics in hip MRI diagnostics: comparing ONFH and OA predictions to experts by Tariq Alkhatatbeh, Ahmad Alkhatatbeh, Qin Guo, Jiechen Chen, Jidong Song, Xingru Qin, Wang Wei

“…This method has the ability to aid both junior and senior medical professionals to precisely diagnose and take prompt treatment measures.…”
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Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients by Sandra Crnko, Markella I. Printezi, Tijn P.J. Jansen, Laurynas Leiteris, Manon G. van derMeer, Hilde Schutte, Martijn vanFaassen, Bastiaan C. duPré, Nicolaas deJonge, Folkert W. Asselbergs, Carlo A.J.M. Gaillard, Hans Kemperman, Pieter A. Doevendans, Joost P.G. Sluijter, Linda W. vanLaake

“…Repeated measurements of sST2 may aid in clinical decision making. The goal of this study was to investigate whether sST2 exhibits diurnal variation in patients with heart failure with reduced ejection fraction (HFrEF) and in control subjects, thereby enhancing its diagnostic and prognostic values. …”
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Validation of heavy metals in geothermal to support water management practices and mitigation strategies by G.M. Idroes, D.P. Rezeki, K. Khairi, K. Khairan, R. Idroes, E. Suhartono, R. Prasetio, S.A. Rahman, S. Suhendrayatna

“…This study primarily sought to investigate the health risks that these heavy metals may present and to deliver vital information that would aid in the advancement of water management practices and mitigation strategies in the locality. …”
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Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression by Tingting Xu, Jianmin Huang, Jiajing Lin, Yuanyuan Liu, Yi Wang, Wenkang Shen, Jianjie He, Shuyun Chen, Xi Zhu, Yuqin Que, Mengting Hu, Yu Chen, Liming Cheng, Honghao He, Xin Liu, Si Liu

“…Understanding these changes could improve our knowledge of molecular mechanisms, aiding in diagnostic improvements and therapeutic development.…”
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Nailfold Capillaroscopy in Early Stages of Mixed Connective Tissue Disease in a Sample of Egyptian Patients by Yasser A Elmotaleb Gazar, Hesham Salah Hamoud, Sherif Mohamed Ismail

“…Conclusion: In this study, the results obtained were qualitatively satisfactory for clear delineation of the nailfold capillaries features in MCTD. Therefore, it aids in the recognition of alternations in nailfold capillaries making an early prediction of course of illness in MCTD patients possible and suggests a potential ability to differentiate from early SSc, thus helps in preventing morbidities and sequelae of the disease.…”
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Patellofemoral Joint Loading During Bodyweight One-Legged and Two-Legged BOSU and Floor Squats by Rafael Escamilla, Naiquan Zheng, Toran D. MacLeod, Rodney Imamura, Kevin E Wilk, Shangcheng Wang, Robert Asuncion, Irwin S. Thompson, Arnel L. Aguinaldo, Glenn S Fleisig

“…Understanding how patellofemoral force and stress magnitudes affects different squat variations will aid clinicians in determining how and when to prescribe and progress these squatting types of exercises in patients with patellofemoral pain…”
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Genetic Variability, Character Association, Path Coefficient, and Diversity Analysis of Rice (Oryza sativa L.) Genotypes Based on Agro-Morphological Traits by Shubh Pravat Singh Yadav, Sujan Bhandari, Netra Prasad Ghimire, Dipesh Kumar Mehata, Soni Kumari Majhi, Susmita Bhattarai, Samaz Shrestha, Bishnu Yadav, Pratima Chaudhary, Sangita Bhujel

“…Genetic variability analysis aids the breeders in determining the best criteria and selection procedure to be utilized in order to enhance the desired attributes. …”
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Low apolipoprotein A1 and high apolipoprotein B levels indicate specific lipid changes in treatment naïve early psoriatic arthritis by Kurt de Vlam, Rik Lories, M Van Mechelen, Sofia Pazmino, P Verschueren, Barbara Neerinckx, Lies Storms, Alla Ishchenko

“…These findings highlight the potential of apolipoprotein measurements to serve as more accurate indicators of lipid disturbances in PsA than traditional serum lipids and as aid to diagnosis of patients presenting with early arthritis.…”
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Correlation Between the Inferior Vena Cava/Aorta (Ivc/Ao) Ratio and Serum Lactate Levels in Children With Renal Disorder by Hakim DDL, Widiasta A, Rachmadi D, Rahayunigsih SE, Apandi PR, Adrizain R, Martiano MRA

“…Understanding these parameters could improve early diagnosis, aid clinical decisions, and enhance outcomes for pediatric AKI patients, offering an accessible monitoring method for clinicians.Methods: This cross-sectional study involved 48 pediatric patients aged 5– 18 years showing Pediatric Early Warning Score (PEWS) ≥ 3 and diagnosed with renal disorders. …”
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Wind speed and direction on predicting wind energy availability for a sustainable ecosystem by B. Baranitharan, D. Sivakumar, M. Perarul Selvan

“…From both the tests on Weibull distribution, beta distribution, and three-parameter Weibull distribution, this study found that the Anderson-Darling test was the most appropriate for forecasting the wind speed corresponding to the wind direction for the periods between 2024 and 2050 to produce sustainable wind energy from the wind turbine.CONCLUSION: The outcomes of this study demonstrate that there is a good likelihood that the parameter Weibull distribution and Anderson-Darling test will be used in other nations to aid in the complementary integration of wind energy. …”
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Biomechanical Performance of Mandibular Molars with Deep Mesio-Occlusal-Distal Cavities Rehabilitated with Horizontal Posts: A 3D Finite Element Analysis by Sonali Sharma, Sindhu Ramesh, Jasmine Rayapudi

“…Rehabilitation of deep mesio-occlusal-distal cavities of molars with intact buccal and lingual walls with the aid of a horizontal post of any diameter has a similar stress distribution to an intact tooth. …”
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Assessment of adequacy and determinants of HIV related knowledge among senior school students in public schools in Abakaliki Southeast Nigeria by Maria-Lauretta Chito Orji, Ngozi Appolonia Ifebunandu, Chinwe Ifeoma Joe-Akunne, Mmeremikwu Appolus Chidiebere, Stella Echefu, Justus Ndulue Eze

“…These questions cut across the knowledge of the meaning of HIV/AIDS, its aetiology, risk factors, modes of transmission, prevention, the knowledge that an infected person may look healthy, testing, and treatment. …”
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Expectation and Satisfaction with Nursing Care among Hypertensives Receiving Care at a Resource-Constrained Hospital in Ghana by Kennedy Dodam Konlan, Mavis Armah-Mensah, Rita Aryee, Theresa Akua Appiah

“…Nvivo 11 software was used to manage the data and aid with the thematic analysis. Results. The results of this study showed that Ghanaian hypertensive patients perceived nurses as key players in the management of patients. …”
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Risk factors of 180-day rebleeding after management of blunt splenic injury without surgery and embolization: a national database study by Chung-Yen Chen, Hung-Yu Lin, Pie-Wen Hsieh, Yi-Kai Huang, Po-Chin Yu, Jian-Han Chen

“…Despite limitations, this study underscores large-scale data’s role in identifying risks which can aid clinicians in prioritizing additional interventions during NOM.…”
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A five-finger mnemonic for teaching schoolchildren the theoretical components of adult basic life support: a modified reactive Delphi-guided development and memorability pilot test... by Nino Fijačko, Robert Greif, Špela Metličar, Gregor Štiglic, Benjamin S. Abella, Matej Strnad, the Delphi study investigators

“…Abstract Background A mnemonic is a cognitive aid frequently used in health-related education. …”
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Predicting the Most Deleterious Missense Nonsynonymous Single-Nucleotide Polymorphisms of Hennekam Syndrome-Causing CCBE1 Gene, In Silico Analysis by Khyber Shinwari, Liu Guojun, Svetlana S. Deryabina, Mikhail A. Bolkov, Irina A. Tuzankina, Valery A. Chereshnev

“…These highly deleterious nsSNPs can be used as marker pathogenic variants in the mutational diagnosis of the HS syndrome, and this research also offers potential insights that will aid in the development of precision medicines. CCBE1 proteins from Hennekam syndrome patients should be tested in animal models for this purpose.…”
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Malignant transformation of proliferative Verrucous Leukoplakia—systematic review & meta-analysis by Khadijah Mohideen, Snehashish Ghosh, Chandrasekaran Krithika, Mutaz Ali-Hassan, Revant Chole, Safal Dhungel

“…Understanding its etiology could aid early detection and management.…”
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Multicenter Randomized Controlled Trial Comparing the Contribution of Proxabrushes with Regular Toothbrushes and Only Regular Toothbrushes to the Oral Health of Thai Elderly by Orachad Gururatana, Warangkana Vejvithee, Narisa Ekpatcha

“…In conclusion, proxabrush has been found to be an effective interdental cleaning aid among Thai elderly. This trial is registered with TCTR20220127004.…”
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Nonimmune Hydrops Fetalis and Early Skeletal Changes in Congenital Syphilis: Case Series and Review of Literature by Kruti N Shah, Shwetal Bhatt, Vaishali Chanpura

“…Due to varied clinical signs and presentations of congenital syphilis, it becomes imperative to diagnose it postnatally for early initiation of treatment. Long bone radiographs aid in the diagnosis of congenital syphilis in neonates of seronegative mothers. …”
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