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    A model‐based approach using GSK3772847, an anti‐interleukin‐33 receptor monoclonal antibody, as a showcase to predict SC administration PK and free target dynamics based on PK and total target measurements after IV administration by Jan Berkhout, Dave Fairman, Martijn vanNoort, Tamara J. vanSteeg

    Published 2025-01-01
    “…GSK3772847, a human immunoglobulin G2 sigma isotype (IgG2f) mAb that binds to the extracellular domain of the interleukin‐33 receptor (IL‐33R or ST2) and neutralizes IL‐33‐mediated ST2 signaling, was used as a model compound for mAbs in this study.…”
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    The crystal structure of (μ4-oxo)-tri(μ4-2,2′-bipyridine-6,6′-bis(olato)-κ5 O,O′:N:N′:O″)tetrazinc(II) – methylformamide (1/1), C33H25N7O8Zn4 by Shi Zhen-Zhen, Chen Shu-Yang, Chen Jun-Ling, Yun Shu-Zhou, Fu Xing-Fang

    Published 2025-02-01
    “…C33H25N7O8Zn4, triclinic, P1̄ (no. 2), a = 12.1524(7) Å, b = 12.2035(7) Å, c = 14.2730(7) Å, α = 78.669(4)°, β = 66.615(5)°, γ = 62.482(6)°, V = 1722.83(19) Å3, Z = 2, R gt(F) = 0.0405, wRref (F 2) = 0.1128, T = 293(2) K.…”
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    The crystal structure of 1,1′-(((2 (dimethylamino)ethyl)azanediyl)bis(methylene)) bis(naphthalen-2-olato-κ4 N,N′,O,O′)-(pyridine-2,6-dicarboxylato-N,O,O′)- titanium(IV) ─ dichloromethane (2/1), C33H29N3O6Ti by Zhao Tiankun, Wang Peng, Ji Mingyu, Li Shanjia, Yang Mingjun, Pu Xiuying

    Published 2021-09-01
    “…C33H29N3O6Ti, monoclinic, C2/c (no. 15), a = 27.4022(15) Å, b = 14.0345(7) Å, c = 17.0047(10) Å, β = 116.009(3)°, V = 5877.3(6) Å3, Z = 8, R gt(F) = 0.0369, wRref (F 2) = 0.1125, T = 100(2) K.…”
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