Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

“…Study screening was conducted independently by two reviewers using a consensus procedure for disagreements, and one reviewer performed data extraction and risk-of-bias assessment (using the Cochrane Risk Of Bias tool), which was confirmed by a second reviewer for a sample of studies. …”
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Medical Assistance in Dying for Persons Suffering Solely from Mental Illness in Canada by Chloe Eunice Panganiban, Srushhti Trivedi

“…., “Euthanasia Requests, Procedures and Outcomes for 100 Belgian Patients Suffering from Psychiatric Disorders: A Retrospective, Descriptive Study,” BMJ Open 5, no. 7 (July 27, 2015): e007454, https://doi.org/10.1136/bmjopen-2014-007454…”
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Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…Following this, formal searches were conducted and the systematic screening procedures were used to select a short list of eligible studies. …”
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Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

“…Exclusion criteria were: (1) a diagnosis of bipolar disorder or current psychosis; (2) adequate use of lithium or quetiapine during the current episode; (3) current use of another atypical antipsychotic, (4) known contraindication to lithium or quetiapine; (5) participation in another Clinical Trial of an Investigational Medicinal Product; (6) insufficient comprehension or attention to engage in trial procedures, (7) pregnancy, trying for pregnancy, or breastfeeding. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Internal validation was conducted to assess optimism of the performance statistics using the bootstrapping procedure. External validation was conducted to assess model performance in another sample from a similar population as the development cohort. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Outcomes of interest were test accuracy (including sensitivity, specificity, positive and negative predictive values), number and proportion of cancers detected (by site and stage), mortality, time to diagnostic resolution, incidental findings, additional tests and procedures, potential harms, HRQoL, acceptability and satisfaction. …”
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Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…The trial included two stages: pre-randomisation to adjust antipsychotics and commencing mood-stabilising medication (where required) and ensuring participant engagement with study procedures, prior to randomisation. Eligibility criteria Inclusion criteria: pre-randomisation stage Under secondary care mental health services. …”
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Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis by Mamidipudi Thirumala Krishna, Yogini H Jani, Iestyn Williams, Ruben Mujica-Mota, Rebecca Bestwick, Michele Siciliano, Robert Michael West, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Rachel Pollard, Nicola Jones, Louise Dunsmure, Mairead McErlean, Neil Powell, Chidanand C Hullur, Ariyur Balaji, Jonathan Sandoe, Amena Warner, Ron Daniels, Caroline Thomas, Siraj A Misbah, Louise Savic

“…The current standard of care involves allergy specialist review, skin tests and a challenge procedure. There is an unmet need for allergy services and penicillin allergy testing is not routinely available. …”
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Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial by Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison

“…Interventions Participants received unlabelled, identical-looking trial interventions of IPE and inulin in 10 g pre-packed, foil-backed sachets, and they were instructed to take one sachet per day, mixed in a cold drink/water, at any time with their normal diet. Study procedures At the screening visit, the study rationale and protocol were explained. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Peer-support specialists can achieve informed consent through a certification procedure and a manualized structured conversation that guides the patient to understand their preferences better.[49] To achieve informed consent, "the patient must have the capacity to be able to understand and assess the information given, communicate their choices, and understand the consequences of their decision.”[50] To this end, professionals must train peer-support specialists to apply standards of competence to service users prior to PAD facilitation. …”
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