Yangxinshi Tablets Versus Trimetazidine on Exercise Tolerance After Percutaneous Coronary Intervention: Rationale and Design of the Double-blind, Randomized HEARTRIP Trial by Yi Li, Jian Zhang, Hong Chen, Yi Zhang, Jing Li, Haichu Yu, Xiaoping Meng, Haitao Yuan, Lili Shao, Yaling Han

“…The HEARTRIP study protocol received approval from the ethics committee of the General Hospital of Northern Theater Command (Shenyang, China). The procedures set out in this protocol are in accordance with the principles of the Declaration of Helsinki and the Good Clinical Practice guidelines. …”
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Elevated thyroglobulin levels in fine-needle aspiration washout fluid from thyroid nodules: a potential marker of benign nature? by Serhat Uysal, Cem Sulu, Banu Betul Kocaman, Ilkin Muradov, Lala Soltanova, Serdar Sahin, Hande Mefkure Ozkaya, Dildar Konukoglu, Taner Damci, Mustafa Sait Gonen

“…Patients with pure cystic nodules, non-thyroid malignancy, and major psychiatric disorders that could interfere with compliance during the procedure were excluded from the study. FNA-Tg samples were obtained from the nodules using a 22-gauge needle on the first attempt. …”
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Comparing the efficacy and safety of three surgical approaches for total hysterectomy (TSATH): protocol for a multicentre, single-blind, parallel-group, randomised controlled trial by Yanzhou Wang, Ying Zheng, Fan Yang, Li Deng, Jianhong Liu, Yonghong Li, Sijing Chen, Wenxi Zhang, Xiaolin You, Jiani Gou, Dan Zi, Xiaoxue Qi

“…Introduction Hysterectomy is the most common surgical procedure in the field of gynaecology. The traditional multiport laparoscopy, transumbilical laparoendoscopic single-site surgery (TU-LESS) and transvaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomy approaches have been implemented to varying degrees in clinical practice. …”
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Safety of Early Carotid Artery Stenting after Systemic Thrombolysis: A Single Center Experience by Fabrizio Sallustio, Giacomo Koch, Alessandro Rocco, Costanza Rossi, Enrico Pampana, Roberto Gandini, Alessandro Meschini, Marina Diomedi, Paolo Stanzione, Silvia Di Legge

“…A single self-expandable stent was implanted to cover the entire lesion in all patients. The procedure was uneventful in all patients. After 12 months, all patients had stent patency, and the functional outcome was favourable (mRS ≤ 2) in all but 1 patient experiencing a recurrent stroke for new-onset atrial fibrillation. …”
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A technique for separating viable islets of Langerhans from a fragment of human pancreatic tail by A. S. Ponomareva, L. A. Kirsanova, N. V. Baranova, G. N. Bubentsova, I. A. Miloserdov, E. A. Volkova, V. I. Sevastyanov

“…The classic method of IL separation is based on enzymatic digestion of pancreatic tissue and further islet purification in ficoll density gradient during centrifugation, which adversely affects the morphofunctional state of IL.The aim of the study was the development of a method for separating viable pancreatic islets from a fragment of human pancreatic tail with different cold ischemia times.Materials and methods. A procedure of IL separation is proposed to be conducted without the use of EP tissue collagenase perfusion in the Ricordi chamber at the stage of IL separation and without ficoll solution with a varying density gradient at the stage of IL purification. …”
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Measurement of schizophrenia symptoms through speech analysis from PANSS interview recordings by Michelle Worthington, Michelle Worthington, Georgios Efstathiadis, Vijay Yadav, Vijay Yadav, Isaac Galatzer-Levy, Isaac Galatzer-Levy, Isaac Galatzer-Levy, Alan Kott, Emanuel Pintilii, Tejendra Patel, Colin Sauder, Inder Kaul, Stephen Brannan, Anzar Abbas

“…Here, we evaluate recordings of clinical interviews conducted as part of standard clinical trial procedures as reliable sources of patient speech for symptom assessment using digital phenotyping. …”
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Frailty and Upper Gastrointestinal Surgery: Initial Findings from Thailand’s First Surgical Frailty Study by Gritin Gonggetyai, Nathawadi Techalertsuwan, Chawisa Nampoolsuksan, Thammawat Parakonthun, Jirawat Swangsri, Asada Methasate, Arunotai Siriussawakul, Onuma Chaiwat, Varalak Srinonprasert

“…Frail patients also underwent fewer resection procedures (61.1% vs 84.2%, p=0.001). While the overall complication rate did not differ significantly between groups (50.0% vs 47.4%; p=0.457), frail patients experienced higher rates of major complications (16.7% vs 10.5%; p=0.045) and non-surgical complications (33.3% vs 21.1%; p=0.044). …”
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Intra-arterial alteplase for acute ischaemic stroke after mechanical thrombectomy (PEARL): rationale and design of a multicentre, prospective, open-label, blinded-endpoint, randomi... by Jie Li, Yajie Liu, Min Zhang, Haoyang Sun, Yingying Zhu, XinGuang Yang, Dong Pan, Yamei Tang, Hongbiao Hou, Xiongjun He, Yongteng Xu, Huiyuan Peng, Kaifeng Li, Yanting Chen, Baixuan He, Hongxing Zhou

“…Participants in the experimental group will receive intra-arterial alteplase (0.225 mg/kg and a maximum dose of 20 mg) after MT and standard medical treatment, while those in the control group will receive standard medical treatment alone after the procedure. The primary outcome is the proportion of patients with a 90-day modified Rankin scale of 0–1. …”
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Aurantio-obtusin improves obesity and protects hepatic inflammation by rescuing mitochondrial damage in overwhelmed brown adipose tissue by Ruiyu Wu, Runping Liu, Ranyun Chen, Yijie Li, Xiaoyong Xue, Yinhao Zhang, Fanghong Li, Jiaorong Qu, Lingling Qin, Chen Wang, Xiaojiaoyang Li

“…Materials and methods After applying high-fat diet and glucose-fructose water (HFHS)-induced obesity mice, different BAT transplant procedures and primary BAT adipocytes, we investigated the anti-obesity effects and mechanism of AO through RNA sequencing and biology techniques. …”
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A novel paradigm in cleft lip education: integration of 3D-printed simulator and problem-based learning by Xiao-Le Wang, Ying Xie, Ye-Xin Yue, Xue-Wen Yang, Jian Li

“…Abstract Purpose The repair of cleft lip is a highly intricate and challenging surgical procedure in plastic surgery. Consequently, it is also a pivotal and difficult subject in clinical education. …”
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Research progress on internal corrosion of supercritical/dense-phase CO2 pipelines for CCUS by Guangyu LIU, Shujie ZHI, Xin LIU, Chong CHAI, Cailin WANG, Xinran YU, Qihui HU, Shiduo RAO

“…Conclusion To ensure the safe and stable operation of CO2 transportation pipelines, current corrosion research challenges for supercritical/dense-phase CO2 pipelines include: standardizing experimental procedures; studying the impact of impurity coupling on corrosion mechanisms and CPF structures; quantifying the protective effects of CPF characteristics on the substrate; measuring and analyzing electrochemical corrosion parameters in thin liquid film environments within watersaturated CO2 phase; and developing a prediction model for supercritical/dense-phase CO2 corrosion considering coupled multi-impurity interactions.…”
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N‐methylation of histidine to tune tautomeric preferences in histidine‐heme coordination and enzyme‐mimetic catalysis by Ruikai Du, Yunbo Lv, Haifeng Wu, Baoli Zhang, Yuanxi Liu, Shichao Xu, Shan Li, Zhen‐Gang Wang

“…However, evaluating the impact of Nδ and Nε is difficult, and directly integrating noncanonical N‐methylated histidine within enzymes poses risks due to laborious procedures. In this study, we present the self‐assembly of Fmoc‐Histidine (Fmoc‐His) with hemin to create a peroxidase‐mimetic catalyst, in which either the Nε or Nδ of histidine is methylated to modify the tautomeric preferences, thereby tuning hemin catalysis. …”
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Bone Tissue Regeneration in the Oral and Maxillofacial Region: A Review on the Application of Stem Cells and New Strategies to Improve Vascularization by Vivian Wu, Marco N. Helder, Nathalie Bravenboer, Christiaan M. ten Bruggenkate, Jianfeng Jin, Jenneke Klein-Nulend, Engelbert A. J. M. Schulten

“…Both adipose tissue-derived SVF and MF are cell sources with clinical feasibility due to their large quantities that can be harvested and applied in a one-step surgical procedure. During the past years, important advancements of stem cell application and vascularization in bone tissue regeneration have been made. …”
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Uniportal Robotic Lobectomy and Lymphadenectomy for Invasive Lung Cancer: A Novel Approach and Perioperative Outcomes by Shengcheng Lin, Xiangyang Yu, Yafei Xu, Yu Xin, Jie He, Zhentao Yu, Hongbo Zhao, Chenglin Yang, Kai Ma

“…The median durations of the operation and the uRATS procedure were 200 min (range, 142–330 min) and 140 min (range, 80–242 min), and the median intraoperative blood loss volume was 20 mL (range, 10–100 mL), respectively. …”
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The articulated laparoscopic total mesorectal excision for rectal cancer (ATOME trial): a single-arm, prospective trial with pre-specified comparison to robotic surgery by Kyeong Eui Kim, Sung Uk Bae, Seung Hyun Lee, Dae-Ro Lim, Heon-Kyun Ha, Jin Kim, Hyo Seon Ryu, Soo Yeon Park, Sung Il Kang, Gyung Mo Son, Soo Young Lee, Chang Hyun Kim, Kyung Ha Lee, Gi Won Ha, Hye Jin Kim, Woong Bae Ji, Woo Ram Kim, Sang Hee Kang, Nak Song Sung, Ji Hoon Kim, Taek-Gu Lee, Myung Jo Kim, Woon Kyung Jeong, Seong Kyu Baek

“…Abstract Background Laparoscopic total mesorectal excision (TME) has become the standard surgical treatment for rectal cancers, despite being a technically challenging procedure due to the straight and rigid nature of the laparoscopic instrument within a narrow bony pelvis. …”
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Protocol for a systematic review and meta-analysis of the prevalence of viral infections in acute apical abscesses by José Ángel Hernández-Mariano, Gustavo Adolfo Sánchez-Ramírez, Guillermo Cano-Verdugo, Myriam Angélica De la Garza-Ramos, Martín Andrés Chávez- Méndez, Claudio Peña-Soto, Mónica Alethia Cureño-Díaz

“…Abstract Background There is no current consensus on the presence of viral infections in acute apical abscesses; therefore, this protocol for a systematic review and meta-analysis is designed to detail the procedures required to investigate the prevalence of viral infections in acute apical abscesses, a common dental condition characterized by pus accumulation due to bacterial infection. …”
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Self-reported health and depression among EIRA cohort: a moderated mediation model of sex and perceived social support by Raquel Sánchez-Recio, Raquel Sánchez-Recio, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Fátima Méndez-López, Fátima Méndez-López, Fátima Méndez-López, Santiago Gascón-Santos, Santiago Gascón-Santos, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Olaya Tamayo-Morales, Olaya Tamayo-Morales, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, Marc Casajuana, Tomas López-Jiménez, Emma Motrico, Emma Motrico, Irene Gómez-Gómez, Irene Gómez-Gómez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, María Luisa Rodero-Cosano, Joan Llobera, Joan Llobera, Joan Llobera, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Patricia Moreno-Peral, Patricia Moreno-Peral, Bonaventura Bolíbar, Bonaventura Bolíbar, José I. Recio-Rodríguez, José I. Recio-Rodríguez, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, Ana Clavería, Ana Clavería

“…To determine the mediating effect between social support and self-perceived health, three regression analyses were carried out using the procedure designed by Hayes through the PROCESS macro for SPSS.Results3,062 people (54.9% women) participated in the study. …”
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Generalized hybrid coronary revascularization vs. conventional off-pump coronary artery bypass grafting for multivessel coronary artery disease by Shuai Zhang, Shuai Zhang, Ping Li, Ping Li, Guang Li, Guang Li, Yunfeng Yan, Yunfeng Yan, Tao Sun, Tao Sun, Ji Lin, Ji Lin, Chenhao Zhang, Shuo Liu, Shuo Liu, Zheng Qu, Zheng Qu, Bin You, Bin You

“…Compared with OPCABG, generalized HCR was associated with a significantly lower intra-aortic balloon pump (IABP) implantation rate (2.7% vs. 9.9%; P = 0.027) and shorter postoperative length of stay (6.3 ± 3.2 vs. 7.7 ± 3.0; P = 0.001).ConclusionsThe generalized HCR procedure appears to be safe and efficacious, with outcomes similar to those of standard off-pump CABG and satisfactory completeness of revascularization.…”
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A Comparison of the Incidences of Venous Thromboembolism after Total Hip Arthroplasty between the Direct Anterior Approach and the Direct Lateral Approach, Especially in the Early... by Tetsuya Kawano, Hiroaki Kijima, Shin Yamada, Natsuo Konishi, Hitoshi Kubota, Hiroshi Tazawa, Takayuki Tani, Norio Suzuki, Keiji Kamo, Yoshihiko Okudera, Masashi Fujii, Ken Sasaki, Yosuke Iwamoto, Itsuki Nagahata, Takanori Miura, Naohisa Miyakoshi, Yoichi Shimada

“…It may be important to shorten the surgical time in the early stage of introducing the DAA, and aggressive anticoagulation therapy may be required until the surgeon becomes familiar with the procedure.…”
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Zero-contrast imaging for the assessment of transcatheter aortic valve implantation in candidates with renal dysfunction by Guy F. A. Prado, Stefano Garzon, Jose Mariani, Adriano Caixeta, Breno O. Almeida, Felipe O. Ramalho, Marcelo L. C. Vieira, Claudio H. Fischer, Gilberto Szarf, Walther Ishikawa, Pedro A. Lemos

“…Background Candidates for transcatheter aortic valve implantation (TAVI) are currently evaluated using computed tomography angiography and invasive cardiac catheterization as an essential part of case selection and pre-procedure interventional planning. However, both imaging methods utilize iodinated agents, which may cause contrast-induced nephropathy, particularly in patients with baseline renal dysfunction. …”
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