Approaches to Assessing the Safety of Medicines during the COVID-19 Pandemic Using the Example of Azithromycin by Yu. M. Gomon, A. R. Kasimova, A. S. Kolbin, V. V. Strizheletsky, I. G. Ivanov, S. O. Mazurenko

“…Most of the medicines used to treat the novel coronavirus infection (COVID-19) are either approved under an accelerated procedure or not approved for the indication. Consequently, their safety requires special attention.The aim of the study was to review methodological approaches to collecting data on the safety of medicines, using COVID-19 treatment regimens involving azithromycin as a case study.Materials and methods: PubMed® (MEDLINE), Scopus, eLIBRARY, and Cyberleninka databases were searched for publications on azithromycin as part of combination therapy for COVID-19 in 2020–2021. …”
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Enhanced recovery after endoscopic sinus surgery: Establishing comprehensive protocols for improvement of perioperative patient care by Louis‐Xavier Barrette, William G. Cohen, Tiffany Chao, Jennifer E. Douglas, James Kearney, Erica Thaler, Michael A. Kohanski, Nithin Adappa, James N. Palmer, Karthik Rajasekaran

“…Where applicable, the authors considered high‐level evidence for recommendations devised for patient cohorts in otorhinolaryngology not undergoing ESS, as well as cohorts undergoing surgical procedures for which ERAS protocols have been extensively evaluated. …”
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California Stress, Trauma, and Resilience Study (CalSTARS) protocol: A multiomics-based cross-sectional investigation and randomized controlled trial to elucidate the biology of AC... by Lauren Y. Kim, Sophia Miryam Schüssler-Fiorenza Rose, Summer Mengelkoch, Daniel P. Moriarity, Jeffrey Gassen, Jenna C. Alley, Lydia G. Roos, Tao Jiang, Arash Alavi, Durga Devi Thota, Xinyue Zhang, Dalia Perelman, Tamar Kodish, Janice L. Krupnick, Michelle May, Katy Bowman, Jenna Hua, Yaping Joyce Liao, Alicia F. Lieberman, Atul J. Butte, Patricia Lester, Shannon M. Thyne, Joan F. Hilton, Michael P. Snyder, George M. Slavich

“…In this protocol paper, we describe the scientific gaps motivating this study as well as the sample, study design, procedures, measures, and planned analyses. Ultimately, our goal is to leverage the power of cutting-edge tools from psychology, multiomics, precision medicine, and translational bioinformatics to identify social, molecular, and immunological processes that can be targeted to reduce stress-related disease risk and enhance biopsychosocial resilience in individuals and communities worldwide.…”
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New Approach to Drug Delivery in Ophthalmological Practice: Development of Composite Ophthalmological Solution for Drug Loading of Soft Contact Lenses by D. K. Naplekov, E. T. Zhilyakova, A. Yu. Malyutina, A. V. Bondarev, N. B. Demina, O. O. Novikov, R. A. Abramovich

“…The choice of active pharmaceutical substances, and excipients has been justified. Technological procedure of preparation of model solution was described and explained, where the most attention was paid on dissolving of sodium hyaluronate in purified water.…”
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Approach to Lung Transplantation in Pulmonary Arterial Hypertension: A Delphi Consensus on Behalf of the Transplant Task Force of the Pulmonary Vascular Research Institute by Nicholas A. Kolaitis, Hayley Barnes, Deborah J. Levine, Howard Castillo, Selim M. Arcasoy, Matthew Bacchetta, Luke Benvenuto, Erika Berman‐Rosenzweig, Marisa Cevasco, Caitlin T. Demarest, Celine Dewachter, Michiel E. Erasmus, Allan R. Glanville, John Granton, Shaf Keshavjee, Vikramjit Khangoora, Sheila Krishnan, Olaf Mercier, Andrea N. Miltiades, David Montani, Edward Murphy, Ivan Robbins, Franck F. Rahaghi, Sahar A. Saddoughi, Laurent Savale, Marc A. Simon, Jean‐Luc Vachiery, Corey E. Ventetuolo, Helen M. Whitford, Reda E. Girgis

“…Bilateral lung transplantation was considered the procedure of choice for most patients, with rare indications for heart‐lung transplantation. …”
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[225Ac]Ac-PSMA-617 production method: development of an efficient and reproducible radiolabelling process for establish a clinical routine production by Michela Aurilio, Aureliana Esposito, Monica Buonanno, Anna Morisco, Costantina Maisto, Stefania Scala, Secondo Lastoria

“…Greater difficulties occurred in defining the optimal procedures for quality controls, due to the unique physical properties of actinium. …”
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Older care home residents’ and their relatives’ knowledge, understanding and views of shift handovers: an exploratory, focused-ethnographic qualitative study using interviews and o... by Jill Manthorpe, Caroline Norrie, Katharine Orellana, Valerie Lipman, Jo Moriarty, Rekha Elaswarapu

“…There appeared to be an underlying assumption that administrative procedures in care homes would operate without input from residents or relatives. …”
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Early versus late pancreatic stent placement for preventing post-ERCP pancreatitis: protocol of a multicenter randomized clinical trial by Shaofei Wang, Bingqing Bai, Jianglong Hong, Wei Xu, Zongyi Shen, Yongju Xue, Yan Zhang, Mengwen Li, Qiming Huang, Weiping Zhang, Lei Jie, Chen Shi, Cui Hu, Bingbing Wang, Hao Ding, Suwen Li, Dapeng Li, Qifeng Lu, Yang Li, Xiaochang Liu, Rutao Hong, Qiao Mei, Junjun Bao

“…In total, 768 patients will be randomly assigned (1:1) to two arms: (1) early pancreatic stent placement (EPSP) (a pancreatic stent will be placed immediately after endoscopic retrograde cholangiography (ERC) or endoscopic sphincterotomy (EST)) and (2) late pancreatic stent placement (LPSP) (a pancreatic stent will be placed after all completion of therapeutic biliary procedures, e.g., biliary stone removal or drainage). …”
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Significant but Overlooked: Atmospheric HONO Formation from Surface Ammonium Oxidation with Superoxide Radicals by Hong Wang, Zehui Hu, Shujun Liu, Xin Zhang, Meijia Jiang, Yanjuan Sun, Fan Dong

“…Under high RH conditions, oxygen molecules (O2) have greatly better access to photogenerated electrons than NO2, resulting in an interruption of the procedure from NO2 to NO2− during NO3− conversion. …”
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Phenotypic Detection of Extended-Spectrum β-lactamases (ESBLs) and Aminopenicillin Cephalosporinase (AmpC)-Producing Bacterial Isolates from Surfaces of Hospital Fomites and Hands... by Musa Y. Tula1*, Osaretin Iyoha2, Richard Elisha3, Joel Filgona4, Abumhere S. Aziegbemhin5

“…Methods: We studied 100 samples collected from hospital fomites - including the hands of healthcare workers - for bacterial growth, which were subsequently identified using standard procedures. Standard disk methods were used to screen Gram-negative bacteria (GNB) for ESBL and AmpC production, including presumptive and confirmatory testing. …”
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Comparative Analysis of Deep Learning Methods for Classification of Ablated Regions in Hyperspectral Images of Atrial Tissue by Yeva Gabrielyan, Arpi Hunanyan, Sona Bezirganyan, Lusine Davtyan, Ani Avetisyan, Narine Sarvazyan, Aram Butavyan, Varduhi Yeghiazaryan

“…These efforts contribute towards the potential future utilization of HSI for surgical guidance in RFA or similar procedures.…”
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Increasing incidences and changes in treatment trends of clavicle fractures in adults during 2 decades in Denmark: a nationwide study on data from the Danish National Patient Regis... by Ida Tryggedsson, Bjarke Viberg, Per Hviid Gundtoft, Ilija Ban, Søren Overgaard, Tazio Maleitzke, Arvind von Keudell

“…Primary treatment was categorized as surgical if a relevant surgical procedure code was registered within 3 weeks of the fracture code, otherwise treatment was defined as non-surgical. …”
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Adenomyosis and it's impact of female infertility by Mateusz Paniak, Paweł Maciej Rycąbel, Oliwia Brygida Woszczyńska, Agnieszka Ewelina Wojciechowska, Marta Szymura, Marek Jarosław Molenda, Maria Wachowska, Mateusz Romaniuk, Wojciech Jan Sowiński, Michał Brunon Krawczyk

“…Long protocols with GnRH analogs can improve treatment outcomes in both medical procedures and natural conception attempts. Surgical treatment may enhance fertility but carries risks of complications, and the effectiveness of surgery remains a topic of debate. …”
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A study on the effect of the number of expansion units in a microfluidic chip on hyaluronidase-free oocyte denudation in mammals by Dessouky Ashraf Hisham, EL-Hussieny Haitham, EL-Sherry Taymour Mohammed, Parque Victor, Fath El-Bab Ahmed M. R.

“…Microfluidic technology has enabled cost-effective egg-handling procedures towards new assistive reproductive devices: oocytes are subjected to microchannels with jagged surfaces to let shear stress remove undesirable cumulus cells, and microchannels with expansion units facilitate the transport of oocytes in chips. …”
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Mortality Associated with Orofacial Clefts in Brazil by Amanda de Andrade Costa, Hildeth Maisa Torres Farias, Daniella Reis B. Martelli, Verônica Oliveira Dias, Brazilian Oral Cleft Group, Ricardo D. Coletta, Hercílio Martelli Junior

“…The rise in mortality between 2020 and 2023 coincided with a reduction in surgical procedures due to the COVID-19 pandemic. <b>Conclusions:</b> This study revealed a decline in deaths from orofacial clefts in Brazil over several decades. …”
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Clinical Characteristics and Visual Outcomes in Patients with Intralenticular Foreign Bodies with Self-Sealing Corneal Penetrating Wounds by Zhitao Su, Yuanqi Wang, Quanyong Yi, Lin Lin, Kairan Lai, Panpan Ye, Yao Wang, Xiaoyun Fang

“…Data regarding the patient demographics, clinical features, surgical procedure, and initial and final best-corrected visual acuity (BCVA) were analyzed. …”
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BACK TO THE “GOLD STANDARD”: HOW PRECISE IS HEMATOCRIT DETECTION TODAY? by Leonid Livshits, Tal Bilu, Sari Peretz, Anna Bogdanova, Max Gassmann, Harel Eitam, Ariel Koren, Carina Levin

“…Conclusions: This study introduces "micro-HCT" assessment technique using the image-analysis module of "ImageJ" software. This procedure allows overcoming most of the data errors associated with the standard "micro-HCT" evaluation and can replace the use of complicated and expensive automated equipment. …”
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First Brazilian consensus on the management of localized and locally advanced urothelial bladder cancer: a SBU-SBOC-SBRT-LACOG-GU panel review by Lucas Nogueira, Icaro Thiago de Carvalho, Ary Adamy, Daher Chade, Luis Felipe Piovesan, Ricardo Favaretto, Allisson Bruno Barcelos Borges, Arthur Accioly, Diogo Assed Bastos, Diogo Augusto Rodrigues da Rosa, Fernando C Maluf, Andrey Soares

“…The panel drew up 73 questions and answers were chosen considering the feasibility according to the access to drugs and the procedures used in this country. Each answer reaching 75% of voters was considered a consensus. …”
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An exogenous encoding sequence based on DNA data storage technology and its application in assisted reproductive technology by Zhiqing Huang, Taoli Ding, Zixuan Ni, Yujie Zheng, Na Liu, Tuan Li, Wenchang Lian, Beihong Zheng, Yan Sun

“…However, confusion and contamination of samples are common problems in embryo laboratories, preimplantation genetic test (PGT) laboratories, and third-party medical testing laboratories due to large sample numbers and complex procedures. Once these problems occur, they are often difficult to trace, posing risks and ethical challenges to hospital reproductive centers, third-party medical testing laboratories, and patient families. …”
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Rationale and design of SCOPE trial: a prospective, multicentre, open-label, randomised controlled trial to evaluate the overall efficacy and safety of a short-term anticoagulation... by Yang Wang, Yan Li, Lihua Zhang, Ran Liu, Wei Wu, Yang Li, Huiping Zhang, Stuart Pocock, Xinmin Liu, Zhinan Lu, Taiyang Luo, Liang Guo, Fei Yuan, Yi-Da Tang, Yingxuan Zhu, Yunfeng Yan, Guangyuan Song, Zhengming Jiang, SCOPE Investigators

“…Follow-up evaluations are scheduled at 1, 3, 6 and 12 months post-procedure. After the initial 1-month antithrombotic therapy, the regimen may be adjusted by the investigator based on the patient’s clinical and imaging follow-up results. …”
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