Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a. by Thomas C Darton, Claire Jones, Christoph J Blohmke, Claire S Waddington, Liqing Zhou, Anna Peters, Kathryn Haworth, Rebecca Sie, Christopher A Green, Catherine A Jeppesen, Maria Moore, Ben A V Thompson, Tessa John, Robert A Kingsley, Ly-Mee Yu, Merryn Voysey, Zoe Hindle, Stephen Lockhart, Marcelo B Sztein, Gordon Dougan, Brian Angus, Myron M Levine, Andrew J Pollard

“…Limitations to the study included the requirement to limit the challenge period prior to treatment to 2 weeks, the intensity of the study procedures and the high challenge dose used resulting in a stringent model.…”
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Descemet Endothelial Thickness Comparison Trial 1 (DETECT 1): outcome masked, placebo-controlled trial comparing two types of corneal transplant surgeries and effect of rho kinase... by Thomas M Lietman, Jennifer Rose-Nussbaumer, Bennie H Jeng, Benjamin F Arnold, Winston Chamberlain, Charles C Lin, Jennifer Y Li, William Gensheimer, Jameson Clover, Nicole Varnado, Sarah Abdelrahman

“…Adverse events, including rebubble procedures, graft failure and graft rejection, will be documented and analysed using appropriate statistical methods.Conclusion DETECT I aims to provide evidence on the comparative effectiveness of UT-DSAEK and DMEK, as well as the potential benefits of adjuvant topical ripasudil in reducing ECL. …”
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Hope is Not a Strategy: Key Lessons from COVID-19 for Future Health Crises by Knudsen SV, Kristensen I, Kure-Biegel N, Bech M, Agerbak H, Hansen CP, Mohr-Jensen C, Valentin JB, Petersen MB, Mainz J

“…Patient-level data on contacts, contact types, and clinical procedures were obtained from health administrative systems and clinical quality registries. …”
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Feasibility and Safety Properties of Metabolic-Flow Anesthesia Driven by Automated Gas Control^® in Pediatric Patients: A Prospective Observational Study by Emre Sertaç Bingül, Meltem Savran Karadeniz, Emre Şentürk, İrem Vuran Yaz, Ayşe Gülşah Atasever, Mukadder Orhan Sungur

“…Changes in fresh gas flow (FGF) throughout the procedure and postoperative recovery data were also compared. …”
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Enable, empower, succeed: a bioinformatics workshop Harnessing open web-based tools for surveillance of bacterial antimicrobial resistance by Luria Leslie Founou, Opeyemi U. Lawal, Armando Djiyou, Erkison Ewomazino Odih, Daniel Gyamfi Amoako, Stephane Fadanka, Mabel Kamweli Aworh, Sindiswa Lukhele, Dusanka Nikolic, Alice Matimba, Raspail Carrel Founou

“…The workshop introduced participants to basic next-generation sequencing concepts, data file formats used in bacterial genomics, data sharing procedures and considerations, as well as the use of web-based bioinformatics software to analyse genomic data, including in silico prediction of AMR, phylogenetics analyses, and a quick introduction to Linux© command line. …”
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Forty-Two Percent of Patients Undergoing Arthroscopic Shoulder Surgery Are Using Psychotropic Medications by Michael R. Cesarek, M.S., Nicholas O. Gerard, III, M.S., Brianna N. Griswold, B.S., Mia V. Rumps, M.S., Michael J. O’Brien, M.D., Felix H. Savoie, III, M.D., Mary K. Mulcahey, M.D.

“…The following data were collected: age, sex, laterality of surgery, prior surgical procedures on the operated shoulder, specific surgery performed, and use of psychotropic medications. …”
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Secondary School and University Results as Predictors of Success in Law by Patrick Parkinson, Karen Tremayne, Julie Stubbs

“…Law schools could also consciously endeavour to address social, economic and racial inequalities through selection procedures. It is important however to distinguish between the mainstream methods of entry and alternative methods which might apply to disadvantaged groups or for other reasons. …”
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Hybrid Multi-Criteria Decision Framework for Prosumers Energy Storage Systems in Smart Grids by Marriam Liaqat, Muhammad Adnan, Mohaira Ahmad, Muhammad Sajid Iqbal, Faizan Ahmad, Sami Ud Din

“…According to the proposed hybrid procedure, LIB was ranked as the first option by both AHP and PROMETHEE methods. …”
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Bacillus spp. supplementation promotes feed efficiency in mid- to late-lactation dairy cows and affects rumen fermentation traits of rumen-fistulated females offered a corn silage–... by Bruno A.V. Arthur, Luiz Gustavo Nussio, Oscar C.M. Queiroz, Greicieli de Morais, Rafael H.P. Reis, Giuseppe Copani, Jens N. Joergensen, Bruno I. Cappellozza

“…All data were analyzed with the MIXED procedure of SAS using cow as the experimental unit. …”
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Exploration of the optimal regimen of gastric mucosal cleansing medication for the H. pylori population before ME-NBI screening: study protocol for a single-center, single-blind, r... by Xinyi Mu, Yi Fan, Jingyu Xu, Rui Xie

“…Secondary endpoints include the early detection rate of gastric cancer, polyp detection rate, adenoma detection rate, procedure time, number of irrigations, patient medication compliance, preoperative anxiety, incidence of adverse reactions, overall patient satisfaction, and willingness to undergo the examination again.ImplicationsThe results of this research project are aimed at improving the quality of gastric mucosal cleansing preparations in the H. pylori population to meet the demand for early diagnosis and treatment prevention screening for early gastric cancer screening. …”
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Efficacy of a Mobile App–Based Behavioral Intervention (DRIVEN) to Help Individuals With Unemployment-Related Emotional Distress Return to Work: Protocol for a Randomized Controlle... by Elizabeth C Danielson, Mystie Saturday, Sarah Leonard, Alexandra Levit, Andrea K Graham, Melissa Marquez, Keith Alperin, Stewart A Shankman, James W Griffith

“…The intervention and control group procedures will be administered remotely, allowing the study to take place in several regions of the United States. …”
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Are caffeine effects equivalent between different modes of administration: the acute effects of 3 mg.kg−1 caffeine on the muscular strength and power of male university Rugby Union... by Jason Tallis, Michael, J. Duncan, Neil, D. Clarke, Rhys O. Morris, Ryan, A. Tamilio

“…Following assessments and reassessment of chest press (CP), shoulder press (SP), Deadlift (DL), and Squat (SQ) 1-repetition maximum (1RM) and familiarization to the experimental procedures, participants completed six experimental trials where they were administered 3 mg.kg−1 caffeine (Caff) or placebo (Plac) capsule(CAP), chewing gum(GUM) or mouth rinse(RINSE) in a randomized, double-blind and counterbalanced fashion prior to force platform assessment of countermovement jump, drop jump and isometric mid-thigh pull performance. …”
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Comparison of TAP block and epidural analgesia for postoperative analgesia after robotic-assisted radical prostatectomy by O.O. Volkov, Lutsenko V.V., M.O. Plis, M.V. Pavlenko, Krishtafor D.A.

“…Despite the fact that laparoscopic procedures are less invasive surgical interventions, they can still be challenging in terms of postoperative pain, as both somatic and visceral pain pathways are involved. …”
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Comparisons of computer simulations and experimental data for capacitive hyperthermia using different split-phantoms by Rami Muratoglu, Dominik Gerster, Jacek Nadobny, Alexander Hansch, Paul Krahl, Paraskevi Danai Veltsista, Marcus Beck, Daniel Zips, Pirus Ghadjar

“…Horizontally and vertically splittable, different multi-slice phantoms with dielectric material properties simulating muscle and electrically low conductive fat were produced and heated. During the heating procedure, temperature-time curves were measured, and thermal images were captured. …”
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Evaluación del potencial de mejoramiento genético en el crecimiento en altura de Acacia mangium Willd. Evaluation of the breeding potential in height growth for Acacia mangium Will... by Iván Javier Pastrana-Vargas, Miguel Espítia-Camacho, Olman Murillo-Gamboa

“…The prediction of genetic parameters individual and of families was conducted by the method BLUP (best linear unbiased prediction) and the variance components by REML (restricted maximum likelihood) procedure using the software SELEGEN. Heritability estimates ranged from <1 to 13%, and between 6 to 68%, for strictly individual heritability (h²a) and family-mean heritability (h²mp), respectively. …”
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Long-Term Outcomes Following Reverse Total Shoulder Arthroplasty by Matthias Biner, MD, Stafan Klotz, MD, Octavian Andronic, MD, PhD, Daniel C. Karczewski, MD, PhD, Lukas Zingg, MD, Wieser Karl, MD, EMBA, Philipp Kriechling, MD

“…Of 673 studies, 7 retrospective case series with Level IV evidence met the inclusion criteria, totaling 469 rTSA procedures in 460 patients. The weighted mean age was 71 years, with 63% female patients. …”
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Postoperative liver dysfunction in gastric cancer patients following early enhanced nutritional protocols: a retrospective observational study by Kazuo Kobayashi, Satoshi Ida, Masanari Tsuji, Arisa Nawa, Takeshi Aoyama, Takashi Yokokawa, Yoshikazu Tateai, Shuichi Watabe, Hisanori Shimizu, Souya Nunobe, Masakazu Yamaguchi

“…Univariate analysis identified acetaminophen use as a significant risk factor for liver dysfunction on POD 7 (p < 0.05), with open surgery and extensive procedures showing trend-level associations. Multivariate analysis confirmed acetaminophen use as an independent risk factor. …”
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Preliminary Feasibility of a Novel Mind-Body Program to Prevent Persistent Concussion Symptoms Among Young Adults With Anxiety: Nonrandomized Open Pilot Study by Molly Elizabeth Becker, Nadine Stratton Levey, Gloria Y Yeh, Joseph Giacino, Grant Iverson, Noah Silverberg, Robert A Parker, Ellen McKinnon, Caitlin Siravo, Priyanca Shah, Ana-Maria Vranceanu, Jonathan Greenberg

“…At the conclusion of the program, participants attended a qualitative interview and provided feedback about the program to help optimize study content and procedures. ResultsFeasibility markers were excellent for credibility and expectancy (5/5, 100% of participants scored above the credibility and expectancy scale midpoint), client satisfaction (4/5, 80% of participants scored above the Client Satisfaction Questionnaire midpoint), therapist adherence (97% adherence), acceptability of treatment (5/5, 100% of participants attended 3 or more sessions), adherence to homework (87% home practice completion), and feasibility of assessments (no measures fully missing). …”
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Enhanced Biomechanical Properties of the Pectineal Ligament Support Its Reliability for Apical Pelvic Organ Prolapse Repair by Micaela Motzko, Makayla M. Swancutt, Edwin Glueck, Brandalynn Holland, Anna Stock, Zubeen Azari, Elif Diricanli, Jennifer F. Dennis, Melissa Zolnierz

“…The standard approach to correcting apical pelvic organ prolapse uses the sacral anterior longitudinal ligament (SALL) to lift the vaginal apex; however, this approach may result in recurrent prolapse. A newer procedure utilizes the pectineal ligament (PL), which may be a more reliable anchor point. …”
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Establishment and Hemodynamic Assessment of the Superior Cavopulmonary Anastomosis in a Reproducible Porcine Model by Benjamin Bierbach, Luca Pieterek, Jan Dauvergne, Carolin Scholl, Christina Oetzmann von Sochaczewski, Johannes Breuer, Boulos Asfour, Mathieu Vergnat, Tobias Kratz

“…Literature on the superior cavopulmonary connection in porcine models lacks information on details of the procedure as well as data on its acute hemodynamic effects. …”
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