Identification of an elusive SERPING1 deletion in a family with hereditary angioedema type I utilizing soft clipping by Keith Wetherby, Joseph Chiao, Emily Faulkner, Yongjian Guo, Shaobin Hou, J. Joanna Yu, Jinguo Chen, Lili Wan, Lili Wan, H. Henry Li, H. Henry Li

“…We propose that a systematic approach to undetected HAE-causing mutation analysis, incorporating soft clipping as part of an overall strategy, would be more effective in identifying a small percentage of causal variants in approximately 5% of C1-esterase inhibitor HAE cases where no mutation is found by standard laboratory procedures, especially when there are high clinical suspicions of a familiar disorder.…”
Get full text

Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a. by Thomas C Darton, Claire Jones, Christoph J Blohmke, Claire S Waddington, Liqing Zhou, Anna Peters, Kathryn Haworth, Rebecca Sie, Christopher A Green, Catherine A Jeppesen, Maria Moore, Ben A V Thompson, Tessa John, Robert A Kingsley, Ly-Mee Yu, Merryn Voysey, Zoe Hindle, Stephen Lockhart, Marcelo B Sztein, Gordon Dougan, Brian Angus, Myron M Levine, Andrew J Pollard

“…Limitations to the study included the requirement to limit the challenge period prior to treatment to 2 weeks, the intensity of the study procedures and the high challenge dose used resulting in a stringent model.…”
Get full text

Feasibility and Safety Properties of Metabolic-Flow Anesthesia Driven by Automated Gas Control^® in Pediatric Patients: A Prospective Observational Study by Emre Sertaç Bingül, Meltem Savran Karadeniz, Emre Şentürk, İrem Vuran Yaz, Ayşe Gülşah Atasever, Mukadder Orhan Sungur

“…Changes in fresh gas flow (FGF) throughout the procedure and postoperative recovery data were also compared. …”
Get full text

Enable, empower, succeed: a bioinformatics workshop Harnessing open web-based tools for surveillance of bacterial antimicrobial resistance by Luria Leslie Founou, Opeyemi U. Lawal, Armando Djiyou, Erkison Ewomazino Odih, Daniel Gyamfi Amoako, Stephane Fadanka, Mabel Kamweli Aworh, Sindiswa Lukhele, Dusanka Nikolic, Alice Matimba, Raspail Carrel Founou

“…The workshop introduced participants to basic next-generation sequencing concepts, data file formats used in bacterial genomics, data sharing procedures and considerations, as well as the use of web-based bioinformatics software to analyse genomic data, including in silico prediction of AMR, phylogenetics analyses, and a quick introduction to Linux© command line. …”
Get full text

Secondary School and University Results as Predictors of Success in Law by Patrick Parkinson, Karen Tremayne, Julie Stubbs

“…Law schools could also consciously endeavour to address social, economic and racial inequalities through selection procedures. It is important however to distinguish between the mainstream methods of entry and alternative methods which might apply to disadvantaged groups or for other reasons. …”
Get full text

Bacillus spp. supplementation promotes feed efficiency in mid- to late-lactation dairy cows and affects rumen fermentation traits of rumen-fistulated females offered a corn silage–... by Bruno A.V. Arthur, Luiz Gustavo Nussio, Oscar C.M. Queiroz, Greicieli de Morais, Rafael H.P. Reis, Giuseppe Copani, Jens N. Joergensen, Bruno I. Cappellozza

“…All data were analyzed with the MIXED procedure of SAS using cow as the experimental unit. …”
Get full text

Evaluación del potencial de mejoramiento genético en el crecimiento en altura de Acacia mangium Willd. Evaluation of the breeding potential in height growth for Acacia mangium Will... by Iván Javier Pastrana-Vargas, Miguel Espítia-Camacho, Olman Murillo-Gamboa

“…The prediction of genetic parameters individual and of families was conducted by the method BLUP (best linear unbiased prediction) and the variance components by REML (restricted maximum likelihood) procedure using the software SELEGEN. Heritability estimates ranged from <1 to 13%, and between 6 to 68%, for strictly individual heritability (h²a) and family-mean heritability (h²mp), respectively. …”
Get full text

Postoperative liver dysfunction in gastric cancer patients following early enhanced nutritional protocols: a retrospective observational study by Kazuo Kobayashi, Satoshi Ida, Masanari Tsuji, Arisa Nawa, Takeshi Aoyama, Takashi Yokokawa, Yoshikazu Tateai, Shuichi Watabe, Hisanori Shimizu, Souya Nunobe, Masakazu Yamaguchi

“…Univariate analysis identified acetaminophen use as a significant risk factor for liver dysfunction on POD 7 (p < 0.05), with open surgery and extensive procedures showing trend-level associations. Multivariate analysis confirmed acetaminophen use as an independent risk factor. …”
Get full text

RESULTS OF QUALITY COMPREHENSIVE EVALUATION OF DENTAL CARE FOR CHILDREN WITH BLOOD CLOTTING (PATHOLOGY) by M. A. Gavrilenko

“…Work of pediatric dentist is prevented by the risk of bleeding, fear of dental procedures, child’s psychoemotional tension and refusal of treatment because of bleeding. …”
Get full text

Knowledge, Attitudes, and Practices of Cardiac Healthcare Workers Toward Thoracoscopic Surgery in Xinjiang: A Cross-Sectional Study by Aibibula A, Liu Z, Tuerxun A, Aini A, Yu G, Mutailifu D, Huo Q, Maimaitiaili A

“…Aili Aibibula, Zheng Liu, Aikeremu Tuerxun, Abudousaimi Aini, Guojun Yu, Duolikun Mutailifu, Qiang Huo, Abudunaibi Maimaitiaili The Department of Cardiac Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi City, Xinjiang Uygur Autonomous Region, 830054, People’s Republic of ChinaCorrespondence: Abudunaibi Maimaitiaili, The Department of Cardiac Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi City, Xinjiang Uygur Autonomous Region, 830054, People’s Republic of China, Tel +86-18999996526, Email docnebi526@163.comPurpose: Thoracoscopic cardiac surgery can achieve better patient outcomes than median sternotomy, but it is a complex procedure with pros and cons. This study investigated the Knowledge, attitude, and practice (KAP) of cardiac healthcare workers (HWs) toward thoracoscopic surgery in Xinjiang.Methods: This cross-sectional study was conducted from September 2023 to May 2024 at the Department of Cardiac Surgery, First Affiliated Hospital of Xinjiang Medical University, and enrolled HWs working in cardiac surgery (convenience sampling). …”
Get full text

Actualización sobre la transmisión vertical o perinatal del VIH by Eliset Sánchez Ramírez, Yaimara Valdés Silva, Lourdes Robles García, Orlando Esquivel Caballero, Abelardo Forjans Paneque

“…In relation to the obstetric procedure, the invasive techniques were preserved together with the use of cesarean section.   …”
Get full text

KEDUDUKAN HUKUM AKTA RISALAH RAPAT UMUM PEMEGANG SAHAM (RUPS) MELALUI MEDIA ELEKTRONIK by Mira Nila Kusuma Dewi

“…A deed which is signed electronically is equivalent with electronic data which position is recognized as valid as evidence based on Law of the ITE and the Law on Combating Corruption. However, this procedure of such deed is contrary to Article 16 paragraph (1) letter m Law number 2 of Year 2014 that the notarial deed shall be read by Notary before the parties and witnesses. …”
Get full text

Rest intolerance and associated factors among Chinese nursing students: a cross-sectional network analysis by Jiukai Zhao, Yibo Wu, Jiayi Xu, Kunshuo Du, Yu Yang, Shuang Zang

“…The network’s stability was assessed using a case-dropping procedure. Results The self-reported level of rest intolerance indicated a median score of 24 points. …”
Get full text

Evaluation of the Proximity of the Maxillary Teeth Root Apices to the Maxillary Sinus Floor in Romanian Subjects: A Cone-Beam Computed Tomography Study by Vlad Ionuţ Iliescu, Vanda Roxana Nimigean, Cristina Teodora Preoteasa, Lavinia Georgescu, Victor Nimigean

“…CBCT provides essential three-dimensional imaging that improves diagnostic precision and supports safer treatment planning for procedures involving the posterior maxilla.…”
Get full text

Time-in-Range Analysis of Responses after Intravitreal Dexamethasone Therapy in Eyes with Diabetic Macular Edema by Igor Kozak, MD, PhD, Diana V. Do, MD, Hongxin Lai, PhD, Miller J. Ogidigben, PhD, Francisco J. López, MD, PhD

“…Intervention: Intravitreal injection of DEX-I 0.7 mg or sham procedure. Main Outcome Measures: Time in range during year 1 was evaluated using BCVA thresholds of ≥69, ≥51, ≥59, and ≥64 letters, and CRT thresholds of <300, <353, <446, and <551 μm (the latter cutoffs being quartile [Q] 1, Q2, and Q3 of pooled baseline BCVA and CRT, respectively). …”
Get full text

Virtual Diabetes Prevention Program Tailored to Increase Participation of Black and Latino Men: Protocol for a Randomized Controlled Trial by Earle C Chambers, Elizabeth A Walker, Clyde Schechter, Eric Gil, Terysia Herbert, Katelyn Diaz, Jeffrey Gonzalez

“…We will also examine the reach of our recruitment methods and engagement in our screening, consenting, and assessment procedures prior to the point of randomization. We hypothesized that men randomized to Power-Up would achieve greater percent weight loss from baseline at 16 weeks (end of Core sessions) and 1 year (end of Maintenance sessions) than men randomized to standard, mixed-gender NDPP. …”
Get full text

Enhancing Bone Repair with &amp;beta;-TCP-Based Composite Scaffolds: A Review of Design Strategies and Biological Mechanisms by Ni X, Feng J, Liang M, Zhou F, Xia Y, Dong Z, Xue Q, Li Z, Pu F, Xia P

“…Xuewen Ni,1– 3,&amp;ast; Jing Feng,2– 4,&amp;ast; Mengxue Liang,1– 3 Fangzheng Zhou,1– 3 Yuanjie Xia,1– 3 Zijie Dong,1– 3 Qingyu Xue,1– 3 Zehao Li,1– 3 Feifei Pu,2– 4 Ping Xia3,5 1First Clinical College, Hubei University of Chinese Medicine, Wuhan, 430065, People’s Republic of China; 2Department of Orthopedics, Wuhan No.1 Hospital, Wuhan, 430022, People’s Republic of China; 3Department of Orthopedics, Traditional Chinese and Western Medicine Hospital, Hubei University of Chinese Medicine, Wuhan, 430022, People’s Republic of China; 4Department of Orthopedics, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 5Department of Orthopedics, Wuhan Fourth Hospital, Wuhan, 430033, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Feifei Pu, Email pufeifei@hust.edu.cn Ping Xia, Email xiapingfm@163.comAbstract: It is reported that there are approximately 2.2 million bone graft procedures every year due to injuries, bone tumors, marginal bone defects, and aging of the population. …”
Get full text

The short-term effect of laparoscopic sleeve gastrectomy with his angle reconstruction (LSG-His) on gastroesophageal reflux disease by Ke Cao, Zhiwei Zhai, Xuyin Shi, Yin Jin, Chunxiang Ye, Yunlong Wu, Mingyu Sun, Jing Wang, Zhenjun Wang, Jiagang Han

“…Abstract Objective While laparoscopic sleeve gastrectomy (LSG) is an established bariatric procedure for obesity, postoperative gastroesophageal reflux disease (GERD) remains a significant complication. …”
Get full text

A Recovery-Oriented Suicide Prevention Program Led by Peer Specialists for Veterans With Serious Mental Illness: Protocol for a Pilot Randomized Controlled Trial by Samantha Chalker, Jillian Carter, Yuki Imai, Colin Depp, Matthew Chinman

“…Outcomes will be tested using mixed-effects models. Safety procedures for all participants are discussed. …”
Get full text

Diseño óptimo de redes hidráulicas bajo criterios múltiples. // Optimal design of water supply nets by means of multiple criteria optimization. by J. R. Hechavarría Hernández, J. Arzola Ruiz, A. Cordovés García, A. M. Lastre Aleaga

“…The devising of designing solutions for these networks must be<br />accomplished on the basis of high integration of information, the application of modern methods of preparation and<br />decision taking, as well as the rational organization of the engineering calculation procedures involved. The designing<br />process must take into account two of the most important problems of the world: energy and cost.…”
Get full text