Aurantio-obtusin improves obesity and protects hepatic inflammation by rescuing mitochondrial damage in overwhelmed brown adipose tissue by Ruiyu Wu, Runping Liu, Ranyun Chen, Yijie Li, Xiaoyong Xue, Yinhao Zhang, Fanghong Li, Jiaorong Qu, Lingling Qin, Chen Wang, Xiaojiaoyang Li

“…Materials and methods After applying high-fat diet and glucose-fructose water (HFHS)-induced obesity mice, different BAT transplant procedures and primary BAT adipocytes, we investigated the anti-obesity effects and mechanism of AO through RNA sequencing and biology techniques. …”
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A novel paradigm in cleft lip education: integration of 3D-printed simulator and problem-based learning by Xiao-Le Wang, Ying Xie, Ye-Xin Yue, Xue-Wen Yang, Jian Li

“…Abstract Purpose The repair of cleft lip is a highly intricate and challenging surgical procedure in plastic surgery. Consequently, it is also a pivotal and difficult subject in clinical education. …”
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Research progress on internal corrosion of supercritical/dense-phase CO2 pipelines for CCUS by Guangyu LIU, Shujie ZHI, Xin LIU, Chong CHAI, Cailin WANG, Xinran YU, Qihui HU, Shiduo RAO

“…Conclusion To ensure the safe and stable operation of CO2 transportation pipelines, current corrosion research challenges for supercritical/dense-phase CO2 pipelines include: standardizing experimental procedures; studying the impact of impurity coupling on corrosion mechanisms and CPF structures; quantifying the protective effects of CPF characteristics on the substrate; measuring and analyzing electrochemical corrosion parameters in thin liquid film environments within watersaturated CO2 phase; and developing a prediction model for supercritical/dense-phase CO2 corrosion considering coupled multi-impurity interactions.…”
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N‐methylation of histidine to tune tautomeric preferences in histidine‐heme coordination and enzyme‐mimetic catalysis by Ruikai Du, Yunbo Lv, Haifeng Wu, Baoli Zhang, Yuanxi Liu, Shichao Xu, Shan Li, Zhen‐Gang Wang

“…However, evaluating the impact of Nδ and Nε is difficult, and directly integrating noncanonical N‐methylated histidine within enzymes poses risks due to laborious procedures. In this study, we present the self‐assembly of Fmoc‐Histidine (Fmoc‐His) with hemin to create a peroxidase‐mimetic catalyst, in which either the Nε or Nδ of histidine is methylated to modify the tautomeric preferences, thereby tuning hemin catalysis. …”
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Bone Tissue Regeneration in the Oral and Maxillofacial Region: A Review on the Application of Stem Cells and New Strategies to Improve Vascularization by Vivian Wu, Marco N. Helder, Nathalie Bravenboer, Christiaan M. ten Bruggenkate, Jianfeng Jin, Jenneke Klein-Nulend, Engelbert A. J. M. Schulten

“…Both adipose tissue-derived SVF and MF are cell sources with clinical feasibility due to their large quantities that can be harvested and applied in a one-step surgical procedure. During the past years, important advancements of stem cell application and vascularization in bone tissue regeneration have been made. …”
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Uniportal Robotic Lobectomy and Lymphadenectomy for Invasive Lung Cancer: A Novel Approach and Perioperative Outcomes by Shengcheng Lin, Xiangyang Yu, Yafei Xu, Yu Xin, Jie He, Zhentao Yu, Hongbo Zhao, Chenglin Yang, Kai Ma

“…The median durations of the operation and the uRATS procedure were 200 min (range, 142–330 min) and 140 min (range, 80–242 min), and the median intraoperative blood loss volume was 20 mL (range, 10–100 mL), respectively. …”
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The articulated laparoscopic total mesorectal excision for rectal cancer (ATOME trial): a single-arm, prospective trial with pre-specified comparison to robotic surgery by Kyeong Eui Kim, Sung Uk Bae, Seung Hyun Lee, Dae-Ro Lim, Heon-Kyun Ha, Jin Kim, Hyo Seon Ryu, Soo Yeon Park, Sung Il Kang, Gyung Mo Son, Soo Young Lee, Chang Hyun Kim, Kyung Ha Lee, Gi Won Ha, Hye Jin Kim, Woong Bae Ji, Woo Ram Kim, Sang Hee Kang, Nak Song Sung, Ji Hoon Kim, Taek-Gu Lee, Myung Jo Kim, Woon Kyung Jeong, Seong Kyu Baek

“…Abstract Background Laparoscopic total mesorectal excision (TME) has become the standard surgical treatment for rectal cancers, despite being a technically challenging procedure due to the straight and rigid nature of the laparoscopic instrument within a narrow bony pelvis. …”
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Protocol for a systematic review and meta-analysis of the prevalence of viral infections in acute apical abscesses by José Ángel Hernández-Mariano, Gustavo Adolfo Sánchez-Ramírez, Guillermo Cano-Verdugo, Myriam Angélica De la Garza-Ramos, Martín Andrés Chávez- Méndez, Claudio Peña-Soto, Mónica Alethia Cureño-Díaz

“…Abstract Background There is no current consensus on the presence of viral infections in acute apical abscesses; therefore, this protocol for a systematic review and meta-analysis is designed to detail the procedures required to investigate the prevalence of viral infections in acute apical abscesses, a common dental condition characterized by pus accumulation due to bacterial infection. …”
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Self-reported health and depression among EIRA cohort: a moderated mediation model of sex and perceived social support by Raquel Sánchez-Recio, Raquel Sánchez-Recio, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Fátima Méndez-López, Fátima Méndez-López, Fátima Méndez-López, Santiago Gascón-Santos, Santiago Gascón-Santos, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Edurne Zabaleta-Del-Olmo, Olaya Tamayo-Morales, Olaya Tamayo-Morales, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, José A. Maderuelo-Fernández, Marc Casajuana, Tomas López-Jiménez, Emma Motrico, Emma Motrico, Irene Gómez-Gómez, Irene Gómez-Gómez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, María Luisa Rodero-Cosano, Joan Llobera, Joan Llobera, Joan Llobera, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Juan A. Bellón, Patricia Moreno-Peral, Patricia Moreno-Peral, Bonaventura Bolíbar, Bonaventura Bolíbar, José I. Recio-Rodríguez, José I. Recio-Rodríguez, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, Ana Clavería, Ana Clavería

“…To determine the mediating effect between social support and self-perceived health, three regression analyses were carried out using the procedure designed by Hayes through the PROCESS macro for SPSS.Results3,062 people (54.9% women) participated in the study. …”
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A Comparison of the Incidences of Venous Thromboembolism after Total Hip Arthroplasty between the Direct Anterior Approach and the Direct Lateral Approach, Especially in the Early... by Tetsuya Kawano, Hiroaki Kijima, Shin Yamada, Natsuo Konishi, Hitoshi Kubota, Hiroshi Tazawa, Takayuki Tani, Norio Suzuki, Keiji Kamo, Yoshihiko Okudera, Masashi Fujii, Ken Sasaki, Yosuke Iwamoto, Itsuki Nagahata, Takanori Miura, Naohisa Miyakoshi, Yoichi Shimada

“…It may be important to shorten the surgical time in the early stage of introducing the DAA, and aggressive anticoagulation therapy may be required until the surgeon becomes familiar with the procedure.…”
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Zero-contrast imaging for the assessment of transcatheter aortic valve implantation in candidates with renal dysfunction by Guy F. A. Prado, Stefano Garzon, Jose Mariani, Adriano Caixeta, Breno O. Almeida, Felipe O. Ramalho, Marcelo L. C. Vieira, Claudio H. Fischer, Gilberto Szarf, Walther Ishikawa, Pedro A. Lemos

“…Background Candidates for transcatheter aortic valve implantation (TAVI) are currently evaluated using computed tomography angiography and invasive cardiac catheterization as an essential part of case selection and pre-procedure interventional planning. However, both imaging methods utilize iodinated agents, which may cause contrast-induced nephropathy, particularly in patients with baseline renal dysfunction. …”
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Ultrasonographic evaluation of testicular and Pampiniform plexus characteristics in young bulls under different microclimatic conditions in a tropical environment by Joedson Dantas Gonçalves, Alexandre Rossetto Garcia, Rubens Paes de Arruda, José Ricardo Macedo Pezzopane, Felipe Tonato, Alda Juliana Castro de Sousa, Lívia Ferreira Pinho, Veronica Schinaider do Amaral Pereira, Gabriel Brun Vergani, Maria Emilia Franco Oliveira

“…Data were analyzed using the PROC MIXED procedure of SAS (p < 0.05), and possible interactions between production systems and animal age are presented. …”
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A rare case of sigmoid colon cancer in which the lower limbs received collateral blood flow from the inferior mesenteric artery owing to peripheral artery disease by Kyoichi Kihara, Hiromu Horie, Kozo Miyatani, Masayuki Endo, Tomoyuki Matsunaga, Manabu Yamamoto, Shinsaku Yata, Naruo Tokuyasu, Teruhisa Sakamoto, Yoshiyuki Fujiwara

“…Lymph node dissection along the inferior mesenteric artery is a vital procedure in cases of left-sided colorectal cancer. …”
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Parents' experiences of parenting a child with profound intellectual and multiple disabilities in France: A qualitative study by Marie‐Anastasie Aim, Marie‐Christine Rousseau, Ilyes Hamouda, Any Beltran Anzola, Thierry Billette deVillemeur, Mathieu Milh, Kim Maincent, Katia Lind, Pascal Auquier, Karine Baumstarck, Lionel Dany

“…Patient or Public Contribution One of the researchers, a parent of a child with PIMD, supported the research design and provided feedback on the study's procedures and manuscript.…”
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Pulsatilla saponin inhibits the proliferation of keratinocytes and ameliorates imiquimod-induced psoriasis through the NF-κB and STAT3 signaling pathways by Jilang Li, Haixin Qiu, Siyuan Li, Shan Han, Yuming He, Jia He, Xiang Gao, Jingjing Li, Jianfang Feng, Shilin Yang, Renyikun Yuan, Hongwei Gao

“…This study aims to investigate the effect and potential mechanisms of Ps on psoriasis. Experimental procedure: Ps underwent quality control through HPLC and NMR analysis. …”
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Evaluation of the Efficacy of Lusutrombopag for Chronic Liver Disease Based on Pre‐Treatment Platelet Counts: A Retrospective Multicenter Study by Takayoshi Suga, Satoru Kakizaki, Atsushi Naganuma, Takeshi Hatanaka, Satoshi Takakusagi, Daichi Takizawa, Hirotaka Arai, Takashi Ueno, Keisuke Iizuka, Toru Fukuchi, Shuichi Saito, Hiroki Tojima, Yuichi Yamazaki, Toshio Uraoka

“…ABSTRACT Background Oral thrombopoietin receptor agonists are used to treat thrombocytopenia in patients with chronic liver disease who are scheduled for invasive procedures. The efficacy of lusutrombopag based on the pretreatment platelet count was investigated. …”
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Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors by Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang

“…Methods From January 2020 to December 2023, the medical records of 391 SELs (364 patients) were retrospectively reviewed and categorized into no EUS, mEUS-only, and SSI-mEUS groups according to the procedure used. To compare variables between the SSI-mEUS and other groups, the no EUS and mEUS-only groups were combined into the non-SSI-mEUS group. …”
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Surgical Hemostasis for Severe Multisystem Pelvic Injuries by I. V. Kazhanov, A. Y. Demko, V. A. Manukovsky, S. I. Mikityuk, V. A. Reva, E. A. Kolchanov, D. V. Pavlov

“…For the treatment of patients with severe multysistem pelvic trauma accompanied by pelvic bleeding, many algorithms have been proposed that have different procedures for the use of various methods of surgical hemostasis, but none of them may guarantee the complete arrest of pelvic bleeding. …”
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Bradykinin measurement by liquid chromatography tandem mass spectrometry in subjects with hereditary angioedema enhanced by cold activation by Jinguo Chen, MD, Yunkou Wu, PhD, J. Joanna Yu, MD, PhD, Joseph Chiao, MD, Jing Yu, PhD, Mark D. Scarupa, MD, Lili Wan, PhD, H. Henry Li, MD, PhD

“…The protocol was developed and validated according to the US Food and Drug Administration Bioanalytical Method Validation guidelines. The procedure was optimized on specimen selection, collection, and process, as well as variable controls such as time windows, temperature, and storage conditions. …”
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The influence of male smoking on success rates after IVF/ICSI by S. De Brucker, E. Dhooge, P. Drakopoulos, V. Uvin, S. Mackens, L. Boudry, M. De Vos, V. Vloeberghs, H. Tournaye, M. De Brucker

“…The crude analysis showed higher positive hCG and LBR in smokers (positive hCG 28.34% in nonsmokers vs 33.95% in smokers, p = 0.015; LBR 23.55% in nonsmokers vs 28.64% in smokers, p = 0.019) However after adjustment for relevant confounders (female age, BMI, cause of infertility, number of oocytes retrieved, insemination procedure, number of embryos transferred and day of embryo transfer) the smoking status was not significantly associated with fresh LBR (OR = 1.16, CI = 0.92–1.48; p = 0.2). …”
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