Soy Isoflavones Protects Against Stroke by Inhibiting Keap1/NQO1/Nrf2/HO-1 Signaling Pathway: Network Pharmacology Analysis Combined with the Experimental Validation by Huiming Xue, Zhen Feng, Chang Jin, Yue Zhang, Yongxing Ai, Jing Wang, Meizhu Zheng, Dongfang Shi

“…., positive control). All procedures were approved by the Institutional Animal Care and Use Committee of Changchun Normal University (Approval No. 2024003, 13 March 2024) and conducted in accordance with the NIH guidelines and ARRIVE 2.0 reporting standards. …”
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Strategic Lessons Learned from The Management of Covid-19 That Can Influence Better Management of Future Pandemics in Nigeria. by Basiru, A. , Erhabor, O. 1 , Erhabor, T.

“…The prices of food, cost of agricultural equipment, fertilizers and seed should be subsidized, agricultural loans and grants should be provided for farmers, the problem of insurgency and insecurity in Northern Nigeria, and other parts of the nation should be aggressively dealt with, aggressive public health interventions and restrictions against mass gatherings should be sustained in the face of a ravaging pandemic like Covid-19 and other future epidemic, the Nigerian Central banks and commercial banks should do more in supporting businesses to enable them weather the storm created by the pandemic by providing liquidity support, borrower assistance, monetary easing for struggling businesses as well as extend banking services including cash dispensing ATM and online banking services and internet connectivity in rural settings across the nation, religious community need to work in partnership with government to ensure strict implementation of infection control measures (hand washing, use of sanitizers, social distancing, prompt testing for members at risk as well as vaccination advocacy) as well as develop a Standard Operation Procedure (SOP) regarding gatherings during times of infectious disease epidemics/pandemics, isolation centers must be fit for purpose and the environment should be conducive and enabling in terms of comfort and availability of equipment, staffing and protective equipment required. …”
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Comparison of the efficacy of high-flow oxygen insufflations and continuous positive airway pressure during one-lung ventilation undergoing video-assisted thoracoscopic surgery by A. G. Farshatov, E. N. Ershov, A. V. Shchegolev

“…The usage of high-flow oxygen insufflation during one-lung ventilation undergoing VATS allows to effectively correcting hypoxemia similar to the CPAP method, but as opposed to CPAP, it can provide comfortable conditions for carrying out the surgical procedures.…”
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Assessment of Maxillary Expansion Techniques by means of 3D Elastoplastic Finite Element Static Simulation by Olesya Shosheva, Mikhail Zhmaylo, Leonid Maslov, Aleksey Borovkov, Nataliia Vishneva, Anastasiia Lanina, Andrey Yaremenko

“…The purpose of this study is to determine the optimal technique from the procedures proposed by doctors for a patient with completed facial skeleton growth. …”
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Comparison of Subconjunctival Triamcinolone with Topical Prednisolone for Routine Anti-Inflammatory Prophylaxis in Manual Small Incision Cataract Surgery: A Single-Center, Randomiz... by Papa-Vettorazzi R, Shorstein NH, Peterson B, Yee Melgar M, Silva Linares L, O'Brien KS

“…Recent studies have shown superior effectiveness of the injection technique compared with topical drops in phacoemulsification surgery, a more costly procedure. This will be the first study of this technique in MSCIS.Keywords: cystoid macular edema, intraocular pressure rise, rebound iritis, triamcinolone acetonide injection, dropfree cataract surgery…”
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APPLICATION OF OBJECTIVE AND SUBJECTIVE EVALUATION METHODS FOR MASTICATORY FUNCTION IN PATIENTS WITH MANDIBULAR OVERDENTURES by R.R. Bratus-Hrynkiv, A.Yu. Kordiiak

“…Patients of the group I underwent physiological masticatory test with agar-agar samples formed according to UMSA method, patients of group II- masticatory test procedure and interview survey. The second stage was performed by the group III–42 persons –23 women, 19 men (aged 56-89 years) at 1, 6 and 12 months after mandibular dental arch restoration with complete removable overdentures, fixed by spherical attachments. …”
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Protocol for a prospective cohort study to determine the multimodal biomarkers of delirium and new dementia after acute illness in older adults: ORCHARD-PS by Jessica Knight, Davide Simonato, Sarah Evans, Nicola G Lovett, Jasmine Ming Gan, Aubretia McColl, Lily Elderton, Meenu Vijayakumar Sheela, John Louca, Kinza Shahab, Mary Sneade, Nycola Muchenje, Mariya Fenchyn, Sarah Tamsin Pendlebury

“…Informant questionnaire data and interview are supplemented by hand searching of medical records and linkage to electronic patient records for nursing risk assessments, vital observations, laboratory results and International Classification of Diseases, Tenth Revision diagnostic and procedure codes.In-person follow-up with more detailed cognitive testing and informant interview is undertaken at 3 months, and 1 and 3 years supplemented with indirect follow-up using medical records. …”
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Circulating biomarkers associated with pediatric sickle cell disease by Cecilia Elorm Lekpor, Cecilia Elorm Lekpor, Cecilia Elorm Lekpor, Felix Abekah Botchway, Adel Driss, Alaijah Bashi, Afua D. Abrahams, Kwadwo Asamoah Kusi, Godfred Futagbi, Ernest Alema-Mensah, William Agbozo, Wesley Solomon, Adriana Harbuzariu, Andrew A. Adjei, Jonathan K. Stiles

“…A cross-sectional study utilized a multiplexed immunoassay procedure to evaluate serum biomarkers, including cytokines, chemokines, vascular injury markers, systemic inflammation markers, cell-free heme scavengers, brain-derived neurotrophic factor (BDNF), and angiogenic factors.ResultsElevated levels of BDNF, Ang-2, CXCL10, CCL11, TNF-α, IL-6, IL-10, IL12p40, ICAM-1, VCAM-1, Tie-2, and VEGFA were observed in HbSS subjects, correlating with hemoglobin level, leukocyte, and erythrocyte counts. …”
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Abstract 254: Imaging Findings of Stroke Following Treatment of Ruptured Cerebral Aneurysm Increases Risk of Postoperative Delirium by Abdullah M. Al Qudah, Mohamed F. Doheim, Varshapriya Suresh, Diti Vinuthna Lavu, Sreeja Sivaguru, Adham Shhadeh, Leen Alkalbani, Abdullah Sultany, Guvanch Kakamyradov, Parthasarathy D. Thirumala

“…According to a recent study, approximately one in five patients undergoing intracranial procedures are vulnerable to postoperative delirium within the first three days of surgery.1‐4 Retrospective cohort studies found a link between postoperative delirium and intraoperative hypotension, indicating reduced cerebral blood flow.5 ICSS‐ MRI study (International Carotid Stenting Study Magnetic Resonance Imaging Study), indicated that patients with periprocedural hemodynamic depression had decreased cerebral blood flow and increased the risk of new lesions in imaging.6 Ruptured intracerebral aneurysms are associated with higher morbidity and mortality than unruptured ones. …”
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Three-dimensional characterization of ascending aortic strain, motion and growth in patients undergoing thoracic endovascular aortic repair by Nicasius Tjahjadi, MD, Carlos Campello Jorge, MD, Prabhvir S. Marway, MD, Taeouk Kim, MSc, Timothy Baker, PhD, Constantijn Hazenberg, MD, PhD, Joost A. van Herwaarden, MD, PhD, C. Alberto Figueroa, PhD, Himanshu J. Patel, MD, Nicholas S. Burris, MD

“…Aortic displacement and strain were compared between patients who underwent TEVAR (both pre- and post-procedure) and in patients with dilated ascending aorta (>4.0 cm) and a non-dilated control group. …”
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Comparison of Hyperbaric 0.5% Levobupivacaine and Hyperbaric 0.75% Ropivacaine for Intrathecal Use in Infraumbilical Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Priya Kishnani, Richa Tailor, Sara Mary Thomas

“…This makes levobupivacaine useful for longer-duration surgeries, while ropivacaine is more suitable for shorter-duration procedures.…”
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Protective role of self-assembled nanoparticle vaccine of Pseudomonas aeruginosa in a mouse model of bronchiectasis with acute infection by WU Ziyu, WU Ziyu, ZHANG Yueyue, ZHANG Yiwen

“…Immunization was conducted at the same dose and procedure as described above, in 21 d after bronchiectasis modeling. …”
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Retained Intrauterine Device (IUD): Triple Case Report and Review of the Literature by Mon-Lai Cheung, Shadi Rezai, Janelle M. Jackman, Neil D. Patel, Basem Z. Bernaba, Omid Hakimian, Dilfuza Nuritdinova, Catherine L. Turley, Ray Mercado, Takeko Takeshige, Sudha M. Reddy, Paul N. Fuller, Cassandra E. Henderson

“…A multidisciplinary procedure with gynecologic-oncologist was scheduled for removal due to the high risk of perioperative bleeding. …”
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Pandemic as an Organizational Paradigm for Neonatal Care: Long-Term Impact of Mother–Infant Separation Practice During COVID-19 by Maria Di Chiara, Benedetta De Santis, Flavia Gloria, Fabio Natale, Annarita Ferazzoli, Gianluigi Laccetta, Alessandra Marciano, Roberto Brunelli, Gianluca Terrin

“…Given the potential of recurrent outbreaks of other viral pandemics, our results suggest more caution early in life towards the disruption of consolidated procedures that may have long-term consequences. However, the COVID-19 pandemic offered a unique context to observe the effects of temporary mother–infant separation; clinicians should be reassured that the temporary separation practice did not affect neurodevelopment and be aware that it could be considered an option, at least if Rooming-In cannot be carried out due to severe reasons such as lack of staff or adequate space.…”
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Hemodynamic parameters and neurogenic pulmonary edema following spinal cord injury: an experimental model Parâmetros hemodinâmicos e edema pulmonar neurogênico após traumatismo raq... by Manoel Baldoino Leal Filho, Rosana C. Morandin, Amanda R. de Almeida, Elizabeth C. Cambiucci, Konradin Metze, Guilherme Borges, José Antonio Rocha Gontijo

“…Six animals died suddenly with pulmonary edema. Using the procedure to investigate the pulmonary edema during 60 seconds of compression, followed by decompression and time-course of 60 seconds, 20 rats were randomly asigned to one of the following groups: control (1, n=4, anesthetized by i.p. s.p., 60 mg/Kg but without compression) and experimental (2, n=7, anesthetized by i.p. xylazine 10 mg/Kg and ketamine 75 mg/Kg) and (3, n=9, anesthetized by i.p. s.p., 60 mg/Kg). …”
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Effectiveness of Glecaprevir/Pibrentasvir in Patients with Chronic HCV-infection Genotypes 1 to 6 in the real-world settings in Russia (EVEREST study) by О. I. Sagalova, V. S. Adonieva, S. V. Zotov, D. A. Gusev, E. A. Strebkova, R. B. Galbraikh, V. G. Morozov, I. M. Khayertynova, I. V. Krasilnikova, I. V. Sannikova, A. Bhagat, D. O. Milenin, A. P. Efremova

“…Real-world data were collected in patient records. Follow-up visits, procedures, and diagnostic methods followed physicians’ routine clinical practice.Results: Overall 161 patients were enrolled in the study in 11 study sites of them 128 patients had sufficient follow-up data to assess sustained virological response 12 weeks [i.e. ≥70 days] after the end of treatment with GLE/PIB (SVR12). …”
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Assessing Facial Thermal Nociceptive Response in Female Dogs After Elective Ovariohysterectomy Anesthetized with Isoflurane and Treated with Cannabidiol and Meloxicam Analgesia by Alejandro Casas-Alvarado, Patricia Mora-Medina, Ismael Hernández-Avalos, Julio Martínez-Burnes, Agatha Miranda-Cortes, Adriana Domínguez-Oliva, Daniel Mota-Rojas

“…After the anesthetic surgical procedure, radiometric images were captured using IRT and physiological parameters during the events E_Basal, E_30min, E_1h, E_2h, E_3h, E_4h, E_8h, E_12h, E_24h and E_48h. …”
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In Vitro Enzymatic and Computational Assessments of Pyrazole–Isatin and Pyrazole–Indole Conjugates as Anti-Diabetic, Anti-Arthritic, and Anti-Inflammatory Agents by Ahmed M. Naglah, Abdulrahman A. Almehizia, Mohammed Ghazwani, Asma S. Al-Wasidi, Abdelrahman A. Naglah, Wael M. Aboulthana, Ashraf S. Hassan

“…<b>Methods</b>: The two series of pyrazole–isatin conjugates <b>12a</b>–<b>h</b> and pyrazole–indole conjugates <b>14a</b>–<b>d</b> were prepared from our previous works via the direct reaction of 5-amino-pyrazoles <b>10a</b>–<b>d</b> with <i>N</i>-alkyl isatin <b>11a</b>,<b>b</b>, and 1<i>H</i>-indole-3-carbaldehyde (<b>13</b>), respectively, using the previously reported procedure. The potential biological activities of <b>12a</b>–<b>h</b> and <b>14a</b>–<b>d</b> as anti-diabetic, anti-arthritic, and anti-inflammatory agents were assessed through estimated inhibition percentage (%) and the median inhibitory concentrations (IC₅₀) using methods described in the literature. …”
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Modelling of increased homocysteine in ischaemic stroke: post-hoc cross-sectional matched case-control analysis in young patients Aumento de homocisteína em acidente vascular cereb... by Penka A. Atanassova, Evgeniya Angelova, Plamen Tzvetanov, Maria Semerdjieva, Borislav D. Dimitrov

“…METHOD: We used clinical methods, instrumental and neuroimmaging procedures, risk factors examination, total plasma homocysteine measurements and other laboratory and statistical modelling techniques. …”
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Associations of serum fatty acids, serum urea nitrogen, and ruminal ammonia nitrogen with residual feed intake in lactating dairy cows by W.M. Coelho, Jr., H.F. Monteiro, C.C. Figueiredo, B. Mion, J.E.P. Santos, R.S. Bisinotto, F. Peñagaricano, P. Vahmani, E.S. Ribeiro, F.S. Lima

“…Rumen fluid samples were collected using an oro-esophageal tubing procedure. Serum samples were used to measure fatty acids using a 2-step assay. …”
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