Aptamer-based dual-enzyme, amplification-free biosensor integrating CRISPR-Cas12a and Exo III for sensitive detection of ATP by Baolin Li, Yaxin Huang, Zixin Zhu, Min Zhong, Guangrong Li, Jinbo Liu

“…The current methods for ATP detection suffer from drawbacks such as complex procedures, reliance on expensive instruments, and prolonged reaction times. …”
Get full text

C²SP-Net: Joint Compression and Classification Network for Epilepsy Seizure Prediction by Di Wu, Yi Shi, Ziyu Wang, Jie Yang, Mohamad Sawan

“…Although many data compression methods can be adopted to compress the signals to reduce communication bandwidth requirement, they require complex compression and reconstruction procedures before the signal can be used for seizure prediction. …”
Get full text

Collection of samples from women at different stages of pregnancy to search for early biomarkers of preterm birth by R. A. Illarionov, O. V. Kosyakova, E. S. Vashukova, N. O. Yurkina, M. O. Bakleicheva, Yu. s. Dolgova, T. A. Sushko, D. R. Eremeeva, M. S. Zainulina, M. I. Yarmolinskaya, O. N. Bespalova, A. S. Glotov

“…In order to standardize the sample collection, standard operation procedures have been developed with a step-by-step protocol for each research member at the clinical (collection of medical data and biological material) and laboratory (transportation, sample preparation, storage, quality control) stages.Results. …”
Get full text

<i>Clostridium difficile</i>-associated disease by V. T. Ivashkin, O. S. Shifrin, A. S. Tertycnhy, Ye. A. Poluektova, T. L. Lapina, O. S. Lyashenko, K. V. Ivashkin

“…This is why it is extremely important to be able to diagnose, treat in due terms this disease and to carry out prophylactic procedures.…”
Get full text

Endoscopic Submucosal Dissection for Early Colorectal Neoplasms: Clinical Experience in a Tertiary Medical Center in Taiwan by Mei-Yu Tseng, Jung-Chun Lin, Tien-Yu Huang, Yu-Lueng Shih, Heng-Cheng Chu, Wei-Kuo Chang, Tsai-Yuan Hsieh, Peng-Jen Chen

“…No delayed perforation or postoperative bleeding was recorded. There were no procedure-related morbidities or mortalities. Conclusion. …”
Get full text

Optimization of multioutlet hydrant location and pressurized irrigation network layout using the GRASP metaheuristic by César González-Pavón, Carmen Virginia Palau, Juan Manzano-Juárez, Santiago Guillem-Picó, Ibán Balbastre-Peralta

“…To address this, the study proposes an optimization approach utilizing geographic information systems (GIS) and the greedy randomized adaptive search procedures (GRASP) algorithm. By determining the optimal location and number of multioutlet hydrants required, the methodology aims to enhance network efficiency, on the one hand, in hydraulic terms when considering the sizing of the multioutlet hydrant and in economic terms in reference to the cost of installation and subsequent maintenance. …”
Get full text

A Randomized Controlled Trial Comparing Subcutaneous Preservation of Bone Flaps with Cryogenic Preservation of Bone Flaps for Cranioplasty in Cases of Traumatic Brain Injury by Rachith Sridhar, Anil Kumar, Harendra Kumar, Abdul Vakil Khan, Abdul Hakeem, Deepak Kumar, Anurag Kumar, Majid Anwer

“…Background and objectives: Decompressive craniectomy (DC) is a surgical procedure, useful for relieving the intracranial pressure following trauma. …”
Get full text

First trimester prenatal screening in multiple pregnancies. Part I: comparative analysis of serum proteins PAPP-A and p-hCG in pregnancies conceived spontaneously or by in vitro fe... by V. I. Tsibizova, I. E. Govorov, T. М. Pervunina, E. V. Komlichenko, E. K. Kudryashova, D. V. Blinov, A. D. Makatsariya, G. C. Di Renzo

“…The study group included multiple pregnancies as a result of IVF procedure (n = 100) and spontaneous multiple pregnancies (n = 121) considered as controls. …”
Get full text

Bivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies by Grayson Hatfield, Lioudmila Tepliakova, Jessica Tran, Huixin Lu, Michel Gilbert, Roger Y. Tam

“…Despite being low in abundance in typical commercial mAbs, the inherent sensitivity of cell culture conditions on glycosylation profiles, and the development of novel glycoengineering strategies, novel antibody-based modalities, and biosimilars by various manufacturers with varying procedures, necessitates a better understanding of the structural requirements for anti-α1–3-Gal IgE binding to the Fc region. …”
Get full text

Is the combination of linagliptin and allopurinol better prophylaxis against post-contrast acute kidney injury? A multicenter prospective randomized controlled study by Ahmed Fayed, Ahmed A. Hammad, Dina O. Abdulazim, Hany Hammad, Mohamed Amin, Samir Elhadidy, Mona M. Salem, Ibrahim M. Abd ElAzim, Lajos Zsom, Eva Csongradi, Karim M. Soliman, Usama A. Sharaf El Din

“…The first control group received N-acetyl cysteine and saline, the 2nd received allopurinol, the 3rd group received linagliptin, and the 4th received both allopurinol and linagliptin. Post-procedure follow-up for kidney functions was conducted for 2 weeks in all patients.Results 20, 19, 14, and 8 patients developed post-contrast AKI in groups 1 through 4, respectively. …”
Get full text

Psychometric properties of the Dental Fear Schedule Subscale in a Portuguese pediatric population: exploratory study by Inês Esteves, Andreia Costa, Ana Coelho Canta, Sónia Mendes

“…Factor analysis identified two factors: “Fear of unknown people” and “Fear of invasive procedures,” explaining 54.1% of the variance. A significant inverse correlation was observed between DFSS-SF and FBRS scores (r=-0.346; p=0.008). …”
Get full text

Association between early initiation of anti-herpesvirus therapy and outcomes in herpesvirus encephalitis: A Nationwide Retrospective Propensity Score Analysis in Japan by Satoshi Kutsuna, Hiroyuki Ohbe, Yuya Kimura, Keito Shinmoto, Yuichiro Matsuo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga

“…Methods: We conducted a nationwide retrospective cohort study using the Diagnosis Procedure Combination (DPC) database in Japan from July 2010 to March 2023. …”
Get full text

Highly Shielded Peroxo‐Cerium(IV)‐Containing Polyoxometalate: Synthesis, Structure, and Oxidative Studies by Anusree Sundar, Danica Bajuk‐Bogdanović, Gordana Ćirić‐Marjanović, Talha Nisar, Veit Wagner, Arnulf Materny, Geoffrey B. Jameson, Bassem S. Bassil, Ulrich Kortz

“…The peroxo‐bridged di‐cerium(IV)‐di‐lithium‐containing polyoxometalate [(CeIV2O2)Li2(P2W16O59)2]16− (Ce2Li2P4W32) is synthesized in a one‐pot aqueous synthetic procedure and isolated as a hydrated mixed alkali salt, K13.6Na1.4Li[(CeIV2O2)Li2(P2W16O59)2]·32H2O (KNaLi‐Ce2Li2P4W32). …”
Get full text

Application of intraorbital magnets in the removal of magnetic intraorbital foreign bodies by Shanyu Li, Li Li, Xiaoxuan Wang, Rui Niu, Jie Zhang, Shaolei Han, Xiujun Liu, Jinchen Jia

“…Conclusion Foreign body removal using a strong magnet is the optimal surgical procedure for treating deep intraorbital metallic foreign bodies.…”
Get full text

Robotic sympathetic trunk reconstruction for compensatory sweating after thoracic sympathectomyCentral MessageProspective by Lisa Wen-Yu Chen, MD, Tommy Nai-Jen Chang, MD, Chin-Pang Lee, MD, Cheyenne Wei-Hsuan Sung, MD, Chuan Cheng, MD, Kuo-Hsuan Chang, MD, PhD, Yin-Kai Chao, MD, PhD

“…Results: The mean age of the study participants was 43.3 ± 7.8 years, and 20 (87%) were men. The reversal procedure was performed after a mean of 19.6 ± 7.8 years from endoscopic thoracic sympathectomy. …”
Get full text

The Cosmic Evolution Early Release Science Survey (CEERS) by Steven L. Finkelstein, Micaela B. Bagley, Pablo Arrabal Haro, Mark Dickinson, Henry C. Ferguson, Jeyhan S. Kartaltepe, Dale D. Kocevski, Anton M. Koekemoer, Jennifer M. Lotz, Casey Papovich, Pablo G. Pérez-González, Nor Pirzkal, Rachel S. Somerville, Jonathan R. Trump, Guang Yang, L. Y. Aaron Yung, Adriano Fontana, Andrea Grazian, Norman A. Grogin, Lisa J. Kewley, Allison Kirkpatrick, Rebecca L. Larson, Laura Pentericci, Swara Ravindranath, Stephen M. Wilkins, Omar Almaini, Ricardo O. Amorín, Guillermo Barro, Rachana Bhatawdekar, Laura Bisigello, Madisyn Brooks, Véronique Buat, Fernando Buitrago, Denis Burgarella, Antonello Calabrò, Marco Castellano, Yingjie Cheng, Nikko J. Cleri, Justin W. Cole, M. C. Cooper, Olivia R. Cooper, Luca Costantin, Isa G. Cox, Darren Croton, Emanuele Daddi, Kelcey Davis, Avishai Dekel, David Elbaz, Vital Fernández, Seiji Fujimoto, Giovanni Gandolfi, Jonathan P. Gardner, Eric Gawiser, Mauro Giavalisco, Carlos Gómez-Guijarro, Yuchen Guo, Ansh R. Gupta, Nimish P. Hathi, Santosh Harish, Aurélien Henry, Michaela Hirschmann, Weida Hu, Taylor A. Hutchison, Kartheik G. Iyer, Anne E. Jaskot, Saurabh W. Jha, Intae Jung, Susan A. Kassin, Vasily Kokorev, Peter Kurczynski, Gene C. K. Leung, Mario Llerena, Arianna S. Long, Ray A. Lucas, Shiying Lu, Elizabeth J. McGrath, Daniel H. McIntosh, Emiliano Merlin, Bahram Mobasher, Alexa M. Morales, Lorenzo Napolitano, Fabio Pacucci, Viraj Pandya, Marc Rafelski, Giulia Rodighiero, Caitlin Rose, Paola Santini, Lise-Marie Seillé, Raymond C. Simons, Lu Shen, Amber N. Straughn, Sandro Tacchella, Anthony J. Taylor, Brittany N. Vanderhoof, Jesús Vega-Ferrero, Benjamin J. Weiner, Christopher N. A. Willmer, Peixin Zhu, Eric F. Bell, Stijn Wuyts, Benne W. Holwerda, Xin Wang, Weichen Wang, Jorge A. Zavala, (CEERS collaboration)

“…As a legacy product for the community, the CEERS team has provided several data releases, accompanied by detailed notes on the data reduction procedures and notebooks to aid in reproducibility. …”
Get full text

Multidimensional perspectives of geo-epidemiology: from interdisciplinary learning and research to cost–benefit oriented decision-making by S. D. Smith, E. M. Geraghty, A. L. Rivas, F. O. Fasina, F. O. Fasina, M. Kosoy, L. Malania, A. L. Hoogesteijn, J. M. Fair

“…Research typically promotes two types of outcomes (inventions and discoveries), which induce a virtuous cycle: something suspected or desired (not previously demonstrated) may become known or feasible once a new tool or procedure is invented and, later, the use of this invention may discover new knowledge. …”
Get full text

Increased adenosine monophosphate–activated protein kinase activity in mice with physical exercise intervention: a systematic review by Suryanto Agung Prabowo, Junian Cahyanto Wibawa, Hamdani Hamdani, Nanang Indriarsa, Muchamad Arif Al Ardha, Taufiq Hidayat, Irmantara Subagio, Iwan Barata, Joseph Lobo, Novadri Ayubi

“…In this study, the standard operating procedure was evaluated using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). …”
Get full text

The effect of rotenone contamination on high-resolution mitochondrial respiration experiments by Dale F. Taylor, Jia Li, Nicholas J. Saner, Jia Wei, Xu Yan, Elizabeth G. Reisman, Hanzhe Li, Matthew J-C Lee, Navabeh Zare, Andrew Garnham, Jujiao Kuang, David J. Bishop

“…Future studies investigating mitochondrial respiratory function should assess the necessity of using inhibitors such as rotenone, ensure thorough wash procedures between experiments, and explicitly report the washing protocols used.…”
Get full text

Prediction of Pilot Performance During Startle Events Based on Neuropsychophysiological Features of Stress Resilience and Cognitive Task Scores by Mate Gambiraza, Sinisa Popovic, Matej Kurtak, Tanja Jovanovic, Seth Norrholm, Kresimir Cosic

“…Optimal neuropsychophysiological stress resilience features and cognitive task scores from Phase 1 were selected as predictors of pilot simulator performance in Phase 2 using multiple regression analysis (MRA) within a leave-one-out cross-validation (LOOCV) procedure. The obtained MRA models demonstrated significant predictive validity across left-out participants, as indicated by a Pearson correlation coefficient of 0.7039 (p =0.0034) between the actual and predicted simulator performance, with a mean absolute error (MAE) of 2.5457&#x00B0; versus a dummy median regressor MAE of 3.4881&#x00B0;. …”
Get full text