Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR by Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal

“…However, the high conservation of its orthosteric binding site poses significant challenges for drug development. …”
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Integrating formal surveys and local knowledge: Insights into the subterranean fauna of Apulia by Sarah Boulamail, Salvatore Inguscio, Sara Ventruti, Benedetta Barzaghi, Damiano Brognoli, Raffaele De Giorgi, Joachim Langeneck, Elia Lo Parrino, Emanuele Mancini, Raoul Manenti, Alejandro Martínez, Martina Pulieri, Emanuela Rossi, Francesco Cozzoli

“…In the Apulian region of Southern Italy, a biodiversity hotspot for subterranean life, the paucity of recent systematic surveys and reliance on expert knowledge poses both opportunities and challenges for ecological research. …”
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The COVID-19 Infection Did Not Aggravate the Mortality of Long-Term Care Facility Residents Under Strict Infection Control and with Immediate Anti-Viral Treatment: Real-World Analy... by Hideyasu Shimizu, Jin Kawase, Yuko Higashi, Hiroyuki Nabeno, Masamichi Hayashi, Kazuyoshi Imaizumi, Yuji Ito, Masaaki Matsunaga, Mitsushi Okazawa

“…Despite reduced virulence, Omicron’s high transmissibility poses ongoing risks. The effect of infection under strict control measures and early antiviral treatment remains unclear. …”
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Multi-layer feature fusion and attention-enhanced YOLOv9 for rapid field detection of greenhouse blueberry maturity at long and short distances by Ziwei Pan, Lei Xu, Wanjin Zhao, Cong Fan, Xihao Zhang, Weihui Chen, Yonglin Shen, Nengcheng Chen

“…Given the dense growth of blueberry plants and small fruit size, detecting blueberry maturity at long distances poses significant challenges. Therefore, this paper presents an improved algorithm, YOLOv9-MSAS, for detecting greenhouse blueberry maturity at long and short distances. …”
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A novel eco-friendly Acinetobacter strain A1-4-2 for bioremediation of aquatic pollutants by Rui Wang, Jiahua Wang, Ling Wang, Yulun Cai, Yuan Wang, Huifang Luo, Bing Chen, Junlv Chen, Jiasong Fang, Zengfu Song

“…Abstract The increasing accumulation of hydrocarbons and aromatic compounds in aquatic ecosystems, stemming from anthropogenic activities, poses severe ecological challenges, including disrupting biodiversity and threatening human health through the food chain. …”
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Process‐Based Atmosphere‐Hydrology‐Malaria Modeling: Performance for Spatio‐Temporal Malaria Transmission Dynamics in Sub‐Saharan Africa by Mame Diarra Bousso Dieng, Adrian M. Tompkins, Joël Arnault, Ali Sié, Benjamin Fersch, Patrick Laux, Maximilian Schwarz, Pascal Zabré, Stephen Munga, Sammy Khagayi, Ibrahima Diouf, Harald Kunstmann

“…Abstract With the goal of eradication by 2030, Malaria poses a significant health threat, profoundly influenced by meteorological and hydrological conditions. …”
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Tuberous Sclerosis Complex: New Insights into Pathogenesis and Therapeutic Breakthroughs by Aurora Alexandra Jurca, Alexandru Daniel Jurca, Codruta Diana Petchesi, Dan Bembea, Claudia Maria Jurca, Emilia Severin, Sanziana Jurca, Cosmin Mihai Vesa

“…Despite these advances, variability in disease expression poses challenges in diagnosis and individualized management strategies. …”
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Navigating Occupational Hazards: Musculoskeletal Disorders Among Slaughterhouse Workers in Brazil by Vando Aparecido Monteiro, Hercules Jose Marzoque, Marcelo Linon Batista, Maria do Carmo Baracho de Alencar, Lilian Dias Pereira, Irenilza de Alencar Nääs

“…(1) Background: The meatpacking industry in Brazil is vital for economic growth. It poses significant occupational health risks, particularly Work-Related Musculoskeletal Disorders (WMSDs). …”
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The Use of a New Benzothiadiazole Derivative for the Control of Cercospora Leaf Spot in Sugar Beet and Its Effect on the Yield by Agnieszka Kiniec, Maciej Spychalski, Rafal Kukawka, Katarzyna Pieczul, Adrian Zajac, Marcin Smiglak

“…Unfortunately, it is widely recognized that the use of PPPs poses a risk not only to the environment but also to human health. …”
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Assessment of heavy metal sources and health risks in soil-crop systems of fragmented farmland by Lei Tong, Aoran Yang, Mingyue Fan, Daikun Zheng, Ji Li, Hanlin Liu, Chenggen Li, Yongqiong Tang, Longfeng Cheng

“…Heavy metal contamination in agricultural ecosystems poses significant risks to human health. Metals accumulating in soil-crop systems can be absorbed and concentrated by crops. …”
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Early-life gut microbiome associates with positive vaccine take and shedding in neonatal schedule of the human neonatal rotavirus vaccine RV3-BB by Josef Wagner, Amanda Handley, Celeste M. Donato, Eleanor A. Lyons, Daniel Pavlic, Darren Suryawijaya Ong, Rhian Bonnici, Nada Bogdanovic-Sakran, Edward P. K. Parker, Christina Bronowski, Jarir At Thobari, Cahya Dewi Satria, Hera Nirwati, Desiree Witte, Khuzwayo C. Jere, Ashley Mpakiza, Emma Watts, Ann Turner, Karen Boniface, Jonathan Mandolo, Frances Justice, Naor Bar-Zeev, Miren Iturriza-Gomara, Jim P. Buttery, Nigel A. Cunliffe, Yati Soenarto, Julie E. Bines

“…RV3-BB vaccine administered in a neonatal schedule modulates the early microbiome environment and presents a window of opportunity to optimise protection from rotavirus disease.…”
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Self-Medication with NSAIDs in Gondar city: prevalence, predictors, and public health implications by Wondim Ayenew, Addisu Afrassa Tegegne, Gebremariam Genet, Liknaw Workie Limenh, Lamrot Yohannes, Abdulwase Mohammed Seid, Tekletsadik Tekleslassie Alemayehu, Wudneh Simegn

“…However, this practice poses significant public health risks, including gastrointestinal complications, renal impairment, and cardiovascular events. …”
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Beyond N-Grams: Enhancing String Kernels With Transformer-Guided Semantic Insights by Nazar Zaki, Reem Alderei, Mahra Alketbi, Alia Alkaabi, Fatima Alneyadi, Nadeen Zaki

“…The rapid advancements in large language models (LLMs) have led to the generation of sophisticated AI-produced texts, posing significant challenges in distinguishing machine-generated content from authentic human writing. …”
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Comparative study of Cd-free Cu(In,Ga)Se2 solar cells with amorphous In2O3:H and ZnO:Al front contact layers by Diego A Garzon, Marina Alves, Pedro Sousa, José Fonseca, Daniel Brito, Joaquim Carneiro, Sascha Sadewasser

“…However, the environmental and health concerns associated with the conventional use of toxic CdS buffer layers, along with the limitations posed by the conductivity of commonly used ZnO:Al (AZO), require further innovation for new alternatives. …”
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Practicing Surya Namaskar: A Sequence of Yogic Postures for Overall Health and Wellness among Healthy Adults by Nita Bandyopadhyay, Tuhin Das, Suvra Mondal

“…The objective of the present systematic review was to analyze the effect of SN on overall health and wellness of healthy adults. …”
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Service Innovation in the Twenty First Century by Ian Miles

“…Many manufacturing firms are coming to resemble traditional kinds of service-oriented firms; and many service firms are coming to be like traditional manufacturing firms. This poses difficulties for evaluating service innovation by exclusively one approach. …”
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Minimum PV curtailment for distribution networks based on moment difference analysis theory by Yi Wang, Junyong Wu

“…The high penetration of distributed photovoltaic (DPV) systems in distribution networks (DNs) can lead to a series of issues such as reverse power flows and voltage violations, posing a significant threat to the safe operation of DNs. …”
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Enhancing automated detection and classification of dementia in individuals with cognitive impairment using artificial intelligence techniques by Shoayee Dlaim Alotaibi, Abeer A. K. Alharbi

“…Abstract Dementia is a degenerative and chronic disorder, increasingly prevalent among older adults, posing significant challenges in providing appropriate care. …”
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Multifunctional PdH-hydride MOFs for synergistic hydrogen and photothermal antibacterial therapy in accelerated wound healing by Qing Wang, Daixing Zhang, Yining Qi, Changbao Huang, Dejun Ding, Chuanliang Liu, Chuanliang Liu

“…IntroductionThe growing threat of bacterial infections poses a critical challenge to public health, underscoring the urgent need for innovative antibacterial agents and therapeutic strategies. …”
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Inteligencia emocional y liderazgo en entidades farmacéuticas venezolanas by Gladys Aracelys Padrón López, Román Augusto Marriaga Zarate

“…El procesamiento de datos se realiza con estadísticas descriptivas, encontrando que el líder posee un nivel de inteligencia emocional muy alto, y una relación entre la misma y los niveles del liderazgo, positiva, de 0,78 con los niveles permiso y pináculo, 0,74 con desarrollo humano, 0,72 con producción y de 0,43 con posición.…”
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