Bridging the gap: how patient-derived lung cancer organoids are transforming personalized medicine by Chaoxing Liu, Chaoxing Liu, Chaoxing Liu, Chao Shi, Chao Shi, Chao Shi, Siya Wang, Rong Qi, Rong Qi, Rong Qi, Weiguo Gu, Weiguo Gu, Weiguo Gu, Feng Yu, Feng Yu, Guohua Zhang, Feng Qiu, Feng Qiu

“…Lung cancer is a major malignancy that poses a significant threat to human health, with its complex pathogenesis and molecular characteristics presenting substantial challenges for treatment. …”
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Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria by Carlos Serna, Bosco R. Matamoros, Mario Pulido-Vadillo, Jose F. Delgado-Blas, Rogier R. Jansen, Rob J. L. Willems, Alexandre Almeida, Ewan M. Harrison, Bruno Dupuy, Francesc Coll, Bruno Gonzalez-Zorn

“…Abstract The npmA gene, encoding a 16S rRNA methyltransferase, confers resistance to all clinically available aminoglycosides, posing a significant threat to effective antibiotic therapy. …”
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Integration of Edge-Lit Quantum Dot Coated Lightguides in Soft Smart Surfaces by Ravi Kishore, Jan Audenaert, Frederick Bossuyt, Pieter Bauwens, Bjorn Vandecasteele, Youri Meuret

“…However, embedding such lightguides into thin, flexible stacks poses significant challenges, particularly in maintaining total internal reflection due to the need for air gaps. …”
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High contamination of Salmonella spp. in raw milk in Ecuador: molecular identification of Salmonella enterica serovars Typhi, Paratyphi, Enteritidis and Typhimurium by Anthony Loor-Giler, Anthony Loor-Giler, Camila Sanchez-Castro, Marcela Robayo-Chico, Byron Puga-Torres, Silvana Santander-Parra, Luis Nuñez, Luis Nuñez

“…In Ecuador, the consumption of raw milk is fundamental, nonetheless it also presents risks due to the presence of Salmonella, a pathogen responsible for foodborne diseases (FBD). …”
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A Machine Learning Platform for Isoform-Specific Identification and Profiling of Human Carbonic Anhydrase Inhibitors by Lisa Piazza, Miriana Di Stefano, Clarissa Poles, Giulia Bononi, Giulio Poli, Gioele Renzi, Salvatore Galati, Antonio Giordano, Marco Macchia, Fabrizio Carta, Claudiu T. Supuran, Tiziano Tuccinardi

“…However, the high degree of structural similarity among isoforms poses a significant challenge for the design of selective inhibitors. …”
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<i>Rahnella aquatilis</i> Isolated from <i>Aedes albopictus</i> Impairs Mosquito Reproduction Capacity by Ling Gu, Lin Li, Jinyang Sun, Yongqiao Zhao, Kai Wan, Meichun Zhang, Julin Li, Meihua Zhang, Guoding Zhu, Jianxia Tang

“…<i>Aedes albopictus</i> is one of the most important vectors of Dengue, which poses a serious threat to public health. The bacterial microbiota has an effect on the parameters of mosquitos, such as larval development and fecundity, and it has emerged as a promising field to be explored for novel environmentally friendly control strategies. …”
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Evaluating the efficacy and acceptability of a digital-based management system for diabetes during pregnancy: protocol for an observational cohort study by Jin Yu, Hyun Sun Ko, Jae-Seung Yun, Byung Soo Kang, Kyuho Kim, Youn Ju Lee, Yoon-Hee Choi

“…Introduction Diabetes during pregnancy poses significant health risks for both mothers and their offspring and requires comprehensive management throughout pregnancy and the postpartum period. …”
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Current Perspectives on the Extraction, Isolation, and Identification of Fats and Fatty Acids Using Conventional and Green Methods by Ytaiara Lima-Pereira, Esther Maria Oliveira de Souza, David Silva dos Reis, Ian Gardel Carvalho Barcellos-Silva, Karine Sayuri Lima Miki, Valdir F. Veiga-Júnior, Barbara Elisabeth Teixeira-Costa

“…The global demand for oils and lipids, particularly those derived from vegetable sources with high polyunsaturated fatty acid content, has posed significant challenges for the food industry. …”
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Assessment of personality disorders in adolescents – a clinical validity and utility study of the structured interview of personality organization (STIPO) by C. Laczkovics, K. Czernin, A. Bründlmayer, M. Zeiler, W. Bangerl, C. Prause, P. L. Plener, S. Doering, V. Blüml, J. Carlitscheck, S. Bender, M. Krischer

“…Abstract Background The diagnosis of personality disorders (PD) in adolescence still poses a challenge. Early diagnosis and targeted intervention are called for, since patients with PD present with severe consequences in terms of psychosocial functioning and personal suffering including higher suicide risk. …”
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Protothecosis in Dogs: A Narrative Review by Tomasz Jagielski, Angelika Proskurnicka, Mateusz Iskra, Sylwia Wronka, Zofia Bakuła, Patrizia Danesi, Marconi Rodrigues deFarias, Fábio Vinícius Ramos Portilho, Márcio Garcia Ribeiro, Uwe Rösler, Rui Kano, Richard Malik

“…Based on this investigation, protothecosis in dogs can be defined as an emerging disease that poses a serious challenge to the veterinary profession in terms of both diagnosis and management. …”
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A high resolution spatial modelling framework for landscape-level, strategic conservation planning by T. Foxley, P. Lintott, S. Stonehouse, J. Flannigan, E.L. Stone

“…Development is needed to improve living standards globally but poses a threat to many species through habitat loss and fragmentation. …”
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Restrictive points of entry into abortion care in Ireland: a qualitative study of expectations and experiences with the service by Dyuti Chakravarty, Joanna Mishtal, Lorraine Grimes, Karli Reeves, Bianca Stifani, Deirdre Duffy, Mark Murphy, Mary Favier, Patricia Horgan, Wendy Chavkin, Antonella Lavelanet

“…Our findings also highlight the compounding challenges for migrants and additional barriers posed by the geographical distribution of the service and the 12-week gestational limit. …”
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A Transition to Discharge Program for the Reduction of Early Readmission in a Mental Health Inpatient Unit: Study Protocol by Vera Carbonell-Aranda, Yaiza García-Illanes, María Traverso-Rodríguez, Antonio Bordallo-Aragón, Berta Moreno-Kustner, José Guzmán-Parra, Jesús Herrera-Imbroda

“…Early readmission to psychiatric units poses a significant challenge for both patients and healthcare institutions. …”
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Photo-responsive polypropylene/zinc oxide/polydopamine-TEMPO composite membranes with light-induced self-sterilization by Huajie Wang, Hao Peng, Wenhao Ji, Jiaxin Wang, Xiaoyan Du, Wen Song, Wen Zhang, Fazli Wahid, Ali Raza

“…However, the capture of infection-sourced particles in face masks poses challenges related to reuse, necessitating proper disposal. …”
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Optimizing health workforce performance in reduced resources settings to sustain continuous improvement of patient outcomes: a retrospective, serial, cross-sectional analysis of a... by Massimo Migani, Kudakwashe Vambe, Rufaro J. Maisva, Federica Cavalieri, Claudio Bellavista, Theresia Dzagonga, Irene Chipuriro, Vasco Chikwasha, Paul F. Matsvimbo

“…Results from a retrospective serial cross-sectional analysis of 17 months of implementation of the approach are presented, with special focus on maternal and neonatal outcomes, to inspire future approach and expansion. …”
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Health Risk Assessment of Potentially Toxic Element Uptake by Lotus (<i>Nelumbo nucifera</i>) in Floating Lake Gardens by Mohssen Elbagory, Farahat S. Moghanm, Ibrahim Mohamed, Sahar El-Nahrawy, Alaa El-Dein Omara, Madhumita Goala, Pankaj Kumar, Boro Mioč, Željko Andabaka, Ivan Širić

“…Health risk assessment indicated that Cr posed the highest non-carcinogenic risk (HRI = 1.8000 in rhizomes). …”
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Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants by Hara Kang, Yun Ji Ga, Jung Won Kim, Chaeyeon Kim, Se-Hwan Son, Chaeeun Gwak, Jung-Yong Yeh

“…However, the emergence of viral escape mutants poses a major barrier to the sustained antiviral activity of siRNA-based therapy. …”
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Mitigating Bovine Mastitis and Raw Milk Pathogen Risks: Inhibition of <i>Staphylococcus xylosus</i> by Mediterranean Plants’ Essential Oil by Rosario De Fazio, Giacomo Di Giacinto, Paola Roncada, Domenico Britti, Rosangela Odore, Paola Badino, Cristian Piras

“…Milk is frequently susceptible to contamination by potential pathogens, posing risks to both food safety and public health. …”
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The role of seed transmission in the spread of cereal viruses: Global challenges and prevalent threats in Ukraine by Halyna Snihur, Tetiana Shevchenko, Oleksiy Shevchenko, Anhelina Kyrychenko

“…Hereby, the biological properties of these viruses, the risks posed by seed transmission, and the economic impact on crop production are discussed. …”
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Architecture of Ti–6Al–4V thin-walled microthrusters fabricated via laser powder bed fusion by Jeongrak Lee, Junghoon Lee, Rae Eon Kim, Seonghyeon Kim, Kyungtae Kim, Youngsam Kwon, Hongjae Kang, Gunsu Yun, Dongsik Kim, Anna Lee, Hyoung Seop Kim

“…While laser powder bed fusion (PBF-LB/M) enables the realisation of complex geometries, the application of PBF-LB/M to fabricate such devices has posed critical challenges, including dimensional inaccuracies, limited feature resolution, and process-induced defects that can compromise mechanical reliability and propulsion performance. …”
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