Acquired syphilis: update on clinical, diagnostic and therapeutic aspects by Carolina Talhari, Kaique Arriel, Marcio Soares Serra, John Verrinder Veasey

“…Despite being a secular disease, it still poses a major challenge for the public health system, since the number of cases continues to increase after years of warnings from the scientific community. …”
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Inflammatory disorders that affect the cerebral small vessels by Fei Han, Siyuan Fan, Bo Hou, Lixin Zhou, Ming Yao, Min Shen, Yicheng Zhu, Joanna M. Wardlaw, Jun Ni, Ting Gao

“…Unlike classical SVD, these inflammatory conditions exhibit unique clinical presentations, imaging patterns, and pathophysiological mechanisms, posing significant diagnostic and therapeutic challenges. …”
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The Figure-8 Crossing Line Technique for Arthroscopic Treatment of Acromioclavicular Joint Dislocation: A Technical Note by Songwen Ou, M.Med., Mingfeng Cui, B.Med., Pu Chen, B.Med., Mingzhou You, B.Med., Zifeng Wu, M.Med., Junmin Hong, M.Med., Jiande Meng, B.Med.

“…However, the procedure poses significant technical challenges, particularly regarding the creation of bone tunnels under arthroscopy. …”
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Laparoscopic Cholecystectomy in Situs Inversus Totalis: A Case Report by Prapti Lakhey, Milan Shrestha, Rishav Sharma, Paleswan Joshi Lakhey

“…Since the gallbladder is located in the left upper quadrant in this subset of patients, the diagnosis of symptomatic cholelithiasis poses a difficulty. Similarly, laparoscopic cholecystectomy in these patients is more demanding and presents technical challenges, especially for right‐handed surgeons. …”
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Gingival Melanin Depigmentation by 808 nm Diode Laser: Report of a Case by Jade Chagra, Adel Bouguezzi, Sameh Sioud, Hajer Hentati, Jamil Selmi

“…Gingival hyperpigmentation frequently poses an aesthetic problem, especially in patients with gingival smile. …”
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Menú a la carta para inestabilidad patelar recurrente by T. Pineda, D.H. Dejour

“…Abstract: Patellar instability is a complex and multifactorial problem that poses difficulties in treatment decision-making. …”
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A comprehensive review of dwell time optimization methods in computer-controlled optical surfacing by Tianyi Wang, Xiaolong Ke, Lei Huang, Qingqing Cui, Zili Zhang, Chunjin Wang, Hyukmo Kang, Weslin Pullen, Heejoo Choi, Daewook Kim, Vipender Negi, Qian Kemao, Yi Zhu, Stefano Giorgio, Philip Boccabella, Nathalie Bouet, Corey Austin, Mourad Idir

“…However, optimizing dwell time presents a challenge due to its ill-posed nature, resulting in non-unique solutions. …”
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Energy-Based Exploration for Reinforcement Learning of Underactuated Mechanical Systems by Jeroen Taets, Tom Lefebvre, Frederik Ostyn, Guillaume Crevecoeur

“…Reinforcement Learning (RL) for underactuated mechanical systems presents unique challenges due to the limited control inputs and complex dynamics of the system. …”
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Pediatric small intestine cavernous lymphangioma detected via wireless capsule endoscopy: a rare case report by Xiaoyu Yang, Xiaoyu Yang, Junwen Guan, Yi Zhang, Yi Zhang, Yi Zhang

“…The diagnosis of small intestinal cavernous lymphangioma poses significant clinical challenges. This case report presents the optimal diagnostic and therapeutic management of pediatric small intestinal cavernous lymphangioma.Case descriptionA 27-month-old male presented with recurrent syncopal episodes, hematochezia, and anemia. …”
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The Concept of the Person as “Subject” and “Place” of Morality According to Paul Ricoeur by Jarosław Sobkowiak

“… e concept of the subjectivity of a person presented in this article has shown that man as a subject appears in constant references and relations in which his existence is embedded. …”
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Learning Feature Fusion in Deep Learning-Based Object Detector by Ehtesham Hassan, Yasser Khalil, Imtiaz Ahmad

“…In this work, we present an object detection framework by learning-based fusion of handcrafted features with deep features. …”
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Acute Pancreatitis (A Clinical Case) by A. I. Khripun, A. N. Alimov, S. Yu. Orlov, T. P. Chelyapina

“…The diagnosis of acute pancreatitis poses no significant difficulties. Nonetheless, accurately predicting the potential severity of the disease during its early stages remains a challenge with existing diagnostic methods. …”
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Navigating coexistence: perspectives of host community and Syrian refugees in Al-Mafraq, Jordan by Palash Kamruzzaman, Najah Al-shanableh, Hanaa Albanna

“…The influx of Syrian refugees into Al Mafraq, Jordan poses complex challenges for the host community. …”
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The Lexicographic Treatment of Xitsonga Kinship Terminologies in Selected Bilingual Dictionaries by Respect Mlambo, Muzi Matfunjwa

“… Kinship terminologies, which vary across cultures and languages, present challenges for lexicographers in creating bilingual dictionaries. …”
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The Potential Return of the German Economy to the «Sick Man Of Europe» Status: Causes, Risks and Possible Implications by ANA-CRISTINA BÂLGĂR

“…Around a quarter of a century since Germany was labelled “the sick man of Europe” for the first time, the weak performances the federal economy experienced this year brought the country back to the centre of European and international debates regarding the likely risks posed by the possible lengthening or acceleration of the current cycle of economic decline. …”
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Transformation of traditional nomadic societies of the Caspian region in the context of socio-economic policy of the Soviet state in 1920–1930: the current state of the issue by E. N. Badmaeva, E. U. Omakaeva

“…At the present stage, the study of nomadic formations of the past arouses unflagging interest among Russian and foreign scientists. …”
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Cartas de crédito como medio de pago que genera confianza en el mundo de los negocios internacionales by Lucía Pico, Ricardo Rafael Coello Yagual

“… La presente investigación responde a un estudio de tipo descriptivo, cuyo objetivo es conocer la seguridad y confianza que proporcionan las cartas de crédito en las transacciones comerciales. …”
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RELIGION AND STATE IN THE EUROPEAN UNION by Joanna Kulska

“…The article aims to present the complex picture of Church-state relations in Europe in the context of the intensification of all-European debate on the place of religion in the European Union. …”
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Prohibition of Cross-Media Ownership as a Means of Limiting Media Concentration (on Example of R. Murdoch’s Companies “News Corp” and “XXI Century Fox” by R. Murdoch in Australia,... by Z. K. Nadirova

“…In the present work this problem is explored on the example of activity of the companies “News Corp” and “XXI Century Fox” owned by R. …”
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Cryo-EM ligand building using AlphaFold3-like model and molecular dynamics. by Nandan Haloi, Rebecca J Howard, Erik Lindahl

“…Using three inputs: 1) a protein amino acid sequence, 2) a ligand specification, and 3) an experimental cryo-EM map, we validated our approach on a set of biomedically relevant protein-ligand complexes including kinases, GPCRs, and solute transporters, none of which were present in the AI training data. In cases for which AI was not sufficient to predict experimental poses outright, integration of flexible fitting into molecular dynamics simulations improved ligand model-to-map cross-correlation relative to the deposited structure from 40-71% to 82-95%. …”
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