Development and validation of optimized lentivirus-like particles for gene editing tool delivery with Gag-Only strategy by Jinlin Jia, Yanzhe Hao, Lu Zhang, Xiaofang Cao, Lisha An, Hu Wang, Qi Ma, Xiaohua Jin, Xu Ma

“…However, the reverse transcriptase and integrase of Pol, pose risks of genomic integration and potential tumorigenesis. …”
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Improving Data Integrity in Samples Obtained From Web-Based Recruitment: Protocol for the Development of a Novel System for Assessing Participant Authenticity in a Remote Longitudi... by Chavez R Rodriguez, Maya Campbell, Erin E Bonar, Jason E Goldstick, Maureen A Walton, Lewei A Lin, Lara N Coughlin

“…However, in some cases, it can be particularly difficult to authenticate participants recruited remotely, which, unless adequately addressed, may pose a threat to data integrity and validity. …”
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Cellular S Values and DNA Damage Induced by 125I Auger Electron and Tritium β-rays by SHEN Jiangyan1, ZHU Kun1, LI Qing1, ZHANG Desong1, LI Junli2, 3, YAN Congchong1

“…Its decay emits β-rays, which pose significant harms to human health. Also, targeted radiotherapy utilizes the ability of ingested Auger electron emitters to enter cancer cells and the release Auger electrons to cause severe damage to DNA, thereby effectively killing cancer cells. …”

Multimodal cross-system virtual reality (VR) ball throwing dataset for VR biometricsGitHub by Mingjun Li, Natasha Kholgade Banerjee, Sean Banerjee

“…In this paper we present a multimodal cross-system dataset for virtual reality (VR) biometrics. …”
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Research progress and application prospect of hydrogen storage technology in underground space by Mincong WANG, Lei HOU, Xueting WANG, Muqingyun YANG, Zicong XU, Yueqi LIU, Shuyan ZHU

“…However, compared to depleted oil and gas reservoirs, salt caverns pose a lower risk of hydrogen leakage through the surrounding rock and result in smaller hydrogen losses due to geochemical and microbial reactions. …”
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Bacterial profile and antimicrobial susceptibility pattern of uropathogens among suspected patients attending Bule Hora University Teaching Hospital, southern Ethiopia by Alo Edin, Dagnamyelew Tilahun, Berhanu Adula Jara, Angefa Ayele

“…The predominant bacteria isolated was Escherichia coli (57.7%) followed by Klebsiella species (n = 9, 27.3%) and Proteus species (n = 3, 9.1%).ConclusionBacterial uropathogens, especially resistant strains of E. coli, pose a significant threat. Amoxicillin–clavulanic acid, trimethoprim–sulfamethoxazole, and ciprofloxacin were found to be ineffective against these strains. …”
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First large-scale assessment of pyrethroid resistance in Anopheles darlingi (Diptera: Culicidae) in Brazil (2021-2024): a crucial step in informing decision-making in malaria contr... by Quesia Santos Amorim, Cynara M. Rodovalho, Aline C. Loureiro, Priscila Serravale, Diogo F. Bellinato, Patrícia Guimarães, Vincent Corbel, Ademir J. Martins, José Bento Pereira Lima

“…Abstract Background Malaria continues to pose a significant public health threat in northern Brazil. …”
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Enhancing brain age estimation under uncertainty: A spectral-normalized neural gaussian process approach utilizing 2.5D slicing by Zeqiang Linli, Xingcheng Liang, Zhenhua Zhang, Kang Hu, Shuixia Guo

“…While deep learning is accurate in estimating brain age, the absence of uncertainty estimation may pose risks in clinical use. Moreover, current 3D brain age models are intricate, and using 2D slices hinders comprehensive dimensional data integration. …”
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An optimization based framework for water quality assessment and pollution source apportionment employing GIS and machine learning techniques for smart surface water governance by Abhijeet Das

“…Abstract Spatial evaluation of the region is associated with the assessment of the quality of water. Dump sites pose a significant threat to surface water resources due to the possibility of leachate contamination. …”
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Investigation into the microscopic mechanism underlying formation damage induced by the reinjection of oil-bearing wastewater by Chao Tang, Chao Tang, Chao Tang, Ke Du, Ke Du, Ke Du, Gongshuai Guan, Gongshuai Guan, Gongshuai Guan, Xiangfu Gai, Xiangfu Gai, Xiangfu Gai, Guo Li, Guo Li, Guo Li, Qingsong Li, Qingsong Li, Qingsong Li, Lichao Wang, Lichao Wang, Lichao Wang, Hongguang Guo, Hongguang Guo, Hongguang Guo, Wenping Sun, Wenping Sun, Wenping Sun, Chao Gao, Chao Gao, Chao Gao, Weiwei Xu, Weiwei Xu, Weiwei Xu, Zhuoyuan Lu, Junwei Su, Dengke Liu

“…However, certain treated waters contain a substantial number of suspended oil droplets, which can lead to the blockage of flow paths and pore channels. At present, there is a deficiency in experimental verification results regarding the reinjection of oily wastewater, and a lack of a reasonable explanation for the micro-mechanism underlying oil droplet migration. …”
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A comprehensive survey on big data privacy and Hadoop security: Insights into encryption mechanisms and emerging trends by Youness Filaly, Nisrine Berros, Fatna El mendili, Younes El Bouzekri EL idrissi

“…Additionally, we analyze new improvements like blockchain integration and post-quantum encryption, analyzing their potential to increase Hadoop security. …”
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Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway by Teng Sun, Jialei Li, Shuang Wang, Yu Han, Xiangyu Tao, Min Yuan, Zhijie Jing, Ting Liu, Yuehong Qi, Siqi Liu, Yanlin Feng, Jiasong Chang, Lan Zhou, Lijuan Gao, Jianyun Shi, Ruihong Ning, Jimin Cao

“…In exploring the underlying mechanisms, we found that Syt1 interacted with Parkin and promoted Parkin-catalyzed CypD ubiquitination, thus inhibited mitochondrial membrane permeability transition pore (mPTP) opening and ultimately suppressed cardiomyocyte necrosis. …”
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Label efficient phenotyping for Long COVID using electronic health records by Chuan Hong, Jun Wen, Harrison G. Zhang, Vidul Ayakulangara Panickan, Doris Y. Yang, Alicia W. Chen, Xin Xiong, Xuan Wang, Michele Morris, Sara Morini, Rahul Sangar, Andrew Dey, Malarkodi J. Samayamuthu, Katherine Liao, Clara-Lea Bonzel, Vidisha Tanukonda, Monika Maripuri, Jacqueline Honerlaw, Yuk-Lam Ho, Shyam Visweswaran, Isaac S. Kohane, Kelly Cho, Gabriel Brat, Zongqi Xia, Tianxi Cai

“…Abstract Long COVID poses a significant disease burden globally, but its heterogeneous presentation and unreliable coding practices render it difficult to study. …”
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Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets by Chetan Pundkar, Rex Jeya Rajkumar Samdavid Thanapaul, Manoj Govindarajulu, Gaurav Phuyal, Joseph B. Long, Peethambaran Arun

“…The results emphasize the therapeutic potential of melatonin in mitigating retinal damage and preserving visual function.…”
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Physicochemical stability, antioxidant and ACE-inhibitory activities of cryoprotected liposomes encapsulating stone fish-derived peptides by Shehu Muhammad Auwal, Chay Shyan Yea, Nazamid Saari

“…Zeta potential was higher in F3 (-42.00±4.96 mV) and F4 (-39.42±3.12 mV) than in F2 (-32.45±2.21 mV) at 25 °C post-storage, indicating greater electrostatic stability. …”
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Treatment options for secondary osteonecrosis of the knee in young adults (Systematic review and meta-analysis) by Vinay Joseph, Joseph Boktor, Stefan Bajada, Ben Coupe

“…The pooled analysis showed an improvement of pre-operative knee score from 50.47 to 89.21 post-operatively. The pooled effect size for failure rate was 8.7 % in joint preserving interventions and 9.2 % in joint replacement group. …”
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Fistula Tract Laser Closure (FiLac) versus Standard Fistulectomy in the Treatment of Simple Perianal Fistula: A Prospective Interventional Study by Shreethi Sasidharan Pillai, D Balaji, Harshwanth Chandhar, G Tilak Ramu, K Shanmugapriya

“…Introduction: Perianal fistulas pose significant challenges due to their impact on patient Quality of Life (QoL) and their recurrent nature. …”
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Ten-year Retrospective Chart Review of Postneonatal Tetanus at Semiurban Tertiary Care Teaching Hospital of Gujarat, Western India by Rajesh N Pankhaniya, Nili Mehta, Kapil Jetha, Krutika R Tandon

“…Trismus and spasms were present in all patients. Among other symptoms, difficulty in swallowing, fever, autonomic instability, and retention of urine/oliguria were present in 10, 8, 7, and 3 patients, respectively. …”
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The Differentiation–Integration Paradox of Hybrid Work: A Focus Group Exploration of Team and Individual Mechanisms by Elena Cristina Manole, Petru Lucian Curșeu, Sabina Ramona Trif

“…At the team level, hybrid work preserves structural differentiation across work locations, while preventing effective integration and coordination across team roles. …”
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Extratropical transition pathways of tropical cyclones and their associated storm intensity and destructiveness by Hung Ming Cheung, Chang-Hoi Ho, Jung-Eun Chu

“…Type 3, in contrast, preserves a relatively symmetric wind field throughout the transition and occurs in a more baroclinic environment. …”
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