The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical an... by Michael G. Fehlings, Karlo M. Pedro, Mohammed Ali Alvi, Ali Moghaddamjou, James S. Harrop, Ralph Stanford, Jonathon Ball, Bizhan Aarabi, Paul M. Arnold, James D. Guest, Shekar N. Kurpad, James M. Schuster, Ahmad N. Nassr, Karl M. Schmitt, Jefferson R. Wilson, Darrel S. Brodke, Faiz U. Ahmad, Albert Yee, Wilson Z. Ray, Nathaniel P. Brooks, Jason Wilson, Diana S-L. Chow, Elizabeth G. Toups, Kevin E. Thorpe, Jiaxin Huang, Peng Huang

“…This strategy fails to adequately capture the full impact of treatment in heterogenous neurological conditions like SCI. A more patient-centric analysis requires assessment of neurological function, functional capacity, and quality of life, incorporating meaningful patient-reported outcomes. …”
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The genomic and epigenomic landscape of iridocorneal endothelial syndrome by Yaoming Liu, Gen Li, Jiaxuan Jiang, Sujie Fan, Lan Lu, Ting Wang, Guigang Li, Wenzong Zhou, Xuequn Liu, Yingjie Li, Hong Sun, Liang Liang, Yuhong Tang, Yang Chen, Jianjun Gu, Fei Li, Xiuli Fang, Tao Sun, Aiguo Lv, Yayi Wang, Peiyuan Wang, Tao Wen, Jiayu Deng, Yuhong Liu, Mingying Lai, Jingni Yu, Danyan Liu, Hua Wang, Meizhu Chen, Li Li, Xiaodan Huang, Jingming Shi, Xu Zhang, Kang Zhang, Lingyi Liang, Xiulan Zhang

“…Among these, 45 recurrent hypomethylated regions (HMRs) in more than 10% of ICE patients showed differential methylation compared to normal controls. …”
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ROSA: An Andean Network of Social–Ecological Observatories by Julieta Carilla, Ricardo Grau, Oriana Osinaga Acosta, Agustina Malizia, Sergio Ceballos, Luis Daniel Llambí, María Piquer-Rodríguez, Lucía Zarbá, Saskia Flores, Francisco Cuesta, Tatiana Ojeda Luna, Wanderley Ferreira, Carolina Tovar, Yohana Jimenez, Ana Belén Hurtado-M, László Nagy, Erika Buscardo, Petra Wallem, Patricia Breuer, Vivien Bonnesoeur, Sophie Hebden, Nicolás Cuvi, Ezequiel Aráoz

“…Currently, ROSA consists of 8 nodal observatories, comprising more than 50 monitoring initiatives focused on hydroclimate, ecological, and land-use dimensions. …”
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Fusion genes in cancers: Biogenesis, functions, and therapeutic implications by Haiqiong Tang, Qiu Peng, Linda Oyang, Shiming Tan, Xianjie Jiang, Zongyao Ren, Xuemeng Xu, Mengzhou Shen, Haofan Li, Mingjing Peng, Longzheng Xia, Wenjuan Yang, Shizhen Li, Jiewen Wang, Yaqian Han, Nayiyuan Wu, Yanyan Tang, Jinguan Lin, Qianjin Liao, Yujuan Zhou

“…In recent years, the advent of sequencing technology and bioinformatics has led to the discovery of more fusion genes associated with specific types of tumors. …”
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SpecDis: Value Added Distance Catalog for 4 Million Stars from DESI Year-1 Data by Songting Li, Wenting Wang, Sergey E. Koposov, Ting S. Li, Youjia Wu, Monica Valluri, Joan Najita, Carlos Allende Prieto, Amanda Byström, Christopher J. Manser, Jiaxin Han, Carles G. Palau, Hao Yang, Andrew P. Cooper, Namitha Kizhuprakkat, Alexander H. Riley, Leandro Beraldo e Silva, Jessica Nicole Aguilar, Steven Ahlen, David Bianchi, David Brooks, Todd Claybaugh, Axel de la Macorra, John Della Costa, Arjun Dey, Peter Doel, Jaime E. Forero-Romero, Enrique Gaztañaga, Satya Gontcho A Gontcho, Gaston Gutierrez, Klaus Honscheid, Mustapha Ishak, Stephanie Juneau, Robert Kehoe, Theodore Kisner, Anthony Kremin, Martin Landriau, Laurent Le Guillou, Michael Levi, Marc Manera, Aaron Meisner, Ramon Miquel, John Moustakas, Nathalie Palanque-Delabrouille, Will Percival, Claire Poppett, Francisco Prada, Ignasi Pérez-Ràfols, Graziano Rossi, Eusebio Sanchez, David Schlegel, Michael Schubnell, Hee-Jong Seo, Joseph Harry Silber, David Sprayberry, Gregory Tarlé, Benjamin Alan Weaver, Rongpu Zhou, Hu Zou

“…We present the S pec D is value-added stellar distance catalog accompanying DESI Data Release 1. …”
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Analyzing Worn-Out Texture Regeneration from Urban Branding Perspective Using Structural Equation Modeling (SEM) (Case Study: Worn-Out Texture of Shahr-e-Kord) by Dvood Mahdavi, Ali Mohammadi Gojani, Waliullah Nazari

“…This component with a path coefficient of 0.508 explained a little more than half of the changes in urban regeneration. …”
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Effects of Supplementation of Synbiotic (DiPro Plus) on Growth Performance, Health Status, Skeletal parameters and Blood Parameters in Holstein Suckling Calves by Vahid Vahedi, Mehrab Hamdam, Taher Yalchi, Sayyad Seifzadeh

“…Synbiotics, a combination of prebiotics and probiotics, may offer synergistic health benefits, improving the survival and colonization of beneficial microorganisms in the GIT more effectively than either prebiotics or probiotics alone. …”
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Feasibility study of Learning Together for Mental Health: fidelity, reach and acceptability of a whole-school intervention aiming to promote health and wellbeing in secondary schoo... by Neisha Sundaram, Oliver Lloyd-Houldey, Joanna Sturgess, Elizabeth Allen, Semina Michalopoulou, Steven Hope, Rosa Legood, Stephen Scott, Lee D Hudson, Dasha Nicholls, Deborah Christie, Russell M Viner, Chris Bonell

“…We adapted Learning Together to develop Learning Together for Mental Health, which focuses more explicitly on improving mental health and well-being. …”
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CONVENTIONAL PRESSURE ANALYSIS FOR NATURALLY FRACTURED RESERVOIRS WITH TRANSITION PERIOD BEFORE AND AFTER THE RADIAL FLOW REGIME by Freddy-Humberto Escobar, Javier-Andrés Martinez, Matilde Montealegre-Madero

“…It is desirable, not only to appropriately identify these types of systems but also to complement the conventional analysis with the adequate expressions, to characterize such formations for a more comprehensive reservoir/well management. So far, the conventional methodology does not account for the equations for interpretation of pressure tests under the above two mentioned conditions. …”
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Effects of di(2-ethylhexyl) phthalate on glucose homeostasis in rats due to impaired autophagy flux of islet β cells mediated by oxidative stress by Hongyang ZHOU, Yuting HU, Xue CHEN, Yunqiang ZHOU, Liping LI, Ling LI, Herong LIU

“…In the 375 and 750 mg·kg−1 DEHP groups, the mitochondria were deformed to varying degrees, and some cristae structures disappeared, presenting vacuolization. Moreover, the chromatin condensation in the nuclei was more severe in the 750 mg·kg−1 DEHP group. …”
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Cosmogenic ³He dating of olivine with tightly retained mantle ³He, Volcano Mountain, Yukon by J. M. Mueller, J. D. Bond, K. A. Farley, B. C. Ward

“…The presence of such unusually small fluid inclusions may relate to the origin of the olivines as disaggregated peridotite xenoliths rather than the more commonly analyzed olivine phenocrysts. We circumvented this problem by step-heating powdered olivine in steps of 800, 1000, and 1400 °C. …”
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Effect of environmental factors and apple varieties on the pathogenic activity of virulent and attenuated Alternaria mali strains by CHEN Xingxu, ZHONG Xiaogang, JIA Xuli, XU Bingliang, ZHANG Shuwu

“…Within the temperature range from 20 ℃ to 30 ℃, disease severity was more pronounced after inoculation, with the virulent strain showing the highest pathogenic activity at 25 ℃, where the disease index reached 23.06 and the attenuated strain showing the highest activity at 30 ℃, with a disease index of 17.53. …”
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Rheumatoid Arthritis Prevention: catalysing PlatfORm Trial delivery (RAPPORT) by Michelle Bardgett, Marie Falahee, Gwenda Simons, John D Isaacs, Luke Ouma, James MS Wason, Arthur G Pratt

“…In addition, people’s risk of developing rheumatoid arthritis varies: a person at slightly increased risk might not want a drug that could cause side effects, but a person at very high risk might. More ‘personalised’ trial designs are therefore needed. …”
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Real-world experience with the diagnosis of bile acid malabsorption (BAM) using serum 7-alpha-C4 and 48-hour stool bile acids by G. Mendoza-Domínguez, Z.M. Garrido-Santos, C. Lau, R. Balbuena, A.D. Santana-Vargas, M. Schmulson-Wasserman

“…Lastly, BAM identified by 7αC4 was more frequent in patients with previous cholecystectomy (22.7%) vs. those without (3.8%). …”
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Mapping Antimicrobial Resistance in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> from Complicated Urinary Tract Infections in Oman: Phenotypic and Genotypic Insights by Nawal AL Shizawi, Zaaima AL Jabri, Fatima Khan, Hiba Sami, Turkiya AL Siyabi, Zakariya AL Muharrmi, Srinivasa Rao Sirasanagandla, Meher Rizvi

“…<i>K. pneumoniae,</i> however, was more susceptible to fluoroquinolones at 47% in comparison to <i>E. coli.…”
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Debut de leucemia linfoblástica aguda infantil con hipercalcemia maligna, presentación inusual: reporte de caso by Arenas-Camacho, Laura Daniela, Peña-Jiménez, Juan Camilo, Delgado-Beltrán, Angélica María, Obregón-Martínez, María del Pilar, Estupiñán-Perico, Diego Iván

“…Hypercalcemia of malignancy is one of the endocrinological oncological emergencies with a low incidence, which is more frequent in the adult population. So, it is not the first diagnostic impression to be considered in pediatrics, leading to delays in aetiological diagnosis and prognosis. …”
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Cognitive analysis of the development of human resource competencies in line with the Fourth Industrial Revolution by Habib Zare ahmadabadi, Sayed Heidar Mirfakhraddini, Fatemeh Zamzam, somayeh amirhosseini

“…The obtained findings indicate that the index of willingness of managers and owners of companies to move towards intelligentization and the creation of smart factories is more central than other measures, and as a result, more attention should be paid to it. …”
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Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation by Ang Lin, Sven Brandau, Stephan Lang, Luca Cassetta, Kirsten Bruderek, Joanna Skrzeczynska-Moncznik, Oktawia Osiecka, Xiaoying Hu, Ida Marie Rundgren, Kim Santegoets, Utku Horzum, Ana Godinho-Santos, Gennadiy Zelinskyy, Thalia Garcia-Tellez, Sunčica Bjelica, Bartłomiej Taciak, Astrid Olsnes Kittang, Benedikt Höing, Michael Dixon, Verena Müller, Jochen Sven Utikal, Derya Karakoç, Kerim Bora Yilmaz, Emilia Górka, Lubomir Bodnar, Olympia Evdoxia Anastasiou, Christine Bourgeois, Robert Badura, Monika Kapinska-Mrowiecka, Mirjana Gotic, Mark ter Laan, Esther Kers-Rebel, Magdalena Król, Juan Francisco Santibañez, Michaela Müller-Trutwin, Ulf Dittmer, Ana Espada de Sousa, Güneş Esendağlı, Gosse Adema, Karin Loré, Elisabeth Ersvær, Viktor Umansky, Jeffrey W Pollard, Joanna Cichy

“…PMN-MDSC expansion was more pronounced in cancer compared with infection and inflammation. …”
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Suitable concentrations of brassinolide application enhances growth performance and saikosaponin biosynthesis by transcriptional activation of triterpenoid pathway genes in Bupleur... by Shengwei Zhou, Shengwei Zhou, Shengwei Zhou, Shengwei Zhou, Linlin Yang, Linlin Yang, Linlin Yang, Linlin Yang, Jie Wan, Lu Chen, Lu Chen, Lu Chen, Lu Chen, Xupeng Gu, Xupeng Gu, Xupeng Gu, Xupeng Gu, Lu Qiao, Lu Qiao, Lu Qiao, Lu Qiao, Leixia Chu, Leixia Chu, Leixia Chu, Leixia Chu, Ning Dong, Ning Dong, Ning Dong, Ning Dong, Chengming Dong, Chengming Dong, Chengming Dong, Chengming Dong, Weisheng Feng, Weisheng Feng, Weisheng Feng, Weisheng Feng

“…In conclusion, the 0.2 mg/L BRs solution demonstrates a more pronounced regulatory impact on the synthesis of saikosaponin A and D. …”
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Clinical and radiological course of asymptomatic and hemodynamically stable moyamoya disease: a systematic review and meta-analysis by Yang Chen, Yang Chen, Yang Chen, Yang Chen, Zixuan Zhou, Zixuan Zhou, Zixuan Zhou, Zixuan Zhou, Bingyang Qin, Bingyang Qin, Bingyang Qin, Bingyang Qin, Yan Liang, Peize Li, Peize Li, Peize Li, Peize Li, Ziao Li, Ziao Li, Ziao Li, Ziao Li, Yu Chen, Yu Chen, Ren Li, Ren Li, Ren Li, Ren Li, Biao Yang, Biao Yang, Biao Yang, Biao Yang, Xiaogang Wang, Xiaogang Wang, Xiaogang Wang, Xiaogang Wang, Yongqiang Wu, Yongqiang Wu, Yongqiang Wu, Yongqiang Wu, Xiaolong Guo, Xiaolong Guo, Xiaolong Guo, Xiaolong Guo, Huidong Zhang, Geng Guo, Geng Guo, Geng Guo, Geng Guo

“…Revascularization did not show a protective effect on TIA and radiological progression for AMMD.ConclusionAMMD and HSMMD present a concerning risk of clinical and radiological progression over a follow-up period of more than 2 years. …”
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