Mice mucosal leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ T cell response by Alisson Amaral Da-Rocha, Alisson Amaral Da-Rocha, Júlio Souza Dos-Santos, Júlio Souza Dos-Santos, Igor Santos Bittencourt, Igor Santos Bittencourt, Douglas B. De-Almeida, Douglas B. De-Almeida, Naiara Carla dos Santos Manhães, Naiara Carla dos Santos Manhães, Hozany Praxedes, Hozany Praxedes, João Victor Paiva Romano, João Victor Paiva Romano, Elias Barbosa da Silva-Junior, Antônio José da Silva-Gonçalves, Marcia Pereira Oliveira, Luciana Polaco Covre, Daniel Claudio de Oliveira Gomes, Alda Maria Da-Cruz, Alda Maria Da-Cruz, Alessandra Marcia da Fonseca-Martins, Alessandra Marcia da Fonseca-Martins, Herbert Leonel de Matos Guedes, Herbert Leonel de Matos Guedes

“…Six weeks post infection, mice presented edema in the nasal and premaxillary region, with progressive growth until twelve weeks. …”
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MSA-3D: Dissecting Galaxies at z ∼ 1 with High Spatial and Spectral Resolution by Ivana Barišić, Tucker Jones, Kris Mortensen, Themiya Nanayakkara, Yuguang Chen, Ryan Sanders, James S. Bullock, Kevin Bundy, Claude-André Faucher-Giguère, Karl Glazebrook, Alaina Henry, Mengting Ju, Matthew Malkan, Takahiro Morishita, Danail Obreschkow, Namrata Roy, Juan M. Espejo Salcedo, Alice E. Shapley, Tommaso Treu, Xin Wang, Kyle B. Westfall

“…Here we describe the multiplexed slit-stepping method, which is >15 times more efficient than the NIRSpec IFS mode for our program. …”
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The ALMA Survey of Gas Evolution of PROtoplanetary Disks (AGE-PRO). II. Dust and Gas Disk Properties in the Ophiuchus Star-forming Region by Dary A. Ruiz-Rodriguez, Camilo González-Ruilova, Lucas A. Cieza, Ke Zhang, Leon Trapman, Anibal Sierra, Paola Pinilla, Ilaria Pascucci, Laura M. Pérez, Dingshan Deng, Carolina Agurto-Gangas, John Carpenter, Benoît Tabone, Giovanni P. Rosotti, Rossella Anania, James Miley, Kamber Schwarz, Aleksandra Kuznetsova, Miguel Vioque, Nicolas Kurtovic

“…Furthermore, the C ^18 O and C ^17 O lines present a larger radial extension than disk dust sizes by factors ranging from ∼1.5 to ∼2.5, as is found for Class II disks using the radial extension of the ^12 CO. …”
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Promise and Peril: Stellar Contamination and Strict Limits on the Atmosphere Composition of TRAPPIST-1 c from JWST NIRISS Transmission Spectra by Michael Radica, Caroline Piaulet-Ghorayeb, Jake Taylor, Louis-Philippe Coulombe, Björn Benneke, Loic Albert, Étienne Artigau, Nicolas B. Cowan, René Doyon, David Lafrenière, Alexandrine L’Heureux, Olivia Lim

“…Here we present the 0.6–2.85 μ m transmission spectrum of the 1.1 R _⊕ ,  ∼ 340 K rocky planet TRAPPIST-1 c obtained over two JWST NIRISS/SOSS transit observations. …”
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The heterogeneity of genomic alterations, metastatic patterns and immune microenvironment in metastatic ovarian cancer originating from colorectal cancer by Chao Chen, Chao Chen, Jian Wang, Binjie Sun, Yuyan Zheng, Yuyan Zheng, Xiaoxu Ge, Xiaoxu Ge, Zhiyuan Gong, Zhiyuan Gong, Haochen Gu, Zhiwei Zhang, Zhiwei Zhang, Akao Zhu, Yingkuan Shao, Yeting Hu, Lijia Ma, Yini Li, Kefeng Ding, Kefeng Ding, Da Wang, Lifeng Sun

“…The subtypes of CRCOM with USP7 mutation, more copy number alterations, lower neoantigens, and immunoscore have a worse prognosis.…”
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Effectiveness of digital interventions for eight mental disorders: A meta-analytic synthesis by Mathias Harrer, Clara Miguel, Lingyao Tong, Paula Kuper, Antonia A. Sprenger, Yuki Furukawa, Yingying Wang, Wouter van Ballegooijen, Marketa Ciharova, Olga M. Panagiotopoulou, Ioana Cristea, Jessica L. Hamblen, Paula P. Schnurr, Heleen Riper, Marit Sijbrandij, Eirini Karyotaki, Annemieke van Straten, Toshi A. Furukawa, Davide Papola, Stefan Leucht, Pim Cuijpers

“…Rising industry involvement may present both opportunities and new challenges for the field.…”
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The X-Ray Luminous Type Ibn SN 2022ablq: Estimates of Preexplosion Mass Loss and Constraints on Precursor Emission by C. Pellegrino, M. Modjaz, Y. Takei, D. Tsuna, M. Newsome, T. Pritchard, R. Baer-Way, K. A. Bostroem, P. Chandra, P. Charalampopoulos, Y. Dong, J. Farah, D. A. Howell, C. McCully, S. Mohamed, E. Padilla Gonzalez, G. Terreran

“…While similar to the prototypical Type Ibn SN 2006jc in the optical, SN 2022ablq is roughly an order of magnitude more luminous in the X-rays, reaching unabsorbed luminosities L _X ∼ 4 × 10 ^40 erg s ^−1 between 0.2–10 keV. …”
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Depletion of regulatory T cells enhances the T cell response induced by the neoantigen vaccine with weak immunogenicity by Ruichen Huang, Qiao Zhou, Jiajun Liu, Yang Xia, Yang Jiao, Bi Zhao, Tangtao Feng, Haosu Zhou, Xiuyan Song, Hao Qin, Jun Wang, Lan Cheng, Yunye Ning, Qinying Sun, Yanfang Liu, Xiaoping Su, Yuchao Dong, Wei Zhang

“…Besides, compared to the Vac group, more neoantigen-targeted and TAA-targeted T cells were detected in the combinational group by TCR sequencing. …”
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Association between tinnitus and hearing impairment among older adults with age-related hearing loss: a multi-center cross-sectional study by Zhifeng Chen, Zhifeng Chen, Zhifeng Chen, Yan Lu, Yan Lu, Chenyu Chen, Chenyu Chen, Shaolian Lin, Shaolian Lin, Ting Xie, Xiaoyang Luo, Xiaoyang Luo, Yanchun Lin, Yanchun Lin, Yuqing Chen, Yuqing Chen, Yong Feng, Guanxia Xiong, Xiulan Ma, Chaojun Zeng, Chaojun Zeng, Chaojun Zeng, Chang Lin, Chang Lin, Chang Lin

“…On the contrary, tinnitus is associated with better hearing in the male elderly with ARHL. More extensive longitudinal studies are needed to give a comprehensive insight of the present findings and the underlying mechanisms.…”
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Lessons learned from a multimodal sensor-based eHealth approach for treating pediatric obsessive-compulsive disorder by Carolin S. Klein, Carolin S. Klein, Karsten Hollmann, Karsten Hollmann, Jan Kühnhausen, Jan Kühnhausen, Annika K. Alt, Annika K. Alt, Anja Pascher, Anja Pascher, Lennart Seizer, Lennart Seizer, Jonas Primbs, Winfried Ilg, Annika Thierfelder, Björn Severitt, Helene Passon, Ursula Wörz, Heinrich Lautenbacher, Wolfgang A. Bethge, Johanna Löchner, Johanna Löchner, Martin Holderried, Walter Swoboda, Enkelejda Kasneci, Martin A. Giese, Christian Ernst, Gottfried M. Barth, Gottfried M. Barth, Annette Conzelmann, Annette Conzelmann, Annette Conzelmann, Michael Menth, Caterina Gawrilow, Caterina Gawrilow, Tobias J. Renner, Tobias J. Renner

“…With eHealth interventions, therapy can be delivered in a patient's home environment, leading to a more ecologically valid symptom assessment and access to experts even in rural areas. …”
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Comprehensive analysis of culture-negative periprosthetic joint infection with metagenomic next-generation sequencing by Lan Lin, Lan Lin, Lan Lin, Jiayu Li, Jiayu Li, Jiayu Li, Canhong Zhang, Juncheng Li, Juncheng Li, Juncheng Li, Baijian Wu, Baijian Wu, Baijian Wu, Zida Huang, Zida Huang, Zida Huang, Jianhua Lv, Mingzhong Liu, Wenbo Li, Wenbo Li, Wenbo Li, Wenming Zhang, Wenming Zhang, Wenming Zhang, Xinyu Fang, Xinyu Fang, Xinyu Fang

“…However, no significant difference was noted in reinfection rates between the two groups (P=0.412).ConclusionCN PJI presents a unique microbial spectrum and distinct clinical therapeutic characteristics. mNGS offers a more comprehensive understanding of infecting microorganisms, particularly those often missed by conventional culture techniques. …”
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A reference equation for peak oxygen uptake for cycle ergometry in Chinese adult participants by Jinan Wang, Chuan Ren, Shunlin Xu, Yifang Yuan, Yanxin Song, Dingding Xie, Kexin Wang, Lei Yuan, Tao Shen, Ling Xu, Yida Tang, Wei Gao, Wei Zhao

“…Compared to existing equations, the PUTH equation shows reduced bias and improved accuracy, providing a more reliable tool for assessing CRF and guiding clinical interventions in the Chinese population.…”
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Spinal muscular atrophy is also a disorder of spermatogenesis by Armelle Magot, Arnaud Reignier, Olivier Binois, Anne Laure Bedat-Millet, Jean-Baptiste Davion, Louise Debergé, Karima Ghorab, Lucie Guyant, Émilie Laheranne, Pascal Laforet, Claire Lefeuvre, Martial Mallaret, Maud Michaud, Chahla Omar, Aleksandra Nadaj-Pakleza, Guillaume Nicolas, Jean Baptiste Noury, Antoine Pegat, Morgane Péré, Emmanuelle Salort-Campana, Guilhem Sole, Marco Spinazzi, Céline Tard, Carole Vuillerot, Yann Péréon

“…Among the patients with available spermograms, 81% (27/33) had abnormal sperm concentration; 30% presented azoospermia. These abnormalities were significantly associated with SMA type (more prevalent in SMA2 patients, p < 0·001), disease motor severity, which included age at the loss of walking ability and wheelchair use duration (p < 0·001). …”
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Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular... by Louis Bherer, Louis Bherer, Louis Bherer, Tudor Vrinceanu, Emma Gabrielle Dupuy, Emma Gabrielle Dupuy, Mathieu Gayda, Thomas Vincent, Pierre-Olivier Magnan, Pierre-Olivier Magnan, Hanieh Mohammadi, Claudine Gauthier, Claudine Gauthier, Christine Gagnon, Simon Duchesne, Kirk I. Erickson, Daniel Gagnon, Frédéric Lesage, Sonia Lupien, Judes Poirier, Marie-Pierre Dubé, Éric Thorin, Martin Juneau, Juliana Breton, Sylvie Belleville, Sylvie Belleville, Guylaine Ferland, Guylaine Ferland, Flavie Gaudreau-Majeau, Flavie Gaudreau-Majeau, Caroll-Ann Blanchette, Caroll-Ann Blanchette, Paolo Vitali, Anil Nigam, Anil Nigam

“…Meta-analyses suggest that longer intervention studies of around 1 year are more likely to show cognitive improvements and changes in brain biomarkers. …”
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Valor de alguns exames complementares na Coréia de Sydenha by Aron J. Diament

“…In concluding, the attempt to characterize Sydenham's chorea by means of some laboratory serum examinations showed that: 1) The classical "acute phase serum reagents" (sedimentation rate, blood count, Weltmann reaction, C reactive protein and mucoproteins) were not conclusive for this purpose; 2) the "acute phase serum reagents" that presented the greatest alterations in Sydenham's chorea were copper and ceruloplasmin, electrophoresis of serum proteins (alpha-2 and gamma globulin fractions) and antistreptolysin-O; 3) the "acute phase serum reagents" when evaluated separately were of little value, but it is quite possible that two or more taken altogether could, in certain instances of the evolution of the disease, characterize "an infectious and/or inflammatory stage"; 4) eosinophilia was observed in a high percentage of cases (81.66%) requiring further studies for confirmation purposes; 5) the correlation of the various "acute phase serum reagents" studied among them and in comparison with other determined parameter (magnesium, sulphur, and EEGs) did not show statistical significance, not only when comparing the three initial groups, but also in its totality, facts that may suggest a unitarian pathogeny for Sydenham's chorea; 6) a high percentage of hypomagnesemia was found (86.84%) although at not too low levels; 7) sulphur was high in 71.79% of the cases. …”
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Developing of the Pattern of Revising the Elementary School math Curriculum based on Fullan's Approach by Reza Jafariharandi

“…The aim of the current research was to present the model of the elementary school math curriculum based on Fulen's approach. …”
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Valor de alguns exames complementares na Coréia de Sydenha The value of some laboratorial data in Sydenham's chorea by Aron J. Diament

“…In concluding, the attempt to characterize Sydenham's chorea by means of some laboratory serum examinations showed that: 1) The classical "acute phase serum reagents" (sedimentation rate, blood count, Weltmann reaction, C reactive protein and mucoproteins) were not conclusive for this purpose; 2) the "acute phase serum reagents" that presented the greatest alterations in Sydenham's chorea were copper and ceruloplasmin, electrophoresis of serum proteins (alpha-2 and gamma globulin fractions) and antistreptolysin-O; 3) the "acute phase serum reagents" when evaluated separately were of little value, but it is quite possible that two or more taken altogether could, in certain instances of the evolution of the disease, characterize "an infectious and/or inflammatory stage"; 4) eosinophilia was observed in a high percentage of cases (81.66%) requiring further studies for confirmation purposes; 5) the correlation of the various "acute phase serum reagents" studied among them and in comparison with other determined parameter (magnesium, sulphur, and EEGs) did not show statistical significance, not only when comparing the three initial groups, but also in its totality, facts that may suggest a unitarian pathogeny for Sydenham's chorea; 6) a high percentage of hypomagnesemia was found (86.84%) although at not too low levels; 7) sulphur was high in 71.79% of the cases. …”
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The Activity of Influenza Viruses during 2017-2018 Season in Russia and Countries of the Northern Hemisphere: Conflict by the B-virus Vaccine Component by D. K. Lvov, E. I. Burtseva, E. A. Mukasheva, L. V. Kolobukhina, S. V. Trushakova, N. V. Breslav, E. L. Feodoritova, L. N. Merkulova, K. G. Krasnoslobotsev, E. O. Morozova, I. T. Fedyakina, A. V. Aristova, R. V. Vartanian, L. B. Kisteneva, A. G. Prilipov, S. V. Alkhovsky, A. G. Rosatkevich, I. S. Kruzhkova, A. L. Belyaev, E. V. Axselrod, M. V. Bazarova, S. V. Smetanina

“…Recommendations on the influenza vaccines composition for the Northern hemisphere for 2019-2020 season are presented as well.…”
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Analysis and Prioritization of Indicators of Urban Development Strategy In the neighborhoods of the eight district of Shiraz by Issa Ebrahimzadeh, Mostafa Istgaldi, Fazel Hajizadeh

“…In the banking index, the numerical mean of "security infrastructure" and "communication infrastructure" is more than the set value of the test, that is, the number 3. …”
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Designing a Model of Maintenance and Sustainability of Expert Human Resources in the Government Organization Province with a Meta-combination Method by Majedreza Dahmardehkemmak, Vahid Pourshahabi, Amin Reza Kamalian, Habibollah Salarzehi

“…Abstract The issue of maintaining expert human resources in less developed areas is of high sensitivity and it is necessary for managers to identify and solve the current and future problems of organizations in the field of maintaining elites with a comprehensive view and architecture of critical points, the present research aims to present The pattern of maintenance and sustainability of expert human resources has been done with a hybrid method. …”
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