Repurposing statins for the treatment of larval cestodiases: in silico evaluation of statin-HMG-CoA reductase interactions and assessment of statin effects on a cestode model by Marina Monteiro Guedes, Jeferson Camargo de Lima, Jéssica Andrade Paes, María del Pilar Cevasco Contreras, Ana María Celentano, Arnaldo Zaha, Karina Mariante Monteiro, Mara Cecilia Rosenzvit, Henrique Bunselmeyer Ferreira

“…A survey for HMG-CoA reductase encoding genes showed that they are present in a single copy in the genomes of parasitic helminths and their mammal hosts. …”
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Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicentre prospective observational cohort study in Japan by Alan Kawarai Lefor, Takayuki Ogura, Kunihiko Takahashi, Kensuke Nakamura, Toru Kotani, Daisuke Taniguchi, Daisuke Kasugai, Keibun Liu, Yasunari Morita, Kenji Fujizuka, Takai Chihiro, Kenzo Ishii, Daisetsu Yasumura, Tomohiro Hamagami, Nobutake Shimojo, Masakazu Nitta, Takashi Hongo, Kazuki Akieda, Maeda Atsuo, Tadashi Kaneko, Yutaka Sakuda, Kohkichi Andoh, Akiyoshi Nagatomi, Yukiko Tanaka, Yuhei Irie, Hiroshi Kamijo, Manabu Hanazawa, Matsuoka Ayaka, Kenji Oike, Hajime Katsukawa

“…All consecutive patients between 1 November 2020 and 30 April 2022, who are 18 years old or older and expected to stay in an ICU for more than 48 hours due to sepsis or septic shock, are enrolled. …”
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EarthRanger: An open‐source platform for ecosystem monitoring, research and management by Jake Wall, Jes Lefcourt, Chris Jones, Chris Doehring, Dan O'Neill, Dennis Schneider, Jordan Steward, Joshua Krautwurst, Tiffany Wong, Bruce Jones, Karen Goodfellow, Ted Schmitt, Kathleen Gobush, Iain Douglas‐Hamilton, Frank Pope, Eric Schmidt, Jonathan Palmer, Emma Stokes, Andrea Reid, L. Mark Elbroch, Peter Kulits, Catherine Villeneuve, Victor Matsanza, Geoff Clinning, Jordi vanOort, Kristen Denninger Snyder, Alina Peter Daati, Wesley Gold, Stephen Cunliffe, Batian Craig, Barry Cork, Grant Burden, Marc Goss, Nathan Hahn, Sarah Carroll, Eric Gitonga, Ray Rao, Jared A. Stabach, Frédéric Dulude‐de Broin, Patrick Omondi, George Wittemyer

“…Abstract Effective approaches are needed to conserve the planet's remaining wildlife and wilderness landscapes, especially concerning global biodiversity conservation targets. Here, we present a new software system called EarthRanger: an open‐source platform built to help monitor, research and manage ecosystems. …”
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Barium Abundances of Common Stars in the Gaia-ESO Survey and the LAMOST Medium-resolution Survey by Tian-Yi Chen, Jian-Rong Shi, Hong-Liang Yan, Shuai Liu, Chun-Qian Li, Xiao-Jin Xie, Ze-Ming Zhou, Yao-Jia Tang, Ming-Yi Ding

“…The NLTE corrections present opposite signs around [Fe/H] = −2.0 dex for the Ba ii line at λ 5853. …”
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Urban environment and health: a cross-sectional multiregional project based on population health surveys in Spain (DAS-EP project) – study protocol by Andrés Cabrera-León, Antonio Daponte, Marc Saez, Katherine Pérez, María Rueda, Ferran Ballester, Ana Esplugues, Aitana Lertxundi, Laia Font-Ribera, Laura Oliveras, Marina Lacasaña, Marisa Estarlich, Mikel Subiza-Pérez, Ainhoa Bereziartua, Gonzalo García-Baquero, Salvador Delís Gomez, Antonio Merelles, Maria Angeles Irles, Carmen Barona, Rosa Mas, X Bartoll, Anne-Claire Binter, Leticia García Mochon, Helena García Cortés, María del Carmen Sánchez-Cantalejo Garrido, Rocío Cáceres

“…This study focuses on the population living in cities or metropolitan areas with more than 100 000 inhabitants. UrbEEs are described by objective estimates at participants’ home addresses by GIS, and subjective indicators present in PHS. …”
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Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

“…Dissemination will be via publications, conference presentations, newsletter articles, social media, talks to clinicians and consumers and meetings with health departments/managers.It is expected that communication of results will allow for the development of more effective evidence-based exercise prescription guidelines in this population while investigating the benefits of HIIT and POWER on subclinical markers of disease.Trial registration number ACTRN12617001440314 Australian New Zealand Clinical Trials Registry.…”
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Effects and formula optimization of Rosa roxbunghii pomace substrate on the yield and volatile flavor compounds of Lentinulaedodes by Tingfei Deng, Tingfei Deng, Liangqun Li, Liangqun Li, Chunyan Li, Chunyan Li, Yanfang Yan, Yanfang Yan, Anqin Gao, Xiaolan Liu, Xiaolan Liu, Xiong Pan, Xiong Pan, Ming Gao, Ming Gao, Lijuan Ge, Lijuan Ge, Mei Peng, Mei Peng, Zhongsheng Luo, Zhongsheng Luo, Yan Tian, Juan Yang, Juan Yang, Xiaosheng Yang, Xiaosheng Yang

“…The optimal formulation (30% RRP) not only supported maximum productivity but also contributed to a more desirable aroma profile. This study presents an innovative and sustainable approach to repurposing agricultural waste, adding value to both mushroom production and resource utilization.…”
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Ice-nucleating particles active below −24 °C in a Finnish boreal forest and their relationship to bioaerosols by F. Vogel, F. Vogel, M. P. Adams, L. Lacher, P. B. Foster, G. C. E. Porter, G. C. E. Porter, B. Bertozzi, B. Bertozzi, K. Höhler, J. Schneider, T. Schorr, N. S. Umo, J. Nadolny, Z. Brasseur, P. Heikkilä, E. S. Thomson, N. Büttner, M. I. Daily, R. Fösig, A. D. Harrison, J. Keskinen, U. Proske, U. Proske, U. Proske, J. Duplissy, J. Duplissy, M. Kulmala, T. Petäjä, O. Möhler, B. J. Murray

“…This study should motivate further work to establish whether the commonality in bioaerosol ice-nucleating properties between spring in Finland and summer in Colorado is more generally applicable to different coniferous forest locations and times and also to determine to what extent these bioaerosols are transported to locations where they may affect clouds.…”
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Metal-strong Inflows at the Outer-galactic-scale of a Quasar by Qiguo Tian, Lei Hao, Yipeng Zhou, Xiheng Shi, Tuo Ji, Peng Jiang, Lin Lin, Zhenya Zheng, Hongyan Zhou

“…Such a relatively rare system may hold important clues to understanding the baryonic cycling of galaxies, and more cases could be picked out using relatively strong Si iv and weak Lyman absorption lines.…”
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High-resolution Observations of an X6.4 Solar Flare in the Mid-infrared by Xu Yang, Wenda Cao, Meiqi Wang, Don Jennings, Jiong Qiu, Wen He, Solomon M. Perriyil, Vasyl Yurchyshyn, Lyndsay Fletcher, Paulo J. A. Simões, Murzy Jhabvala, Allen Lunsford, Xingyao Chen, Hugh Hudson

“…We present a unique observation of the X6.4-class flare SOL2024-02-22T22:34 using the Mid-InfraRed Imager (MIRI) at the Goode Solar Telescope. …”
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Risk factors associated with low bone mineral density and childhood osteoporosis in a population undergoing skeletal growth: a cross-sectional analytic study by Berta Magallares, Berta Magallares, Berta Magallares, Dacia Cerdá, Jocelyn Betancourt, Jocelyn Betancourt, Gloria Fraga, Gloria Fraga, HyeSang Park, HyeSang Park, Helena Codes-Méndez, Helena Codes-Méndez, Estefanía Quesada-Masachs, Estefanía Quesada-Masachs, Mireia López-Corbeto, Montserrat Torrent, Ana Marín, Silvia Herrera, Silvia Herrera, Ignasi Gich, Ignasi Gich, Ignasi Gich, Susana Boronat, Susana Boronat, Jordi Casademont, Jordi Casademont, Jordi Casademont, Héctor Corominas, Héctor Corominas, Jorge Malouf

“…Up to 10.5% of children with risk factors present LBMca and 4.8% have an undiagnosed or unknown cOP. …”
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Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages by Jingyun Yang, Xuemei He, Huashan Shi, Cai He, Hong Lei, Heng He, Li Yang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Zhenling Wang, Guangwen Lu, Jiong Li, Yuquan Wei

“…Abstract The newly emerged variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) demonstrate resistance to present therapeutic antibodies as well as the capability to evade vaccination-elicited antibodies. …”
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Multicentre pragmatic embedded stepped wedge cluster randomised trial comparing glucose 5% with sodium chloride 0.9% as the default drug diluent in the ICU: the sweet-water trial p... by Alexander Zarbock, Kai-Uwe Eckardt, Claudia Spies, Felix Balzer, Martin Witzenrath, Philipp Enghard, Björn Tampe, Oliver Hunsicker, Steffen Weber-Carstens, Bjoern Weiss, Jens Nee, Christian Strauss, Heiko Schenk, Jan-Hendrik Bernhard Hardenberg, Ricarda Merle Hinz, Mareen Pigorsch, Alexander Uhrig, Holger Müller-Redetzky, Tim Schroeder, Ulrike Trost, Daniel Zickler, Rainer Borgstedt, Mariam Abu-Tair, Uta Hildebrand, Dario von Wedel

“…The results will be submitted for publication in a peer-reviewed journal and presented at one or more scientific conferences.Trial registration number The trial protocol was registered with the German Clinical Trials Register on 21 June 2024 prior to initiation of patient enrolment (DRKS00033397).…”
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Source apportionment of PM10 based on offline chemical speciation data at 24 European sites by Xiansheng Liu, Xun Zhang, Bowen Jin, Tao Wang, Siyuan Qian, Jin Zou, Vy Ngoc Thuy Dinh, Jean-Luc Jaffrezo, Gaëlle Uzu, Pamela Dominutti, Sophie Darfeuil, Olivier Favez, Sébastien Conil, Nicolas Marchand, Sonia Castillo, Jesús D. de la Rosa, Stuart Grange, Christoph Hueglin, Konstantinos Eleftheriadis, Evangelia Diapouli, Manousos-Ioannis Manousakas, Maria Gini, Silvia Nava, Giulia Calzolai, Célia Alves, Marta Monge, Cristina Reche, Roy M. Harrison, Philip K. Hopke, Andrés Alastuey, Xavier Querol

“…Crustal sources were present at all sites (3–33%). Industrial sources contributed relatively less PM10 mass, which was identified at 10 sites with contributions ranging from 2% to 14%. …”
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Genomic and clinical characterization of pediatric lymphoepithelioma-like carcinoma by Yi Que, Xiuxia Lu, Suying Lu, Feifei Sun, Jia Zhu, Yu Zhang, Juan Wang, Junting Huang, Wei Liu, Fenghua Wang, Liping Li, Li Zhang, Min Gao, Zijun Zhen, Yizhuo Zhang

“…The mutational landscape of pediatric LELC presented more genes mutated in pathways associated with immune, DNA repair, cell cycle and NOTCH. …”
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El patrimoni educatiu, element d'una pedagògia cultural i ciutadana Educational Heritage: Culture and Citizenship in Education El patrimonio educativo, elemento de una pedagogía cu... by Isabel Carrillo, Eulàlia Collelldemont Pujadas, Pedro Luís Moreno

“…El present article desenvolupa els eixos de pensament que s’estan elaborant des de diferents angles sobre el patrimoni educatiu. …”
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Investigating the hatchability and nauplii biometry of Artemia franciscana in unconventional waters of Sistan region, Southeast Iran by Hashem Khandan Barani, Abdolali Rahdari, Narjes Sanchooli, Ali Khosravanizadeh

“…Materials and methods: The present study was carried out in the Laboratory of Reproduction and Breeding Aquatic Animals, Hamoun International Wetland Research Institute located in Zabol Research Institute in February 2024. …”
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Critical discourse analysis of “Rostam and Esfandiyar” story of Ferdowsi’s Shahnameh based on Van Dijk’s (2006) ideological square by Abbas Ali Ahangar, Saeid Oveisi Kahkha

“…On the contrary, if the significance rate is more than 0.05, then the frequency application of such a strategy is not significant.  …”
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Familial hypercholesterolemia in Chinese children and adolescents: a multicenter study by Meng-Na Huang, Chen-Cen Wang, Ming-Sheng Ma, Mei-Zhu Chi, Qing Zhou, Li-Hong Jiang, Chun-Lin Wang, Mei Lu, Xiao-Quan Chen, Ya-Ying Cheng, Qing Ke, Da-Yan Wang, Xiao-Xia Qian, Xiao-Ming Ying, Jian-Ping Zhang, Qun-Hua Shen, Li-Fang Liu, Rui Gu, Zhen-Jie Zhang, Jian-Hua Feng, Min Wang, Ming-Qiang Zhu, Ke Huang, Jun-Fen Fu, Chao‑Chun Zou

“…Furthermore, the older age at diagnosis and treatment highlights the underdiagnosis and undertreatment of Chinese FH pediatric patients, suggesting that early identification should be improved through lipid or genetic screening, and that more timely and regular pharmacological treatments should be implemented.…”
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Clinical and epidemiological characteristics of influenza and SARS-CoV-2 virus among patients with acute febrile illness in selected sites of Ethiopia 2021–2022 by Musse Tadesse Chekol, Musse Tadesse Chekol, David Sugerman, Adamu Tayachew, Adamu Tayachew, Zelalem Mekuria, Neamin Tesfay, Aynalem Alemu, Aynalem Alemu, Andargachew Gashu, Andargachew Gashu, Wolde Shura, Melaku Gonta, Admikew Agune, Aster Hailemariam, Yonas Assefa, Mesfin Wossen, Abdulhafiz Hassen, Parsons Michele, Rachel Silver, Hulemenaw Delelegn, Lozano Briana, Tesfu Kasa, Nigatu Kebede

“…Per the multivariable analysis, cases ≥65 years of age were three [AOR = 3.3,95% CI:(1.9–5.7)] times more likely to be positive for SARS-CoV-2.ConclusionSARS-CoV-2 and influenza viruses were highly prevalent among AFI cases. …”
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